Editorials:

Modulating Multidrug Resistance: Can We Target this Therapy?

John R. Murren
Clin Cancer Res 2002 8: 633 [Full Text] [PDF]  

Minireviews:

A View to a Kill: Signals Triggering Cytotoxicity

Julie Y. Djeu, Kun Jiang, and Sheng Wei
Clin Cancer Res 2002 8: 636 [Abstract] [Full Text] [PDF]  

Current Perspectives on the Clinical Experience, Pharmacology, and Continued Development of the Camptothecins

Rocio Garcia-Carbonero and Jeffrey G. Supko
Clin Cancer Res 2002 8: 641 [Abstract] [Full Text] [PDF]  

The Biology Behind:

Histone Deacetylase Inhibitors: A New Class of Potential Therapeutic Agents for Cancer Treatment : Commentary re: V. Sandor et al., Phase I Trial of the Histone Deacetylase Inhibitor, Depsipeptide (FR901228, NSC 630176), in Patients with Refractory Neoplasms. Clin. Cancer Res., 8: 718–728, 2002.

Victoria M. Richon and James P. O’Brien
Clin Cancer Res 2002 8: 662 [Full Text] [PDF]  

Report from the FDA:

Approval Summary: Letrozole in the Treatment of Postmenopausal Women with Advanced Breast Cancer

Martin H. Cohen, John R. Johnson, Ning Li, Gang Chen, and Richard Pazdur
Clin Cancer Res 2002 8: 665 [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Safety and Efficacy of the Multidrug Resistance Inhibitor Incel (Biricodar; VX-710) in Combination with Paclitaxel for Advanced Breast Cancer Refractory to Paclitaxel

Deborah Toppmeyer, Andrew D. Seidman, Michael Pollak, Christy Russell, Katherine Tkaczuk, Shailendra Verma, Beth Overmoyer, Varun Garg, Ene Ette, Matthew W. Harding, and George D. Demetri
Clin Cancer Res 2002 8: 670 [Abstract] [Full Text] [PDF]  

Phase I Trial of BCL-2 Antisense Oligonucleotide (G3139) Administered by Continuous Intravenous Infusion in Patients with Advanced Cancer

Michael J. Morris, William P. Tong, Carlos Cordon-Cardo, Marija Drobnjak, William K. Kelly, Susan F. Slovin, Kathryn L. Terry, Karen Siedlecki, Paul Swanson, Mohmed Rafi, Robert S. DiPaola, Neal Rosen, and Howard I. Scher
Clin Cancer Res 2002 8: 679 [Abstract] [Full Text] [PDF]  

Phase I Study of N¹,N¹¹-Diethylnorspermine in Patients with Non-Small Cell Lung Cancer

Hillary A. Hahm, David S. Ettinger, Kathy Bowling, Beth Hoker, Tian Ling Chen, Yelena Zabelina, and Robert A. Casero, Jr.
Clin Cancer Res 2002 8: 684 [Abstract] [Full Text] [PDF]  

A Phase I Clinical Trial of Sequentially Administered Doxorubicin and Topotecan in Refractory Solid Tumors

Michael V. Seiden, Shu-Wing Ng, Jeffrey G. Supko, David P. Ryan, Jeffrey W. Clark, Thomas Lynch, Kuan-Chun Huang, David Kwiatkowski, Arthur Skarin, and Joseph P. Eder, Jr.
Clin Cancer Res 2002 8: 691 [Abstract] [Full Text] [PDF]  

Association of High-dose Cyclophosphamide, Cisplatin, and Carmustine Pharmacokinetics with Survival, Toxicity, and Dosing Weight in Patients with Primary Breast Cancer

William P. Petros, Gloria Broadwater, Donald Berry, Roy B. Jones, James J. Vredenburgh, Colleen J. Gilbert, John P. Gibbs, O. Michael Colvin, and William P. Peters
Clin Cancer Res 2002 8: 698 [Abstract] [Full Text] [PDF]  

Phase I Clinical and Pharmacokinetic Study of Oral Penclomedine (NSC 338720) in Adults with Advanced Solid Malignancy

Glenn Liu, Jordan Berlin, Kendra D. Tutsch, Lynn Van Ummersen, Amy Dresen, Rebecca Marnocha, Rhoda Arzomanian, Dona Alberti, Chris Feierabend, Kimberly Binger, and George Wilding
Clin Cancer Res 2002 8: 706 [Abstract] [Full Text] [PDF]  

A Phase I Study of Bizelesin (NSC 615291) in Patients with Advanced Solid Tumors

Henry C. Pitot, Joel M. Reid, Jeff A. Sloan, Matthew M. Ames, Alex A. Adjei, Joseph Rubin, Pamela G. Bagniewski, Pamela Atherton, Daniel Rayson, Richard M. Goldberg, and Charles Erlichman
Clin Cancer Res 2002 8: 712 [Abstract] [Full Text] [PDF]  

Phase I Trial of the Histone Deacetylase Inhibitor, Depsipeptide (FR901228, NSC 630176), in Patients with Refractory Neoplasms

Victor Sandor, Susan Bakke, Robert W. Robey, Min H. Kang, Mikhail V. Blagosklonny, Jonathon Bender, Rebecca Brooks, Richard L. Piekarz, Eben Tucker, William D. Figg, Kenneth K. Chan, Barry Goldspiel, Antonio Tito Fojo, Stanley P. Balcerzak, and Susan E. Bates
Clin Cancer Res 2002 8: 718 [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Cyclin D3 Is a Predictive and Prognostic Factor in Diffuse Large B-cell Lymphoma

Martin Filipits, Ulrich Jaeger, Gudrun Pohl, Thomas Stranzl, Ingrid Simonitsch, Alexandra Kaider, Cathrin Skrabs, and Robert Pirker
Clin Cancer Res 2002 8: 729 [Abstract] [Full Text] [PDF]  

Differential Expression of Growth Factors in Squamous Cell Carcinoma and Precancerous Lesions of the Lung

Chandrika J. Piyathilake, Andra R. Frost, Uppender Manne, Heidi Weiss, Walter C. Bell, Douglas C. Heimburger, and William E. Grizzle
Clin Cancer Res 2002 8: 734 [Abstract] [Full Text] [PDF]  

Clinical Significance of Poor CD3 Response in Head and Neck Cancer

Terry Y. Shibuya, Nghia Nugyen, Christine E. McLaren, Kuo-Tung Li, Wei-Zen Wei, Sanghun Kim, George H. Yoo, Amy Rogowski, John Ensley, and Wael Sakr
Clin Cancer Res 2002 8: 745 [Abstract] [Full Text] [PDF]  

Autoimmunity to the M_r 32,000 Subunit of Replication Protein A in Breast Cancer

J. E. Tomkiel, H. Alansari, N. Tang, J. B. Virgin, X. Yang, P. VandeVord, R. L. Karvonen, J. L. Granda, M. J. Kraut, J. F. Ensley, and F. Fernández-Madrid
Clin Cancer Res 2002 8: 752 [Abstract] [Full Text] [PDF]  

Immunohistochemical Assessment of Localization and Frequency of Micrometastases in Lymph Nodes of Colorectal Cancer

Shingo Noura, Hirofumi Yamamoto, Yasuhiro Miyake, Byung no Kim, Osamu Takayama, Iwao Seshimo, Masakazu Ikenaga, Masataka Ikeda, Mitsugu Sekimoto, Nariaki Matsuura, and Morito Monden
Clin Cancer Res 2002 8: 759 [Abstract] [Full Text] [PDF]  

Profound Dihydropyrimidine Dehydrogenase Deficiency Resulting from a Novel Compound Heterozygote Genotype

Martin R. Johnson, Kangsheng Wang, and Robert B. Diasio
Clin Cancer Res 2002 8: 768 [Abstract] [Full Text] [PDF]  

The Association of p21^(WAF-1/CIP1) with Progression to Androgen-independent Prostate Cancer

Karim Fizazi, Luis A. Martinez, Charles R. Sikes, Dennis A. Johnston, L. Clifton Stephens, Timothy J. McDonnell, Christopher J. Logothetis, Jon Trapman, Louis L. Pisters, Nelson G. Ordoñez, Patricia Troncoso, and Nora M. Navone
Clin Cancer Res 2002 8: 775 [Abstract] [Full Text] [PDF]  

Methylthioadenosine Phosphorylase Gene Deletions Are Common in Osteosarcoma

José M. García-Castellano, Alberto Villanueva, John H. Healey, Rebecca Sowers, Carlos Cordon-Cardo, Andrew Huvos, Joseph R. Bertino, Paul Meyers, and Richard Gorlick
Clin Cancer Res 2002 8: 782 [Abstract] [Full Text] [PDF]  

Absence of HER2/neu Gene Expression in Osteosarcoma and Skeletal Ewing’s Sarcoma

Dafydd G. Thomas, Thomas J. Giordano, Donita Sanders, J. Sybil Biermann, and Laurence Baker
Clin Cancer Res 2002 8: 788 [Abstract] [Full Text] [PDF]  

The Feasibility of Using Fine Needle Aspiration from Primary Breast Cancers for cDNA Microarray Analyses

Laura Assersohn, Lisa Gangi, Yingdong Zhao, Mitch Dowsett, Richard Simon, Trevor J. Powles, and Edison T. Liu
Clin Cancer Res 2002 8: 794 [Abstract] [Full Text] [PDF]  

Polymorphisms in Genes Encoding Drugs and Xenobiotic Metabolizing Enzymes, DNA Repair Enzymes, and Response to Treatment of Childhood Acute Lymphoblastic Leukemia

Maja Krajinovic, Damian Labuda, Geraldine Mathonnet, Marcin Labuda, Albert Moghrabi, Josette Champagne, and Daniel Sinnett
Clin Cancer Res 2002 8: 802 [Abstract] [Full Text] [PDF]  

The Predictive Value of bcl-2, bax, bcl-xL, bag-1, fas, and fasL for Chemotherapy Response in Advanced Breast Cancer

Johanna Sjöström, Carl Blomqvist, Kristina von Boguslawski, Nils-Olof Bengtsson, Ingvil Mjaaland, Per Malmström, Björn Ostenstadt, Erik Wist, Vahur Valvere, Shinichi Takayama, John C. Reed, and Eero Saksela
Clin Cancer Res 2002 8: 811 [Abstract] [Full Text] [PDF]  

Significance of Cyclin B1 Expression as an Independent Prognostic Indicator of Patients with Squamous Cell Carcinoma of the Esophagus

Tadahiro Nozoe, Daisuke Korenaga, Akira Kabashima, Takefumi Ohga, Hiroshi Saeki, and Keizo Sugimachi
Clin Cancer Res 2002 8: 817 [Abstract] [Full Text] [PDF]  

Significance of the Expression of the Growth Factor Pleiotrophin in Pancreatic Cancer Patients

Hans-Jürgen Klomp, Oliver Zernial, Sabine Flachmann, Anton Wellstein, and Hartmut Juhl
Clin Cancer Res 2002 8: 823 [Abstract] [Full Text] [PDF]  

High Prevalence of Decreased Expression of KAI1 Metastasis Suppressor in Human Oral Carcinogenesis

Katsuhiro Uzawa, Kanae Ono, Hiroyoshi Suzuki, Chihaya Tanaka, Takashi Yakushiji, Nobuharu Yamamoto, Hidetaka Yokoe, and Hideki Tanzawa
Clin Cancer Res 2002 8: 828 [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Rituximab Modifies the Cisplatin-mitochondrial Signaling Pathway, Resulting in Apoptosis in Cisplatin-resistant Non-Hodgkin’s Lymphoma

Steve Alas, Chuen-Pei Ng, and Benjamin Bonavida
Clin Cancer Res 2002 8: 836 [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Induction by Paclitaxel, Docetaxel, and Taxane Analogues in Human Monocytes and Murine Macrophages: Structure-Activity Relationships and Their Implications

Pamela B. Cassidy, Philip J. Moos, Robert C. Kelly, and F. A. Fitzpatrick
Clin Cancer Res 2002 8: 846 [Abstract] [Full Text] [PDF]  

Structural Identification and Biological Activity of 7-Methyl-10,11-Ethylenedioxy-20(S)-Camptothecin, a Photodegradant of Lurtotecan

Walter J. Loos, Jaap Verweij, Diederik F. S. Kehrer, Peter de Bruijn, Franciscus M. H. de Groot, Marta Hamilton, Kees Nooter, Gerrit Stoter, and Alex Sparreboom
Clin Cancer Res 2002 8: 856 [Abstract] [Full Text] [PDF]  

Vitamin E Succinate Is a Potent Novel Antineoplastic Agent with High Selectivity and Cooperativity with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (Apo2 Ligand) in Vivo

Tobias Weber, Min Lu, Ladislav Andera, Harald Lahm, Nina Gellert, Marc W. Fariss, Vladimir Korinek, Wolfgang Sattler, David S. Ucker, Alexei Terman, Andreas Schröder, Wolfgang Erl, Ulf T. Brunk, Robert J. Coffey, Christian Weber, and Jiri Neuzil
Clin Cancer Res 2002 8: 863 [Abstract] [Full Text] [PDF]  

Anticancer Activity of Docetaxel in Murine Salivary Gland Carcinoma

Marie P. Piechocki, Fulvio Lonardo, John F. Ensley, Tam Nguyen, Harold Kim, and George H. Yoo
Clin Cancer Res 2002 8: 870 [Abstract] [Full Text] [PDF]  

Limited Penetration of Anticancer Drugs through Tumor Tissue: A Potential Cause of Resistance of Solid Tumors to Chemotherapy

Ian F. Tannock, Carol M. Lee, Jonathon K. Tunggal, David S. M. Cowan, and Merrill J. Egorin
Clin Cancer Res 2002 8: 878 [Abstract] [Full Text] [PDF]  

Local Recurrence in Head and Neck Cancer: Relationship to Radiation Resistance and Signal Transduction

Anjali K. Gupta, W. Gillies McKenna, Charles N. Weber, Michael D. Feldman, Jeffrey D. Goldsmith, Rosemarie Mick, Mitchell Machtay, David I. Rosenthal, Vincent J. Bakanauskas, George J. Cerniglia, Eric J. Bernhard, Randal S. Weber, and Ruth J. Muschel
Clin Cancer Res 2002 8: 885 [Abstract] [Full Text] [PDF]  

Resveratrol Induces Growth Inhibition, S-phase Arrest, Apoptosis, and Changes in Biomarker Expression in Several Human Cancer Cell Lines

Andrew K. Joe, Hui Liu, Masumi Suzui, Muhammet E. Vural, Danhua Xiao, and I. Bernard Weinstein
Clin Cancer Res 2002 8: 893 [Abstract] [Full Text] [PDF]  

Exisulind in Combination with Docetaxel Inhibits Growth and Metastasis of Human Lung Cancer and Prolongs Survival in Athymic Nude Rats with Orthotopic Lung Tumors

Daniel C. Chan, Keith A. Earle, Tom L. M. Zhao, Barbara Helfrich, Chan Zeng, Anna Baron, Clark M. Whitehead, Gary Piazza, Rifat Pamukcu, W. Joseph Thompson, Hector Alila, Peter Nelson, and Paul A. Bunn, Jr.
Clin Cancer Res 2002 8: 904 [Abstract] [Full Text] [PDF]  

Reduced Transduction Efficiency of Adenoviral Vectors Expressing Human p53 Gene by Repeated Transduction into Glioma Cells in Vitro

Shinji Yamamoto, Yoko Yoshida, Masaru Aoyagi, Kikuo Ohno, Kimiyoshi Hirakawa, and Hirofumi Hamada
Clin Cancer Res 2002 8: 913 [Abstract] [Full Text] [PDF]  

Direct Costimulation of Tumor-reactive CTL by Helper T Cells Potentiate Their Proliferation, Survival, and Effector Function

Robert L. Giuntoli, II, Jun Lu, Hiroya Kobayashi, Richard Kennedy, and Esteban Celis
Clin Cancer Res 2002 8: 922 [Abstract] [Full Text] [PDF]  

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