The Biology Behind:

Donald S. Coffey

Nuclear Matrix Proteins as Proteomic Markers of Preneoplastic and Cancer Lesions : Commentary re: G. Brunagel et al., Nuclear Matrix Protein Alterations Associated with Colon Cancer Metastasis to the Liver. Clin. Cancer Res., 8: 3039–3045, 2002.
Clin Cancer Res 2002 8: 3031-3033. [Full Text] [PDF]  

Report from the FDA:

Ramzi Dagher, Martin Cohen, Gene Williams, Mark Rothmann, Jogarao Gobburu, Gabriel Robbie, Atiqur Rahman, Gang Chen, Ann Staten, Donna Griebel, and Richard Pazdur

Approval Summary: Imatinib Mesylate in the Treatment of Metastatic and/or Unresectable Malignant Gastrointestinal Stromal Tumors
Clin Cancer Res 2002 8: 3034-3038. [Abstract] [Full Text] [PDF]  

Advances in Brief:

   Molecular Oncology, Markers, Clinical Correlates:

Gisela Brünagel, Robert E. Schoen, Anthony J. Bauer, Barbara N. Vietmeier, and Robert H. Getzenberg

Nuclear Matrix Protein Alterations Associated with Colon Cancer Metastasis to the Liver
Clin Cancer Res 2002 8: 3039-3045. [Abstract] [Full Text] [PDF]  

Nobuhiko Seki, Tasaburo Takasu, Koichi Mandai, Masao Nakata, Hideyuki Saeki, Yuji Heike, Ichiro Takata, Yoshihiko Segawa, Toshiaki Hanafusa, and Kenji Eguchi

Expression of Eukaryotic Initiation Factor 4E in Atypical Adenomatous Hyperplasia and Adenocarcinoma of the Human Peripheral Lung
Clin Cancer Res 2002 8: 3046-3053. [Abstract] [Full Text] [PDF]  

Richard J. Gilbertson, Lyndsay Bentley, Roberto Hernan, Teemu T. Junttila, Adrian J. Frank, Hannu Haapasalo, Michele Connelly, Cynthia Wetmore, Tom Curran, Klaus Elenius, and David W. Ellison

ERBB Receptor Signaling Promotes Ependymoma Cell Proliferation and Represents a Potential Novel Therapeutic Target for This Disease
Clin Cancer Res 2002 8: 3054-3064. [Abstract] [Full Text] [PDF]  

Andreas Widschwendter, Sibylle Tonko-Geymayer, Thomas Welte, Günter Daxenbichler, Christian Marth, and Wolfgang Doppler

Prognostic Significance of Signal Transducer and Activator of Transcription 1 Activation in Breast Cancer
Clin Cancer Res 2002 8: 3065-3074. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Michael B. Atkins, Jared A. Gollob, Jeffrey A. Sosman, David F. McDermott, Linda Tutin, Patricia Sorokin, Robert A. Parker, and James W. Mier

A Phase II Pilot Trial of Concurrent Biochemotherapy with Cisplatin, Vinblastine, Temozolomide, Interleukin 2, and IFN-2B in Patients with Metastatic Melanoma
Clin Cancer Res 2002 8: 3075-3081. [Abstract] [Full Text] [PDF]  

Luis A. Santana-Blank, Elizabeth Rodríguez-Santana, Fernando Vargas, Heberto Reyes, Pablo Fernández-Andrade, Saide Rukos, and Karin E. Santana-Rodríguez

Phase I Trial of an Infrared Pulsed Laser Device in Patients with Advanced Neoplasias
Clin Cancer Res 2002 8: 3082-3091. [Abstract] [Full Text] [PDF]  

James A. Posey, Mohammad B. Khazaeli, Michael A. Bookman, Anahit Nowrouzi, William E. Grizzle, Jennifer Thornton, Delicia E. Carey, Jennifer M. Lorenz, Amy P. Sing, Clay B. Siegall, Albert F. LoBuglio, and Mansoor N. Saleh

A Phase I Trial of the Single-Chain Immunotoxin SGN-10 (BR96 sFv-PE40) in Patients with Advanced Solid Tumors
Clin Cancer Res 2002 8: 3092-3099. [Abstract] [Full Text] [PDF]  

Weijing Sun, James P. Stevenson, James M. Gallo, Maryann Redlinger, Daniel Haller, Kenneth Algazy, Bruce Giantonio, Hector Alila, and Peter J. O’Dwyer

Phase I and Pharmacokinetic Trial of the Proapoptotic Sulindac Analog CP-461 in Patients with Advanced Cancer
Clin Cancer Res 2002 8: 3100-3104. [Abstract] [Full Text] [PDF]  

Carol J. Fabian, Bruce F. Kimler, Deborah A. Brady, Matthew S. Mayo, C. H. Joseph Chang, John A. Ferraro, Carola M. Zalles, Annette L. Stanton, Shahla Masood, William E. Grizzle, Norman F. Boyd, Dora W. Arneson, and Karen A. Johnson

A Phase II Breast Cancer Chemoprevention Trial of Oral -Difluoromethylornithine: Breast Tissue, Imaging, and Serum and Urine Biomarkers
Clin Cancer Res 2002 8: 3105-3117. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Philip J. Moos, Elizabeth A. Raetz, Marlee A. Carlson, Aniko Szabo, Fiona E. Smith, Cheryl Willman, Qi Wei, Stephen P. Hunger, and William L. Carroll

Identification of Gene Expression Profiles That Segregate Patients with Childhood Leukemia
Clin Cancer Res 2002 8: 3118-3130. [Abstract] [Full Text] [PDF]  

Masahide Ikeguchi, Tsuyoshi Ueta, Yoshiaki Yamane, Yasuaki Hirooka, and Nobuaki Kaibara

Inducible Nitric Oxide Synthase and Survivin Messenger RNA Expression in Hepatocellular Carcinoma
Clin Cancer Res 2002 8: 3131-3136. [Abstract] [Full Text] [PDF]  

Torsten E. Reichert, Laura Strauss, Eva M. Wagner, William Gooding, and Theresa L. Whiteside

Signaling Abnormalities, Apoptosis, and Reduced Proliferation of Circulating and Tumor-infiltrating Lymphocytes in Patients with Oral Carcinoma
Clin Cancer Res 2002 8: 3137-3145. [Abstract] [Full Text] [PDF]  

Luigi A. M. Castagnetta, Orazia M. Granata, Adele Traina, Barbara Ravazzolo, Maria Amoroso, Monica Miele, Vincenzo Bellavia, Biagio Agostara, and Giuseppe Carruba

Tissue Content of Hydroxyestrogens in Relation to Survival of Breast Cancer Patients
Clin Cancer Res 2002 8: 3146-3155. [Abstract] [Full Text] [PDF]  

Asif Rashid, Takashi Ueki, Yu-Tang Gao, Patrick Scott Houlihan, Charita Wallace, Bing-Sheng Wang, Ming-Chang Shen, Jie Deng, and Ann W. Hsing

K-ras Mutation, p53 Overexpression, and Microsatellite Instability in Biliary Tract Cancers: A Population-based Study in China
Clin Cancer Res 2002 8: 3156-3163. [Abstract] [Full Text] [PDF]  

Kazuhiro Ogi, Minoru Toyota, Mutsumi Ohe-Toyota, Nobuyuki Tanaka, Makoto Noguchi, Tomoko Sonoda, Geniku Kohama, and Takashi Tokino

Aberrant Methylation of Multiple Genes and Clinicopathological Features in Oral Squamous Cell Carcinoma
Clin Cancer Res 2002 8: 3164-3171. [Abstract] [Full Text] [PDF]  

Richard Linforth, Neil Anderson, Richard Hoey, Tania Nolan, Sarah Downey, Gerard Brady, Linda Ashcroft, and Nigel Bundred

Coexpression of Parathyroid Hormone Related Protein and Its Receptor in Early Breast Cancer Predicts Poor Patient Survival
Clin Cancer Res 2002 8: 3172-3177. [Abstract] [Full Text] [PDF]  

Philippe Riou, Raphaël Saffroy, Jérome Comoy, Marine Gross-Goupil, Jean-Paul Thiéry, Jean-François Emile, Daniel Azoulay, Dominique Piatier-Tonneau, Antoinette Lemoine, and Brigitte Debuire

Investigation in Liver Tissues and Cell Lines of the Transcription of 13 Genes Mapping to the 16q24 Region That Are Frequently Deleted in Hepatocellular Carcinoma
Clin Cancer Res 2002 8: 3178-3186. [Abstract] [Full Text] [PDF]  

Elin Ringström, Edward Peters, Masayuki Hasegawa, Marshall Posner, Mei Liu, and Karl T. Kelsey

Human Papillomavirus Type 16 and Squamous Cell Carcinoma of the Head and Neck
Clin Cancer Res 2002 8: 3187-3192. [Abstract] [Full Text] [PDF]  

Brian C. Cooper, Justine M. Ritchie, Carrie L. W. Broghammer, Jeremy Coffin, Joel I. Sorosky, Richard E. Buller, Mary J. C. Hendrix, and Anil K. Sood

Preoperative Serum Vascular Endothelial Growth Factor Levels: Significance in Ovarian Cancer
Clin Cancer Res 2002 8: 3193-3197. [Abstract] [Full Text] [PDF]  

Linda M. Pilarski and Andrew R. Belch

Clonotypic Myeloma Cells Able to Xenograft Myeloma to Nonobese Diabetic Severe Combined Immunodeficient Mice Copurify with CD34⁺ Hematopoietic Progenitors
Clin Cancer Res 2002 8: 3198-3204. [Abstract] [Full Text] [PDF]  

Kerstin Maaser, Patricia Grabowski, Andreas P. Sutter, Michael Höpfner, Hans-Dieter Foss, Harald Stein, Gerd Berger, Moshe Gavish, Martin Zeitz, and Hans Scherübl

Overexpression of the Peripheral Benzodiazepine Receptor Is a Relevant Prognostic Factor in Stage III Colorectal Cancer
Clin Cancer Res 2002 8: 3205-3209. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Daniel J. Lindner, Xinrong Ma, Jiadi Hu, Sreenivasu Karra, and Dhananjaya V. Kalvakolanu

Thioredoxin Reductase Plays a Critical Role in IFN Retinoid-mediated Tumor-Growth Control in Vivo
Clin Cancer Res 2002 8: 3210-3218. [Abstract] [Full Text] [PDF]  

Hiroya Kobayashi, Ryusuke Omiya, Marta Ruiz, Eduardo Huarte, Pablo Sarobe, Juan José Lasarte, Maite Herraiz, Bruno Sangro, Jesús Prieto, Francisco Borras-Cuesta, and Esteban Celis

Identification of an Antigenic Epitope for Helper T Lymphocytes from Carcinoembryonic Antigen
Clin Cancer Res 2002 8: 3219-3225. [Abstract] [Full Text] [PDF]  

William D. Fox, Brian Higgins, Krista M. Maiese, Marija Drobnjak, Carlos Cordon-Cardo, Howard I. Scher, and David B. Agus

Antibody to Vascular Endothelial Growth Factor Slows Growth of an Androgen-independent Xenograft Model of Prostate Cancer
Clin Cancer Res 2002 8: 3226-3231. [Abstract] [Full Text] [PDF]  

Wei-Gang Tong, Xian-Zhong Ding, Rene Hennig, Richard C. Witt, Jens Standop, Parviz M. Pour, and Thomas E. Adrian

Leukotriene B4 Receptor Antagonist LY293111 Inhibits Proliferation and Induces Apoptosis in Human Pancreatic Cancer Cells
Clin Cancer Res 2002 8: 3232-3242. [Abstract] [Full Text] [PDF]  

Michiyo Saimura, Eishi Nagai, Kazuhiro Mizumoto, Naoki Maehara, Yohji A. Minamishima, Mitsuo Katano, Kunio Matsumoto, Toshikazu Nakamura, and Masao Tanaka

Tumor Suppression through Angiogenesis Inhibition by SUIT-2 Pancreatic Cancer Cells Genetically Engineered to Secrete NK4
Clin Cancer Res 2002 8: 3243-3249. [Abstract] [Full Text] [PDF]  

Cataldo Bianco, Giampaolo Tortora, Roberto Bianco, Roberta Caputo, Bianca Maria Veneziani, Rosa Caputo, Vincenzo Damiano, Teresa Troiani, Gabriella Fontanini, David Raben, Stefano Pepe, A. Raffaele Bianco, and Fortunato Ciardiello

Enhancement of Antitumor Activity of Ionizing Radiation by Combined Treatment with the Selective Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor ZD1839 (Iressa)
Clin Cancer Res 2002 8: 3250-3258. [Abstract] [Full Text] [PDF]  

Niels Reinmuth, Wenbiao Liu, Fan Fan, Young D. Jung, Syed A. Ahmad, Oliver Stoeltzing, Corazon D. Bucana, Robert Radinsky, and Lee M. Ellis

Blockade of Insulin-like Growth Factor I Receptor Function Inhibits Growth and Angiogenesis of Colon Cancer
Clin Cancer Res 2002 8: 3259-3269. [Abstract] [Full Text] [PDF]  

Nanjoo Suh, William W. Lamph, Andrew L. Glasebrook, Timothy A. Grese, Alan D. Palkowitz, Charlotte R. Williams, Renee Risingsong, M. Rendi Farris, Richard A. Heyman, and Michael B. Sporn

Prevention and Treatment of Experimental Breast Cancer with the Combination of a New Selective Estrogen Receptor Modulator, Arzoxifene, and a New Rexinoid, LG 100268
Clin Cancer Res 2002 8: 3270-3275. [Abstract] [Full Text] [PDF]  

Tobias Zellweger, Kim Chi, Hideaki Miyake, Hans Adomat, Satoshi Kiyama, Kirsten Skov, and Martin E. Gleave

Enhanced Radiation Sensitivity in Prostate Cancer by Inhibition of the Cell Survival Protein Clusterin
Clin Cancer Res 2002 8: 3276-3284. [Abstract] [Full Text] [PDF]  

Amjad H. Talukder, Rozita Bagheri-Yarmand, Ruth R. E. Williams, Jiannis Ragoussis, Rakesh Kumar, and Avraham Raz

Antihuman Epidermal Growth Factor Receptor 2 Antibody Herceptin Inhibits Autocrine Motility Factor (AMF) Expression and Potentiates Antitumor Effects of AMF Inhibitors
Clin Cancer Res 2002 8: 3285-3289. [Abstract] [Full Text] [PDF]  

Yi Ding, Yong Wen, Bill Spohn, Li Wang, Weiya Xia, Ka Yin Kwong, Ruping Shao, Zheng Li, Gabriel N. Hortobagyi, Mien-Chie Hung, and Duen-Hwa Yan

Proapoptotic and Antitumor Activities of Adenovirus-mediated p202 Gene Transfer
Clin Cancer Res 2002 8: 3290-3297. [Abstract] [Full Text] [PDF]  

Florence Gattacceca, Yannick Pilatte, Christian Billard, Isabelle Monnet, Sylviane Moritz, Jérôme Le Carrou, Marc Eloit, and Marie-Claude Jaurand

Ad-IFN Induces Antiproliferative and Antitumoral Responses in Malignant Mesothelioma
Clin Cancer Res 2002 8: 3298-3304. [Abstract] [Full Text] [PDF]  

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