Minireviews:

Allan J. Pantuck, Gang Zeng, Arie S. Belldegrun, and Robert A. Figlin

Pathobiology, Prognosis, and Targeted Therapy for Renal Cell Carcinoma: Exploiting the Hypoxia-Induced Pathway
Clin Cancer Res 2003 9: 4641-4652. [Abstract] [Full Text] [PDF]  

Perspectives:

Mohit Trikha, Robert Corringham, Bernard Klein, and Jean-François Rossi

Targeted Anti-Interleukin-6 Monoclonal Antibody Therapy for Cancer: A Review of the Rationale and Clinical Evidence
Clin Cancer Res 2003 9: 4653-4665. [Abstract] [Full Text] [PDF]  

Stephen A. Butler and Ray K. Iles

Ectopic Human Chorionic Gonadotropin ß Secretion by Epithelial Tumors and Human Chorionic Gonadotropin ß-Induced Apoptosis in Kaposi’s Sarcoma: Is There a Connection?
Clin Cancer Res 2003 9: 4666-4673. [Abstract] [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

Heike Pfeifer, Barbara Wassmann, Wolf-Karsten Hofmann, Martina Komor, Urban Scheuring, Patrick Brück, Anja Binckebanck, Eberhard Schleyer, Nicola Gökbuget, Thomas Wolff, Michael Lübbert, Lothar Leimer, Harald Gschaidmeier, Dieter Hoelzer, and Oliver G. Ottmann

Risk and Prognosis of Central Nervous System Leukemia in Patients with Philadelphia Chromosome-Positive Acute Leukemias Treated with Imatinib Mesylate
Clin Cancer Res 2003 9: 4674-4681. [Abstract] [Full Text] [PDF]  

Jeremy P. Braybrooke, Nicola C. Levitt, Simon Joel, Theresa Davis, Srinivasan Madhusudan, Helen Turley, Sue Wilner, Adrian L. Harris, and Denis C. Talbot

Pharmacokinetic Study of Cisplatin and Infusional Etoposide Phosphate in Advanced Breast Cancer with Correlation of Response to Topoisomerase II Expression
Clin Cancer Res 2003 9: 4682-4688. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Sarah Freitas, David H. Moore, Helen Michael, and Mark R. Kelley

Studies of Apurinic/Apyrimidinic Endonuclease/ref-1 Expression in Epithelial Ovarian Cancer: Correlations with Tumor Progression and Platinum Resistance
Clin Cancer Res 2003 9: 4689-4694. [Abstract] [Full Text] [PDF]  

Noboru Yamagata, Yu Shyr, Kiyoshi Yanagisawa, Mary Edgerton, Thao P. Dang, Adriana Gonzalez, Sorena Nadaf, Paul Larsen, John R. Roberts, Jonathan C. Nesbitt, Roy Jensen, Shawn Levy, Jason H. Moore, John D. Minna, and David P. Carbone

A Training-Testing Approach to the Molecular Classification of Resected Non-Small Cell Lung Cancer
Clin Cancer Res 2003 9: 4695-4704. [Abstract] [Full Text] [PDF]  

Sana Yokoi, Kohichiroh Yasui, Toshihiko Iizasa, Issei Imoto, Takehiko Fujisawa, and Johji Inazawa

TERC Identified as a Probable Target within the 3q26 Amplicon That Is Detected Frequently in Non-Small Cell Lung Cancers
Clin Cancer Res 2003 9: 4705-4713. [Abstract] [Full Text] [PDF] Supplementary Data  

Anne L. Clark, Ann M. Gillenwater, Thomas G. Collier, Reza Alizadeh-Naderi, Adel K. El-Naggar, and Rebecca R. Richards-Kortum

Confocal Microscopy for Real-Time Detection of Oral Cavity Neoplasia
Clin Cancer Res 2003 9: 4714-4721. [Abstract] [Full Text] [PDF]  

Andrea Decensi, Umberto Veronesi, Rosalba Miceli, Harriet Johansson, Luigi Mariani, Tiziana Camerini, Maria Gaetana Di Mauro, Elena Cavadini, Giuseppe De Palo, Alberto Costa, Marjorie Perloff, Winfred F. Malone, and Franca Formelli

Relationships between Plasma Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3 and Second Breast Cancer Risk in a Prevention Trial of Fenretinide
Clin Cancer Res 2003 9: 4722-4729. [Abstract] [Full Text] [PDF]  

Asha Padar, Ubaradka G. Sathyanarayana, Makoto Suzuki, Riichiroh Maruyama, Jer-Tsong Hsieh, Eugene P. Frenkel, John D. Minna, and Adi F. Gazdar

Inactivation of Cyclin D2 Gene in Prostate Cancers by Aberrant Promoter Methylation
Clin Cancer Res 2003 9: 4730-4734. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Nicolas Magné, Jean-Louis Fischel, Alain Dubreuil, Patricia Formento, Joseph Ciccolini, Jean-Louis Formento, Céline Tiffon, Nicole Renée, Sandrine Marchetti, Marie-Christine Etienne, and Gérard Milano

ZD1839 (Iressa) Modifies the Activity of Key Enzymes Linked to Fluoropyrimidine Activity: Rational Basis for a New Combination Therapy with Capecitabine
Clin Cancer Res 2003 9: 4735-4742. [Abstract] [Full Text] [PDF]  

Roland Schroers, Lei Shen, Lisa Rollins, Cliona M. Rooney, Kevin Slawin, Grete Sonderstrup, Xue F. Huang, and Si-Yi Chen

Human Telomerase Reverse Transcriptase-Specific T-Helper Responses Induced by Promiscuous Major Histocompatibility Complex Class II-Restricted Epitopes
Clin Cancer Res 2003 9: 4743-4755. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Tetsuro Higuchi, Takeo Iwama, Keigo Yoshinaga, Masahiro Toyooka, Makoto M. Taketo, and Kenichi Sugihara

A Randomized, Double-Blind, Placebo-Controlled Trial of the Effects of Rofecoxib, a Selective Cyclooxygenase-2 Inhibitor, on Rectal Polyps in Familial Adenomatous Polyposis Patients
Clin Cancer Res 2003 9: 4756-4760. [Abstract] [Full Text] [PDF]  

Amita Patnaik, S. Gail Eckhardt, Elzbieta Izbicka, Anthony A. Tolcher, Lisa A. Hammond, Chris H. Takimoto, Garry Schwartz, Heather McCreery, Andrew Goetz, Masataka Mori, Kazutoyo Terada, Lou Gentner, Mary-Ellen Rybak, Henry Richards, Steven Zhang, and Eric K. Rowinsky

A Phase I, Pharmacokinetic, and Biological Study of the Farnesyltransferase Inhibitor Tipifarnib in Combination with Gemcitabine in Patients with Advanced Malignancies
Clin Cancer Res 2003 9: 4761-4771. [Abstract] [Full Text] [PDF]  

Primo N. Lara, Jr., David I. Quinn, Kim Margolin, Frederick J. Meyers, Jeff Longmate, Paul Frankel, Philip C. Mack, Corinne Turrell, Peter Valk, Jyotsna Rao, Penelope Buckley, Ted Wun, Robert Gosselin, Irina Galvin, Paul H. Gumerlock, Heinz Josef Lenz, James H. Doroshow, and David R. Gandara

SU5416 Plus Interferon in Advanced Renal Cell Carcinoma: A Phase II California Cancer Consortium Study with Biological and Imaging Correlates of Angiogenesis Inhibition
Clin Cancer Res 2003 9: 4772-4781. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Jae-Hoon Kim, Dorothee Herlyn, Kwong-kwok Wong, Dong-Choon Park, John O. Schorge, Karen H. Lu, Steven J. Skates, Daniel W. Cramer, Ross S. Berkowitz, and Samuel C. Mok

Identification of Epithelial Cell Adhesion Molecule Autoantibody in Patients with Ovarian Cancer
Clin Cancer Res 2003 9: 4782-4791. [Abstract] [Full Text] [PDF]  

Gustavo Ayala, Jennifer A. Tuxhorn, Thomas M. Wheeler, Anna Frolov, Peter T. Scardino, Makoto Ohori, Marcus Wheeler, Jeffrey Spitler, and David R. Rowley

Reactive Stroma as a Predictor of Biochemical-Free Recurrence in Prostate Cancer
Clin Cancer Res 2003 9: 4792-4801. [Abstract] [Full Text] [PDF]  

Hiroki Kuniyasu, Hitoshi Ohmori, Takamistu Sasaki, Tomonori Sasahira, Kazuhiro Yoshida, Yasuhiko Kitadai, and Isaiah J. Fidler

Production of Interleukin 15 by Human Colon Cancer Cells Is Associated with Induction of Mucosal Hyperplasia, Angiogenesis, and Metastasis
Clin Cancer Res 2003 9: 4802-4810. [Abstract] [Full Text] [PDF]  

Kristin K. Zorn, Amir A. Jazaeri, Christopher S. Awtrey, Ginger J. Gardner, Samuel C. Mok, Jeff Boyd, and Michael J. Birrer

Choice of Normal Ovarian Control Influences Determination of Differentially Expressed Genes in Ovarian Cancer Expression Profiling Studies
Clin Cancer Res 2003 9: 4811-4818. [Abstract] [Full Text] [PDF]  

Charles T. Miller, Justin R. Moy, Lin Lin, Matthew Schipper, Daniel Normolle, Dean E. Brenner, Mark D. Iannettoni, Mark B. Orringer, and David G. Beer

Gene Amplification in Esophageal Adenocarcinomas and Barrett’s with High-Grade Dysplasia
Clin Cancer Res 2003 9: 4819-4825. [Abstract] [Full Text] [PDF]  

Wilma E. Mesker, Fania S. Doekhie, Hans Vrolijk, Rob Keyzer, Willem C. R. Sloos, Hans Morreau, Paddy S. O’Kelly, Geertruida H. de Bock, Rob A. E. M. Tollenaar, and Hans J. Tanke

Automated Analysis of Multiple Sections for the Detection of Occult Cells in Lymph Nodes
Clin Cancer Res 2003 9: 4826-4834. [Abstract] [Full Text] [PDF]  

Ruediger Spitz, Barbara Hero, Karen Ernestus, and Frank Berthold

Gain of Distal Chromosome Arm 17q Is Not Associated with Poor Prognosis in Neuroblastoma
Clin Cancer Res 2003 9: 4835-4840. [Abstract] [Full Text] [PDF]  

Carol Walker, Daniel G. du Plessis, Kathy A. Joyce, Yvonne Machell, Joanne Thomson-Hehir, Syed A. Al Haddad, John C. Broome, and Peter C. Warnke

Phenotype versus Genotype in Gliomas Displaying Inter- or Intratumoral Histological Heterogeneity
Clin Cancer Res 2003 9: 4841-4851. [Abstract] [Full Text] [PDF]  

Hiroyuki Hisai, Junji Kato, Masayoshi Kobune, Tsuzuku Murakami, Koji Miyanishi, Minoru Takahashi, Naohito Yoshizaki, Rishu Takimoto, Takeshi Terui, and Yoshiro Niitsu

Increased Expression of Angiogenin in Hepatocellular Carcinoma in Correlation with Tumor Vascularity
Clin Cancer Res 2003 9: 4852-4859. [Abstract] [Full Text] [PDF]  

Massimiliano Bonafé, Claudio Ceccarelli, Fulvia Farabegoli, Donatella Santini, Mario Taffurelli, Cristiana Barbi, Erika Marzi, Chiara Trapassi, Gianluca Storci, Fabiola Olivieri, and Claudio Franceschi

Retention of the p53 Codon 72 Arginine Allele Is Associated with a Reduction of Disease-Free and Overall Survival in Arginine/Proline Heterozygous Breast Cancer Patients
Clin Cancer Res 2003 9: 4860-4864. [Abstract] [Full Text] [PDF]  

Megan K. Baker, Kaidi Mikhitarian, Walid Osta, Kathi Callahan, Rana Hoda, Frank Brescia, Rayna Kneuper-Hall, Michael Mitas, David J. Cole, and William E. Gillanders

Molecular Detection of Breast Cancer Cells in the Peripheral Blood of Advanced-Stage Breast Cancer Patients Using Multimarker Real-Time Reverse Transcription-Polymerase Chain Reaction and a Novel Porous Barrier Density Gradient Centrifugation Technology
Clin Cancer Res 2003 9: 4865-4871. [Abstract] [Full Text] [PDF]  

Anil Potti, Apar Kishor Ganti, Kaley Sholes, Eric Langness, Vijay Koka, Linda Horvarth, and Michael Koch

Effect of Pesticide Exposure on HER-2/neu Overexpression Seen in Patients with Extensive Stage Small Cell Lung Carcinoma
Clin Cancer Res 2003 9: 4872-4876. [Abstract] [Full Text] [PDF]  

Christian F. Singer, Nicole Kronsteiner, Gernot Hudelist, Erika Marton, Ingrid Walter, Marion Kubista, Klaus Czerwenka, Martin Schreiber, Michael Seifert, and Ernst Kubista

Interleukin 1 System and Sex Steroid Receptor Expression in Human Breast Cancer: Interleukin 1 Protein Secretion Is Correlated with Malignant Phenotype
Clin Cancer Res 2003 9: 4877-4883. [Abstract] [Full Text] [PDF]  

Takao Watanabe, Yoichi Katayama, Atsuo Yoshino, Chiaki Komine, and Takakazu Yokoyama

Deregulation of the TP53/p14^ARF Tumor Suppressor Pathway in Low-Grade Diffuse Astrocytomas and Its Influence on Clinical Course
Clin Cancer Res 2003 9: 4884-4890. [Abstract] [Full Text] [PDF]  

Yu-Wen Tien, Po-Huang Lee, Rey-Heng Hu, Su-Ming Hsu, and King-Jen Chang

The Role of Gelatinase in Hepatic Metastasis of Colorectal Cancer
Clin Cancer Res 2003 9: 4891-4896. [Abstract] [Full Text] [PDF]  

Hui Chun Zhan, Lorraine J. Gudas, Dean Bok, Robert Rando, David M. Nanus, and Satish K. Tickoo

Differential Expression of the Enzyme That Esterifies Retinol, Lecithin:Retinol Acyltransferase, in Subtypes of Human Renal Cancer and Normal Kidney
Clin Cancer Res 2003 9: 4897-4905. [Abstract] [Full Text] [PDF]  

Glen Kristiansen, Klaus-Jürgen Winzer, Empar Mayordomo, Joachim Bellach, Karsten Schlüns, Carsten Denkert, Edgar Dahl, Christian Pilarsky, Peter Altevogt, Hans Guski, and Manfred Dietel

CD24 Expression Is a New Prognostic Marker in Breast Cancer
Clin Cancer Res 2003 9: 4906-4913. [Abstract] [Full Text] [PDF]  

Maryla Krajewska, Stan Krajewski, Steven Banares, Xianshu Huang, Bruce Turner, Lukas Bubendorf, Olli-P. Kallioniemi, Ahmed Shabaik, Antonella Vitiello, Donna Peehl, Guo-Jian Gao, and John C. Reed

Elevated Expression of Inhibitor of Apoptosis Proteins in Prostate Cancer
Clin Cancer Res 2003 9: 4914-4925. [Abstract] [Full Text] [PDF]  

Kotaro Kameyama, Cheng-long Huang, Dage Liu, Daiki Masuya, Takashi Nakashima, Shinichi Sumitomo, Yuji Takami, Moritoshi Kinoshita, and Hiroyasu Yokomise

Reduced ING1b Gene Expression Plays an Important Role in Carcinogenesis of Non-Small Cell Lung Cancer Patients
Clin Cancer Res 2003 9: 4926-4934. [Abstract] [Full Text] [PDF]  

Shashi R. Harvey, Thelma C. Hurd, Gabor Markus, Maisie I. Martinick, Remedios M. Penetrante, Dongfeng Tan, Preeti Venkataraman, Nisha DeSouza, Sheila N. J. Sait, Deborah L. Driscoll, and John F. Gibbs

Evaluation of Urinary Plasminogen Activator, Its Receptor, Matrix Metalloproteinase-9, and von Willebrand Factor in Pancreatic Cancer
Clin Cancer Res 2003 9: 4935-4943. [Abstract] [Full Text] [PDF]  

Yoshihiro Azuma, Shu-Chuan Chou, Ruth A. Lininger, Brian J. Murphy, Mahesh A. Varia, and James A. Raleigh

Hypoxia and Differentiation in Squamous Cell Carcinomas of the Uterine Cervix: Pimonidazole and Involucrin
Clin Cancer Res 2003 9: 4944-4952. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Jiehua Zhou, Jian Chen, Michael Mokotoff, Ruikun Zhong, Leonard D. Shultz, and Edward D. Ball

Bombesin/Gastrin-Releasing Peptide Receptor: A Potential Target for Antibody-Mediated Therapy of Small Cell Lung Cancer
Clin Cancer Res 2003 9: 4953-4960. [Abstract] [Full Text] [PDF]  

Jason Beliakoff, Rochelle Bagatell, Gillian Paine-Murrieta, Charles W. Taylor, Anne E. Lykkesfeldt, and Luke Whitesell

Hormone-Refractory Breast Cancer Remains Sensitive to the Antitumor Activity of Heat Shock Protein 90 Inhibitors
Clin Cancer Res 2003 9: 4961-4971. [Abstract] [Full Text] [PDF]  

Jin T. E. Lim, Gary A. Piazza, Rifat Pamukcu, W. Joseph Thompson, and I. Bernard Weinstein

Exisulind and Related Compounds Inhibit Expression and Function of the Androgen Receptor in Human Prostate Cancer Cells
Clin Cancer Res 2003 9: 4972-4982. [Abstract] [Full Text] [PDF]  

Sonal P. Sanghani, Sara K. Quinney, Tyler B. Fredenburg, Zejin Sun, Wilhelmina I. Davis, Daryl J. Murry, Oscar W. Cummings, David E. Seitz, and William F. Bosron

Carboxylesterases Expressed in Human Colon Tumor Tissue and Their Role in CPT-11 Hydrolysis
Clin Cancer Res 2003 9: 4983-4991. [Abstract] [Full Text] [PDF]  

Min Qin, Shuang Chen, Tina Yu, Brian Escuadro, Sherven Sharma, and Raj K. Batra

Coxsackievirus Adenovirus Receptor Expression Predicts the Efficiency of Adenoviral Gene Transfer into Non-Small Cell Lung Cancer Xenografts
Clin Cancer Res 2003 9: 4992-4999. [Abstract] [Full Text] [PDF]  

José García-Manteiga, Míriam Molina-Arcas, F. Javier Casado, Adela Mazo, and Marçal Pastor-Anglada

Nucleoside Transporter Profiles in Human Pancreatic Cancer Cells: Role of hCNT1 in 2',2'-Difluorodeoxycytidine- Induced Cytotoxicity
Clin Cancer Res 2003 9: 5000-5008. [Abstract] [Full Text] [PDF]  

Mariska C. de Jong, George L. Scheffer, Henk J. Broxterman, Jan H. Hooijberg, Jerry W. Slootstra, Rob H. Meloen, Robert J. Kreitman, Syed R. Husain, Bharat H. Joshi, Raj K. Puri, and Rik J. Scheper

Multidrug-Resistant Tumor Cells Remain Sensitive to a Recombinant Interleukin-4-Pseudomonas Exotoxin, Except When Overexpressing the Multidrug Resistance Protein MRP1
Clin Cancer Res 2003 9: 5009-5017. [Abstract] [Full Text] [PDF]  

June-Won Cheong, So Young Chong, Ji Yeon Kim, Ju In Eom, Hoi Kyung Jeung, Ho Young Maeng, Seung Tae Lee, and Yoo Hong Min

Induction of Apoptosis by Apicidin, a Histone Deacetylase Inhibitor, via the Activation of Mitochondria-Dependent Caspase Cascades in Human Bcr-Abl-Positive Leukemia Cells
Clin Cancer Res 2003 9: 5018-5027. [Abstract] [Full Text] [PDF]  

Hideo Niwa, Abbey L. Wentzel, Mengfeng Li, William E. Gooding, Vivian Wai Yan Lui, and Jennifer Rubin Grandis

Antitumor Effects of Epidermal Growth Factor Receptor Antisense Oligonucleotides in Combination with Docetaxel in Squamous Cell Carcinoma of the Head and Neck
Clin Cancer Res 2003 9: 5028-5035. [Abstract] [Full Text] [PDF]  

Mariana S. De Lorenzo, Kentaro Yamaguchi, Kotha Subbaramaiah, and Andrew J. Dannenberg

Bryostatin-1 Stimulates the Transcription of Cyclooxygenase-2: Evidence for an Activator Protein-1-Dependent Mechanism
Clin Cancer Res 2003 9: 5036-5043. [Abstract] [Full Text] [PDF]  

   Cancer Biology, Immunology, Cytokines:

Liviu P. Lefter, Makoto Sunamura, Toru Furukawa, Kazunori Takeda, Noriko Kotobuki, Mitsuo Oshimura, Seiki Matsuno, and Akira Horii

Inserting Chromosome 18 into Pancreatic Cancer Cells Switches Them to a Dormant Metastatic Phenotype
Clin Cancer Res 2003 9: 5044-5052. [Abstract] [Full Text] [PDF]  

Corrections:

Correction for vol. 9, p. 3469
Clin Cancer Res 2003 9: 5053. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.