Editorials:

End Points in Cancer Clinical Trials and the Drug Approval Process

Richard L. Schilsky
Clin Cancer Res 2002 8: 935 [Abstract] [Full Text] [PDF]  

Differentiation Therapy for Myelodysplastic Syndrome

Wolf-K. Hofmann and H. Phillip Koeffler
Clin Cancer Res 2002 8: 939 [Full Text] [PDF]  

Increased Sophistication of Immunotoxins

Arthur E. Frankel
Clin Cancer Res 2002 8: 942 [Full Text] [PDF]  

Minireviews:

Activated STAT Signaling in Human Tumors Provides Novel Molecular Targets for Therapeutic Intervention

Ralf Buettner, Linda B. Mora, and Richard Jove
Clin Cancer Res 2002 8: 945 [Abstract] [Full Text] [PDF]  

The Biology Behind:

The Potential of Drug-carrying Immunoliposomes as Anticancer Agents : Commentary re: J. W. Park et al., Anti-HER2 Immunoliposomes: Enhanced Efficacy due to Targeted Delivery. Clin. Cancer Res., 8: 1172–1181, 2002.

Doris R. Siwak, Ana M. Tari, and Gabriel Lopez-Berestein
Clin Cancer Res 2002 8: 955 [Full Text] [PDF]  

Special Article:

The Department of Defense Congressionally Directed Medical Research Program: Innovations in the Federal Funding of Biomedical Research

Stacey Young-McCaughan, Irene M. Rich, Gaylord C. Lindsay, and Kenneth A. Bertram
Clin Cancer Res 2002 8: 957 [Abstract] [Full Text] [PDF]  

Advances in Brief:

Impact of Prolonged Infusions of the Putative Differentiating Agent Sodium Phenylbutyrate on Myelodysplastic Syndromes and Acute Myeloid Leukemia

Steven D. Gore, Li-Jun Weng, William D. Figg, Suoping Zhai, Ross C. Donehower, George Dover, Michael R. Grever, Constance Griffin, Louise B. Grochow, Anita Hawkins, Kathleen Burks, Yelena Zabelena, and Carole B. Miller
Clin Cancer Res 2002 8: 963 [Abstract] [Full Text] [PDF]  

2-[¹⁸F]Fluoro-2-deoxyglucose and Glucose Uptake in Malignant Gliomas before and after Radiotherapy: Correlation with Outcome

Alexander M. Spence, Mark Muzi, Michael M. Graham, Finbarr O’Sullivan, Jeanne M. Link, Thomas K. Lewellen, Barbara Lewellen, Scott D. Freeman, David A. Mankoff, Janet F. Eary, and Kenneth A. Krohn
Clin Cancer Res 2002 8: 971 [Abstract] [Full Text] [PDF]  

p14ARF Promoter Hypermethylation in Plasma DNA as an Indicator of Disease Recurrence in Bladder Cancer Patients

Gemma Domínguez, Joaquín Carballido, Javier Silva, Jose M. Silva, Jose M. García, Josefa Menéndez, Mariano Provencio, Pilar España, and Felix Bonilla
Clin Cancer Res 2002 8: 980 [Abstract] [Full Text] [PDF]  

Circulating Epstein-Barr Virus DNA in Serum of Patients with Lymphoepithelioma-like Carcinoma of the Lung: A Potential Surrogate Marker for Monitoring Disease

Roger K. C. Ngan, Timothy T. C. Yip, Wai-Wai Cheng, John K. C. Chan, William C. S. Cho, Victor W. S. Ma, Kwong-Kee Wan, Siu-Kie Au, Chun-Key Law, and Wai-Hon Lau
Clin Cancer Res 2002 8: 986 [Abstract] [Full Text] [PDF]  

Improved Cytotoxic Activity toward Cell Lines and Fresh Leukemia Cells of a Mutant Anti-CD22 Immunotoxin Obtained by Antibody Phage Display

Giuliana Salvatore, Richard Beers, Inger Margulies, Robert J. Kreitman, and Ira Pastan
Clin Cancer Res 2002 8: 995 [Abstract] [Full Text] [PDF]  

Inhibition of Androgen-independent Growth of Prostate Cancer Xenografts by 17ß-Estradiol

Eva Corey, Janna E. Quinn, Mary J. Emond, Kent R. Buhler, Lisha G. Brown, and Robert L. Vessella
Clin Cancer Res 2002 8: 1003 [Abstract] [Full Text] [PDF]  

Role of Host Microenvironment in Angiogenesis and Microvascular Functions in Human Breast Cancer Xenografts: Mammary Fat Pad versus Cranial Tumors

Wayne L. Monsky, Carla Mouta Carreira, Yoshikazu Tsuzuki, Takeshi Gohongi, Dai Fukumura, and Rakesh K. Jain
Clin Cancer Res 2002 8: 1008 [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Therapeutic Potential of a Reduced-Intensity Preparative Regimen for Allogeneic Transplantation with Cladribine, Busulfan, and Antithymocyte Globulin against Advanced/Refractory Acute Leukemia/Lymphoma

Takeshi Saito, Yoshinobu Kanda, Masahiro Kami, Kazunori Kato, Nahoko Shoji, Sachiyo Kanai, Toshihiro Ohnishi, Yoshifumi Kawano, Kunihisa Nakai, Toshie Ogasawara, Hiroshi Matsubara, Atsushi Makimoto, Ryuji Tanosaki, Kensei Tobinai, Hiro Wakasugi, Yoichi Takaue, and Shin Mineishi
Clin Cancer Res 2002 8: 1014 [Abstract] [Full Text] [PDF]  

A Phase I Trial of Tumor Lysate-pulsed Dendritic Cells in the Treatment of Advanced Cancer

Alfred E. Chang, Bruce G. Redman, Joel R. Whitfield, Brian J. Nickoloff, Thomas M. Braun, Peter P. Lee, James D. Geiger, and James J. Mulé
Clin Cancer Res 2002 8: 1021 [Abstract] [Full Text] [PDF]  

Phase I and Pharmacokinetics Study of Crotoxin (Cytotoxic PLA₂, NSC-624244) in Patients with Advanced Cancer

Jorge E. Cura, Daniel P. Blanzaco, Cecilia Brisson, Marco A. Cura, Rosa Cabrol, Luis Larrateguy, Carlos Mendez, Jose Carlos Sechi, Jorge Solana Silveira, Elvira Theiller, Adolfo R. de Roodt, and Juan Carlos Vidal
Clin Cancer Res 2002 8: 1033 [Abstract] [Full Text] [PDF]  

Phase I Clinical and Pharmacokinetic Study of Protein Kinase C- Antisense Oligonucleotide ISIS 3521 Administered in Combination with 5-Fluorouracil and Leucovorin in Patients with Advanced Cancer

Sridhar Mani, Charles M. Rudin, Katie Kunkel, Jon T. Holmlund, Richard S. Geary, Hedy L. Kindler, F. Andrew Dorr, and Mark J. Ratain
Clin Cancer Res 2002 8: 1042 [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Importance of Serum Hemoglobin in Hormone Refractory Prostate Cancer

Robin T. Vollmer, Philip W. Kantoff, Nancy A. Dawson, and Nicholas J. Vogelzang
Clin Cancer Res 2002 8: 1049 [Abstract] [Full Text] [PDF]  

Regulation of Stromal Versican Expression by Breast Cancer Cells and Importance to Relapse-free Survival in Patients with Node-negative Primary Breast Cancer

Carmela Ricciardelli, John H. Brooks, Supaporn Suwiwat, Andrew J. Sakko, Keiko Mayne, Wendy A. Raymond, Ram Seshadri, Richard G. LeBaron, and David J. Horsfall
Clin Cancer Res 2002 8: 1054 [Abstract] [Full Text] [PDF]  

Amplification and Overexpression of Topoisomerase II Predict Response to Anthracycline-based Therapy in Locally Advanced Breast Cancer

John S. Coon, Elizabeth Marcus, Shalina Gupta-Burt, Steven Seelig, Kris Jacobson, Shande Chen, Vivian Renta, Geraldo Fronda, and Harvey D. Preisler
Clin Cancer Res 2002 8: 1061 [Abstract] [Full Text] [PDF]  

Expression of the Breast Cancer Resistance Protein in Breast Cancer

Ian F. Faneyte, Petra M. P. Kristel, Marc Maliepaard, George L. Scheffer, Rik J. Scheper, Jan H. M. Schellens, and Marc J. van de Vijver
Clin Cancer Res 2002 8: 1068 [Abstract] [Full Text] [PDF]  

Minichromosome Maintenance Protein 2 Expression in Normal Kidney and Renal Cell Carcinomas: Relationship to Tumor Dormancy and Potential Clinical Utility

Karl Rodins, Michelle Cheale, Nicholas Coleman, and Stephen B. Fox
Clin Cancer Res 2002 8: 1075 [Abstract] [Full Text] [PDF]  

Quantitative Reverse Transcription-Polymerase Chain Reaction Measurement of HASH1 (ASCL1), a Marker for Small Cell Lung Carcinomas with Neuroendocrine Features

Bart A. Westerman, Sari Neijenhuis, Ankie Poutsma, Renske D. M. Steenbergen, Roderick H. J. Breuer, Monique Egging, Inge J. van Wijk, and Cees B. M. Oudejans
Clin Cancer Res 2002 8: 1082 [Abstract] [Full Text] [PDF]  

Silencing of GSTP1 Gene by CpG Island DNA Hypermethylation in HBV-associated Hepatocellular Carcinomas

Sheng Zhong, Mandy W. Tang, Winnie Yeo, Cuiling Liu, Y. M. Dennis Lo, and Philip J. Johnson
Clin Cancer Res 2002 8: 1087 [Abstract] [Full Text] [PDF]  

Squamous Cell Carcinoma of the Tonsils: A Molecular Analysis of HPV Associations

Scott E. Strome, Athanasia Savva, Anthony E. Brissett, Bobbie S. Gostout, Jean Lewis, Amy C. Clayton, Renee McGovern, Amy L. Weaver, David Persing, and Jan L. Kasperbauer
Clin Cancer Res 2002 8: 1093 [Abstract] [Full Text] [PDF]  

Expression of the Serine Protease Matriptase and Its Inhibitor HAI-1 in Epithelial Ovarian Cancer: Correlation with Clinical Outcome and Tumor Clinicopathological Parameters

Michael D. Oberst, Michael D. Johnson, Robert B. Dickson, Chen-Yong Lin, Baljit Singh, Moira Stewart, Alastair Williams, Awatif al-Nafussi, John F. Smyth, Hani Gabra, and Grant C. Sellar
Clin Cancer Res 2002 8: 1101 [Abstract] [Full Text] [PDF]  

Analysis of Chemokines and Chemokine Receptor Expression in Ovarian Cancer Ascites

David Milliken, Chris Scotton, Shanti Raju, Fran Balkwill, and Julia Wilson
Clin Cancer Res 2002 8: 1108 [Abstract] [Full Text] [PDF]  

Polymorphisms in the Promoter Region of the Neutrophil Elastase Gene Are Associated with Lung Cancer Development

Ken Taniguchi, Ping Yang, James Jett, Eric Bass, Rebecca Meyer, Yunjie Wang, Claude Deschamps, and Wanguo Liu
Clin Cancer Res 2002 8: 1115 [Abstract] [Full Text] [PDF]  

Infrequent Mutation in the BRCA2 Gene in Esophageal Squamous Cell Carcinoma

Nan Hu, Guang Li, Wen-Jun Li, Chaoyu Wang, Alisa M. Goldstein, Ze-Zhong Tang, Mark J. Roth, Sanford M. Dawsey, Jing Huang, Quan-Hong Wang, Ti Ding, Carol Giffen, Philip R. Taylor, and Michael R. Emmert-Buck
Clin Cancer Res 2002 8: 1121 [Abstract] [Full Text] [PDF]  

Differential Gene Expression in Human Lung Adenocarcinomas and Squamous Cell Carcinomas

Amy L. McDoniels-Silvers, Caramella F. Nimri, Gary D. Stoner, Ronald A. Lubet, and Ming You
Clin Cancer Res 2002 8: 1127 [Abstract] [Full Text] [PDF]  

Bombesin Receptor Subtypes in Human Cancers: Detection with the Universal Radioligand ¹²⁵I-[D-TYR⁶, ß-ALA¹¹, PHE¹³, NLE¹⁴] Bombesin(6–14)

Jean Claude Reubi, Sandra Wenger, Jacqueline Schmuckli-Maurer, Jean-Claude Schaer, and Mathias Gugger
Clin Cancer Res 2002 8: 1139 [Abstract] [Full Text] [PDF]  

Increased Expression of CD40 Ligand on Activated T Cells of Patients with Colon Cancer

Carsten Büning, Katrin Krüger, Thomas Sieber, Dagmar Schoeler, and Folke Schriever
Clin Cancer Res 2002 8: 1147 [Abstract] [Full Text] [PDF]  

Degradation of Tenascin-C and Activity of Matrix Metalloproteinase-2 Are Associated with Tumor Recurrence in Early Stage Non-Small Cell Lung Cancer

Ming Cai, Koji Onoda, Motoshi Takao, Imanaka-Yoshida Kyoko, Hideto Shimpo, Toshimichi Yoshida, and Isao Yada
Clin Cancer Res 2002 8: 1152 [Abstract] [Full Text] [PDF]  

Expressions of Cyclooxygenase-2 and Prostaglandin E-Receptors in Carcinoma of the Gallbladder: Crucial Role of Arachidonate Metabolism in Tumor Growth and Progression

Toru Asano, Junichi Shoda, Tetsuya Ueda, Toru Kawamoto, Takeshi Todoroki, Manabu Shimonishi, Tadashi Tanabe, Yukihiko Sugimoto, Atsushi Ichikawa, Michihiro Mutoh, Naomi Tanaka, and Masanao Miwa
Clin Cancer Res 2002 8: 1157 [Abstract] [Full Text] [PDF]  

Immunohistochemical Demonstration of Phospho-Akt in High Gleason Grade Prostate Cancer

Shazli N. Malik, Michael Brattain, Paramita M. Ghosh, Dean A. Troyer, Thomas Prihoda, Roble Bedolla, and Jeffrey I. Kreisberg
Clin Cancer Res 2002 8: 1168 [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Anti-HER2 Immunoliposomes: Enhanced Efficacy Attributable to Targeted Delivery

John W. Park, Keelung Hong, Dmitri B. Kirpotin, Gail Colbern, Refaat Shalaby, Jose Baselga, Yvonne Shao, Ulrik B. Nielsen, James D. Marks, Dan Moore, Demetrios Papahadjopoulos, and Christopher C. Benz
Clin Cancer Res 2002 8: 1172 [Abstract] [Full Text] [PDF]  

Antiangiogenic and Antitumor Activity of IDN 5390, a New Taxane Derivative

Giulia Taraboletti, Gianluca Micheletti, Monica Rieppi, Maura Poli, Michele Turatto, Cosmo Rossi, Patrizia Borsotti, Paola Roccabianca, Eugenio Scanziani, Maria Ines Nicoletti, Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, and Raffaella Giavazzi
Clin Cancer Res 2002 8: 1182 [Abstract] [Full Text] [PDF]  

Enhancement of DNA Ligase I Level by Gemcitabine in Human Cancer Cells

Daekyu Sun, Rheanna Urrabaz, Susan Kelly, Myhanh Nguyen, and Steve Weitman
Clin Cancer Res 2002 8: 1189 [Abstract] [Full Text] [PDF]  

A Novel Design of Targeted Endocrine and Cytokine Therapy for Breast Cancer

Guorong Zhang, Wei Li, Lori Holle, Nianyi Chen, and Wen Yuan Chen
Clin Cancer Res 2002 8: 1196 [Abstract] [Full Text] [PDF]  

Enhanced Growth Inhibition by Combination Differentiation Therapy with Ligands of Peroxisome Proliferator-activated Receptor- and Inhibitors of Histone Deacetylase in Adenocarcinoma of the Lung

Tsg-Hui Chang and Eva Szabo
Clin Cancer Res 2002 8: 1206 [Abstract] [Full Text] [PDF]  

Tumor-specific Regulation of Angiogenic Growth Factors and Their Receptors during Recovery from Cytotoxic Therapy

Alice P. Taylor, Louis Osorio, Russell Craig, James A. Raleigh, Zhiliang Ying, David M. Goldenberg, and Rosalyn D. Blumenthal
Clin Cancer Res 2002 8: 1213 [Abstract] [Full Text] [PDF]  

Radiation-induced Increase in Invasive Potential of Human Pancreatic Cancer Cells and Its Blockade by a Matrix Metalloproteinase Inhibitor, CGS27023

Li-Wu Qian, Kazuhiro Mizumoto, Taro Urashima, Eishi Nagai, Naoki Maehara, Norihiro Sato, Motowo Nakajima, and Masao Tanaka
Clin Cancer Res 2002 8: 1223 [Abstract] [Full Text] [PDF]  

Akt Inactivation Is a Key Event in Indole-3-carbinol-induced Apoptosis in PC-3 Cells

Sreenivasa R. Chinni and Fazlul H. Sarkar
Clin Cancer Res 2002 8: 1228 [Abstract] [Full Text] [PDF]  

Influence of Cremophor EL on the Bioavailability of Intraperitoneal Paclitaxel

Hans Gelderblom, Jaap Verweij, Desirée M. van Zomeren, Dirk Buijs, Linda Ouwens, Kees Nooter, Gerrit Stoter, and Alex Sparreboom
Clin Cancer Res 2002 8: 1237 [Abstract] [Full Text] [PDF]  

The Antiangiogenic Agent Neovastat (Æ-941) Inhibits Vascular Endothelial Growth Factor-mediated Biological Effects

Richard Béliveau, Denis Gingras, Erwin A. Kruger, Sylvie Lamy, Pierre Sirois, Bryan Simard, Martin G. Sirois, Leone Tranqui, Fabienne Baffert, Édith Beaulieu, Violetta Dimitriadou, Marie-Claude Pépin, Frank Courjal, Isabelle Ricard, Patrick Poyet, Pierre Falardeau, William D. Figg, and Éric Dupont
Clin Cancer Res 2002 8: 1242 [Abstract] [Full Text] [PDF]  

Luteinizing Hormone-releasing Hormone Agonist Limits DU-145 Prostate Cancer Growth by Attenuating Epidermal Growth Factor Receptor Signaling

Alan Wells, Jose Carlos S. Souto, James Solava, Jareer Kassis, Karlyn J. Bailey, and Timothy Turner
Clin Cancer Res 2002 8: 1251 [Abstract] [Full Text] [PDF]  

Inhibition of Tumorigenicity and Metastasis of Human Bladder Cancer Growing in Athymic Mice by Interferon-ß Gene Therapy Results Partially from Various Antiangiogenic Effects Including Endothelial Cell Apoptosis

Jonathan I. Izawa, Paul Sweeney, Paul Perrotte, Daniel Kedar, Zhongyun Dong, Joel W. Slaton, Takashi Karashima, Keji Inoue, William F. Benedict, and Colin P. N. Dinney
Clin Cancer Res 2002 8: 1258 [Abstract] [Full Text] [PDF]  

Trojan p16 Peptide Suppresses Pancreatic Cancer Growth and Prolongs Survival in Mice

Ryo Hosotani, Yoshiharu Miyamoto, Koji Fujimoto, Ryuichiro Doi, Akira Otaka, Nobutaka Fujii, and Masayuki Imamura
Clin Cancer Res 2002 8: 1271 [Abstract] [Full Text] [PDF]  

Bcl-2 Antisense Oligonucleotides Are Effective against Systemic but not Central Nervous System Disease in Severe Combined Immunodeficient Mice Bearing Human t(14;18) Follicular Lymphoma

Ramzi Mohammad, Yousif Abubakr, Maria Dan, Amro Aboukameel, Christine Chow, Anwar Mohamed, Nayera Hamdy, and Ayad Al-Katib
Clin Cancer Res 2002 8: 1277 [Abstract] [Full Text] [PDF]  

   Cancer Biology, Immunology, Cytokines:

Acid Production in Glycolysis-impaired Tumors Provides New Insights into Tumor Metabolism

Gabriel Helmlinger, Axel Sckell, Marc Dellian, Neil S. Forbes, and Rakesh K. Jain
Clin Cancer Res 2002 8: 1284 [Abstract] [Full Text] [PDF]  

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