Editorials:

Michael S. O’Reilly

Targeting Multiple Biological Pathways as a Strategy to Improve the Treatment of Cancer
Clin Cancer Res 2002 8: 3309-3310. [Full Text] [PDF]  

The Biology Behind:

Robert S. DiPaola

To Arrest or Not To G₂-M Cell-Cycle Arrest : Commentary re: A. K. Tyagi et al., Silibinin Strongly Synergizes Human Prostate Carcinoma DU145 Cells to Doxorubicin-induced Growth Inhibition, G₂-M Arrest, and Apoptosis. Clin. Cancer Res., 8: 3512–3519, 2002.
Clin Cancer Res 2002 8: 3311-3314. [Full Text] [PDF]  

Advances in Brief:

   Clinical Trials:

Hubert Vesselle, John Grierson, Mark Muzi, Jeffrey M. Pugsley, Rodney A. Schmidt, Peter Rabinowitz, Lanell M. Peterson, Eric Vallières, and Douglas E. Wood

In Vivo Validation of 3'deoxy-3'-[¹⁸F]fluorothymidine ([¹⁸F]FLT) as a Proliferation Imaging Tracer in Humans: Correlation of [¹⁸F]FLT Uptake by Positron Emission Tomography with Ki-67 Immunohistochemistry and Flow Cytometry in Human Lung Tumors
Clin Cancer Res 2002 8: 3315-3323. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Asha Rathi, Arvind K. Virmani, John O. Schorge, Keren J. Elias, Riichiroh Maruyama, John D. Minna, Samuel C. Mok, Luc Girard, David A. Fishman, and Adi F. Gazdar

Methylation Profiles of Sporadic Ovarian Tumors and nonmalignant Ovaries from High-Risk Women
Clin Cancer Res 2002 8: 3324-3331. [Abstract] [Full Text] [PDF]  

Luis Del Valle, Sahnila Enam, César Lara, Carlos Ortiz-Hidalgo, Christos D. Katsetos, and Kamel Khalili

Detection of JC Polyomavirus DNA Sequences and Cellular Localization of T-Antigen and Agnoprotein in Oligodendrogliomas
Clin Cancer Res 2002 8: 3332-3340. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Tetsuzo Tauchi, Akihiro Nakajima, Goro Sashida, Takashi Shimamoto, Junko H. Ohyashiki, Kenji Abe, Kohtaro Yamamoto, and Kazuma Ohyashiki

Inhibition of Human Telomerase Enhances the Effect of the Tyrosine Kinase Inhibitor, Imatinib, in BCR-ABL-positive Leukemia Cells
Clin Cancer Res 2002 8: 3341-3347. [Abstract] [Full Text] [PDF]  

Kaori Suzuki, Ramón Alemany, Masato Yamamoto, and David T. Curiel

The Presence of the Adenovirus E3 Region Improves the Oncolytic Potency of Conditionally Replicative Adenoviruses
Clin Cancer Res 2002 8: 3348-3359. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Sharon H. Giordano, Daniel J. Booser, James L. Murray, Nuhad K. Ibrahim, Zia U. Rahman, Vicente Valero, Richard L. Theriault, Marguerite F. Rosales, Edgardo Rivera, Debbie Frye, Michael Ewer, Nelson G. Ordonez, Aman U. Buzdar, and Gabriel N. Hortobagyi

A Detailed Evaluation of Cardiac Toxicity: A Phase II Study of Doxorubicin and One- or Three-Hour-Infusion Paclitaxel in Patients with Metastatic Breast Cancer
Clin Cancer Res 2002 8: 3360-3368. [Abstract] [Full Text] [PDF]  

Lorenz Höltl, Claudia Zelle-Rieser, Hubert Gander, Christine Papesh, Reinhold Ramoner, Georg Bartsch, Hermann Rogatsch, Adel L. Barsoum, Joseph H. Coggin, Jr., and Martin Thurnher

Immunotherapy of Metastatic Renal Cell Carcinoma with Tumor Lysate-pulsed Autologous Dendritic Cells
Clin Cancer Res 2002 8: 3369-3376. [Abstract] [Full Text] [PDF]  

Kai Neben, Thomas Moehler, Axel Benner, Alwin Kraemer, Gerlinde Egerer, Anthony D. Ho, and Hartmut Goldschmidt

Dose-dependent Effect of Thalidomide on Overall Survival in Relapsed Multiple Myeloma
Clin Cancer Res 2002 8: 3377-3382. [Abstract] [Full Text] [PDF]  

Michael J. Robertson, David Pelloso, Rafat Abonour, Robert A. Hromas, Robert P. Nelson, Jr., Lisa Wood, and Kenneth Cornetta

Interleukin 12 Immunotherapy after Autologous Stem Cell Transplantation for Hematological Malignancies
Clin Cancer Res 2002 8: 3383-3393. [Abstract] [Full Text] [PDF]  

Koji Kono, Akihiro Takahashi, Hidemitsu Sugai, Hideki Fujii, A. Raja Choudhury, Rolf Kiessling, and Yoshiro Matsumoto

Dendritic Cells Pulsed with HER-2/neu-derived Peptides Can Induce Specific T-Cell Responses in Patients with Gastric Cancer
Clin Cancer Res 2002 8: 3394-3400. [Abstract] [Full Text] [PDF]  

David R. Colnot, Gert J. Ossenkoppele, Jan C. Roos, Jasper J. Quak, Remco de Bree, Pontus K. Börjesson, Peter C. Huijgens, Gordon B. Snow, and Guus A. M. S. van Dongen

Reinfusion of Unprocessed, Granulocyte Colony-stimulating Factor-stimulated Whole Blood Allows Dose Escalation of ¹⁸⁶Relabeled Chimeric Monoclonal Antibody U36 Radioimmunotherapy in a Phase I Dose Escalation Study
Clin Cancer Res 2002 8: 3401-3406. [Abstract] [Full Text] [PDF]  

James L. Murray, Michael E. Gillogly, Donna Przepiorka, Hannah Brewer, Nuhad K. Ibrahim, Daniel J. Booser, Gabriel N. Hortobagyi, Andrzej P. Kudelka, Kenneth H. Grabstein, Martin A. Cheever, and Constantin G. Ioannides

Toxicity, Immunogenicity, and Induction of E75-specific Tumor-lytic CTLs by HER-2 Peptide E75 (369–377) Combined with Granulocyte Macrophage Colony-stimulating Factor in HLA-A2+ Patients with Metastatic Breast and Ovarian Cancer
Clin Cancer Res 2002 8: 3407-3418. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Guang Yang, Gustavo Ayala, Angelo De Marzo, Weihua Tian, Anna Frolov, Thomas M. Wheeler, Timothy C. Thompson, and J. Wade Harper

Elevated Skp2 Protein Expression in Human Prostate Cancer: Association with Loss of the Cyclin-dependent Kinase Inhibitor p27 and PTEN and with Reduced Recurrence-free Survival
Clin Cancer Res 2002 8: 3419-3426. [Abstract] [Full Text] [PDF]  

Thomas Bachleitner-Hofmann, Barbara Pichler-Gebhard, Margarethe Rudas, Michael Gnant, Susanne Taucher, Daniela Kandioler, Elisabeth Janschek, Peter Dubsky, Sebastian Roka, Emanuel Sporn, and Raimund Jakesz

Pattern of Hormone Receptor Status of Secondary Contralateral Breast Cancers in Patients Receiving Adjuvant Tamoxifen
Clin Cancer Res 2002 8: 3427-3432. [Abstract] [Full Text] [PDF]  

Rui M. Medeiros, Antonio Morais, André Vasconcelos, Sandra Costa, Daniela Pinto, Jorge Oliveira, Paula Ferreira, and Carlos Lopes

Outcome in Prostate Cancer: Association with Endothelial Nitric Oxide Synthase Glu-Asp298 Polymorphism at Exon 7
Clin Cancer Res 2002 8: 3433-3437. [Abstract] [Full Text] [PDF]  

Giuseppe Di Lorenzo, Giampaolo Tortora, Francesco P. D’Armiento, Gaetano De Rosa, Stefania Staibano, Riccardo Autorino, Massimo D’Armiento, Michele De Laurentiis, Sabino De Placido, Giuseppe Catalano, A. Raffaele Bianco, and Fortunato Ciardiello

Expression of Epidermal Growth Factor Receptor Correlates with Disease Relapse and Progression to Androgen-independence in Human Prostate Cancer
Clin Cancer Res 2002 8: 3438-3444. [Abstract] [Full Text] [PDF]  

Stacy A. Geisler, Andrew F. Olshan, Mark C. Weissler, Jainwen Cai, William K. Funkhouser, Joanna Smith, and Katie Vick

p16 and p53 Protein Expression as Prognostic Indicators of Survival and Disease Recurrence from Head and Neck Cancer
Clin Cancer Res 2002 8: 3445-3453. [Abstract] [Full Text] [PDF]  

Shinichi Tsutsui, Akemi Kataoka, Shinji Ohno, Shigeru Murakami, Junko Kinoshita, and Yoichi Hachitanda

Prognostic and Predictive Value of Epidermal Growth Factor Receptor in Recurrent Breast Cancer
Clin Cancer Res 2002 8: 3454-3460. [Abstract] [Full Text] [PDF]  

Jaclyn A. Biegel, Lu Tan, Fan Zhang, Luanne Wainwright, Pierre Russo, and Lucy B. Rorke

Alterations of the hSNF5/INI1 Gene in Central Nervous System Atypical Teratoid/Rhabdoid Tumors and Renal and Extrarenal Rhabdoid Tumors
Clin Cancer Res 2002 8: 3461-3467. [Abstract] [Full Text] [PDF]  

Katarina Omholt, Sofia Karsberg, Anton Platz, Lena Kanter, Ulrik Ringborg, and Johan Hansson

Screening of N-ras Codon 61 Mutations in Paired Primary and Metastatic Cutaneous Melanomas: Mutations Occur Early and Persist throughout Tumor Progression
Clin Cancer Res 2002 8: 3468-3474. [Abstract] [Full Text] [PDF]  

Hiroshi Inoue, Ayumi Matsuyama, Koshi Mimori, Hiroaki Ueo, and Masaki Mori

Prognostic Score of Gastric Cancer Determined by cDNA Microarray
Clin Cancer Res 2002 8: 3475-3479. [Abstract] [Full Text] [PDF]  

Naoko Inoshima, Yoichi Nakanishi, Takahiro Minami, Miiru Izumi, Koichi Takayama, Ichiro Yoshino, and Nobuyuki Hara

The Influence of Dendritic Cell Infiltration and Vascular Endothelial Growth Factor Expression on the Prognosis of Non-Small Cell Lung Cancer
Clin Cancer Res 2002 8: 3480-3486. [Abstract] [Full Text] [PDF]  

Johanna Pellikainen, Vesa Kataja, Kirsi Ropponen, Jari Kellokoski, Timo Pietiläinen, Jan Böhm, Matti Eskelinen, and Veli-Matti Kosma

Reduced Nuclear Expression of Transcription Factor AP-2 Associates with Aggressive Breast Cancer
Clin Cancer Res 2002 8: 3487-3495. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Amy B. Heimberger, Chris A. Learn, Gary E. Archer, Roger E. McLendon, Tracy A. Chewning, Frank L. Tuck, John B. Pracyk, Allan H. Friedman, Henry S. Friedman, Darell D. Bigner, and John H. Sampson

Brain Tumors in Mice Are Susceptible to Blockade of Epidermal Growth Factor Receptor (EGFR) with the Oral, Specific, EGFR-Tyrosine Kinase Inhibitor ZD1839 (Iressa)
Clin Cancer Res 2002 8: 3496-3502. [Abstract] [Full Text] [PDF]  

Mariko Kawakami, Koji Kawakami, Vitaly A. Stepensky, Richard A. Maki, Howard Robin, Wayne Muller, Syed R. Husain, and Raj K. Puri

Interleukin 4 Receptor on Human Lung Cancer: A Molecular Target for Cytotoxin Therapy
Clin Cancer Res 2002 8: 3503-3511. [Abstract] [Full Text] [PDF]  

Anil K. Tyagi, Rana P. Singh, Chapla Agarwal, Daniel C. F. Chan, and Rajesh Agarwal

Silibinin Strongly Synergizes Human Prostate Carcinoma DU145 Cells to Doxorubicin-induced Growth Inhibition, G₂-M Arrest, and Apoptosis
Clin Cancer Res 2002 8: 3512-3519. [Abstract] [Full Text] [PDF]  

Raffit Hassan, Megan R. Lerner, Doris Benbrook, Stan A. Lightfoot, Daniel J. Brackett, Qing-Cheng Wang, and Ira Pastan

Antitumor Activity of SS(dsFv)PE38 and SS1(dsFv)PE38, Recombinant Antimesothelin Immunotoxins against Human Gynecologic Cancers Grown in Organotypic Culture in Vitro
Clin Cancer Res 2002 8: 3520-3526. [Abstract] [Full Text] [PDF]  

Ivana Gojo, Bin Zhang, and Robert G. Fenton

The Cyclin-dependent Kinase Inhibitor Flavopiridol Induces Apoptosis in Multiple Myeloma Cells through Transcriptional Repression and Down-Regulation of Mcl-1
Clin Cancer Res 2002 8: 3527-3538. [Abstract] [Full Text] [PDF]  

Lorenzo Bello, Carlo Giussani, Giorgio Carrabba, Mauro Pluderi, Valeria Lucini, Marilou Pannacci, Dario Caronzolo, Giustino Tomei, Roberto Villani, Francesco Scaglione, Rona S. Carroll, and Andreas Bikfalvi

Suppression of Malignant Glioma Recurrence in a Newly Developed Animal Model by Endogenous Inhibitors
Clin Cancer Res 2002 8: 3539-3548. [Abstract] [Full Text] [PDF]  

Vyomesh Patel, Tyler Lahusen, Chidchanok Leethanakul, Tadashi Igishi, Marcus Kremer, Leticia Quintanilla-Martinez, John F. Ensley, Edward A. Sausville, J. Silvio Gutkind, and Adrian M. Senderowicz

Antitumor Activity of UCN-01 in Carcinomas of the Head and Neck Is Associated with Altered Expression of Cyclin D3 and p27^KIP1
Clin Cancer Res 2002 8: 3549-3560. [Abstract] [Full Text] [PDF]  

Jay M. Lee, Ali Mahtabifard, Reiko Yamada, Ronald G. Crystal, and Robert J. Korst

Adenovirus Vector-mediated Overexpression of a Truncated Form of the p65 Nuclear Factor B cDNA in Dendritic Cells Enhances Their Function Resulting in Immune-mediated Suppression of Preexisting Murine Tumors
Clin Cancer Res 2002 8: 3561-3569. [Abstract] [Full Text] [PDF]  

Mengfeng Li, Caisheng Ye, Chong Feng, Frank Riedel, Xiaoning Liu, Qing Zeng, and Jennifer Rubin Grandis

Enhanced Antiangiogenic Therapy of Squamous Cell Carcinoma by Combined Endostatin and Epidermal Growth Factor Receptor-Antisense Therapy
Clin Cancer Res 2002 8: 3570-3578. [Abstract] [Full Text] [PDF]  

Robert G. Uzzo, Paul Leavis, William Hatch, Vladimir L. Gabai, Nickolai Dulin, Nadezhda Zvartau, and Vladimir M. Kolenko

Zinc Inhibits Nuclear Factor-B Activation and Sensitizes Prostate Cancer Cells to Cytotoxic Agents
Clin Cancer Res 2002 8: 3579-3583. [Abstract] [Full Text] [PDF]  

Eric C. McGary, Kristy Weber, Lisa Mills, Michelle Doucet, Valerie Lewis, Dina Chelouche Lev, Isaiah J. Fidler, and Menashe Bar-Eli

Inhibition of Platelet-derived Growth Factor-mediated Proliferation of Osteosarcoma Cells by the Novel Tyrosine Kinase Inhibitor STI571
Clin Cancer Res 2002 8: 3584-3591. [Abstract] [Full Text] [PDF]  

Daniel Kedar, Cheryl H. Baker, Jerald J. Killion, Colin P. N. Dinney, and Isaiah J. Fidler

Blockade of the Epidermal Growth Factor Receptor Signaling Inhibits Angiogenesis Leading to Regression of Human Renal Cell Carcinoma Growing Orthotopically in Nude Mice
Clin Cancer Res 2002 8: 3592-3600. [Abstract] [Full Text] [PDF]  

Leena Hilakivi-Clarke, Elisabeth Cho, Ana Cabanes, Sonia DeAssis, Susan Olivo, William Helferich, Marc E. Lippman, and Robert Clarke

Dietary Modulation of Pregnancy Estrogen Levels and Breast Cancer Risk among Female Rat Offspring
Clin Cancer Res 2002 8: 3601-3610. [Abstract] [Full Text] [PDF]  

Prafulla C. Gokhale, Chuanbo Zhang, Joseph T. Newsome, Jin Pei, Imran Ahmad, Aquilur Rahman, Anatoly Dritschilo, and Usha N. Kasid

Pharmacokinetics, Toxicity, and Efficacy of Ends-modified raf Antisense Oligodeoxyribonucleotide Encapsulated in a Novel Cationic Liposome
Clin Cancer Res 2002 8: 3611-3621. [Abstract] [Full Text] [PDF]  

   Cancer Biology, Immunology, Cytokines:

Marcela F. Bolontrade, Rong-Rong Zhou, and Eugenie S. Kleinerman

Vasculogenesis Plays a Role in the Growth of Ewing’s Sarcoma in Vivo
Clin Cancer Res 2002 8: 3622-3627. [Abstract] [Full Text] [PDF]  

Bailu Peng, Jason B. Fleming, Tara Breslin, Ana M. Grau, Shuichi Fojioka, James L. Abbruzzese, Douglas B. Evans, Dan Ayers, Kyle Wathen, Tianai Wu, Kimberly D. Robertson, and Paul J. Chiao

Suppression of Tumorigenesis and Induction of p15^ink4b by Smad4/DPC4 in Human Pancreatic Cancer Cells
Clin Cancer Res 2002 8: 3628-3638. [Abstract] [Full Text] [PDF]  

Corrections:

Correction for vol. 8, p. 2812
Clin Cancer Res 2002 8: 3639. [Full Text] [PDF]  

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