Editorials:

Lung Cancer Prevention: Retinoids and the Epidermal Growth Factor Receptor—A Phoenix Rising?

Steven D. Averbuch
Clin Cancer Res 2002 8: 1 [Full Text] [PDF]  

Membrane Transport of Chemotherapeutics and Drug Resistance: Beyond the ABC Family of Exporters to the Role of Carrier-mediated Processes

I. David Goldman
Clin Cancer Res 2002 8: 4 [Full Text] [PDF]  

Mechanisms Underlying Chemoprevention of Ovarian Cancer

Gordon B. Mills
Clin Cancer Res 2002 8: 7 [Abstract] [Full Text] [PDF]  

Special Article:

Cancer Prevention: Past, Present, and Future

Robert C. Young and Christine M. Wilson
Clin Cancer Res 2002 8: 11 [Abstract] [Full Text] [PDF]  

The Biology Behind:

The Potential Prognostic, Predictive, and Therapeutic Values of DNA Methylation in Cancer : Commentary re: J. Kwong et al., Promoter Hypermethylation of Multiple Genes in Nasopharyngeal Carcinoma. Clin. Cancer Res., 8: 131–137, 2002, and H-Z. Zou et al., Detection of Aberrant p16 Methylation in the Serum of Colorectal Cancer Patients. Clin. Cancer Res., 8: 188–191, 2002.

Martin Widschwendter and Peter A. Jones
Clin Cancer Res 2002 8: 17 [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

The Multidrug Resistance Transporter ABCG2 (Breast Cancer Resistance Protein 1) Effluxes Hoechst 33342 and Is Overexpressed in Hematopoietic Stem Cells

Min Kim, Heth Turnquist, John Jackson, Magda Sgagias, Ying Yan, Maokai Gong, Michael Dean, John G. Sharp, and Kenneth Cowan
Clin Cancer Res 2002 8: 22 [Abstract] [Full Text] [PDF]  

Diagnostic and Prognostic Implications of Circulating Cell-free Epstein-Barr Virus DNA in Natural Killer/T-Cell Lymphoma

Kenny I. K. Lei, Lisa Y. S. Chan, Wing-Yee Chan, Philip J. Johnson, and Y. M. Dennis Lo
Clin Cancer Res 2002 8: 29 [Abstract] [Full Text] [PDF]  

Microsatellite Analysis of Free Tumor DNA in Urine, Serum, and Plasma of Patients: A Minimally Invasive Method for the Detection of Bladder Cancer

Michael Utting, Wolfram Werner, Regine Dahse, Jörg Schubert, and Kerstin Junker
Clin Cancer Res 2002 8: 35 [Abstract] [Full Text] [PDF]  

Identification and Characterization of a Human Agonist Cytotoxic T-Lymphocyte Epitope of Human Prostate-specific Antigen

Hiroshi Terasawa, Kwong-Yok Tsang, James Gulley, Philip Arlen, and Jeffrey Schlom
Clin Cancer Res 2002 8: 41 [Abstract] [Full Text] [PDF]  

Evidence for the Epidermal Growth Factor Receptor As a Target for Lung Cancer Prevention

Fulvio Lonardo, Konstantin H. Dragnev, Sarah J. Freemantle, Yan Ma, Natalie Memoli, David Sekula, Elisabeth A. Knauth, Jean S. Beebe, and Ethan Dmitrovsky
Clin Cancer Res 2002 8: 54 [Abstract] [Full Text] [PDF]  

Patterns of Elevation of Plasma 2'-Deoxyuridine, a Surrogate Marker of Thymidylate Synthase (TS) Inhibition, after Administration of Two Different Schedules of 5-Fluorouracil and the Specific TS Inhibitors Raltitrexed (Tomudex) and ZD9331

Hugo E. R. Ford, Fraser Mitchell, David Cunningham, David C. Farrugia, Mark E. Hill, Charlotte Rees, A. Hilary Calvert, Ian R. Judson, and Ann L. Jackman
Clin Cancer Res 2002 8: 103 [Abstract] [Full Text] [PDF]  

Immunohistochemical Variation of Human Equilibrative Nucleoside Transporter 1 Protein in Primary Breast Cancers

John R. Mackey, Lori L. Jennings, Marilyn L. Clarke, Cheryl L. Santos, Laith Dabbagh, Michaela Vsianska, Sheryl L. Koski, Robert W. Coupland, Stephen A. Baldwin, James D. Young, and Carol E. Cass
Clin Cancer Res 2002 8: 110 [Abstract] [Full Text] [PDF]  

Dysregulation of Annexin I Protein Expression in High-Grade Prostatic Intraepithelial Neoplasia and Prostate Cancer

John S. Kang, Benjamin F. Calvo, Susan J. Maygarden, Laura S. Caskey, James L. Mohler, and David K. Ornstein
Clin Cancer Res 2002 8: 117 [Abstract] [Full Text] [PDF]  

Biopsy Specimen Microvessel Density Is a Useful Prognostic Marker in Patients with T_2–4M₀ Esophageal Cancer Treated with Chemoradiotherapy

Shuichi Hironaka, Takahiro Hasebe, Tomoyuki Kamijo, Atsushi Ohtsu, Narikazu Boku, Shigeaki Yoshida, Hiroki Saitoh, and Atsushi Ochiai
Clin Cancer Res 2002 8: 124 [Abstract] [Full Text] [PDF]  

Promoter Hypermethylation of Multiple Genes in Nasopharyngeal Carcinoma

Joseph Kwong, Kwok-Wai Lo, Ka-Fai To, Peter M. L. Teo, Philip J. Johnson, and Dolly Poon Huang
Clin Cancer Res 2002 8: 131 [Abstract] [Full Text] [PDF]  

Loss of hMSH2 and hMSH6 Expression Is Frequent in Sporadic Endometrial Carcinomas with Microsatellite Instability: A Population-based Study

Ingunn Stefansson, Lars A. Akslen, Nicola MacDonald, Andy Ryan, Soma Das, Ian J. Jacobs, and Helga B. Salvesen
Clin Cancer Res 2002 8: 138 [Abstract] [Full Text] [PDF]  

Matrix Metalloproteinase-7 Expression in Colorectal Cancer Liver Metastases: Evidence for Involvement of MMP-7 Activation in Human Cancer Metastases

Zhao-Shi Zeng, Wei-Ping Shu, Alfred M. Cohen, and José G. Guillem
Clin Cancer Res 2002 8: 144 [Abstract] [Full Text] [PDF]  

Modulation of Biologic Endpoints by Topical Difluoromethylornithine (DFMO), in Subjects at High-Risk for Nonmelanoma Skin Cancer

Janine G. Einspahr, Mark A. Nelson, Kathylynn Saboda, James Warneke, G. Timothy Bowden, and David S. Alberts
Clin Cancer Res 2002 8: 149 [Abstract] [Full Text] [PDF]  

Total Levels of Tissue Inhibitor of Metalloproteinases 1 in Plasma Yield High Diagnostic Sensitivity and Specificity in Patients with Colon Cancer

Mads N. Holten-Andersen, Ib Jarle Christensen, Hans Jørgen Nielsen, Ross W. Stephens, Vibeke Jensen, Ole Haagen Nielsen, Steen Sørensen, Jens Overgaard, Hans Lilja, Adrian Harris, Gillian Murphy, and Nils Brünner
Clin Cancer Res 2002 8: 156 [Abstract] [Full Text] [PDF]  

p73 Overexpression Is a Prognostic Factor in Patients with Colorectal Adenocarcinoma

Xiao-Feng Sun
Clin Cancer Res 2002 8: 165 [Abstract] [Full Text] [PDF]  

Impact of Alterations Affecting the p53 Pathway in Bladder Cancer on Clinical Outcome, Assessed by Conventional and Array-based Methods

Ming-Lan Lu, Friedrik Wikman, Torben F. Orntoft, Elizabeth Charytonowicz, Farhang Rabbani, Zuofeng Zhang, Guido Dalbagni, Kamal S. Pohar, Guopei Yu, and Carlos Cordon-Cardo
Clin Cancer Res 2002 8: 171 [Abstract] [Full Text] [PDF]  

Aberrant p53, mdm2, and Proliferation Differ in Glioblastomas from Long-Term Compared with Typical Survivors¹

Eric C. Burton, Kathleen R. Lamborn, Peter Forsyth, James Scott, Jason O’Campo, Jane Uyehara-Lock, Michael Prados, Mitchel Berger, Sandra Passe, Joon Uhm, Brian P. O’Neill, Robert B. Jenkins, and Ken D. Aldape
Clin Cancer Res 2002 8: 180 [Abstract] [Full Text] [PDF]  

Detection of Aberrant p16 Methylation in the Serum of Colorectal Cancer Patients

Hong-Zhi Zou, Bao-Ming Yu, Zhi-Wei Wang, Ji-Yuan Sun, Hui Cang, Fei Gao, Dong Hua Li, Ren Zhao, Guo-Guang Feng, and Jing Yi
Clin Cancer Res 2002 8: 188 [Abstract] [Full Text] [PDF]  

PGP9.5 as a Marker for Invasive Colorectal Cancer

Taiji Yamazaki, Kenji Hibi, Tsunenobu Takase, Ekmel Tezel, Hiroshi Nakayama, Yasushi Kasai, Katsuki Ito, Seiji Akiyama, Tetsuro Nagasaka, and Akimasa Nakao
Clin Cancer Res 2002 8: 192 [Abstract] [Full Text] [PDF]  

Correlation of Histology and Molecular Genetic Analysis of 1p, 19q, 10q, TP53, EGFR, CDK4, and CDKN2A in 91 Astrocytic and Oligodendroglial Tumors

Keisuke Ueki, Ryo Nishikawa, Yoichi Nakazato, Takanori Hirose, Junko Hirato, Nobuaki Funada, Takamitsu Fujimaki, Shuntaro Hojo, Osami Kubo, Takafumi Ide, Masaaki Usui, Chikayuki Ochiai, Shoichi Ito, Hiroshi Takahashi, Akitake Mukasa, Akio Asai, and Takaaki Kirino
Clin Cancer Res 2002 8: 196 [Abstract] [Full Text] [PDF]  

Cancer Biology, Immunology, Cytokines:

Contrasting Expression of Thrombospondin-1 and Osteopontin Correlates with Absence or Presence of Metastatic Phenotype in an Isogenic Model of Spontaneous Human Breast Cancer Metastasis

Virginia Urquidi, Derek Sloan, Kanji Kawai, Dianne Agarwal, Anthony C. Woodman, David Tarin, and Steve Goodison
Clin Cancer Res 2002 8: 61 [Abstract] [Full Text] [PDF]  

An Orthotopic Nude Mouse Model of Oral Tongue Squamous Cell Carcinoma

Jeffrey N. Myers, F. Christopher Holsinger, Samar A. Jasser, B. Nebiyou Bekele, and Isaiah J. Fidler
Clin Cancer Res 2002 8: 293 [Abstract] [Full Text] [PDF]  

Clinical Trials:

A Phase I and Pharmacokinetic Study of Ecteinascidin-743 on a Daily x 5 Schedule in Patients with Solid Malignancies

Miguel A. Villalona-Calero, S. Gail Eckhardt, Geoffrey Weiss, Manuel Hidalgo, Jos H. Beijnen, Charlotte van Kesteren, Hilde Rosing, Elizabeth Campbell, Maura Kraynak, Luis Lopez-Lazaro, Cecilia Guzman, Daniel D. Von Hoff, Jose Jimeno, and Eric K. Rowinsky
Clin Cancer Res 2002 8: 75 [Abstract] [Full Text] [PDF]  

Phase I and Pharmacokinetic Study of a Micronized Formulation of Carboxyamidotriazole, a Calcium Signal Transduction Inhibitor: Toxicity, Bioavailability and the Effect of Food

Jordan Berlin, Kendra D. Tutsch, Rhoda Z. Arzoomanian, Dona Alberti, Kim Binger, Chris Feierabend, Amy Dresen, Rebecca Marnocha, James Pluda, and George Wilding
Clin Cancer Res 2002 8: 86 [Abstract] [Full Text] [PDF]  

Influence of Amifostine on the Toxicity and Pharmacokinetics of Docetaxel in Metastatic Breast Cancer Patients: A Pilot Study

Gilles Freyer, Philippe Hennebert, Ahmad Awada, Thierry Gil, Joseph Kerger, Jean Selleslags, Christiane Brassinne, Martine Piccart, and Dominique de Valeriola
Clin Cancer Res 2002 8: 95 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Effects of Nonsteroidal Anti-Inflammatory Agents (NSAIDs) on Ovarian Carcinoma Cell Lines: Preclinical Evaluation of NSAIDs as Chemopreventive Agents

Cristina Rodríguez-Burford, Mack N. Barnes, Denise K. Oelschlager, Russell B. Myers, Lynya I. Talley, Edward E. Partridge, and William E. Grizzle
Clin Cancer Res 2002 8: 202 [Abstract] [Full Text] [PDF]  

Improved Circulating Half-Life and Efficacy of an Antibody-Interleukin 2 Immunocytokine Based on Reduced Intracellular Proteolysis

Stephen D. Gillies, Kin-Ming Lo, Christa Burger, Yan Lan, Thomas Dahl, and Wai-Keung Wong
Clin Cancer Res 2002 8: 210 [Abstract] [Full Text] [PDF]  

Cooperative Interaction between Interleukin 10 and Galectin-3 against Liver Ischemia-Reperfusion Injury

Yong J. Lee and Young K. Song
Clin Cancer Res 2002 8: 217 [Abstract] [Full Text] [PDF]  

Differences in Therapeutic Indexes of Combination Metronomic Chemotherapy and an Anti-VEGFR-2 Antibody in Multidrug-resistant Human Breast Cancer Xenografts

Giannoula Klement, Ping Huang, Barbara Mayer, Shane K. Green, Shan Man, Peter Bohlen, Daniel Hicklin, and Robert S. Kerbel
Clin Cancer Res 2002 8: 221 [Abstract] [Full Text] [PDF]  

In Vitro Schedule-dependent Interactions between the Multitargeted Antifolate LY231514 and Gemcitabine in Human Colon Adenocarcinoma Cell Lines

Anna Tesei, Luca Ricotti, Franca De Paola, Dino Amadori, Giovanni L. Frassineti, and Wainer Zoli
Clin Cancer Res 2002 8: 233 [Abstract] [Full Text] [PDF]  

Model of Inhibition of the NPM-ALK Kinase Activity by Herbimycin A

Francesco Turturro, Marilyn D. Arnold, Audrey Y. Frist, and Karen Pulford
Clin Cancer Res 2002 8: 240 [Abstract] [Full Text] [PDF]  

Antitumor Activity of Fibroblast Growth Factors (FGFs) for Medulloblastoma May Correlate with FGF Receptor Expression and Tumor Variant

Sabine M. Duplan, Yves Théorêt, and Rhoda L. Kenigsberg
Clin Cancer Res 2002 8: 246 [Abstract] [Full Text] [PDF]  

Internalization Property of Interleukin-4 Receptor Chain Increases Cytotoxic Effect of Interleukin-4 Receptor-targeted Cytotoxin in Cancer Cells

Koji Kawakami, Mariko Kawakami, Pamela Leland, and Raj K. Puri
Clin Cancer Res 2002 8: 258 [Abstract] [Full Text] [PDF]  

The Chemopreventive Agent Oltipraz Possesses Potent Antiangiogenic Activity in Vitro, ex Vivo, and in Vivo and Inhibits Tumor Xenograft Growth

Bruce A. Ruggeri, Candy Robinson, Thelma Angeles, John Wilkinson, IV, and Margie L. Clapper
Clin Cancer Res 2002 8: 267 [Abstract] [Full Text] [PDF]  

Targeting Adenovirus to the Serotype 3 Receptor Increases Gene Transfer Efficiency to Ovarian Cancer Cells

Anna Kanerva, Galina V. Mikheeva, Victor Krasnykh, Candace J. Coolidge, John T. Lam, Parameshwar J. Mahasreshti, Shannon D. Barker, Michael Straughn, Mack N. Barnes, Ronald D. Alvarez, Akseli Hemminki, and David T. Curiel
Clin Cancer Res 2002 8: 275 [Abstract] [Full Text] [PDF]  

Interleukin 4 Receptor-directed Cytotoxin Therapy for Human Head and Neck Squamous Cell Carcinoma in Animal Models

Scott E. Strome, Koji Kawakami, Danielle Alejandro, Stephen Voss, Jan L. Kasperbauer, Diva Salomao, Lieping Chen, Richard A. Maki, and Raj K. Puri
Clin Cancer Res 2002 8: 281 [Abstract] [Full Text] [PDF]  

Synergistic Effects of Topoisomerase I Inhibitor, 7-ethyl-10-hydroxycamptothecin, and Irradiation in a Cisplatin-resistant Human Small Cell Lung Cancer Cell Line

Hiroyuki Kohara, Masahiro Tabata, Katsuyuki Kiura, Hiroshi Ueoka, Kazuhiko Kawata, Masakazu Chikamori, Keisuke Aoe, Kenichi Chikamori, Akio Matsushita, and Mine Harada
Clin Cancer Res 2002 8: 287 [Abstract] [Full Text] [PDF]  

Corrections:

Correction

Clin Cancer Res 2002 8: 299 [Abstract] [Full Text] [PDF]  

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