The Biology Behind:

William S. Dalton

Targeting the Mitochondria: An Exciting New Approach to Myeloma Therapy: Commentary re: N. J. Bahlis et al., Feasibility and Correlates of Arsenic Trioxide Combined with Ascorbic Acid-mediated Depletion of Intracellular Glutathione for the Treatment of Relapsed/Refractory Multiple Myeloma. Clin. Cancer Res., 8: 3658-3668, 2002.
Clin Cancer Res 2002 8: 3643-3645. [Full Text] [PDF]  

The Cooperative Group Bulletin Board:

Peter J. Houghton, Peter C. Adamson, Susan Blaney, Howard A. Fine, Richard Gorlick, Michelle Haber, Lee Helman, Steve Hirschfeld, Melinda G. Hollingshead, Mark A. Israel, Richard B. Lock, John M. Maris, Glenn Merlino, Wendy Patterson, C. Patrick Reynolds, Kevin Shannon, Alice Yu, John Yu, and Malcolm A. Smith

Testing of New Agents in Childhood Cancer Preclinical Models: Meeting Summary
Clin Cancer Res 2002 8: 3646-3657. [Abstract] [Full Text] [PDF]  

Advances in Brief:

   Clinical Trials:

Nizar J. Bahlis, Jennifer McCafferty-Grad, Ileana Jordan-McMurry, Jim Neil, Isildinha Reis, Mohamed Kharfan-Dabaja, James Eckman, Mark Goodman, Hugo F. Fernandez, Lawrence H. Boise, and Kelvin P. Lee

Feasibility and Correlates of Arsenic Trioxide Combined with Ascorbic Acid-mediated Depletion of Intracellular Glutathione for the Treatment of Relapsed/Refractory Multiple Myeloma
Clin Cancer Res 2002 8: 3658-3668. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Yoon Soo Chang, Luo Wang, Diane Liu, Li Mao, Waun Ki Hong, Fadlo R. Khuri, and Ho-Young Lee

Correlation between Insulin-like Growth Factor-binding Protein-3 Promoter Methylation and Prognosis of Patients with Stage I Non-Small Cell Lung Cancer
Clin Cancer Res 2002 8: 3669-3675. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Andreas M. Kaufmann, Peter L. Stern, Elaine M. Rankin, Harald Sommer, Volkmar Nuessler, Achim Schneider, Malcom Adams, Toli S. Onon, Thomas Bauknecht, Uwe Wagner, Karlijn Kroon, Julian Hickling, Christopher M. Boswell, Simon N. Stacey, Henry C. Kitchener, Jennifer Gillard, Jantien Wanders, John St. C. Roberts, and Heinz Zwierzina

Safety and Immunogenicity of TA-HPV, a Recombinant Vaccinia Virus Expressing Modified Human Papillomavirus (HPV)-16 and HPV-18 E6 and E7 Genes, in Women with Progressive Cervical Cancer
Clin Cancer Res 2002 8: 3676-3685. [Abstract] [Full Text] [PDF]  

Renato Lenzi, Michael Rosenblum, Claire Verschraegen, Andrzej P. Kudelka, John J. Kavanagh, Marshall E. Hicks, Eric A. Lang, Michael A. Nash, Lawrence B. Levy, Michael E. Garcia, Chris D. Platsoucas, James L. Abbruzzese, and Ralph S. Freedman

Phase I Study of Intraperitoneal Recombinant Human Interleukin 12 in Patients with Müllerian Carcinoma, Gastrointestinal Primary Malignancies, and Mesothelioma
Clin Cancer Res 2002 8: 3686-3695. [Abstract] [Full Text] [PDF]  

Ulka Vaishampayan, Judith Abrams, Denise Darrah, Vicky Jones, and Malcolm S. Mitchell

Active Immunotherapy of Metastatic Melanoma with Allogeneic Melanoma Lysates and Interferon
Clin Cancer Res 2002 8: 3696-3701. [Abstract] [Full Text] [PDF]  

Giuseppe Giaccone, Cornelis J. A. Punt, Yoshitaka Ando, Rita Ruijter, Nobusuke Nishi, Marlies Peters, B. Mary E. von Blomberg, Rik J. Scheper, Hans J. J. van der Vliet, Alfons J. M. van den Eertwegh, Marja Roelvink, Jos Beijnen, Heinz Zwierzina, and Herbert M. Pinedo

A Phase I Study of the Natural Killer T-Cell Ligand -Galactosylceramide (KRN7000) in Patients with Solid Tumors
Clin Cancer Res 2002 8: 3702-3709. [Abstract] [Full Text] [PDF]  

Eric H. Rubin, Dinesh P. de Alwis, Isabelle Pouliquen, Lisa Green, Phil Marder, Yong Lin, Rita Musanti, Stephanie L. Grospe, Sharon L. Smith, Deborah L. Toppmeyer, Judy Much, Michael Kane, Ajai Chaudhary, Christopher Jordan, Michael Burgess, and Christopher A. Slapak

A Phase I Trial of a Potent P-Glycoprotein Inhibitor, Zosuquidar.3HCl Trihydrochloride (LY335979), Administered Orally in Combination with Doxorubicin in Patients with Advanced Malignancies
Clin Cancer Res 2002 8: 3710-3717. [Abstract] [Full Text] [PDF]  

Gini F. Fleming, Neal J. Meropol, Gary L. Rosner, Donna R. Hollis, William E. Carson, III, Michael Caligiuri, Joanne Mortimer, Katherine Tkaczuk, Robin Parihar, Richard L. Schilsky, and Mark J. Ratain

A Phase I Trial of Escalating Doses of Trastuzumab Combined with Daily Subcutaneous Interleukin 2: Report of Cancer and Leukemia Group B 9661
Clin Cancer Res 2002 8: 3718-3727. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Cynthia Cohen, Angel Zavala-Pompa, Judy H. Sequeira, Mamoru Shoji, Deborah G. Sexton, George Cotsonis, Francesca Cerimele, Baskaran Govindarajan, Nada Macaron, and Jack L. Arbiser

Mitogen-actived Protein Kinase Activation Is an Early Event in Melanoma Progression
Clin Cancer Res 2002 8: 3728-3733. [Abstract] [Full Text] [PDF]  

Jörn Sträter, Ulf Hinz, Henning Walczak, Gunhild Mechtersheimer, Karin Koretz, Christian Herfarth, Peter Möller, and Thomas Lehnert

Expression of TRAIL and TRAIL Receptors in Colon Carcinoma: TRAIL-R1 Is an Independent Prognostic Parameter
Clin Cancer Res 2002 8: 3734-3740. [Abstract] [Full Text] [PDF]  

Eunice C. Chan, Shui Y. Lam, Kenneth W. Tsang, Bing Lam, James C. M. Ho, Kin H. Fu, Wah K. Lam, and Yok L. Kwong

Aberrant Promoter Methylation in Chinese Patients with Non-Small Cell Lung Cancer: Patterns in Primary Tumors and Potential Diagnostic Application in Bronchoalevolar Lavage
Clin Cancer Res 2002 8: 3741-3746. [Abstract] [Full Text] [PDF]  

Yvette van Hensbergen, Henk J. Broxterman, Roeland Hanemaaijer, Anita S. Jorna, Natascha A. van Lent, Henk M. W. Verheul, Herbert M. Pinedo, and Klaas Hoekman

Soluble Aminopeptidase N/CD13 in Malignant and Nonmalignant Effusions and Intratumoral Fluid
Clin Cancer Res 2002 8: 3747-3754. [Abstract] [Full Text] [PDF]  

Makiko Tomiyasu, Ichiro Yoshino, Ryuichi Suemitsu, Tatsuro Okamoto, and Keizo Sugimachi

Quantification of Macrophage Migration Inhibitory Factor mRNA Expression in Non-Small Cell Lung Cancer Tissues and Its Clinical Significance
Clin Cancer Res 2002 8: 3755-3760. [Abstract] [Full Text] [PDF]  

Jose M. Silva, Javier Silva, Antonio Sanchez, Jose M. Garcia, Gemma Dominguez, Mariano Provencio, Luis Sanfrutos, Eugenia Jareño, Antonio Colas, Pilar España, and Felix Bonilla

Tumor DNA in Plasma at Diagnosis of Breast Cancer Patients Is a Valuable Predictor of Disease-free Survival
Clin Cancer Res 2002 8: 3761-3766. [Abstract] [Full Text] [PDF]  

Yoshihiro Ohishi, Yoshinao Oda, Takeshi Uchiumi, Hiroaki Kobayashi, Toshio Hirakawa, Shingo Miyamoto, Naoko Kinukawa, Hitoo Nakano, Michihiko Kuwano, and Masazumi Tsuneyoshi

ATP-binding Cassette Superfamily Transporter Gene Expression in Human Primary Ovarian Carcinoma
Clin Cancer Res 2002 8: 3767-3775. [Abstract] [Full Text] [PDF]  

Jaya M. Satagopan, Jeff Boyd, Noah D. Kauff, Mark Robson, Lauren Scheuer, Steven Narod, and Kenneth Offit

Ovarian Cancer Risk in Ashkenazi Jewish Carriers of BRCA1 and BRCA2 Mutations
Clin Cancer Res 2002 8: 3776-3781. [Abstract] [Full Text] [PDF]  

Alessandra Bearzatto, Davide Conte, Milo Frattini, Nadia Zaffaroni, Francesca Andriani, Debora Balestra, Luca Tavecchio, Maria Grazia Daidone, and Gabriella Sozzi

p16^INK4A Hypermethylation Detected by Fluorescent Methylation-specific PCR in Plasmas from Non-Small Cell Lung Cancer
Clin Cancer Res 2002 8: 3782-3787. [Abstract] [Full Text] [PDF]  

Adewale Adeyinka, Ethan Emberley, Yulian Niu, Linda Snell, Leigh C. Murphy, Heidi Sowter, Charles C. Wykoff, Adrian L. Harris, and Peter H. Watson

Analysis of Gene Expression in Ductal Carcinoma in Situ of the Breast
Clin Cancer Res 2002 8: 3788-3795. [Abstract] [Full Text] [PDF]  

Yoon Soo Chang, Koo Gong, Shihua Sun, Diane Liu, Adel K. El-Naggar, Fadlo R. Khuri, Waun Ki Hong, and Ho-Young Lee

Clinical Significance of Insulin-like Growth Factor-binding Protein-3 Expression in Stage I Non-Small Cell Lung Cancer
Clin Cancer Res 2002 8: 3796-3802. [Abstract] [Full Text] [PDF]  

Christopher J. Moran, Douglas A. Arenberg, Chiang-Ching Huang, Thomas J. Giordano, Dafydd G. Thomas, David E. Misek, Guoan Chen, Mark D. Iannettoni, Mark B. Orringer, Samir Hanash, and David G. Beer

RANTES Expression Is a Predictor of Survival in Stage I Lung Adenocarcinoma
Clin Cancer Res 2002 8: 3803-3812. [Abstract] [Full Text] [PDF]  

Kenneth Offit, Shlomit Gilad, Shoshana Paglin, Prema Kolachana, Laila C. Roisman, Khedoudja Nafa, Vincent Yeugelewitz, Maria Gonzales, Mark Robson, Deborah McDermott, Heather Hanson Pierce, Noah D. Kauff, Paz Einat, Suresh Jhanwar, Jaya M. Satagopan, Carole Oddoux, Nathan Ellis, Rami Skaliter, and Joachim Yahalom

Rare Variants of ATM and Risk for Hodgkin’s Disease and Radiation-associated Breast Cancers
Clin Cancer Res 2002 8: 3813-3819. [Abstract] [Full Text] [PDF]  

Giorgio Ghilardi, Maria Luisa Biondi, Maria Caputo, Simona Leviti, Marco DeMonti, Emma Guagnellini, and Roberto Scorza

A Single Nucleotide Polymorphism in the Matrix Metalloproteinase-3 Promoter Enhances Breast Cancer Susceptibility
Clin Cancer Res 2002 8: 3820-3823. [Abstract] [Full Text] [PDF]  

Shuho Semba, Nanami Itoh, Masafumi Ito, Emile M. Youssef, Masaru Harada, Toshiyuki Moriya, Wataru Kimura, and Mitsunori Yamakawa

Down-Regulation of PIK3CG, a Catalytic Subunit of Phosphatidylinositol 3-OH Kinase, by CpG Hypermethylation in Human Colorectal Carcinoma
Clin Cancer Res 2002 8: 3824-3831. [Abstract] [Full Text] [PDF]  

Abdul K. Siraj, Ugur Ozbek, Sudha Sazawal, Sema Sirma, Georgina Timson, Abdallah Al-Nasser, Manorama Bhargava, Hassan El Solh, Kishor Bhatia, and Marina I. Gutiérrez

Preclinical Validation of a Monochrome Real-Time Multiplex Assay for Translocations in Childhood Acute Lymphoblastic Leukemia
Clin Cancer Res 2002 8: 3832-3840. [Abstract] [Full Text] [PDF]  

Axel Hoos, Aviram Nissan, Alexander Stojadinovic, Jinru Shia, Cyrus V. Hedvat, Denis H. Y. Leung, Philip B. Paty, David Klimstra, Carlos Cordon-Cardo, and W. Douglas Wong

Tissue Microarray Molecular Profiling of Early, Node-negative Adenocarcinoma of the Rectum: A Comprehensive Analysis
Clin Cancer Res 2002 8: 3841-3849. [Abstract] [Full Text] [PDF]  

Mario Caputi, Angela M. Groeger, Vincenzo Esposito, Antonio De Luca, Valeria Masciullo, Alessandro Mancini, Feliciano Baldi, Ernst Wolner, and Antonio Giordano

Loss of pRb2/p130 Expression Is Associated with Unfavorable Clinical Outcome in Lung Cancer
Clin Cancer Res 2002 8: 3850-3856. [Abstract] [Full Text] [PDF]  

Nicole J. McCarthy, Xiaowei Yang, Ilona R. Linnoila, Maria J. Merino, Stephen M. Hewitt, Allyson L. Parr, Soonmyung Paik, Seth M. Steinberg, Dan P. Hartmann, Nejib Mourali, Paul H. Levine, and Sandra M. Swain

Microvessel Density, Expression of Estrogen Receptor , MIB-1, p53, and c-erbB-2 in Inflammatory Breast Cancer
Clin Cancer Res 2002 8: 3857-3862. [Abstract] [Full Text] [PDF]  

Joan Climent, Jose A. Martinez-Climent, David Blesa, Maria J. Garcia-Barchino, Rosana Saez, Dolors Sánchez-Izquierdo, Pilar Azagra, Ana Lluch, and Javier Garcia-Conde

Genomic Loss of 18p Predicts an Adverse Clinical Outcome in Patients with High-Risk Breast Cancer
Clin Cancer Res 2002 8: 3863-3869. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Francis M. Sirotnak, Yohung She, Fei Lee, Jing Chen, and Howard I. Scher

Studies with CWR22 Xenografts in Nude Mice Suggest That ZD1839 May Have a Role in the Treatment of Both Androgen-dependent and Androgen-independent Human Prostate Cancer
Clin Cancer Res 2002 8: 3870-3876. [Abstract] [Full Text] [PDF]  

Jun Lu, Robert L. Giuntoli, II, Ryusuke Omiya, Hiroya Kobayashi, Richard Kennedy, and Esteban Celis

Interleukin 15 Promotes Antigen-independent in Vitro Expansion and Long-Term Survival of Antitumor Cytotoxic T Lymphocytes
Clin Cancer Res 2002 8: 3877-3884. [Abstract] [Full Text] [PDF]  

Yutaka Horiguchi, Ikuei Nukaya, Kazuhide Okazawa, Ichiro Kawashima, John Fikes, Allesandro Sette, Masaaki Tachibana, Kazutoh Takesako, and Masaru Murai

Screening of HLA-A24-restricted Epitope Peptides from Prostate-specific Membrane Antigen That Induce Specific Antitumor Cytotoxic T Lymphocytes
Clin Cancer Res 2002 8: 3885-3892. [Abstract] [Full Text] [PDF]  

Katia Scotlandi, Stefania Perdichizzi, Maria Cristina Manara, Massimo Serra, Stefania Benini, Vanessa Cerisano, Rosaria Strammiello, Mario Mercuri, Gemma Reverter-Branchat, Glynn Faircloth, Maurizio D’Incalci, and Piero Picci

Effectiveness of Ecteinascidin-743 against Drug-sensitive and -resistant Bone Tumor Cells
Clin Cancer Res 2002 8: 3893-3903. [Abstract] [Full Text] [PDF]  

Graziella Pratesi, Michelandrea De Cesare, Nives Carenini, Paola Perego, Sabina C. Righetti, Carla Cucco, Lucio Merlini, Claudio Pisano, Sergio Penco, Paolo Carminati, Loredana Vesci, and Franco Zunino

Pattern of Antitumor Activity of a Novel Camptothecin, ST1481, in a Large Panel of Human Tumor Xenografts
Clin Cancer Res 2002 8: 3904-3909. [Abstract] [Full Text] [PDF]  

George H. Yoo, Marie P. Piechocki, John F. Ensley, Tam Nguyen, Jeffery Oliver, Hong Meng, Danny Kewson, Terry Y. Shibuya, Fulvio Lonardo, and Michael A. Tainsky

Docetaxel Induced Gene Expression Patterns in Head and Neck Squamous Cell Carcinoma Using cDNA Microarray and PowerBlot
Clin Cancer Res 2002 8: 3910-3921. [Abstract] [Full Text] [PDF]  

Lisa Drew, Robert L. Fine, Tamara N. Do, Geoffrey P. Douglas, and Daniel P. Petrylak

The Novel Antimicrotubule Agent Cryptophycin 52 (LY355703) Induces Apoptosis via Multiple Pathways in Human Prostate Cancer Cells
Clin Cancer Res 2002 8: 3922-3932. [Abstract] [Full Text] [PDF]  

Lynn M. R. Gilmour, Kenneth G. Macleod, Alison McCaig, Jane M. Sewell, William J. Gullick, John F. Smyth, and Simon P. Langdon

Neuregulin Expression, Function, and Signaling in Human Ovarian Cancer Cells
Clin Cancer Res 2002 8: 3933-3942. [Abstract] [Full Text] [PDF]  

Yasuyuki Sadzuka, Yasuyo Yamashita, and Takashi Sonobe

Effects of Glutamate Transporter Inhibitors on the Antitumor Activity of Doxorubicin
Clin Cancer Res 2002 8: 3943-3947. [Abstract] [Full Text] [PDF]  

David Dingli, Michael Timm, Stephen J. Russell, Thomas E. Witzig, and S. Vincent Rajkumar

Promising Preclinical Activity of 2-Methoxyestradiol in Multiple Myeloma
Clin Cancer Res 2002 8: 3948-3954. [Abstract] [Full Text] [PDF]  

Gregory P. Schneider, Rosalba Salcedo, Hui Fang Dong, Hynda K. Kleinman, Joost J. Oppenheim, and O. M. Zack Howard

Suradista NSC 651016 Inhibits the Angiogenic Activity of CXCL12-Stromal Cell-derived Factor 1
Clin Cancer Res 2002 8: 3955-3960. [Abstract] [Full Text] [PDF]  

Retraction:

Retraction
Clin Cancer Res 2002 8: 3961. [Full Text] [PDF]  

Acknowledgment to Reviewers:

Acknowledgment to Reviewers
Clin Cancer Res 2002 8: 3965-3970. [Full Text] [PDF]  

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