Report from the FDA:

Approval Summary for Imatinib Mesylate Capsules in the Treatment of Chronic Myelogenous Leukemia

Martin H. Cohen, Grant Williams, John R. Johnson, John Duan, Jogarao Gobburu, Atiqur Rahman, Kimberly Benson, John Leighton, Sung K. Kim, Rebecca Wood, Mark Rothmann, Gang Chen, Khin Maung U, Ann M. Staten, and Richard Pazdur
Clin Cancer Res 2002 8: 935 [Abstract] [Full Text] [PDF]  

The Cooperative Group Bulletin Board:

Cooperative Group Tissue Banks As Research Resources: The Cancer and Leukemia Group B Tissue Repositories

Richard L. Schilsky, Lynn M. Dressler, Donna Bucci, Laura Monovich, Scott Jewell, Saul Suster, Michael A. Caligiuri, Philip W. Kantoff, and Carolyn Compton
Clin Cancer Res 2002 8: 943 [Full Text] [PDF]  

Review:

Transcription Factors and Neoplasia: Vistas in Novel Drug Design

Mihalis V. Karamouzis, Vassilis G. Gorgoulis, and Athanasios G. Papavassiliou
Clin Cancer Res 2002 8: 949 [Abstract] [Full Text] [PDF]  

The Biology Behind:

Heat Shock Protein 90 Inhibition by 17-Allylamino-17- demethoxygeldanamycin: A Novel Therapeutic Approach for Treating Hormone-refractory Prostate Cancer : Commentary re: D. B. Solit et al., 17-Allylamino-17-demethoxygeldanamycin Induces the Degradation of Androgen Receptor and Her-2/neu and Inhibits the Growth of Prostate Cancer Xenografts. Clin. Cancer Res., 8: 986–993, 2002.

Len Neckers
Clin Cancer Res 2002 8: 962 [Full Text] [PDF]  

Advances in Brief:

T-Cell Responses against Tyrosinase 368–376(370D) Peptide in HLA_*A0201⁺ Melanoma Patients: Randomized Trial Comparing Incomplete Freund’s Adjuvant, Granulocyte Macrophage Colony-stimulating Factor, and QS-21 as Immunological Adjuvants

Susanne G. Schaed, Virginia M. Klimek, Katherine S. Panageas, Cristina M. Musselli, Leah Butterworth, Wen-Jen Hwu, Philip O. Livingston, Linda Williams, Jonathan J. Lewis, Alan N. Houghton, and Paul B. Chapman
Clin Cancer Res 2002 8: 967 [Abstract] [Full Text] [PDF]  

p53 Mutations in Leukemia and Myelodysplastic Syndrome after Ovarian Cancer

Debra G. B. Leonard, Lois B. Travis, Kathakali Addya, Graca M. Dores, Eric J. Holowaty, Kjell Bergfeldt, David Malkin, Betsy A. Kohler, Charles F. Lynch, Tom Wiklund, Marilyn Stovall, Per Hall, Eero Pukkala, Diana J. Slater, and Carolyn A. Felix
Clin Cancer Res 2002 8: 973 [Abstract] [Full Text] [PDF]  

17-Allylamino-17-demethoxygeldanamycin Induces the Degradation of Androgen Receptor and HER-2/neu and Inhibits the Growth of Prostate Cancer Xenografts

David B. Solit, Fuzhong F. Zheng, Maria Drobnjak, Pamela N. Münster, Brian Higgins, David Verbel, Glenn Heller, William Tong, Carlos Cordon-Cardo, David B. Agus, Howard I. Scher, and Neal Rosen
Clin Cancer Res 2002 8: 986 [Abstract] [Full Text] [PDF]  

Enhanced Antitumor Activity of Anti-epidermal Growth Factor Receptor Monoclonal Antibody IMC-C225 in Combination with Irinotecan (CPT-11) against Human Colorectal Tumor Xenografts

Marie C. Prewett, Andrea T. Hooper, Rajiv Bassi, Lee M. Ellis, Harlan W. Waksal, and Daniel J. Hicklin
Clin Cancer Res 2002 8: 994 [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Phase I Trial of a Novel Diphtheria Toxin/Granulocyte Macrophage Colony-stimulating Factor Fusion Protein (DT₃₈₈GMCSF) for Refractory or Relapsed Acute Myeloid Leukemia

Arthur E. Frankel, Bayard L. Powell, Philip D. Hall, L. Douglas Case, and Robert J. Kreitman
Clin Cancer Res 2002 8: 1004 [Abstract] [Full Text] [PDF]  

Immunization of Cancer Patients with a HER-2/neu, HLA-A2 Peptide, p369–377, Results in Short-lived Peptide-specific Immunity

Keith L. Knutson, Kathy Schiffman, Martin A. Cheever, and Mary L. Disis
Clin Cancer Res 2002 8: 1014 [Abstract] [Full Text] [PDF]  

Induction of p53-specific Immune Responses in Colorectal Cancer Patients Receiving a Recombinant ALVAC-p53 Candidate Vaccine

Sjoerd H. van der Burg, Anand G Menon, Anke Redeker, Marie-Claude Bonnet, Jan Wouter Drijfhout, Rob A. E. M. Tollenaar, Cornelis J. H. van de Velde, Philippe Moingeon, Peter J. K. Kuppen, Rienk Offringa, and Cornelis J. M. Melief
Clin Cancer Res 2002 8: 1019 [Abstract] [Full Text] [PDF]  

Encapsulated Plasmid DNA Treatment for Human Papillomavirus 16-associated Anal Dysplasia: A Phase I Study of ZYC101

Barbara Klencke, Mark Matijevic, Robert G. Urban, Janet L. Lathey, Mary Lynne Hedley, Michael Berry, Joe Thatcher, Vivian Weinberg, Jennifer Wilson, Teresa Darragh, Naomi Jay, Maria Da Costa, and Joel M. Palefsky
Clin Cancer Res 2002 8: 1028 [Abstract] [Full Text] [PDF]  

Phase I and Pharmacokinetic Study of ABI-007, a Cremophor-free, Protein-stabilized, Nanoparticle Formulation of Paclitaxel

Nuhad K. Ibrahim, Neil Desai, Sewa Legha, Patrick Soon-Shiong, Richard L. Theriault, Edgardo Rivera, Bita Esmaeli, Sigrid E. Ring, Agop Bedikian, Gabriel N. Hortobagyi, and Julie A. Ellerhorst
Clin Cancer Res 2002 8: 1038 [Abstract] [Full Text] [PDF]  

Impact of Two Weekly Schedules of Oral Eniluracil Given with Fluorouracil and Leucovorin on the Duration of Dihydropyrimidine Dehydrogenase Inhibition

Bruce Keith, Xiao-Du Guo, Suzanne Zentko, Nancy Harold, Barbara Schuler, Mary Quinn, Jeremy Shapiro, and Jean L. Grem
Clin Cancer Res 2002 8: 1045 [Abstract] [Full Text] [PDF]  

Treatment of Advanced Breast Cancer with Docetaxel and Gemcitabine with and without Human Granulocyte Colony-stimulating Factor

Gabriela V. Kornek, Karin Haider, Werner Kwasny, Markus Raderer, Birgit Schüll, Thomas Payrits, Dieter Depisch, Erwin Kovats, Fritz Lang, and Werner Scheithauer
Clin Cancer Res 2002 8: 1051 [Abstract] [Full Text] [PDF]  

A Phase I/Pilot Study of Sequential Doxorubicin/Vinorelbine: Effects on p53 and Microtubule-associated Protein 4

Judy Bash-Babula, Deborah Toppmeyer, Marie Labassi, Janice Reidy, Michelle Orlick, Rachelle Senzon, Elizabeth Alli, Thomas Kearney, David August, Weichung Shih, Jin-Ming Yang, and William N. Hait
Clin Cancer Res 2002 8: 1057 [Abstract] [Full Text] [PDF]  

A Phase I Trial of the Farnesyltransferase Inhibitor L-778,123 and Radiotherapy for Locally Advanced Lung and Head and Neck Cancer

Stephen M. Hahn, Eric J. Bernhard, William Regine, Mohammed Mohiuddin, Daniel G. Haller, James P. Stevenson, Debbie Smith, Barnali Pramanik, Joel Tepper, Thomas F. DeLaney, Krystina D. Kiel, Briggs Morrison, Paul Deutsch, Ruth J. Muschel, and W. Gillies McKenna
Clin Cancer Res 2002 8: 1065 [Abstract] [Full Text] [PDF]  

Evaluation of Paclitaxel in Adjuvant Chemotherapy for Patients with Operable Breast Cancer: Preliminary Data of a Prospective Randomized Trial

Aman U. Buzdar, S. Eva Singletary, Vicente Valero, Daniel J. Booser, Nuhad K. Ibrahim, Zia Rahman, Richard L. Theriault, Ronald Walters, Edgardo Rivera, Terry L. Smith, Frankie A. Holmes, Emma Hoy, Debra K. Frye, Nikki Manuel, Shu-Wan Kau, Marsha D. McNeese, Eric Strom, Eva Thomas, Kelly Hunt, Fred Ames, Donald Berry, and Gabriel N. Hortobagyi
Clin Cancer Res 2002 8: 1073 [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Pamidronate Induces Modifications of Circulating Angiogenetic Factors in Cancer Patients

Daniele Santini, Bruno Vincenzi, Giuseppe Avvisati, Giordano Dicuonzo, Fabrizio Battistoni, Michele Gavasci, Alfredo Salerno, Vincenzo Denaro, and Giuseppe Tonini
Clin Cancer Res 2002 8: 1080 [Abstract] [Full Text] [PDF]  

Detection of Circulating Cytokeratin-positive Cells in the Blood of Breast Cancer Patients Using Immunomagnetic Enrichment and Digital Microscopy

Thomas E. Witzig, Blaise Bossy, Teresa Kimlinger, Patrick C. Roche, James N. Ingle, Clive Grant, John Donohue, Vera J. Suman, Douglas Harrington, Jose Torre-Bueno, and Kenneth D. Bauer
Clin Cancer Res 2002 8: 1085 [Abstract] [Full Text] [PDF]  

Intestinal Trefoil Factor: A Marker of Poor Prognosis in Gastric Carcinoma

Takasuke Yamachika, J. Lawrence Werther, Carol Bodian, Mark Babyatsky, Masae Tatematsu, Yoshitaka Yamamura, Anli Chen, and Steven Itzkowitz
Clin Cancer Res 2002 8: 1092 [Abstract] [Full Text] [PDF]  

Dysregulation of PTEN and Protein Kinase B Is Associated with Glioma Histology and Patient Survival

Ralph P. Ermoian, Constance S. Furniss, Kathleen R. Lamborn, Daniel Basila, Mitchel S. Berger, Alexander R. Gottschalk, M. Kelly Nicholas, David Stokoe, and Daphne A. Haas-Kogan
Clin Cancer Res 2002 8: 1100 [Abstract] [Full Text] [PDF]  

HER-2 Amplification and Topoisomerase II Gene Aberrations as Predictive Markers in Node-positive Breast Cancer Patients Randomly Treated Either with an Anthracycline-based Therapy or with Cyclophosphamide, Methotrexate, and 5-Fluorouracil

Angelo Di Leo, David Gancberg, Denis Larsimont, Minna Tanner, Tero Jarvinen, Ghizlane Rouas, Stella Dolci, Jean-Yves Leroy, Marianne Paesmans, Jorma Isola, and Martine J. Piccart
Clin Cancer Res 2002 8: 1107 [Abstract] [Full Text] [PDF]  

Prognostic Impact of TP53 Mutations and P53 Protein Overexpression in Supratentorial WHO Grade II Astrocytomas and Oligoastrocytomas

Aurelia Peraud, Friedrich W. Kreth, Otmar D. Wiestler, Paul Kleihues, and Hans-Jürgen Reulen
Clin Cancer Res 2002 8: 1117 [Abstract] [Full Text] [PDF]  

Inhibition of Infiltration and Angiogenesis by Thrombospondin-1 in Papillary Thyroid Carcinoma

Katsuhiro Tanaka, Hiroshi Sonoo, Junichi Kurebayashi, Tsunehisa Nomura, Sumiko Ohkubo, Yutaka Yamamoto, and Shigeru Yamamoto
Clin Cancer Res 2002 8: 1125 [Abstract] [Full Text] [PDF]  

Prognostic Significance of Soluble Urokinase Plasminogen Activator Receptor in Serum and Cytosol of Tumor Tissue from Patients with Primary Breast Cancer

Rikke Riisbro, Ib J. Christensen, Timo Piironen, Michael Greenall, Berthe Larsen, Ross W. Stephens, Cheng Han, Gunilla Høyer-Hansen, Kenneth Smith, Nils Brünner, and Adrian L. Harris
Clin Cancer Res 2002 8: 1132 [Abstract] [Full Text] [PDF]  

Doppler Ultrasonography of the Uterine Artery and the Response to Chemotherapy in Patients with Gestational Trophoblastic Tumors

Roshan Agarwal, Sarah Strickland, Iain A. McNeish, Daksha C. Patel, Marianne Foskett, Joe E. Boultbee, Edward S. Newlands, and Michael J. Seckl
Clin Cancer Res 2002 8: 1142 [Abstract] [Full Text] [PDF]  

Ki-67 Staining Is an Independent Correlate of Biochemical Failure in Prostate Cancer Treated with Radiotherapy

Didier Cowen, Patricia Troncoso, Vincent S. Khoo, Gunar K. Zagars, Andrew C. von Eschenbach, Marvin L. Meistrich, and Alan Pollack
Clin Cancer Res 2002 8: 1148 [Abstract] [Full Text] [PDF]  

Development and Validation of a Method for Using Breast Core Needle Biopsies for Gene Expression Microarray Analyses

Matthew Ellis, Natalie Davis, Andrew Coop, Minetta Liu, Lisa Schumaker, Richard Y. Lee, Rujirutana Srikanchana, Chris G. Russell, Baljit Singh, William R. Miller, Vered Stearns, Marie Pennanen, Theodore Tsangaris, Ann Gallagher, Aiyi Liu, Alan Zwart, Daniel F. Hayes, Marc E. Lippman, Yue Wang, and Robert Clarke
Clin Cancer Res 2002 8: 1155 [Abstract] [Full Text] [PDF]  

High Expression of Wilms’ Tumor Suppressor Gene Predicts Poor Prognosis in Breast Cancer Patients

Yasuo Miyoshi, Akiko Ando, Chiyomi Egawa, Tetsuya Taguchi, Yasuhiro Tamaki, Hiroya Tamaki, Haruo Sugiyama, and Shinzaburo Noguchi
Clin Cancer Res 2002 8: 1167 [Abstract] [Full Text] [PDF]  

Maspin Expression Profile in Human Prostate Cancer (CaP) and in Vitro Induction of Maspin Expression by Androgen Ablation

Zhiqiang Zou, Wei Zhang, Denise Young, Martin G. Gleave, Paul Rennie, Theresa Connell, Roger Connelly, Judd Moul, Shiv Srivastava, and Isabell Sesterhenn
Clin Cancer Res 2002 8: 1172 [Abstract] [Full Text] [PDF]  

Lack of PTEN Expression in Non-Small Cell Lung Cancer Could Be Related to Promoter Methylation

Jean-Charles Soria, Ho-Young Lee, Janet I. Lee, Luo Wang, Jean-Pierre Issa, Bonnie L. Kemp, Diane D. Liu, Jonathan M. Kurie, Li Mao, and Fadlo R. Khuri
Clin Cancer Res 2002 8: 1178 [Abstract] [Full Text] [PDF]  

Differential Assessment of Vascular Survival Ability and Tumor Angiogenic Activity in Colorectal Cancer

Alexandra Giatromanolaki, Efthimios Sivridis, George Minopoulos, Alexandros Polychronidis, Constantinos Manolas, Constantinos Simopoulos, and Michael I. Koukourakis
Clin Cancer Res 2002 8: 1185 [Abstract] [Full Text] [PDF]  

p53 Mutation Arising in Arg72 Allele in the Tumorigenesis and Development of Carcinoma of the Urinary Tract

Mutsuo Furihata, Tamotsu Takeuchi, Manabu Matsumoto, Atsushi Kurabayashi, Yuji Ohtsuki, Naotami Terao, Morimasa Kuwahara, and Taro Shuin
Clin Cancer Res 2002 8: 1192 [Abstract] [Full Text] [PDF]  

Failure of BRCA1 Dysfunction to Alter Ovarian Cancer Survival

Richard E. Buller, Mark S. Shahin, John P. Geisler, Melanie Zogg, Barry R. De Young, and Charles S. Davis
Clin Cancer Res 2002 8: 1196 [Abstract] [Full Text] [PDF]  

Real-Time Quantitative PCR Demonstrates Low Prevalence of Human Papillomavirus Type 16 in Premalignant and Malignant Lesions of the Oral Cavity

Patrick K. Ha, Sara I. Pai, William H. Westra, Maura L. Gillison, Betty C. Tong, David Sidransky, and Joseph A. Califano
Clin Cancer Res 2002 8: 1203 [Abstract] [Full Text] [PDF]  

DNA Sequence Losses on Chromosomes 11p and 18q Are Associated with Clinical Outcome in Lymph Node-negative Ductal Breast Cancer

Athanassios Dellas, Joachim Torhorst, Elisabeth Schultheiss, Michael J. Mihatsch, and Holger Moch
Clin Cancer Res 2002 8: 1210 [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Oral (13),(14)-ß-D-Glucan Synergizes with Antiganglioside GD2 Monoclonal Antibody 3F8 in the Therapy of Neuroblastoma

Nai-Kong V. Cheung and Shakeel Modak
Clin Cancer Res 2002 8: 1217 [Abstract] [Full Text] [PDF]  

In Vivo Pharmacokinetic Features, Toxicity Profile, and Chemosensitizing Activity of -Cyano-ß-hydroxy-ß- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), a Novel Antileukemic Agent Targeting Bruton’s Tyrosine Kinase

Fatih M. Uckun, Yaguo Zheng, Marina Cetkovic-Cvrlje, Alexei Vassilev, Elizabeth Lisowski, Barbara Waurzyniak, Hao Chen, Randy Carpenter, and Chun-Lin Chen
Clin Cancer Res 2002 8: 1224 [Abstract] [Full Text] [PDF]  

Induction of Apoptosis by Bexarotene in Cutaneous T-Cell Lymphoma Cells: Relevance to Mechanism of Therapeutic Action

Chunlei Zhang, Parul Hazarika, Xiao Ni, Douglas A. Weidner, and Madeleine Duvic
Clin Cancer Res 2002 8: 1234 [Abstract] [Full Text] [PDF]  

Detoxification of the Polyamine Analogue N¹-Ethyl-N¹¹-[(cycloheptyl)methy]-4,8-diazaundecane (CHENSpm) by Polyamine Oxidase

Kathryn R. Lawson, Sarah Marek, Jennifer A. Linehan, Patrick M. Woster, Robert A. Casero, Jr., Claire M. Payne, and Eugene W. Gerner
Clin Cancer Res 2002 8: 1241 [Abstract] [Full Text] [PDF]  

Overexpression of PTEN Increases Sensitivity to SN-38, an Active Metabolite of the Topoisomerase I Inhibitor Irinotecan, in Ovarian Cancer Cells

Yasushi Saga, Hiroaki Mizukami, Mitsuaki Suzuki, Takahiro Kohno, Masashi Urabe, Keiya Ozawa, and Ikuo Sato
Clin Cancer Res 2002 8: 1248 [Abstract] [Full Text] [PDF]  

Inhibition of Angiogenesis by the Antiepidermal Growth Factor Receptor Antibody ImClone C225 in Androgen-independent Prostate Cancer Growing Orthotopically in Nude Mice

Takashi Karashima, Paul Sweeney, Joel W. Slaton, Sun J. Kim, Daniel Kedar, Jonathan I. Izawa, Zhen Fan, Curtis Pettaway, Daniel J. Hicklin, Taro Shuin, and Colin P. N. Dinney
Clin Cancer Res 2002 8: 1253 [Abstract] [Full Text] [PDF]  

Erythropoietin Restores the Antitumor Effectiveness of Photodynamic Therapy in Mice with Chemotherapy- induced Anemia

Jakub Golab, Dominika Olszewska, Pawel Mróz, Katarzyna Kozar, Rafal Kaminski, Ahmad Jalili, and Marek Jakóbisiak
Clin Cancer Res 2002 8: 1265 [Abstract] [Full Text] [PDF]  

Overexpression of HER-2/Neu in Uterine Serous Papillary Cancer

Alessandro D. Santin, Stefania Bellone, Murat Gokden, Michela Palmieri, Donna Dunn, Jamshed Agha, Juan J. Roman, Laura Hutchins, Sergio Pecorelli, Timothy O’Brien, Martin J. Cannon, and Groesbeck P. Parham
Clin Cancer Res 2002 8: 1271 [Abstract] [Full Text] [PDF]  

Bradykinin Antagonist Dimer, CU201, Inhibits the Growth of Human Lung Cancer Cell Lines in Vitro and in Vivo and Produces Synergistic Growth Inhibition in Combination with Other Antitumor Agents

Daniel C. Chan, Lajos Gera, John M. Stewart, Barbara Helfrich, Tom Limin Zhao, Wan Yong Feng, Kenneth K. Chan, Joseph M. Covey, and Paul A. Bunn, Jr.
Clin Cancer Res 2002 8: 1280 [Abstract] [Full Text] [PDF]  

Nuclear Receptor Agonists As Potential Differentiation Therapy Agents for Human Osteosarcoma

Rex C. Haydon, Lan Zhou, Tao Feng, Benjamin Breyer, Hongwei Cheng, Wei Jiang, Akira Ishikawa, Terrance Peabody, Anthony Montag, Michael A. Simon, and Tong-Chuan He
Clin Cancer Res 2002 8: 1288 [Abstract] [Full Text] [PDF]  

Selective Exclusion by the Polyamine Transporter as a Mechanism for Differential Radioprotection of Amifostine Derivatives

Herson I. Quiñones, Alan F. List, and Eugene W. Gerner
Clin Cancer Res 2002 8: 1295 [Abstract] [Full Text] [PDF]  

Modulation of Marrow Proliferation and Chemosensitivity by Tumor-produced Cytokines from Syngeneic Pancreatic Tumor Lines

Rosalyn D. Blumenthal, Albert Reising, Evelyn Leon, and David M. Goldenberg
Clin Cancer Res 2002 8: 1301 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: M. Follen et al., A Randomized Clinical Trial of 4-Hydroxyphenylretinamide for High-Grade Squamous Intraepithelial Lesions of the Cervix. Clin. Cancer Res., 7: 3356–3365, 2001

Franca Formelli
Clin Cancer Res 2002 8: 1310 [Full Text] [PDF]  

Reply

Michele Follen and Herbert A. Fritsche
Clin Cancer Res 2002 8: 1313 [Full Text] [PDF]  

Correspondence re: Raida, M. et al., Prevalence of a Common Point Mutation in the Dihydropyrimidine Dehydrogenase (DPD) Gene within the 5'-Splice Donor Site of Intron 14 in Patients with Severe 5-Fluorouracil (5-FU)-related Toxicity Compared with Controls. Clin. Cancer Res., 7: 2832–2839, 2001.

Federico Innocenti and Mark J. Ratain
Clin Cancer Res 2002 8: 1314 [Full Text] [PDF]  

Reply

Detlev Behnke, Martin Raida, Kay-Oliver Kliche, and Uwe Pichlmeier
Clin Cancer Res 2002 8: 1315 [Full Text] [PDF]  

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