Editorials:

John Mendelsohn

A Message from the Editor-in-Chief
Clin Cancer Res 2003 9: 3517. [Full Text] [PDF]  

Philip J. Tofilon, Scott Saxman, and C. Norman Coleman

Molecular Targets for Radiation Therapy: Bringing Preclinical Data into Clinical Trials
Clin Cancer Res 2003 9: 3518-3520. [Full Text] [PDF]  

The Biology Behind:

Jerry W. Shay

Telomerase Therapeutics: Telomeres Recognized as a DNA Damage Signal: Commentary re: K. Kraemer et al., Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cells. Clin. Cancer Res., 9: 3794–3800, 2003.
Clin Cancer Res 2003 9: 3521-3525. [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

Mirjam Crul, Nadja E. Schoemaker, Dick Pluim, Marc Maliepaard, René W. M. Underberg, Margaret Schot, Rolf W. Sparidans, Paul Baas, Jos H. Beijnen, Nico van Zandwijk, and Jan H. M. Schellens

Randomized Phase I Clinical and Pharmacologic Study of Weekly versus Twice-Weekly Dose-intensive Cisplatin and Gemcitabine in Patients with Advanced Non-Small Cell Lung Cancer
Clin Cancer Res 2003 9: 3526-3533. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Janos L. Tanyi, Yutaka Hasegawa, Ruth Lapushin, Andrew J. Morris, Judith K. Wolf, Andrew Berchuck, Karen Lu, David I. Smith, Kimberly Kalli, Lynn C. Hartmann, Karen McCune, David Fishman, Russell Broaddus, Kwai W. Cheng, Edward N. Atkinson, Jose M. Yamal, Robert C. Bast, Edward A. Felix, Robert A. Newman, and Gordon B. Mills

Role of Decreased Levels of Lipid Phosphate Phosphatase-1 in Accumulation of Lysophosphatidic Acid in Ovarian Cancer
Clin Cancer Res 2003 9: 3534-3545. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Ignacio Melero, Izaskun Gabari, Iñigo Tirapu, Ainhoa Arina, Guillermo Mazzolini, Elena Baixeras, Esperanza Feijoo, Carlos Alfaro, Cheng Qian, and Jesús Prieto

Anti-ICAM-2 Monoclonal Antibody Synergizes with Intratumor Gene Transfer of Interleukin-12 Inhibiting Activation-induced T-Cell Death
Clin Cancer Res 2003 9: 3546-3554. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Arthur E. Frankel, Donald R. Fleming, Philip D. Hall, Bayard L. Powell, Jennifer H. Black, Carole Leftwich, and Ronald Gartenhaus

A Phase II Study of DT Fusion Protein Denileukin Diftitox in Patients with Fludarabine-refractory Chronic Lymphocytic Leukemia
Clin Cancer Res 2003 9: 3555-3561. [Abstract] [Full Text] [PDF]  

John A. Thompson, Robert A. Figlin, Christi Sifri-Steele, Ronald J. Berenson, and Mark W. Frohlich

A Phase I Trial of CD3/CD28-activated T Cells (Xcellerated T Cells) and Interleukin-2 in Patients with Metastatic Renal Cell Carcinoma
Clin Cancer Res 2003 9: 3562-3570. [Abstract] [Full Text] [PDF]  

Shohei Koyama and Hirohiko Tsujii

Proton Beam Therapy with High-Dose Irradiation for Superficial and Advanced Esophageal Carcinomas
Clin Cancer Res 2003 9: 3571-3577. [Abstract] [Full Text] [PDF]  

Wm. Kevin Kelly, Victoria M. Richon, Owen O’Connor, Tracy Curley, Barbara MacGregor-Curtelli, William Tong, Mark Klang, Lawrence Schwartz, Stacie Richardson, Eddie Rosa, Marija Drobnjak, Carlos Cordon-Cordo, Judy H. Chiao, Richard Rifkind, Paul A. Marks, and Howard Scher

Phase I Clinical Trial of Histone Deacetylase Inhibitor: Suberoylanilide Hydroxamic Acid Administered Intravenously
Clin Cancer Res 2003 9: 3578-3588. [Abstract] [Full Text] [PDF]  

Antonio C. Wolff, Ross C. Donehower, M. Katherine Carducci, Michael A. Carducci, Julie R. Brahmer, Yelena Zabelina, Matthews O. Bradley, Forrest H. Anthony, Charles S. Swindell, Philip A. Witman, Nigel L. Webb, and Sharyn D. Baker

Phase I Study of Docosahexaenoic Acid-Paclitaxel: a Taxane-Fatty Acid Conjugate with a Unique Pharmacology and Toxicity Profile
Clin Cancer Res 2003 9: 3589-3597. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Wouter H. de Vos tot Nederveen Cappel, G. Johan A. Offerhaus, Marjo van Puijenbroek, Eric Caspers, Nelleke A. Gruis, Femke A. de Snoo, Cornelis B. H. W. Lamers, Gerrit Griffioen, Wilma Bergman, Hans F. A. Vasen, and Hans Morreau

Pancreatic Carcinoma in Carriers of a Specific 19 Base Pair Deletion of CDKN2A/p16 (p16-Leiden)
Clin Cancer Res 2003 9: 3598-3605. [Abstract] [Full Text] [PDF]  

José Palacios, Emiliano Honrado, Ana Osorio, Alicia Cazorla, David Sarrió, Alicia Barroso, Sandra Rodríguez, Juan C. Cigudosa, Orland Diez, Carmen Alonso, Enrique Lerma, Lydia Sánchez, Carmen Rivas, and Javier Benítez

Immunohistochemical Characteristics Defined by Tissue Microarray of Hereditary Breast Cancer Not Attributable to BRCA1 or BRCA2 Mutations: Differences from Breast Carcinomas Arising in BRCA1 and BRCA2 Mutation Carriers
Clin Cancer Res 2003 9: 3606-3614. [Abstract] [Full Text] [PDF]  

Ignacio I. Wistuba, Carmen Behrens, Jorge Albores-Saavedra, Ruby Delgado, Francisco Lopez, and Adi F. Gazdar

Distinct K-ras Mutation Pattern Characterizes Signet Ring Cell Colorectal Carcinoma
Clin Cancer Res 2003 9: 3615-3619. [Abstract] [Full Text] [PDF]  

Richard J. Gilbertson, D. Ashley Hill, Roberto Hernan, Mehmet Kocak, Russell Geyer, Jim Olson, Amar Gajjar, Lisa Rush, Ronald L. Hamilton, Sydney D. Finkelstein, and Ian F. Pollack

ERBB1 Is Amplified and Overexpressed in High-grade Diffusely Infiltrative Pediatric Brain Stem Glioma
Clin Cancer Res 2003 9: 3620-3624. [Abstract] [Full Text] [PDF]  

Takashi Ishida, Atae Utsunomiya, Shinsuke Iida, Hiroshi Inagaki, Yoshifusa Takatsuka, Shigeru Kusumoto, Genji Takeuchi, Shigeki Shimizu, Masato Ito, Hirokazu Komatsu, Atsushi Wakita, Tadaaki Eimoto, Kouji Matsushima, and Ryuzo Ueda

Clinical Significance of CCR4 Expression in Adult T-Cell Leukemia/Lymphoma: Its Close Association with Skin Involvement and Unfavorable Outcome
Clin Cancer Res 2003 9: 3625-3634. [Abstract] [Full Text] [PDF]  

Seung Myung Dong, Dong-Il Sun, Nicole E. Benoit, Igor Kuzmin, Michael I. Lerman, and David Sidransky

Epigenetic Inactivation of RASSF1A in Head and Neck Cancer
Clin Cancer Res 2003 9: 3635-3640. [Abstract] [Full Text] [PDF]  

Yoon Soo Chang, Weiguo Wu, Garrett Walsh, Waun Ki Hong, and Li Mao

Enolase- Is Frequently Down-Regulated in Non-Small Cell Lung Cancer and Predicts Aggressive Biological Behavior
Clin Cancer Res 2003 9: 3641-3644. [Abstract] [Full Text] [PDF]  

Caterina Pellegrini, Monica Falleni, Antonio Marchetti, Barbara Cassani, Monica Miozzo, Fiamma Buttitta, Massimo Roncalli, Guido Coggi, and Silvano Bosari

HER-2/Neu Alterations in Non-Small Cell Lung Cancer: A Comprehensive Evaluation by Real Time Reverse Transcription-PCR, Fluorescence in Situ Hybridization, and Immunohistochemistry
Clin Cancer Res 2003 9: 3645-3652. [Abstract] [Full Text] [PDF]  

Salahaldin A. Tahir, Chengzhen Ren, Terry L. Timme, Yehoshua Gdor, Ron Hoogeveen, Joel D. Morrisett, Anna Frolov, Gustavo Ayala, Thomas M. Wheeler, and Timothy C. Thompson

Development of an Immunoassay for Serum Caveolin-1: A Novel Biomarker for Prostate Cancer
Clin Cancer Res 2003 9: 3653-3659. [Abstract] [Full Text] [PDF]  

Lin Wang, Ashraful Hoque, Robert Z. Luo, Jiuhong Yuan, Zhen Lu, Arata Nishimoto, Jinsong Liu, Aysegul A. Sahin, Scott M. Lippman, Robert C. Bast, Jr., and Yinhua Yu

Loss of the Expression of the Tumor Suppressor Gene ARHI Is Associated with Progression of Breast Cancer
Clin Cancer Res 2003 9: 3660-3666. [Abstract] [Full Text] [PDF]  

Andrew J. Li, Rae Lynn Baldwin, and Beth Y. Karlan

Short Androgen Receptor Allele Length Is a Poor Prognostic Factor in Epithelial Ovarian Carcinoma
Clin Cancer Res 2003 9: 3667-3673. [Abstract] [Full Text] [PDF]  

Asha Rathi, Arvind K. Virmani, Kenichi Harada, Charles F. Timmons, Kuniharu Miyajima, Robert J. Hay, Domenico Mastrangelo, Anirban Maitra, Gail E. Tomlinson, and Adi F. Gazdar

Aberrant Methylation of the HIC1 Promoter Is a Frequent Event in Specific Pediatric Neoplasms
Clin Cancer Res 2003 9: 3674-3678. [Abstract] [Full Text] [PDF]  

Keiji Sano, Tadatoshi Takayama, Koji Murakami, Ikuo Saiki, and Masatoshi Makuuchi

Overexpression of Retinoic Acid Receptor in Hepatocellular Carcinoma
Clin Cancer Res 2003 9: 3679-3683. [Abstract] [Full Text] [PDF]  

Gianluigi Giannelli, Emilia Fransvea, Carlo Bergamini, Felice Marinosci, and Salvatore Antonaci

Laminin-5 Chains Are Expressed Differentially in Metastatic and Nonmetastatic Hepatocellular Carcinoma
Clin Cancer Res 2003 9: 3684-3691. [Abstract] [Full Text] [PDF]  

Joseph D. Khoury, L. Jeffrey Medeiros, George Z. Rassidakis, Marwan A. Yared, Panagiota Tsioli, Vasiliki Leventaki, Annette Schmitt-Graeff, Marco Herling, Hesham M. Amin, and Raymond Lai

Differential Expression and Clinical Significance of Tyrosine-phosphorylated STAT3 in ALK⁺ and ALK^- Anaplastic Large Cell Lymphoma
Clin Cancer Res 2003 9: 3692-3699. [Abstract] [Full Text] [PDF]  

Takashi Tsuji, Shigekazu Hidaka, Terumitsu Sawai, Tohru Nakagoe, Hiroshi Yano, Masatoshi Haseba, Hideaki Komatsu, Hisakazu Shindou, Hidetoshi Fukuoka, Megumi Yoshinaga, Shinichi Shibasaki, Atsushi Nanashima, Hiroyuki Yamaguchi, Tohru Yasutake, and Yutaka Tagawa

Polymorphism in the Thymidylate Synthase Promoter Enhancer Region Is Not an Efficacious Marker for Tumor Sensitivity to 5-Fluorouracil-based Oral Adjuvant Chemotherapy in Colorectal Cancer
Clin Cancer Res 2003 9: 3700-3704. [Abstract] [Full Text] [PDF]  

Rhonda A. Kwong, Tuan V. Nguyen, Ronaldo J. Bova, James G. Kench, Ian E. Cole, Elizabeth A. Musgrove, Susan M. Henshall, and Robert L. Sutherland

Overexpression of E2F-1 Is Associated with Increased Disease-free Survival in Squamous Cell Carcinoma of the Anterior Tongue
Clin Cancer Res 2003 9: 3705-3711. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Scott S. Graves, Erica Dearstyne, Yukang Lin, Yuting Zuo, James Sanderson, Jody Schultz, Anastasia Pantalias, David Gray, Don Axworthy, H. Mark Jones, and Karen Auditore-Hargreaves

Combination Therapy with Pretarget CC49 Radioimmunotherapy and Gemcitabine Prolongs Tumor Doubling Time in a Murine Xenograft Model of Colon Cancer More Effectively Than Either Monotherapy
Clin Cancer Res 2003 9: 3712-3721. [Abstract] [Full Text] [PDF]  

Eunice Laurent, David L. Mitchell, Zeev Estrov, Megan Lowery, Susan L. Tucker, Moshe Talpaz, and Razelle Kurzrock

Impact of p210^Bcr-Abl on Ultraviolet C Wavelength-induced DNA Damage and Repair
Clin Cancer Res 2003 9: 3722-3730. [Abstract] [Full Text] [PDF]  

Donald J. Buchsbaum, Tong Zhou, William E. Grizzle, Patsy G. Oliver, Charlotte J. Hammond, Sijian Zhang, Mark Carpenter, and Albert F. LoBuglio

Antitumor Efficacy of TRA-8 Anti-DR5 Monoclonal Antibody Alone or in Combination with Chemotherapy and/or Radiation Therapy in a Human Breast Cancer Model
Clin Cancer Res 2003 9: 3731-3741. [Abstract] [Full Text] [PDF]  

Ana M. Bajo, Andrew V. Schally, Gabor Halmos, and Attila Nagy

Targeted Doxorubicin-containing Luteinizing Hormone-releasing Hormone Analogue AN-152 Inhibits the Growth of Doxorubicin-resistant MX-1 Human Breast Cancers
Clin Cancer Res 2003 9: 3742-3748. [Abstract] [Full Text] [PDF]  

Jeffery S. Russell, William Burgan, Kelli A. Oswald, Kevin Camphausen, and Philip J. Tofilon

Enhanced Cell Killing Induced by the Combination of Radiation and the Heat Shock Protein 90 Inhibitor 17-Allylamino-17- Demethoxygeldanamycin: A Multitarget Approach to Radiosensitization
Clin Cancer Res 2003 9: 3749-3755. [Abstract] [Full Text] [PDF]  

Marcelo Mamede, Tsuneo Saga, Hisataka Kobayashi, Takayoshi Ishimori, Tatsuya Higashi, Noriko Sato, Martin W. Brechbiel, and Junji Konishi

Radiolabeling of Avidin with Very High Specific Activity for Internal Radiation Therapy of Intraperitoneally Disseminated Tumors
Clin Cancer Res 2003 9: 3756-3762. [Abstract] [Full Text] [PDF]  

Taoufik Ouatas, Douglas Halverson, and Patricia S. Steeg

Dexamethasone and Medroxyprogesterone Acetate Elevate Nm23-H1 Metastasis Suppressor Gene Expression in Metastatic Human Breast Carcinoma Cells: New Uses for Old Compounds
Clin Cancer Res 2003 9: 3763-3772. [Abstract] [Full Text] [PDF]  

Yuhong She, Fei Lee, Jing Chen, Adriana Haimovitz-Friedman, Vincent A. Miller, Valerie R. Rusch, Mark G. Kris, and F. M. Sirotnak

The Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 Selectively Potentiates Radiation Response of Human Tumors in Nude Mice, with a Marked Improvement in Therapeutic Index
Clin Cancer Res 2003 9: 3773-3778. [Abstract] [Full Text] [PDF]  

Kristian Pietras, Michael Stumm, Martine Hubert, Elisabeth Buchdunger, Kristofer Rubin, Carl-Henrik Heldin, Paul McSheehy, Markus Wartmann, and Arne Östman

STI571 Enhances the Therapeutic Index of Epothilone B by a Tumor-selective Increase of Drug Uptake
Clin Cancer Res 2003 9: 3779-3787. [Abstract] [Full Text] [PDF]  

David J. Gross, Israel Reibstein, Lola Weiss, Shimon Slavin, Hagit Dafni, Michal Neeman, Mark Pines, and Arnon Nagler

Treatment with Halofuginone Results in Marked Growth Inhibition of a von Hippel-Lindau Pheochromocytoma in Vivo
Clin Cancer Res 2003 9: 3788-3793. [Abstract] [Full Text] [PDF]  

Kai Kraemer, Susanne Fuessel, Uta Schmidt, Matthias Kotzsch, Bernd Schwenzer, Manfred P. Wirth, and Axel Meye

Antisense-mediated hTERT Inhibition Specifically Reduces the Growth of Human Bladder Cancer Cells
Clin Cancer Res 2003 9: 3794-3800. [Abstract] [Full Text] [PDF]  

Demetrius M. Kokkinakis, Mansoor M. Ahmed, Damodaran Chendil, Robert C. Moschel, and Anthony E. Pegg

Sensitization of Pancreatic Tumor Xenografts to Carmustine and Temozolomide by Inactivation of Their O⁶-Methylguanine-DNA Methyltransferase with O⁶-Benzylguanine or O⁶-Benzyl-2'-Deoxyguanosine
Clin Cancer Res 2003 9: 3801-3807. [Abstract] [Full Text] [PDF]  

   Biology:

Steve Goodison, Kanji Kawai, Jun Hihara, Ping Jiang, Meng Yang, Virginia Urquidi, Robert M. Hoffman, and David Tarin

Prolonged Dormancy and Site-specific Growth Potential of Cancer Cells Spontaneously Disseminated from Nonmetastatic Breast Tumors as Revealed by Labeling with Green Fluorescent Protein
Clin Cancer Res 2003 9: 3808-3814. [Abstract] [Full Text] [PDF]  

Letter to the Editor:

Cecile G. Colpaert, Peter B. Vermeulen, Luc Y. Dirix, Eric A. Van Marck, Sandra M. Swain, and Xiaowei Yang

Commentary re: N. J. McCarthy et al., Microvessel density, expression of estrogen receptor , MIB-1, p53 and c-erbB-2 in inflammatory breast cancer. Clin. Cancer Res., 8: 3857–3862, 2002.
Clin Cancer Res 2003 9: 3815-3816. [Full Text] [PDF]  

Supplement Articles:

David M. Goldenberg

Introduction to the Ninth Conference on Cancer Therapy with Antibodies and Immunoconjugates
Clin Cancer Res 2003 9: 3819S-3820S. [Full Text] [PDF]  

   Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer:

Päivi Karnani and Kalevi Kairemo

Targeting Endothelial Growth with Monoclonal Antibodies against Tie-1 Kinase in Mouse Models
Clin Cancer Res 2003 9: 3821S-3826S. [Abstract] [Full Text] [PDF]  

Päivi Karnani and Kalevi Kairemo

The New Tie-1 Monoclonal Antibodies Detect Angiogenesis in Metastatic Malignancies
Clin Cancer Res 2003 9: 3827S-3830S. [Abstract] [Full Text] [PDF]  

Alan Solomon, Deborah T. Weiss, and Jonathan S. Wall

Therapeutic Potential of Chimeric Amyloid-reactive Monoclonal Antibody 11-1F4
Clin Cancer Res 2003 9: 3831S-3838S. [Abstract] [Full Text] [PDF]  

   Session I: ANTIBODIES AND NON-ISOTOPIC IMMUNOCONJUGATES

Rick V. Hay, Brian Cao, R. Scot Skinner, Ling-Mei Wang, Yanli Su, James H. Resau, Beatrice S. Knudsen, Margaret F. Gustafson, Han-Mo Koo, George F. Vande Woude, and Milton D. Gross

Radioimmunoscintigraphy of Human Met-Expressing Tumor Xenografts Using Met3, a New Monoclonal Antibody
Clin Cancer Res 2003 9: 3839S-3844S. [Abstract] [Full Text] [PDF]  

Michelle D. Winthrop, Sally J. DeNardo, Huguette Albrecht, Gary R. Mirick, Linda A. Kroger, Kathleen R. Lamborn, Ceslovas Venclovas, Michael E. Colvin, Patricia A. Burke, and Gerald L. DeNardo

Selection and Characterization of Anti-MUC-1 scFvs Intended for Targeted Therapy
Clin Cancer Res 2003 9: 3845S-3853S. [Abstract] [Full Text] [PDF]  

Sally J. DeNardo, Zhengsheng Yao, Kit S. Lam, Aimin Song, Patricia A. Burke, Gary R. Mirick, Kathleen R. Lamborn, Robert T. O’Donnell, and Gerald L. DeNardo

Effect of Molecular Size of Pegylated Peptide on the Pharmacokinetics and Tumor Targeting in Lymphoma-Bearing Mice
Clin Cancer Res 2003 9: 3854S-3864S. [Abstract] [Full Text] [PDF]  

Gerald L. DeNardo, Sally J. DeNardo, James J. Peterson, Laird A. Miers, Kit S. Lam, Christine Hartmann-Siantar, and Kathleen R. Lamborn

Preclinical Evaluation of Cathepsin-degradable Peptide Linkers for Radioimmunoconjugates
Clin Cancer Res 2003 9: 3865S-3872S. [Abstract] [Full Text] [PDF]  

Sture Lindegren, Börje Karlsson, Lars Jacobsson, Håkan Andersson, Ragnar Hultborn, and Gunnar Skarnemark

²¹¹At-labeled and Biotinylated Effector Molecules for Pretargeted Radioimmunotherapy Using Poly-L- and Poly-D-Lysine as Multicarriers
Clin Cancer Res 2003 9: 3873S-3879S. [Abstract] [Full Text] [PDF]  

Frank G. van Schaijk, Egbert Oosterwijk, Annemiele C. Soede, Wim J. G. Oyen, William J. McBride, Gary L. Griffiths, David M. Goldenberg, Frans H. M. Corstens, and Otto C. Boerman

Pretargeting with Labeled Bivalent Peptides Allowing the Use of Four Radionuclides: ¹¹¹In, ¹³¹I, ^99mTc, and ¹⁸⁸Re
Clin Cancer Res 2003 9: 3880S-3885S. [Abstract] [Full Text] [PDF]  

Edmund A. Rossi, Robert M. Sharkey, William McBride, Habibe Karacay, Li Zeng, Hans J. Hansen, David M. Goldenberg, and Chien-Hsing Chang

Development of New Multivalent-bispecific Agents for Pretargeting Tumor Localization and Therapy
Clin Cancer Res 2003 9: 3886S-3896S. [Abstract] [Full Text] [PDF]  

Robert M. Sharkey, Habibe Karacay, Heidi Richel, William J. McBride, Edmund A. Rossi, Ken Chang, Dion Yeldell, Gary L. Griffiths, Hans J. Hansen, and David M. Goldenberg

Optimizing Bispecific Antibody Pretargeting for Use in Radioimmunotherapy
Clin Cancer Res 2003 9: 3897S-3913S. [Abstract] [Full Text] [PDF]  

   Session II: ISOTOPIC CONJUGATES, PRECLINICAL AND PRETARGETING

Håkan Andersson, Jörgen Elgqvist, György Horvath, Ragnar Hultborn, Lars Jacobsson, Holger Jensen, Börje Karlsson, Sture Lindegren, and Stig Palm

Astatine-211-labeled Antibodies for Treatment of Disseminated Ovarian Cancer: An Overview of Results in an Ovarian Tumor Model
Clin Cancer Res 2003 9: 3914S-3921S. [Abstract] [Full Text] [PDF]  

Roswitha Huber, Christof Seidl, Ernst Schmid, Sabine Seidenschwang, Karl-Friedrich Becker, Christoph Schuhmacher, Christos Apostolidis, Tuomo Nikula, Elisabeth Kremmer, Markus Schwaiger, and Reingard Senekowitsch-Schmidtke

Locoregional -Radioimmunotherapy of Intraperitoneal Tumor Cell Dissemination Using a Tumor-specific Monoclonal Antibody
Clin Cancer Res 2003 9: 3922S-3928S. [Abstract] [Full Text] [PDF]  

David V. Gold, Keith Schutsky, David Modrak, and Thomas M. Cardillo

Low-Dose Radioimmunotherapy (⁹⁰Y-PAM4) Combined with Gemcitabine for the Treatment of Experimental Pancreatic Cancer
Clin Cancer Res 2003 9: 3929S-3937S. [Abstract] [Full Text] [PDF]  

   Session III: EXPERIMENTAL RADIOIMMUNOTHERAPY

Sally J. DeNardo, Gerald L. DeNardo, A. Yuan, Carol M. Richman, Robert T. O’Donnell, Primo N. Lara, David L. Kukis, Arutselvan Natarajan, Kathleen R. Lamborn, Frederik Jacobs, and Christine L. Hartmann Siantar

Enhanced Therapeutic Index of Radioimmunotherapy (RIT) in Prostate Cancer Patients: Comparison of Radiation Dosimetry for 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-Tetraacetic Acid (DOTA)-Peptide versus 2IT-DOTA Monoclonal Antibody Linkage for RIT
Clin Cancer Res 2003 9: 3938S-3944S. [Abstract] [Full Text] [PDF]  

Manuela Orjuela, Thomas G. Gross, Ying-Kuen Cheung, Bachir Alobeid, Erin Morris, and Mitchell S. Cairo

A Pilot Study of Chemoimmunotherapy (Cyclophosphamide, Prednisone, and Rituximab) in Patients with Post-Transplant Lymphoproliferative Disorder following Solid Organ Transplantation
Clin Cancer Res 2003 9: 3945S-3952S. [Abstract] [Full Text] [PDF]  

Adrienne H. Brouwers, Wilhelmina C. A. M. Buijs, Egbert Oosterwijk, Otto C. Boerman, Carola Mala, Pieter H. M. De Mulder, Frans H. M. Corstens, Peter F. A. Mulders, and Wim J. G. Oyen

Targeting of Metastatic Renal Cell Carcinoma with the Chimeric Monoclonal Antibody G250 Labeled with ¹³¹I or ¹¹¹In: An Intrapatient Comparison
Clin Cancer Res 2003 9: 3953S-3960S. [Abstract] [Full Text] [PDF]  

Pontus K. E. Börjesson, Ernst J. Postema, Jan C. Roos, David R. Colnot, Henri A. M. Marres, Mathijs H. van Schie, Gerd Stehle, Remco de Bree, Gordon B. Snow, Wim J. G. Oyen, and Guus A. M. S. van Dongen

Phase I Therapy Study with ¹⁸⁶Re-labeled Humanized Monoclonal Antibody BIWA 4 (Bivatuzumab) in Patients with Head and Neck Squamous Cell Carcinoma
Clin Cancer Res 2003 9: 3961S-3972S. [Abstract] [Full Text] [PDF]  

Françoise Kraeber-Bodéré, Alain Faivre-Chauvet, Ludovic Ferrer, Jean-Philippe Vuillez, Pierre-Yves Brard, Caroline Rousseau, Isabelle Resche, Anne Devillers, Sophie Laffont, Manuel Bardiès, Ken Chang, Robert M. Sharkey, David M. Goldenberg, Jean-François Chatal, and Jacques Barbet

Pharmacokinetics and Dosimetry Studies for Optimization of Anti-Carcinoembryonic Antigen x Anti-Hapten Bispecific Antibody-mediated Pretargeting of Iodine-131-labeled Hapten in a Phase I Radioimmunotherapy Trial
Clin Cancer Res 2003 9: 3973S-3981S. [Abstract] [Full Text] [PDF]  

   Session IV: CLINICAL STUDIES: SOLID TUMORS

Josette Carnahan, Paul Wang, Richard Kendall, Ching Chen, Sylvia Hu, Tom Boone, Todd Juan, Jane Talvenheimo, Silvia Montestruque, Jilin Sun, Gary Elliott, John Thomas, John Ferbas, Brent Kern, Robert Briddell, John P. Leonard, and Alessandra Cesano

Epratuzumab, a Humanized Monoclonal Antibody Targeting CD22: Characterization of in Vitro Properties
Clin Cancer Res 2003 9: 3982S-3990S. [Abstract] [Full Text] [PDF]  

Morton Coleman, David M. Goldenberg, Abby B. Siegel, Jamie C. Ketas, Michelle Ashe, Jennifer M. Fiore, and John P. Leonard

Epratuzumab: Targeting B-Cell Malignancies through CD22
Clin Cancer Res 2003 9: 3991S-3994S. [Abstract] [Full Text] [PDF]  

Ernst J. Postema, John M. M. Raemaekers, Wim J. G. Oyen, Otto C. Boerman, Caroline M. P. W. Mandigers, David M. Goldenberg, Guus A. M. S. van Dongen, and Frans H. M. Corstens

Final Results of a Phase I Radioimmunotherapy Trial Using ¹⁸⁶Re-Epratuzumab for the Treatment of Patients with Non-Hodgkin’s Lymphoma
Clin Cancer Res 2003 9: 3995S-4002S. [Abstract] [Full Text] [PDF]  

Cecilia Hindorf, Ola Lindén, Lars Stenberg, Jan Tennvall, and Sven-Erik Strand

Change in Tumor-absorbed Dose due to Decrease in Mass during Fractionated Radioimmunotherapy in Lymphoma Patients
Clin Cancer Res 2003 9: 4003S-4006S. [Abstract] [Full Text] [PDF]  

Bonnie M. Bradt, Sally J. DeNardo, Gary R. Mirick, and Gerald L. DeNardo

Documentation of Idiotypic Cascade after Lym-1 Radioimmunotherapy in a Patient with Non-Hodgkin’s Lymphoma: Basis for Extended Survival?
Clin Cancer Res 2003 9: 4007S-4012S. [Abstract] [Full Text] [PDF]  

Gerald L. DeNardo, Gary R. Mirick, Linda A. Kroger, Bonnie M. Bradt, Kathleen R. Lamborn, and Sally J. DeNardo

Characterization of Human IgG Antimouse Antibody in Patients with B-Cell Malignancies
Clin Cancer Res 2003 9: 4013S-4021S. [Abstract] [Full Text] [PDF]  

Edward A. Sausville

Concluding Remarks: Ninth Conference on Cancer Therapy with Antibodies and Immunoconjugates
Clin Cancer Res 2003 9: 4022S-4023S. [Full Text] [PDF]  

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