The Biology Behind:

The Prognostic and Predictive Values of ECD-HER-2

William N. Hait
Clin Cancer Res 2001 7: 2601 [Abstract] [Full Text] [PDF]  

Editorials:

Is Circulating HER-2 More Than Just a Tumor Marker?

Jose Baselga
Clin Cancer Res 2001 7: 2605 [Full Text] [PDF]  

Prostaglandin E Synthase: Another Enzyme in the Cyclooxygenase Pathway Driving Epithelial Cancer?

Jonathan M. Kurie and Raymond N. Dubois
Clin Cancer Res 2001 7: 2608 [Full Text] [PDF]  

Minireviews:

Practical Guidelines for the Management of Biochemotherapy-related Toxicity in Melanoma

Antonio C. Buzaid and Michael Atkins
Clin Cancer Res 2001 7: 2611 [Abstract] [Full Text] [PDF]  

Review:

Advances in Aromatase Inhibition: Clinical Efficacy and Tolerability in the Treatment of Breast Cancer

Aman Buzdar and Anthony Howell
Clin Cancer Res 2001 7: 2620 [Full Text] [PDF]  

Advances in Brief:

PTEN Mutation Located Only Outside Exons 5, 6, and 7 Is an Independent Predictor of Favorable Survival in Endometrial Carcinomas

Takeo Minaguchi, Hiroyuki Yoshikawa, Katsutoshi Oda, Tomomi Ishino, Toshiharu Yasugi, Takashi Onda, Shunsuke Nakagawa, Koji Matsumoto, Kei Kawana, and Yuji Taketani
Clin Cancer Res 2001 7: 2636 [Abstract] [Full Text] [PDF]  

HER-2/neu (p185neu) Protein Expression in the Natural or Treated History of Prostate Cancer

Iman Osman, Howard I. Scher, Marija Drobnjak, David Verbel, Michael Morris, David Agus, Jeffrey S. Ross, and Carlos Cordon-Cardo
Clin Cancer Res 2001 7: 2643 [Abstract] [Full Text] [PDF]  

Comprehensive Allelotyping of Human Intrahepatic Cholangiocarcinoma

Hirohito Momoi, Hiroshi Okabe, Tatsuhiko Kamikawa, Seiji Satoh, Iwao Ikai, Masayuki Yamamoto, Akira Nakagawara, Yasuyuki Shimahara, Yoshio Yamaoka, and Manabu Fukumoto
Clin Cancer Res 2001 7: 2648 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Tamoxifen Modulates the Expression of Ki67, Apoptosis, and Microvessel Density in Cervical Cancer

Gabriella Ferrandina, Franco O. Ranelletti, Luigi M. Larocca, Nicola Maggiano, Erika Fruscella, Francesco Legge, Giuseppe Santeusanio, Alessandro Bombonati, Salvatore Mancuso, and Giovanni Scambia
Clin Cancer Res 2001 7: 2656 [Abstract] [Full Text] [PDF]  

Virus-directed, Enzyme Prodrug Therapy with Nitroimidazole Reductase: A Phase I and Pharmacokinetic Study of its Prodrug, CB1954

Guy Chung-Faye, Daniel Palmer, David Anderson, Joanna Clark, Mandy Downes, Joanna Baddeley, Syed Hussain, Philip I. Murray, Peter Searle, Leonard Seymour, Peter A. Harris, David Ferry, and David J. Kerr
Clin Cancer Res 2001 7: 2662 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

Inducible Prostaglandin E Synthase Is Overexpressed in Non-Small Cell Lung Cancer

Kazuhiko Yoshimatsu, Nasser K. Altorki, Dragan Golijanin, Fan Zhang, Per-Johan Jakobsson, Andrew J. Dannenberg, and Kotha Subbaramaiah
Clin Cancer Res 2001 7: 2669 [Abstract] [Full Text] [PDF]  

High Plasma Basic Fibroblast Growth Factor Concentration Is Associated with Response to Thalidomide in Progressive Multiple Myeloma

Kai Neben, Thomas Moehler, Gerlinde Egerer, Alwin Kraemer, Jens Hillengass, Axel Benner, Anthony D. Ho, and Hartmut Goldschmidt
Clin Cancer Res 2001 7: 2675 [Abstract] [Full Text] [PDF]  

Fas Ligand Expression by Neoplastic T Lymphocytes Mediates Elimination of CD8+ Cytotoxic T Lymphocytes in Mycosis Fungoides: A Potential Mechanism of Tumor Immune Escape?

Xiao Ni, Parul Hazarika, Chunlei Zhang, Rakhashandra Talpur, and Madeleine Duvic
Clin Cancer Res 2001 7: 2682 [Abstract] [Full Text] [PDF]  

Interleukin 8 Is an Autocrine Growth Factor and a Surrogate Marker for Kaposi’s Sarcoma

Rizwan Masood, Jie Cai, Anil Tulpule, Tong Zheng, Ann Hamilton, Sanjai Sharma, Byron M. Espina, D. Lynne Smith, and Parkash S. Gill
Clin Cancer Res 2001 7: 2693 [Abstract] [Full Text] [PDF]  

Circulating HER-2/erbB-2/c-neu (HER-2) Extracellular Domain as a Prognostic Factor in Patients with Metastatic Breast Cancer: Cancer and Leukemia Group B Study 8662

Daniel F. Hayes, Hideko Yamauchi, Gloria Broadwater, Constance T. Cirrincione, Stephen P. Rodrigue, Donald A. Berry, Jerry Younger, Lawrence L. Panasci, Frederick Millard, David B. Duggan, Larry Norton, and I. Craig Henderson
Clin Cancer Res 2001 7: 2703 [Abstract] [Full Text] [PDF]  

Minichromosome Maintenance Protein 2 Expression in Prostate: Characterization and Association with Outcome after Therapy for Cancer

Maxwell V. Meng, Gary D. Grossfeld, Gareth H. Williams, Stephen Dilworth, Kai Stoeber, Thaddeus W. Mulley, Vivian Weinberg, Peter R. Carroll, and Thea D. Tlsty
Clin Cancer Res 2001 7: 2712 [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor and Cellular Chemotaxis: A Possible Autocrine Pathway in Adult T-Cell Leukemia Cell Invasion

Toshihisa Hayashibara, Yasuaki Yamada, Takayuki Miyanishi, Hiroyuki Mori, Tatsuroh Joh, Takahiro Maeda, Naoki Mori, Tetsuo Maita, Shimeru Kamihira, and Masao Tomonaga
Clin Cancer Res 2001 7: 2719 [Abstract] [Full Text] [PDF]  

Molecular Detection of Prostate Cancer in Urine by GSTP1 Hypermethylation

Paul Cairns, Manel Esteller, James G. Herman, Mark Schoenberg, Carmen Jeronimo, Montserrat Sanchez-Cespedes, Nan-Haw Chow, Marc Grasso, Li Wu, William B. Westra, and David Sidransky
Clin Cancer Res 2001 7: 2727 [Abstract] [Full Text] [PDF]  

Prostate Epithelium-derived Ets Transcription Factor mRNA Is Overexpressed in Human Breast Tumors and Is A Candidate Breast Tumor Marker and A Breast Tumor Antigen

Ali Ghadersohi and Ashwani K. Sood
Clin Cancer Res 2001 7: 2731 [Abstract] [Full Text] [PDF]  

Clinical Characteristics of Prostate Cancer in an Analysis of Linkage to Four Putative Susceptibility Loci

Ellen L. Goode, Janet L. Stanford, Mette A. Peters, Marta Janer, Mark Gibbs, Suzanne Kolb, Michael D. Badzioch, Leroy Hood, Elaine A. Ostrander, and Gail P. Jarvik
Clin Cancer Res 2001 7: 2739 [Abstract] [Full Text] [PDF]  

The Accumulation of Angiostatin-like Fragments in Human Prostate Carcinoma

Toshiro Migita, Yoshinao Oda, Seiji Naito, Wataru Morikawa, Michihiko Kuwano, and Masazumi Tsuneyoshi
Clin Cancer Res 2001 7: 2750 [Abstract] [Full Text] [PDF]  

Prognostic Impact of Proteolytic Factors (Urokinase-Type Plasminogen Activator, Plasminogen Activator Inhibitor 1, and Cathepsins B, D, and L) in Primary Breast Cancer Reflects Effects of Adjuvant Systemic Therapy

Nadia Harbeck, Uta Alt, Ursula Berger, Achim Krüger, Christoph Thomssen, Fritz Jänicke, Heinz Höfler, Ronald E. Kates, and Manfred Schmitt
Clin Cancer Res 2001 7: 2757 [Abstract] [Full Text] [PDF]  

Frequent Hypermethylation of the 5' CpG Island of E-Cadherin in Esophageal Adenocarcinoma

Paul G. Corn, Elisabeth I. Heath, Richard Heitmiller, Franz Fogt, Arlene A. Forastiere, James G. Herman, and Tsung-Teh Wu
Clin Cancer Res 2001 7: 2765 [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor Expression and Activation in Nonseminomatous Germ Cell Tumors

Mauro Moroni, Silvio Veronese, Roberta Schiavo, Ornella Carminati, Boe S. Sorensen, Marcello Gambacorta, and Salvatore Siena
Clin Cancer Res 2001 7: 2770 [Abstract] [Full Text] [PDF]  

Reduction of p12^DOC-1 Expression Is a Negative Prognostic Indicator in Patients with Surgically Resected Oral Squamous Cell Carcinoma

Satoru Shintani, Mariko Mihara, Nagaaki Terakado, Yuuji Nakahara, Tomohiro Matsumura, Yohko Kohno, Hiroe Ohyama, Jim McBride, Ralph Kent, Randy Todd, Takanori Tsuji, and David T. W. Wong
Clin Cancer Res 2001 7: 2776 [Abstract] [Full Text] [PDF]  

Variations in 5-Fluorouracil Concentrations of Colorectal Tissues as Compared with Dihydropyrimidine Dehydrogenase (DPD) Enzyme Activities and DPD Messenger RNA Levels

Motoko Tanaka-Nozaki, Masahiko Onda, Noritake Tanaka, and Shunji Kato
Clin Cancer Res 2001 7: 2783 [Abstract] [Full Text] [PDF]  

The Early Growth Response Gene EGR-1 Behaves as a Suppressor Gene That Is Down-Regulated Independent of ARF/Mdm2 but not p53 Alterations in Fresh Human Gliomas

Antonella Calogero, Antonietta Arcella, Giorgia De Gregorio, Antonio Porcellini, Dan Mercola, Chaoting Liu, Vincenza Lombari, Massimo Zani, Giuseppe Giannini, Franco Maria Gagliardi, Riccardo Caruso, Alberto Gulino, Luigi Frati, and Giuseppe Ragona
Clin Cancer Res 2001 7: 2788 [Abstract] [Full Text] [PDF]  

Genetic Alterations in TP53 in Recurrent Urothelial Cancer: A Longitudinal Study

Guido Dalbagni, Zhi-Ping Ren, Harry Herr, Carlos Cordon-Cardo, and Victor Reuter
Clin Cancer Res 2001 7: 2797 [Abstract] [Full Text] [PDF]  

Isolation of Human Antibodies against the Central DNA Binding Domain of p53 from an Individual with Colorectal Cancer Using Antibody Phage Display

David W. J. Coomber and Robyn L. Ward
Clin Cancer Res 2001 7: 2802 [Abstract] [Full Text] [PDF]  

Image Analysis of Microvessel Surface Area Predicts Radiosensitivity in Early-Stage Laryngeal Carcinoma Treated with Radiotherapy

Tomoyuki Kamijo, Tomoyuki Yokose, Takahiro Hasebe, Hiroyuki Yonou, Ryuichi Hayashi, Satoshi Ebihara, and Atsushi Ochiai
Clin Cancer Res 2001 7: 2809 [Abstract] [Full Text] [PDF]  

Overexpression of HRad17 mRNA in Human Breast Cancer: Correlation with Lymph Node Metastasis

Akemi Kataoka, Noriaki Sadanaga, Koshi Mimori, Hiroaki Ueo, Graham F. Barnard, Keizo Sugimachi, Daniel Auclair, Lan Bo Chen, and Masaki Mori
Clin Cancer Res 2001 7: 2815 [Abstract] [Full Text] [PDF]  

Detection of Epithelial Messenger RNA in the Plasma of Breast Cancer Patients Is Associated with Poor Prognosis Tumor Characteristics

Jose M. Silva, Gemma Dominguez, Javier Silva, Jose M. Garcia, Antonio Sanchez, Oscar Rodriguez, Mariano Provencio, Pilar España, and Felix Bonilla
Clin Cancer Res 2001 7: 2821 [Abstract] [Full Text] [PDF]  

Thrombospondin-1 and -2 Messenger RNA Expression in Invasive Cervical Cancer: Correlation with Angiogenesis and Prognosis

Junichi Kodama, Ichiro Hashimoto, Noriko Seki, Atsushi Hongo, Mitsuo Yoshinouchi, Hiroyuki Okuda, and Takafumi Kudo
Clin Cancer Res 2001 7: 2826 [Abstract] [Full Text] [PDF]  

Prevalence of a Common Point Mutation in the Dihydropyrimidine Dehydrogenase (DPD) Gene within the 5'-Splice Donor Site of Intron 14 in Patients with Severe 5-Fluorouracil (5-FU)- related Toxicity Compared with Controls

Martin Raida, Wolfgang Schwabe, Peter Häusler, André B. P. Van Kuilenburg, Albert H. Van Gennip, Detlev Behnke, and Klaus Höffken
Clin Cancer Res 2001 7: 2832 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Treatment with Low-Dose Interferon- Restores the Balance between Matrix Metalloproteinase-9 and E-Cadherin Expression in Human Transitional Cell Carcinoma of the Bladder

Joel W. Slaton, Takashi Karashima, Paul Perrotte, Keiji Inoue, Sun J. Kim, Jonathan Izawa, Daniel Kedar, David J. McConkey, Randall Millikan, Paul Sweeney, Chiaki Yoshikawa, Taro Shuin, and Colin P. N. Dinney
Clin Cancer Res 2001 7: 2840 [Abstract] [Full Text] [PDF]  

Targeting of Cytotoxic Somatostatin Analog AN-238 to Somatostatin Receptor Subtypes 5 and/or 3 in Experimental Pancreatic Cancers

Karoly Szepeshazi, Andrew V. Schally, Gabor Halmos, Baodong Sun, Francine Hebert, Balazs Csernus, and Attila Nagy
Clin Cancer Res 2001 7: 2854 [Abstract] [Full Text] [PDF]  

Augmentation of Antitumor Activity of an Antibody-Interleukin 2 Immunocytokine with Chemotherapeutic Agents

Sylvia A. Holden, Yan Lan, Ana Maria Pardo, John S. Wesolowski, and Stephen D. Gillies
Clin Cancer Res 2001 7: 2862 [Abstract] [Full Text] [PDF]  

Bone Marrow-derived Cells Contribute to Tumor Neovasculature and, When Modified to Express an Angiogenesis Inhibitor, Can Restrict Tumor Growth in Mice

Andrew M. Davidoff, Catherine Y. C. Ng, Peggy Brown, Margaret A. Leary, William W. Spurbeck, Junfang Zhou, Edwin Horwitz, Elio F. Vanin, and Arthur W. Nienhuis
Clin Cancer Res 2001 7: 2870 [Abstract] [Full Text] [PDF]  

Effect of Progesterone on the Invasive Properties and Tumor Growth of Progesterone Receptor-transfected Breast Cancer Cells MDA-MB-231

Valerie C. L. Lin, Aw Swee Eng, Ng Eng Hen, Esther H. L. Ng, and Sanaul H. Chowdhury
Clin Cancer Res 2001 7: 2880 [Abstract] [Full Text] [PDF]  

Synergistic Inhibition of Human Lung Cancer Cell Growth by Adenovirus-mediated Wild-Type p53 Gene Transfer in Combination with Docetaxel and Radiation Therapeutics in Vitro and in Vivo

Masahiko Nishizaki, Raymond E. Meyn, Lawrence B. Levy, Edward N. Atkinson, R. Allen White, Jack A. Roth, and Lin Ji
Clin Cancer Res 2001 7: 2887 [Abstract] [Full Text] [PDF]  

Role of the Raf Signal Transduction Cascade in the in Vitro Resistance to the Anticancer Drug Doxorubicin

Caroline R. Weinstein-Oppenheimer, Carlos F. Henríquez-Roldán, Julianne M. Davis, Patrick M. Navolanic, Oussama A. Saleh, Linda S. Steelman, Richard A. Franklin, Penni J. Robinson, Martin McMahon, and James A. McCubrey
Clin Cancer Res 2001 7: 2898 [Abstract] [Full Text] [PDF]  

Sensitivity of Soft Tissue Sarcoma Cell Lines to Chemotherapeutic Agents: Identification of Ecteinascidin-743 as a Potent Cytotoxic Agent

Wei Wei Li, Naoto Takahashi, Suresh Jhanwar, Carlos Cordon-Cardo, Yaroslav Elisseyeff, Jose Jimeno, Glynn Faircloth, and Joseph R. Bertino
Clin Cancer Res 2001 7: 2908 [Abstract] [Full Text] [PDF]  

Expression of ß-Tubulin Isotypes in Human Ovarian Carcinoma Xenografts and in a Sub-Panel of Human Cancer Cell Lines from the NCI-Anticancer Drug Screen: Correlation with Sensitivity to Microtubule Active Agents

Maria Ines Nicoletti, Giorgio Valoti, Paraskevi Giannakakou, Zhirong Zhan, Jon-Hyeok Kim, Valeria Lucchini, Fabio Landoni, Joseph G. Mayo, Raffaella Giavazzi, and Tito Fojo
Clin Cancer Res 2001 7: 2912 [Abstract] [Full Text] [PDF]  

Pharmacokinetic/Pharmacodynamic Study of ZD9331, a Nonpolyglutamatable Inhibitor of Thymidylate Synthase, in a Murine Model Following Two Curative Administration Schedules

G. Wynne Aherne, Anthea Hardcastle, Emma Ward, Donna Dobinson, Thomas Crompton, Melanie Valenti, Lisa Brunton, and Ann L. Jackman
Clin Cancer Res 2001 7: 2923 [Abstract] [Full Text] [PDF]  

Cancer Biology, Immunology, Cytokines:

Soluble Type II Transforming Growth Factor-ß (TGF-ß) Receptor Inhibits TGF-ß Signaling in COLO-357 Pancreatic Cancer Cells in Vitro and Attenuates Tumor Formation

Melissa A. Rowland-Goldsmith, Haruhisa Maruyama, Toshiyuki Kusama, Sonia Ralli, and Murray Korc
Clin Cancer Res 2001 7: 2931 [Abstract] [Full Text] [PDF]  

Prostate Cancer Cells (LNCaP) Generated after Long-Term Interleukin 6 (IL-6) Treatment Express IL-6 and Acquire an IL-6 Partially Resistant Phenotype

Alfred Hobisch, Reinhold Ramoner, Dietmar Fuchs, Sonia Godoy-Tundidor, Georg Bartsch, Helmut Klocker, and Zoran Culig
Clin Cancer Res 2001 7: 2941 [Abstract] [Full Text] [PDF]  

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