Editorials:

Protein Kinase A Type I: A Target For Cancer Therapy

Giampaolo Tortora and Fortunato Ciardiello
Clin Cancer Res 2002 8: 303 [Full Text] [PDF]  

The Biology Behind:

Cancer Prevention by Delay : Commentary re: J. A. O’Shaughnessy et al., Treatment and Prevention of Intraepithelial Neoplasia: An Important Target for Accelerated New Agent Development. Clin. Cancer Res., 8: 314–346, 2002.

Scott M. Lippman and Waun Ki Hong
Clin Cancer Res 2002 8: 305 [Full Text] [PDF]  

Special Article:

Treatment and Prevention of Intraepithelial Neoplasia: An Important Target for Accelerated New Agent Development : Recommendations of the American Association for Cancer Research Task Force on the Treatment and Prevention of Intraepithelial Neoplasia

Joyce A. O’Shaughnessy, Gary J. Kelloff, Gary B. Gordon, Andrew J. Dannenberg, Waun Ki Hong, Carol J. Fabian, Caroline C. Sigman, Monica M. Bertagnolli, Steven P. Stratton, Stephen Lam, William G. Nelson, Frank L. Meyskens, David S. Alberts, Michele Follen, Anil K. Rustgi, Vali Papadimitrakopoulou, Peter T. Scardino, Adi F. Gazdar, Lee W. Wattenberg, Michael B. Sporn, Wael A. Sakr, Scott M. Lippman, and Daniel D. Von Hoff
Clin Cancer Res 2002 8: 314 [Abstract] [Full Text] [PDF]  

Molecular Oncology, Markers, Clinical Correlates:

NH₂-terminal Truncated HER-2 Protein but not Full-Length Receptor Is Associated with Nodal Metastasis in Human Breast Cancer

Miguel A. Molina, Rosana Sáez, Elizabeth E. Ramsey, María-José Garcia-Barchino, Federico Rojo, Adam J. Evans, Joan Albanell, Edward J. Keenan, Ana Lluch, Javier García-Conde, José Baselga, and Gail M. Clinton
Clin Cancer Res 2002 8: 347 [Abstract] [Full Text] [PDF]  

Quantitative Evaluation of Somatostatin Receptor Subtype 2 Expression in Sporadic Colorectal Tumor and in the Corresponding Normal Mucosa

Claudia Casini Raggi, Antonino Calabrò, Daniela Renzi, Vittorio Briganti, Fabio Cianchi, Luca Messerini, Rosa Valanzano, Michela Cameron Smith, Camillo Cortesini, Francesco Tonelli, Mario Serio, Mario Maggi, and Claudio Orlando
Clin Cancer Res 2002 8: 419 [Abstract] [Full Text] [PDF]  

Breast Epithelium Procurement from Stereotactic Core Biopsy Washings: Flow Cytometry-sorted Cell Count Analysis

Daniel L. Stoler, Carleton C. Stewart, and Paul C. Stomper
Clin Cancer Res 2002 8: 428 [Abstract] [Full Text] [PDF]  

High Frequency of Promoter Hypermethylation of the Death-associated Protein-Kinase Gene in Nasopharyngeal Carcinoma and Its Detection in the Peripheral Blood of Patients

Thian Sze Wong, Hsiao Wen Chang, Kwong Chi Tang, William Ignace Wei, Dora Lai Wen Kwong, Jonathan Shun Tong Sham, Anthony Po Wing Yuen, and Yok Lam Kwong
Clin Cancer Res 2002 8: 433 [Abstract] [Full Text] [PDF]  

The Role of Retinoid X Receptor Messenger RNA Expression in Curatively Resected Non-Small Cell Lung Cancer

Jan Brabender, Kathleen D. Danenberg, Ralf Metzger, Paul M. Schneider, Reginald V. Lord, Susan Groshen, Denice D. Tsao-Wei, JiMin Park, Dennis Salonga, Arnulf H. Hölscher, and Peter V. Danenberg
Clin Cancer Res 2002 8: 438 [Abstract] [Full Text] [PDF]  

Immunomagnetic Detection of Micrometastatic Cells in Bone Marrow of Colorectal Cancer Patients

Kjersti Flatmark, Kristin Bjørnland, Hans Olaf Johannessen, Elisabeth Hegstad, Rocio Rosales, Lisbeth Hårklau, Jan Helge Solhaug, Ragnar S. Faye, Odd Søreide, and Øystein Fodstad
Clin Cancer Res 2002 8: 444 [Abstract] [Full Text] [PDF]  

Expression and Prognostic Roles of ß-Catenin in Hepatocellular Carcinoma: Correlation with Tumor Progression and Postoperative Survival

Satoshi Inagawa, Masayuki Itabashi, Shinya Adachi, Toru Kawamoto, Masao Hori, Jiro Shimazaki, Fuyo Yoshimi, and Katashi Fukao
Clin Cancer Res 2002 8: 450 [Abstract] [Full Text] [PDF]  

RET Oligonucleotide Microarray for the Detection of RET Mutations in Multiple Endocrine Neoplasia Type 2 Syndromes

Il-Jin Kim, Hio Chung Kang, Jae-Hyun Park, Ja-Lok Ku, Jong-Soo Lee, Hyuk-Joon Kwon, Kyong-Ah Yoon, Seung Chul Heo, Hee-Young Yang, Bo Youn Cho, Seong Yeon Kim, Seung Keun Oh, Yeo-Kyu Youn, Do-Jun Park, Myung-Shik Lee, Kwang-Woo Lee, and Jae-Gahb Park
Clin Cancer Res 2002 8: 457 [Abstract] [Full Text] [PDF]  

Hypermethylation of Multiple Genes in Tumor Tissues and Voided Urine in Urinary Bladder Cancer Patients

Michael W. Y. Chan, Lun W. Chan, Nelson L. S. Tang, Joanna H. M. Tong, Kwok W. Lo, Tin L. Lee, Ho Y. Cheung, Wai S. Wong, Peter S. F. Chan, Fernand M. M. Lai, and Ka F. To
Clin Cancer Res 2002 8: 464 [Abstract] [Full Text] [PDF]  

Hypoxia-induced, Perinecrotic Expression of Endothelial Per–ARNT–Sim Domain Protein-1/Hypoxia-inducible Factor-2 Correlates with Tumor Progression, Vascularization, and Focal Macrophage Infiltration in Bladder Cancer

Toru Onita, Ping Guang Ji, Jim W. Xuan, Hideki Sakai, Hiroshi Kanetake, Patrick H. Maxwell, Guo-Hua Fong, Manal Y Gabril, Madeleine Moussa, and Joseph L. Chin
Clin Cancer Res 2002 8: 471 [Abstract] [Full Text] [PDF]  

Mitochondrial D-loop Mutations As Clonal Markers in Multicentric Hepatocellular Carcinoma and Plasma

Shuji Nomoto, Katsuya Yamashita, Katsumi Koshikawa, Akimasa Nakao, and David Sidransky
Clin Cancer Res 2002 8: 481 [Abstract] [Full Text] [PDF]  

BAX Expression in Hodgkin and Reed-Sternberg Cells of Hodgkin’s Disease: Correlation with Clinical Outcome

George Z. Rassidakis, L. Jeffrey Medeiros, Timothy J. McDonnell, Simonetta Viviani, Valeria Bonfante, Gianpaolo Nadali, Theodoros P. Vassilakopoulos, Roberto Giardini, Marco Chilosi, Christos Kittas, Alessandro M. Gianni, Gianni Bonadonna, Giovanni Pizzolo, Gerassimos A. Pangalis, Fernando Cabanillas, and Andreas H. Sarris
Clin Cancer Res 2002 8: 488 [Abstract] [Full Text] [PDF]  

p63 Expression Profiles in Human Normal and Tumor Tissues

Charles J. Di Como, Marshall J. Urist, Irina Babayan, Marija Drobnjak, Cyrus V. Hedvat, Julie Teruya-Feldstein, Kamal Pohar, Axel Hoos, and Carlos Cordon-Cardo
Clin Cancer Res 2002 8: 494 [Abstract] [Full Text] [PDF]  

Intraclonal Homogeneity of Clonotypic Immunoglobulin M and Diversity of Nonclinical Post-Switch Isotypes in Multiple Myeloma: Insights into the Evolution of the Myeloma Clone

Brian J. Taylor, Julie A. Pittman, Karen Seeberger, Michael J. Mant, Tony Reiman, Andrew R. Belch, and Linda M. Pilarski
Clin Cancer Res 2002 8: 502 [Abstract] [Full Text] [PDF]  

Aberrant Promoter Methylation Profile of Prostate Cancers and Its Relationship to Clinicopathological Features

Riichiroh Maruyama, Shinichi Toyooka, Kiyomi O. Toyooka, Arvind K. Virmani, Sabine Zöchbauer-Müller, Alfredo J. Farinas, John D. Minna, John McConnell, Eugene P. Frenkel, and Adi F. Gazdar
Clin Cancer Res 2002 8: 514 [Abstract] [Full Text] [PDF]  

HER-2-positive Breast Carcinomas As a Particular Subset with Peculiar Clinical Behaviors

Sylvie Ménard, Andrea Balsari, Patrizia Casalini, Elda Tagliabue, Manuela Campiglio, Rosaria Bufalino, and Natale Cascinelli
Clin Cancer Res 2002 8: 520 [Abstract] [Full Text] [PDF]  

Gain of 5p15 Detected by Comparative Genomic Hybridization as an Independent Marker of Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma

Takashi Ueno, Akira Tangoku, Shigefumi Yoshino, Toshihiro Abe, Hiroaki Toshimitsu, Tomoko Furuya, Shigeto Kawauchi, Atsunori Oga, Masaaki Oka, and Kohsuke Sasaki
Clin Cancer Res 2002 8: 526 [Abstract] [Full Text] [PDF]  

Detection of Genetic Prognostic Markers in Uveal Melanoma Biopsies Using Fluorescence in Situ Hybridization

Nicole C. Naus, Anette C. A. Verhoeven, Ellen van Drunen, Rosalyn Slater, Cornelia M. Mooy, Dion A. Paridaens, Grégorius P. M. Luyten, and Annelies de Klein
Clin Cancer Res 2002 8: 534 [Abstract] [Full Text] [PDF]  

Characterization of the HER-2/neu Oncogene by Immunohistochemical and Fluorescence in Situ Hybridization Analysis in Oral and Oropharyngeal Squamous Cell Carcinoma

Atif J. Khan, Bonnie L. King, Benjamin D. Smith, Grace L. Smith, Michael P. DiGiovanna, Darryl Carter, and Bruce G. Haffty
Clin Cancer Res 2002 8: 540 [Abstract] [Full Text] [PDF]  

Utilization of the Human Genome Sequence Localizes Human Papillomavirus Type 16 DNA Integrated into the TNFAIP2 Gene in a Fatal Cervical Cancer from a 39-Year-Old Woman

Mark H. Einstein, Yvette Cruz, Mustafa K. El-Awady, Nicolas C. Popescu, Joseph A. DiPaolo, Marc van Ranst, Anna S. Kadish, Seymour Romney, Carolyn D. Runowicz, and Robert D. Burk
Clin Cancer Res 2002 8: 549 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Preclinical Pharmacology:

Sulindac Enhances Tumor Necrosis Factor--mediated Apoptosis of Lung Cancer Cell Lines by Inhibition of Nuclear Factor-B

Kevin S. Berman, Udit N. Verma, Gwyndolen Harburg, John D. Minna, Melanie H. Cobb, and Richard B. Gaynor
Clin Cancer Res 2002 8: 354 [Abstract] [Full Text] [PDF]  

Expression Profile of Tyrosine Kinases in Breast Cancer

Funda Meric, Wei-Ping Lee, Aysegul Sahin, Haixia Zhang, Hsing-Jien Kung, and Mien-Chie Hung
Clin Cancer Res 2002 8: 361 [Abstract] [Full Text] [PDF]  

The Ras Inhibitor S-trans,trans-Farnesylthiosalicylic Acid Chemosensitizes Human Tumor Cells Without Causing Resistance

Mali Gana-Weisz, Julius Halaschek-Wiener, Burkhard Jansen, Galit Elad, Ronit Haklai, and Yoel Kloog
Clin Cancer Res 2002 8: 555 [Abstract] [Full Text] [PDF]  

Arsenic Trioxide Cytotoxicity in Steroid and Chemotherapy-resistant Myeloma Cell Lines: Enhancement of Apoptosis by Manipulation of Cellular Redox State

Ronald B. Gartenhaus, Sheila N. Prachand, Mary Paniaqua, Yuyu Li, and Leo I. Gordon
Clin Cancer Res 2002 8: 566 [Abstract] [Full Text] [PDF]  

Superior Therapeutic Profile of Poly-L-Glutamic Acid-Paclitaxel Copolymer Compared with Taxol in Xenogeneic Compartmental Models of Human Ovarian Carcinoma

Edmond Auzenne, Nicholas J. Donato, Chun Li, Elena Leroux, Roger E. Price, David Farquhar, and Jim Klostergaard
Clin Cancer Res 2002 8: 573 [Abstract] [Full Text] [PDF]  

MS-209, a Quinoline-type Reversal Agent, Potentiates Antitumor Efficacy of Docetaxel in Multidrug-resistant Solid Tumor Xenograft Models

Mikihiko Naito, Yasuhiro Matsuba, Shigeo Sato, Hiroshi Hirata, and Takashi Tsuruo
Clin Cancer Res 2002 8: 582 [Abstract] [Full Text] [PDF]  

Inhibition of PDE3B Augments PDE4 Inhibitor-induced Apoptosis in a Subset of Patients with Chronic Lymphocytic Leukemia

Eunyi Moon, Richard Lee, Richard Near, Lewis Weintraub, Sharon Wolda, and Adam Lerner
Clin Cancer Res 2002 8: 589 [Abstract] [Full Text] [PDF]  

Paclitaxel Triggers Cell Death Primarily via Caspase-independent Routes in the Non-Small Cell Lung Cancer Cell Line NCI-H460

Cynthia Huisman, Carlos G. Ferreira, Linda E. Bröker, Jose A. Rodriguez, Egbert F. Smit, Pieter E. Postmus, Frank A. E. Kruyt, and Giuseppe Giaccone
Clin Cancer Res 2002 8: 596 [Abstract] [Full Text] [PDF]  

Protein Kinase A RI Antisense Inhibition of PC3M Prostate Cancer Cell Growth: Bcl-2 Hyperphosphorylation, Bax Up-Regulation, and Bad-Hypophosphorylation

Yee Sook Cho, Meyoung-Kon Kim, Langzhu Tan, Rakesh Srivastava, Sudhir Agrawal, and Yoon S. Cho-Chung
Clin Cancer Res 2002 8: 607 [Abstract] [Full Text] [PDF]  

Clinical Trials:

Evidence of Determinant Spreading in the Antibody Responses to Prostate Cell Surface Antigens in Patients Immunized with Prostate-specific Antigen

Lisa A. Cavacini, Mark Duval, J. Paul Eder, and Marshall R. Posner
Clin Cancer Res 2002 8: 368 [Abstract] [Full Text] [PDF]  

Liposomal Doxorubicin in Conjunction with Reirradiation and Local Hyperthermia Treatment in Recurrent Breast Cancer: A Phase I/II Trial

Vassilios E. Kouloulias, Costas E. Dardoufas, John R. Kouvaris, Costas S. Gennatas, Aris K. Polyzos, Helen J. Gogas, Panagiotis H. Sandilos, Nikolaos K. Uzunoglu, Elias G. Malas, and Lambros J. Vlahos
Clin Cancer Res 2002 8: 374 [Abstract] [Full Text] [PDF]  

Safety and Efficacy of the Multidrug-Resistance Inhibitor Biricodar (VX-710) with Concurrent Doxorubicin in Patients with Anthracycline-resistant Advanced Soft Tissue Sarcoma

Vivien H. C. Bramwell, Donald Morris, D. Scott Ernst, Ingrid Hings, Martin Blackstein, Peter M. Venner, Ene I. Ette, Matthew W. Harding, Allison Waxman, and George D. Demetri
Clin Cancer Res 2002 8: 383 [Abstract] [Full Text] [PDF]  

Individual Adaptive Dosing of Topotecan in Ovarian Cancer

Ashraf Montazeri, Stéphane Culine, Brigitte Laguerre, Frédéric Pinguet, François Lokiec, Nicolas Albin, Alain Goupil, Régine Déporte-Féty, Roland Bugat, Pierre Canal, and Etienne Chatelut
Clin Cancer Res 2002 8: 394 [Abstract] [Full Text] [PDF]  

Picking the Winners in a Sea of Plenty

Howard I. Scher and Glenn Heller
Clin Cancer Res 2002 8: 400 [Abstract] [Full Text] [PDF]  

Continuous Administration of Irinotecan by Hepatic Arterial Infusion: A Phase I and Pharmacokinetic Study

Johanna M. G. H. van Riel, Cees J. van Groeningen, Mark A. Kedde, Helen Gall, Johanna M. A. Leisink, Gabriella Gruia, Herbert M. Pinedo, Wim J. F. van der Vijgh, and Giuseppe Giaccone
Clin Cancer Res 2002 8: 405 [Abstract] [Full Text] [PDF]  

Dose Escalation and Pharmacokinetics of Pegylated Liposomal Doxorubicin (Doxil) in Children with Solid Tumors: A Pediatric Oncology Group Study

Neyssa M. Marina, Debon Cochrane, Elaine Harney, Katie Zomorodi, Susan Blaney, Naomi Winick, Mark Bernstein, and Michael P. Link
Clin Cancer Res 2002 8: 413 [Abstract] [Full Text] [PDF]  

Cell Biology:

Automated Electrorotation to Reveal Dielectric Variations Related to HER-2/neu Overexpression in MCF-7 Sublines

Massimo Cristofanilli, Giovanni De Gasperis, Lisha Zhang, Mien-Chie Hung, Peter R. C. Gascoyne, and Gabriel N. Hortobagyi
Clin Cancer Res 2002 8: 615 [Abstract] [Full Text] [PDF]  

Modulation of the c-Met/Hepatocyte Growth Factor Pathway in Small Cell Lung Cancer

Gautam Maulik, Takashi Kijima, Patrick C. Ma, Sudip K. Ghosh, Jeffrey Lin, Geoffrey I. Shapiro, Erik Schaefer, Elena Tibaldi, Bruce E. Johnson, and Ravi Salgia
Clin Cancer Res 2002 8: 620 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: Seki et al., Diagnosis of pancreatic adenocarcinoma by detection of human telomerase reverse transcriptase messenger RNA in pancreatic juice with sample qualification. Clin. Cancer Res., 7: 1976–1981, 2001.

Kirsten S. Hindle, Katherine Kirkpatrick, and Kefah Mokbel
Clin Cancer Res 2002 8: 628 [Full Text] [PDF]  

Reply:

Keiichi Seki, Takeshi Suda, and Yutaka Aoyagi
Clin Cancer Res 2002 8: 629 [Full Text] [PDF]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.