Review:

Quynh-Thu Le and Amato J. Giaccia

Therapeutic Exploitation of the Physiological and Molecular Genetic Alterations in Head and Neck Cancer
Clin Cancer Res 2003 9: 4287-4295. [Abstract] [Full Text] [PDF]  

Perspectives:

Dirk Nagorsen, Carmen Scheibenbogen, Francesco M. Marincola, Anne Letsch, and Ulrich Keilholz

Natural T Cell Immunity against Cancer
Clin Cancer Res 2003 9: 4296-4303. [Abstract] [Full Text] [PDF]  

The Biology Behind:

Yun Yen

Ribonucleotide Reductase Subunit One as Gene Therapy Target: Commentary re: M-Y. Cao et al., Adenovirus-mediated Ribonucleotide Reductase R1 Gene Therapy of Human Colon Adenocarcinoma. Clin. Cancer Res., 9: 4304-4308, 2003.
Clin Cancer Res 2003 9: 4304-4308. [Full Text] [PDF]  

Report from the FDA:

Peter F. Bross, Amy Baird, Gang Chen, Josephine M. Jee, Richard T. Lostritto, David E. Morse, Liliam A. Rosario, Gene M. Williams, Peiling Yang, Atiqur Rahman, Grant Williams, and Richard Pazdur

Fulvestrant in Postmenopausal Women with Advanced Breast Cancer
Clin Cancer Res 2003 9: 4309-4317. [Abstract] [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

Lawrence H. Schwartz, Madhu Mazumdar, Wendy Brown, Alex Smith, and David M. Panicek

Variability in Response Assessment in Solid Tumors: Effect of Number of Lesions Chosen for Measurement
Clin Cancer Res 2003 9: 4318-4323. [Abstract] [Full Text] [PDF]  

Gabriella Ferrandina, Franco O. Ranelletti, Francesco Legge, Libero Lauriola, Vanda Salutari, Marco Gessi, Antonia C. Testa, Ulrike Werner, Pierluigi Navarra, Giuseppe Tringali, Alessandra Battaglia, and Giovanni Scambia

Celecoxib Modulates the Expression of Cyclooxygenase-2, Ki67, Apoptosis-Related Marker, and Microvessel Density in Human Cervical Cancer: A Pilot Study
Clin Cancer Res 2003 9: 4324-4331. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Emma Hormbrey, Cheng Han, Anthony Roberts, Duncan Angus McGrouther, and Adrian L. Harris

The Relationship of Human Wound Vascular Endothelial Growth Factor (VEGF) After Breast Cancer Surgery to Circulating VEGF and Angiogenesis
Clin Cancer Res 2003 9: 4332-4339. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Qing-Bai She, David Solit, Andrea Basso, and Mark M. Moasser

Resistance to Gefitinib in PTEN-Null HER-Overexpressing Tumor Cells Can Be Overcome through Restoration of PTEN Function or Pharmacologic Modulation of Constitutive Phosphatidylinositol 3'-Kinase/Akt Pathway Signaling
Clin Cancer Res 2003 9: 4340-4346. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Igor Astsaturov, Teresa Petrella, E. Umit Bagriacik, Mark de Benedette, Robert Uger, Gail Lumber, Neil Berinstein, Ileana Elias, Neill Iscoe, Caitlin Hammond, Paul Hamilton, and David E. Spaner

Amplification of Virus-Induced Antimelanoma T-Cell Reactivity by High-Dose Interferon-2b: Implications for Cancer Vaccines
Clin Cancer Res 2003 9: 4347-4355. [Abstract] [Full Text] [PDF]  

Primo N. Lara, Jr., Paul Frankel, Philip C. Mack, Paul H. Gumerlock, Irina Galvin, Cynthia L. Martel, Jeff Longmate, James H. Doroshow, Heinz Josef Lenz, Derick H. M. Lau, and David R. Gandara

Tirapazamine Plus Carboplatin and Paclitaxel in Advanced Malignant Solid Tumors: A California Cancer Consortium Phase I and Molecular Correlative Study
Clin Cancer Res 2003 9: 4356-4362. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

André B. P. van Kuilenburg, Rutger Meinsma, Bernard A. Zonnenberg, Lida Zoetekouw, Frank Baas, Koichi Matsuda, Nanaya Tamaki, and Albert H. van Gennip

Dihydropyrimidinase Deficiency and Severe 5-Fluorouracil Toxicity
Clin Cancer Res 2003 9: 4363-4367. [Abstract] [Full Text] [PDF]  

Kentaro Kishi, Yuichiro Doki, Masahiko Yano, Takushi Yasuda, Yoshiyuki Fujiwara, Syuji Takiguchi, Sontae Kim, Ichiro Higuchi, and Morito Monden

Reduced MLH1 Expression after Chemotherapy Is an Indicator for Poor Prognosis in Esophageal Cancers
Clin Cancer Res 2003 9: 4368-4375. [Abstract] [Full Text] [PDF]  

Christine Rentzsch, Simone Kayser, Susanne Stumm, Iris Watermann, Steffen Walter, Stefan Stevanoviç, Diethelm Wallwiener, and Brigitte Gückel

Evaluation of Pre-existent Immunity in Patients with Primary Breast Cancer: Molecular and Cellular Assays to Quantify Antigen-Specific T Lymphocytes in Peripheral Blood Mononuclear Cells
Clin Cancer Res 2003 9: 4376-4386. [Abstract] [Full Text] [PDF]  

Richard W. Tsang, Stephen Juvet, Melania Pintilie, Richard P. Hill, C. Shun Wong, Michael Milosevic, William Chapman, and Anthony W. Fyles

Pretreatment Proliferation Parameters Do Not Add Predictive Power to Clinical Factors in Cervical Cancer Treated with Definitive Radiation Therapy
Clin Cancer Res 2003 9: 4387-4395. [Abstract] [Full Text] [PDF]  

Robert M. Wenham, Joellen M. Schildkraut, Kia McLean, Brian Calingaert, Rex C. Bentley, Jeffrey Marks, and Andrew Berchuck

Polymorphisms in BRCA1 and BRCA2 and Risk of Epithelial Ovarian Cancer
Clin Cancer Res 2003 9: 4396-4403. [Abstract] [Full Text] [PDF]  

Fumiko Ichihara, Koji Kono, Akihiro Takahashi, Hiromichi Kawaida, Hidemitsu Sugai, and Hideki Fujii

Increased Populations of Regulatory T Cells in Peripheral Blood and Tumor-Infiltrating Lymphocytes in Patients with Gastric and Esophageal Cancers
Clin Cancer Res 2003 9: 4404-4408. [Abstract] [Full Text] [PDF]  

Derek L. Dai, Nikita Makretsov, Eric I. Campos, Changzheng Huang, Youwen Zhou, David Huntsman, Madgalena Martinka, and Gang Li

Increased Expression of Integrin-Linked Kinase Is Correlated with Melanoma Progression and Poor Patient Survival
Clin Cancer Res 2003 9: 4409-4414. [Abstract] [Full Text] [PDF]  

Igor Girault, Sengül Tozlu, Rosette Lidereau, and Ivan Bièche

Expression Analysis of DNA Methyltransferases 1, 3A, and 3B in Sporadic Breast Carcinomas
Clin Cancer Res 2003 9: 4415-4422. [Abstract] [Full Text] [PDF]  

Benny Vittrup Jensen, Julia S. Johansen, and Paul A. Price

High Levels of Serum HER-2/neu and YKL-40 Independently Reflect Aggressiveness of Metastatic Breast Cancer
Clin Cancer Res 2003 9: 4423-4434. [Abstract] [Full Text] [PDF]  

Dana Mihaila, Jorge A. Gutiérrez, Mark L. Rosenblum, Irene F. Newsham, Oliver Bögler, and Sandra A. Rempel

Meningiomas: Analysis of Loss of Heterozygosity on Chromosome 10 in Tumor Progression and the Delineation of Four Regions of Chromosomal Deletion in Common with Other Cancers
Clin Cancer Res 2003 9: 4435-4442. [Abstract] [Full Text] [PDF]  

Dana Mihaila, Michelle Jankowski, Jorge A. Gutiérrez, Mark L. Rosenblum, Irene F. Newsham, Oliver Bögler, and Sandra A. Rempel

Meningiomas: Loss of Heterozygosity on Chromosome 10 and Marker-Specific Correlations with Grade, Recurrence, and Survival
Clin Cancer Res 2003 9: 4443-4451. [Abstract] [Full Text] [PDF]  

Eliza Kwiatkowska, Marek Teresiak, Violetta Filas, Aldona Karczewska, Danuta Breborowicz, and Andrzej Mackiewicz

BRCA2 Mutations and Androgen Receptor Expression as Independent Predictors of Outcome of Male Breast Cancer Patients
Clin Cancer Res 2003 9: 4452-4459. [Abstract] [Full Text] [PDF]  

Gad Singer, Vera Rebmann, Yu-Chi Chen, Hsu-Tai Liu, Syed Z. Ali, Jochen Reinsberg, Michael T. McMaster, Kerstin Pfeiffer, Daniel W. Chan, Eva Wardelmann, Hans Grosse-Wilde, Chih-Chien Cheng, Robert J. Kurman, and Ie-Ming Shih

HLA-G Is a Potential Tumor Marker in Malignant Ascites
Clin Cancer Res 2003 9: 4460-4464. [Abstract] [Full Text] [PDF]  

Vassilis L. Souliotis, Meletios A. Dimopoulos, and Petros P. Sfikakis

Gene-specific Formation and Repair of DNA Monoadducts and Interstrand Cross-links after Therapeutic Exposure to Nitrogen Mustards
Clin Cancer Res 2003 9: 4465-4474. [Abstract] [Full Text] [PDF]  

Vernon Pais, Irwin Leav, Kin-Mang Lau, Zhong Jiang, and Shuk-Mei Ho

Estrogen Receptor-ß Expression in Human Testicular Germ Cell Tumors
Clin Cancer Res 2003 9: 4475-4482. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Qing Yao, Ritsuo Nishiuchi, Quanzhi Li, Ashish R. Kumar, Wendy A. Hudson, and John H. Kersey

FLT3 Expressing Leukemias Are Selectively Sensitive to Inhibitors of the Molecular Chaperone Heat Shock Protein 90 through Destabilization of Signal Transduction-Associated Kinases
Clin Cancer Res 2003 9: 4483-4493. [Abstract] [Full Text] [PDF]  

Steven S. Clark, Li Zhong, Daniele Filiault, Sarah Perman, Zhibin Ren, Michael Gould, and Xinhai Yang

Anti-Leukemia Effect of Perillyl Alcohol in Bcr/Abl-Transformed Cells Indirectly Inhibits Signaling through Mek in a Ras- and Raf-Independent Fashion
Clin Cancer Res 2003 9: 4494-4504. [Abstract] [Full Text] [PDF]  

Markus Letsch, Andrew V. Schally, Karoly Szepeshazi, Gabor Halmos, and Attila Nagy

Preclinical Evaluation of Targeted Cytotoxic Luteinizing Hormone-Releasing Hormone Analogue AN-152 in Androgen-Sensitive and Insensitive Prostate Cancers
Clin Cancer Res 2003 9: 4505-4513. [Abstract] [Full Text] [PDF]  

Susan K. Lutgendorf, Steven Cole, Erin Costanzo, Sarah Bradley, Jeremy Coffin, Sarvenaz Jabbari, Kaitlin Rainwater, Justine M. Ritchie, Maria Yang, and Anil K. Sood

Stress-Related Mediators Stimulate Vascular Endothelial Growth Factor Secretion by Two Ovarian Cancer Cell Lines
Clin Cancer Res 2003 9: 4514-4521. [Abstract] [Full Text] [PDF]  

Qinghui Wu, Ratha Mahendran, and Kesavan Esuvaranathan

Nonviral Cytokine Gene Therapy on an Orthotopic Bladder Cancer Model
Clin Cancer Res 2003 9: 4522-4528. [Abstract] [Full Text] [PDF]  

Jonathan P. Dyke, Kristen L. Zakian, William M. Spees, Cornelia Matei, Yuchen Chen, Xiangling Mao, Dikoma C. Shungu, and Jason A. Koutcher

Metabolic Response of the CWR22 Prostate Tumor Xenograft after 20 Gy of Radiation Studied by ¹H Spectroscopic Imaging
Clin Cancer Res 2003 9: 4529-4536. [Abstract] [Full Text] [PDF]  

Jiabin An, Yi-Ping Sun, Julian Adams, Myrna Fisher, Arie Belldegrun, and Matthew B. Rettig

Drug Interactions between the Proteasome Inhibitor Bortezomib and Cytotoxic Chemotherapy, Tumor Necrosis Factor (TNF) , and TNF-Related Apoptosis-Inducing Ligand in Prostate Cancer
Clin Cancer Res 2003 9: 4537-4545. [Abstract] [Full Text] [PDF]  

Fabrice Denis, Séverine Colas, Linda Chami, Pascal Louisot, Olivier le Floch, François Tranquart, and Philippe Bougnoux

Changes in Tumor Vascularization after Irradiation, Anthracyclin, or Antiangiogenic Treatment in Nitrosomethyl Ureas-Induced Rat Mammary Tumors
Clin Cancer Res 2003 9: 4546-4552. [Abstract] [Full Text] [PDF]  

Ming-Yu Cao, Yoon Lee, Ning-Ping Feng, Keyong Xiong, Hongnan Jin, Ming Wang, Aikaterini Vassilakos, Stéphane Viau, Jim A. Wright, and Aiping H. Young

Adenovirus-Mediated Ribonucleotide Reductase R1 Gene Therapy of Human Colon Adenocarcinoma
Clin Cancer Res 2003 9: 4553-4561. [Abstract] [Full Text] [PDF]  

Pierre Champelovier, Annick Simon, Catherine Garrel, Geraldine Levacher, Vincent Praloran, and Daniel Seigneurin

Is Interferon One Key of Metastatic Potential Increase in Human Bladder Carcinoma?
Clin Cancer Res 2003 9: 4562-4569. [Abstract] [Full Text] [PDF]  

Jessica C. Pahler, Stacey Ruiz, Irina Niemer, Leslie R. Calvert, Michael Andreeff, Michael Keating, Stefan Faderl, and David J. McConkey

Effects of the Proteasome Inhibitor, Bortezomib, on Apoptosis in Isolated Lymphocytes Obtained from Patients with Chronic Lymphocytic Leukemia
Clin Cancer Res 2003 9: 4570-4577. [Abstract] [Full Text] [PDF]  

Marc A. Brockmann, Apollon Papadimitriou, Michael Brandt, Regina Fillbrandt, Manfred Westphal, and Katrin Lamszus

Inhibition of Intracerebral Glioblastoma Growth by Local Treatment with the Scatter Factor/Hepatocyte Growth Factor-Antagonist NK4
Clin Cancer Res 2003 9: 4578-4585. [Abstract] [Full Text] [PDF]  

Julie Litz, Patricia Carlson, G. Sakuntala Warshamana-Greene, Steven Grant, and Geoffrey W. Krystal

Flavopiridol Potently Induces Small Cell Lung Cancer Apoptosis during S Phase in a Manner That Involves Early Mitochondrial Dysfunction
Clin Cancer Res 2003 9: 4586-4594. [Abstract] [Full Text] [PDF]  

Fabio Pastorino, Chiara Brignole, Danilo Marimpietri, Gabriella Pagnan, Adriana Morando, Domenico Ribatti, Sean C. Semple, Claudio Gambini, Theresa M. Allen, and Mirco Ponzoni

Targeted Liposomal c-myc Antisense Oligodeoxynucleotides Induce Apoptosis and Inhibit Tumor Growth and Metastases in Human Melanoma Models
Clin Cancer Res 2003 9: 4595-4605. [Abstract] [Full Text] [PDF]  

Anita L. Sabichi, Hui Xu, Susan Fischer, Changchan Zou, Xiulan Yang, Vernon E. Steele, Gary J. Kelloff, Reuben Lotan, and John L. Clifford

Retinoid Receptor-Dependent and Independent Biological Activities of Novel Fenretinide Analogues and Metabolites
Clin Cancer Res 2003 9: 4606-4613. [Abstract] [Full Text] [PDF]  

Wu Licun and Ian F. Tannock

Selective Estrogen Receptor Modulators as Inhibitors of Repopulation of Human Breast Cancer Cell Lines after Chemotherapy
Clin Cancer Res 2003 9: 4614-4618. [Abstract] [Full Text] [PDF]  

Stacy M. Plum, Arthur D. Hanson, Kirk M. Volker, Hong A. Vu, B. Kim Lee Sim, William E. Fogler, and Anne H. Fortier

Synergistic Activity of Recombinant Human Endostatin in Combination with Adriamycin: Analysis of in Vitro Activity on Endothelial Cells and in Vivo Tumor Progression in an Orthotopic Murine Mammary Carcinoma Model
Clin Cancer Res 2003 9: 4619-4626. [Abstract] [Full Text] [PDF]  

Shouwei Han, Hiroyasu Inoue, Lisa C. Flowers, and Neil Sidell

Control of COX-2 Gene Expression through Peroxisome Proliferator-Activated Receptor in Human Cervical Cancer Cells
Clin Cancer Res 2003 9: 4627-4635. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

José M. Buesa, Paula García-Teijido, Raquel Losa, and Joaquín Fra

Treatment of Ifosfamide Encephalopathy with Intravenous Thiamin
Clin Cancer Res 2003 9: 4636-4637. [Full Text] [PDF]  

Corrections:

Correction for vol. 9, p. 3021
Clin Cancer Res 2003 9: 4638. [Full Text] [PDF]  

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