Featured Articles:

   Clinical Trials:

Laurens V. Beerepoot, Els O. Witteveen, Gerard Groenewegen, William E. Fogler, B. Kim Leel Sim, Carolyn Sidor, Bernard A. Zonnenberg, Franz Schramel, Martijn F. B. G. Gebbink, and Emile E. Voest

Recombinant Human Angiostatin by Twice-Daily Subcutaneous Injection in Advanced Cancer: A Pharmacokinetic and Long-Term Safety Study
Clin Cancer Res 2003 9: 4025-4033. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Hongyu Yang, Chuan-Mu Chen, Pearlly Yan, Tim H-M. Huang, Huidong Shi, Mattias Burger, Inko Nimmrich, Sabine Maier, Kurt Berlin, and Charles W. Caldwell

The Androgen Receptor Gene is Preferentially Hypermethylated in Follicular Non-Hodgkin’s Lymphomas
Clin Cancer Res 2003 9: 4034-4042. [Abstract] [Full Text] [PDF]  

Takeshi Ogino, Nobuyuki Bandoh, Tatsuya Hayashi, Naoyuki Miyokawa, Yasuaki Harabuchi, and Soldano Ferrone

Association of Tapasin and HLA Class I Antigen Down-Regulation in Primary Maxillary Sinus Squamous Cell Carcinoma Lesions with Reduced Survival of Patients
Clin Cancer Res 2003 9: 4043-4051. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Kiranmai Gumireddy, Leslie N. Sutton, Peter C. Phillips, and C. Damodar Reddy

All-trans-Retinoic Acid-induced Apoptosis in Human Medulloblastoma: Activation of Caspase-3/Poly(ADP-ribose) Polymerase 1 Pathway
Clin Cancer Res 2003 9: 4052-4059. [Abstract] [Full Text] [PDF]  

Luis Molto, Pat Rayman, Ewa Paszkiewicz-Kozik, Mark Thornton, Lisa Reese, John C. Thomas, Tanya Das, Daisuke Kudo, Ronald Bukowski, James Finke, and Charles Tannenbaum

The Bcl-2 Transgene Protects T Cells from Renal Cell Carcinoma-mediated Apoptosis
Clin Cancer Res 2003 9: 4060-4068. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Sanjay Goel, Kavita Desai, Anca Bulgaru, Abbie Fields, Gary Goldberg, Sudhir Agrawal, Russell Martin, Michael Grindel, and Sridhar Mani

A Safety Study of a Mixed-backbone Oligonucleotide (GEM231) Targeting the Type I Regulatory Subunit of Protein Kinase A Using a Continuous Infusion Schedule in Patients with Refractory Solid Tumors
Clin Cancer Res 2003 9: 4069-4076. [Abstract] [Full Text] [PDF]  

Glenn Liu, George Wilding, Mary Jane Staab, Dorthea Horvath, Kelly Miller, Amy Dresen, Dona Alberti, Rhoda Arzoomanian, Rick Chappell, and Howard H. Bailey

Phase II Study of 1-Hydroxyvitamin D₂ in the Treatment of Advanced Androgen-independent Prostate Cancer
Clin Cancer Res 2003 9: 4077-4083. [Abstract] [Full Text] [PDF]  

Miloslav Beran, Susan O’Brien, Deborah A. Thomas, Hai T. Tran, Jorge E. Cortes-Franco, Francis Giles, Elihu Estey, and Hagop M. Kantarjian

Phase I Study of Oral Topotecan in Hematological Malignancies
Clin Cancer Res 2003 9: 4084-4091. [Abstract] [Full Text] [PDF]  

John Murren, Manuel Modiano, Caroline Clairmont, Paula Lambert, Niramol Savaraj, Terry Doyle, and Mario Sznol

Phase I and Pharmacokinetic Study of Triapine, a Potent Ribonucleotide Reductase Inhibitor, Administered Daily for Five Days in Patients with Advanced Solid Tumors
Clin Cancer Res 2003 9: 4092-4100. [Abstract] [Full Text] [PDF]  

Hans Gelderblom, Ramon Salazar, Jaap Verweij, George Pentheroudakis, Maja J. A. de Jonge, Martin Devlin, Christel van Hooije, Francis Seguy, Rosendo Obach, Joan Pruñonosa, Paola Principe, and Chris Twelves

Phase I Pharmacological and Bioavailability Study of Oral Diflomotecan (BN80915), a Novel E-Ring-modified Camptothecin Analogue in Adults with Solid Tumors
Clin Cancer Res 2003 9: 4101-4107. [Abstract] [Full Text] [PDF]  

Roy S. Herbst, Lisa A. Hammond, David P. Carbone, Hai T. Tran, Kenneth J. Holroyd, Avinash Desai, Jon I. Williams, B. Nebiyou Bekele, Howard Hait, Victoria Allgood, Stephen Solomon, and Joan H. Schiller

A Phase I/IIA Trial of Continuous Five-Day Infusion of Squalamine Lactate (MSI-1256F) Plus Carboplatin and Paclitaxel in Patients with Advanced Non-Small Cell Lung Cancer
Clin Cancer Res 2003 9: 4108-4115. [Abstract] [Full Text] [PDF]  

Marko Kornmann, Wolfgang Schwabe, Silvia Sander, Martina Kron, Jörn Sträter, Sucan Polat, Erika Kettner, Hans F. Weiser, Wolfram Baumann, Harald Schramm, Peter Häusler, Kati Ott, Detlev Behnke, Ludger Staib, Hans G. Beger, and Karl H. Link

Thymidylate Synthase and Dihydropyrimidine Dehydrogenase mRNA Expression Levels: Predictors for Survival in Colorectal Cancer Patients Receiving Adjuvant 5-Fluorouracil
Clin Cancer Res 2003 9: 4116-4124. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Pia Wülfing, Raihanatou Diallo, Christian Kersting, Christian Wülfing, Christopher Poremba, Achim Rody, Robert R. Greb, Werner Böcker, and Ludwig Kiesel

Expression of Endothelin-1, Endothelin-A, and Endothelin-B Receptor in Human Breast Cancer and Correlation with Long-Term Follow-Up
Clin Cancer Res 2003 9: 4125-4131. [Abstract] [Full Text] [PDF]  

Federica Perrone, Silvia Tabano, Federica Colombo, Gianpaolo Dagrada, Sarah Birindelli, Alessandro Gronchi, Maurizio Colecchia, Marco A. Pierotti, and Silvana Pilotti

p15^INK4b, p14^ARF, and p16^INK4a Inactivation in Sporadic and Neurofibromatosis Type 1-related Malignant Peripheral Nerve Sheath Tumors
Clin Cancer Res 2003 9: 4132-4138. [Abstract] [Full Text] [PDF]  

Stephen L. Rose, Andrew D. Robertson, Michael J. Goodheart, Brian J. Smith, Barry R. DeYoung, and Richard E. Buller

The Impact of p53 Protein Core Domain Structural Alteration on Ovarian Cancer Survival
Clin Cancer Res 2003 9: 4139-4144. [Abstract] [Full Text] [PDF]  

Samuel S. Im, Sharon P. Wilczynski, Robert A. Burger, and Bradley J. Monk

Early Stage Cervical Cancers Containing Human Papillomavirus Type 18 DNA Have More Nodal Metastasis and Deeper Stromal Invasion
Clin Cancer Res 2003 9: 4145-4150. [Abstract] [Full Text] [PDF]  

L. Magnus Bäcklund, Bo R. Nilsson, Helena M. Goike, Esther E. Schmidt, Lu Liu, Koichi Ichimura, and V. Peter Collins

Short Postoperative Survival for Glioblastoma Patients with a Dysfunctional Rb1 Pathway in Combination with No Wild-type PTEN
Clin Cancer Res 2003 9: 4151-4158. [Abstract] [Full Text] [PDF]  

Subramanian Krishnakumar, Dhiraj Abhyankar, Amirtha Lakshmi Sundaram, Vaijayanthi Pushparaj, Mahesh Palanivelu Shanmugam, and Jyotirmay Biswas

Major Histocompatibility Antigens and Antigen-processing Molecules in Uveal Melanoma
Clin Cancer Res 2003 9: 4159-4164. [Abstract] [Full Text] [PDF]  

Ying Chuan Hu, Richard A. Komorowski, Shannon Graewin, Galen Hostetter, Olli-P. Kallioniemi, Henry A. Pitt, and Steven A. Ahrendt

Thymidylate Synthase Expression Predicts the Response to 5-Fluorouracil-based Adjuvant Therapy in Pancreatic Cancer
Clin Cancer Res 2003 9: 4165-4171. [Abstract] [Full Text] [PDF]  

James W. F. Catto, Derek A. Linkens, Maysam F. Abbod, Minyou Chen, Julian L. Burton, Kenneth M. Feeley, and Freddie C. Hamdy

Artificial Intelligence in Predicting Bladder Cancer Outcome: A Comparison of Neuro-Fuzzy Modeling and Artificial Neural Networks
Clin Cancer Res 2003 9: 4172-4177. [Abstract] [Full Text] [PDF]  

Claus F. Eisenberger, Wolfram T. Knoefel, Matthias Peiper, Petra Merkert, Emre F. Yekebas, Peter Scheunemann, Katharina Steffani, Nikolas H. Stoecklein, Stefan B. Hosch, and Jakob R. Izbicki

Squamous Cell Carcinoma of the Esophagus Can Be Detected by Microsatellite Analysis in Tumor and Serum
Clin Cancer Res 2003 9: 4178-4183. [Abstract] [Full Text] [PDF]  

Florence Lerebours, Philippe Bertheau, Ivan Bieche, Louis-François Plassa, Marie-Helene Champeme, Kamel Hacene, Christine Toulas, Marc Espie, Michel Marty, and Rosette Lidereau

Two Prognostic Groups of Inflammatory Breast Cancer Have Distinct Genotypes
Clin Cancer Res 2003 9: 4184-4189. [Abstract] [Full Text] [PDF]  

Eline E. Hanekamp, Susanne C. J. P. Gielen, Ellen Smid-Koopman, Liesbeth C. M. Kühne, Petra E. de Ruiter, Savi Chadha-Ajwani, Albert O. Brinkmann, J. Anton Grootegoed, Curt W. Burger, Frans J. Huikeshoven, and Leen J. Blok

Consequences of Loss of Progesterone Receptor Expression in Development of Invasive Endometrial Cancer
Clin Cancer Res 2003 9: 4190-4199. [Abstract] [Full Text] [PDF]  

Jung-Ta Chen, Ya-Wen Cheng, Ming-Chih Chou, Tong Sen-Lin, Wu-Wei Lai, William L. Ho, and Huei Lee

The Correlation between Aberrant Connexin 43 mRNA Expression Induced by Promoter Methylation and Nodal Micrometastasis in Non-Small Cell Lung Cancer
Clin Cancer Res 2003 9: 4200-4204. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Miriam Lango, Abbey L. Wentzel, John I. Song, Sichuan Xi, Daniel E. Johnson, William W. Lamph, Lori Miller, and Jennifer Rubin Grandis

Responsiveness to the Retinoic Acid Receptor-selective Retinoid LGD1550 Correlates with Abrogation of Transforming Growth Factor /Epidermal Growth Factor Receptor Autocrine Signaling in Head and Neck Squamous Carcinoma Cells
Clin Cancer Res 2003 9: 4205-4213. [Abstract] [Full Text] [PDF]  

Luigi Biancone, Vincenzo Cantaluppi, Lorenzo Del Sorbo, Simona Russo, Larry W. Tjoelker, and Giovanni Camussi

Platelet-activating Factor Inactivation by Local Expression of Platelet-activating Factor Acetyl-Hydrolase Modifies Tumor Vascularization and Growth
Clin Cancer Res 2003 9: 4214-4220. [Abstract] [Full Text] [PDF]  

Maximilian Bockhorn, Yoshikazu Tsuzuki, Lei Xu, Andreja Frilling, Christoph E. Broelsch, and Dai Fukumura

Differential Vascular and Transcriptional Responses to Anti-Vascular Endothelial Growth Factor Antibody in Orthotopic Human Pancreatic Cancer Xenografts
Clin Cancer Res 2003 9: 4221-4226. [Abstract] [Full Text] [PDF]  

Theodora Voskoglou-Nomikos, Joseph L. Pater, and Lesley Seymour

Clinical Predictive Value of the in Vitro Cell Line, Human Xenograft, and Mouse Allograft Preclinical Cancer Models
Clin Cancer Res 2003 9: 4227-4239. [Abstract] [Full Text] [PDF]  

Ulrich Wahl, Elfriede Nößner, Konrad Kronenberger, Rainer Gangnus, Heike Pohla, Martin S. Staege, Hans-Jochem Kolb, Michael Hallek, and Ralph Mocikat

Vaccination against B-cell Chronic Lymphocytic Leukemia with Trioma Cells: Preclinical Evaluation
Clin Cancer Res 2003 9: 4240-4246. [Abstract] [Full Text] [PDF]  

Amy B. Heimberger, Laura E. Crotty, Gary E. Archer, Kenneth R. Hess, Carol J. Wikstrand, Allan H. Friedman, Henry S. Friedman, Darell D. Bigner, and John H. Sampson

Epidermal Growth Factor Receptor VIII Peptide Vaccination Is Efficacious against Established Intracerebral Tumors
Clin Cancer Res 2003 9: 4247-4254. [Abstract] [Full Text] [PDF]  

Jin H. Song, Doyoun K. Song, Meenhard Herlyn, Kenneth C. Petruk, and Chunhai Hao

Cisplatin Down-Regulation of Cellular Fas-associated Death Domain-like Interleukin-1ß-converting Enzyme-like Inhibitory Proteins to Restore Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis in Human Melanoma Cells
Clin Cancer Res 2003 9: 4255-4266. [Abstract] [Full Text] [PDF]  

Tetsuzo Tauchi, Masahiko Sumi, Akihiro Nakajima, Goro Sashida, Takashi Shimamoto, and Kazuma Ohyashiki

BCL-2 Antisense Oligonucleotide Genasense Is Active against Imatinib-resistant BCR-ABL-positive Cells
Clin Cancer Res 2003 9: 4267-4273. [Abstract] [Full Text] [PDF]  

Wen G. Jiang, David Grimshaw, Tracey A. Martin, Gaynor Davies, Christian Parr, Gareth Watkins, Jane Lane, Roger Abounader, John Laterra, and Robert E. Mansel

Reduction of Stromal Fibroblast-induced Mammary Tumor Growth, by Retroviral Ribozyme Transgenes to Hepatocyte Growth Factor/Scatter Factor and its Receptor, c-MET
Clin Cancer Res 2003 9: 4274-4281. [Abstract] [Full Text] [PDF]  

   Cancer Biology, Immunology, Cytokines:

Kenji Hibi, Shin-ichi Fujitake, Tsunenobu Takase, Yasuhiro Kodera, Katsuki Ito, Seiji Akiyama, Masatoshi Shirane, and Akimasa Nakao

Identification of S100A2 as a Target of the Np63 Oncogenic Pathway
Clin Cancer Res 2003 9: 4282-4285. [Abstract] [Full Text] [PDF]  

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