Review:

Chulso Moon, Yun Oh, and Jack A. Roth

Current Status of Gene Therapy for Lung Cancer and Head and Neck Cancer
Clin Cancer Res 2003 9: 5055-5067. [Abstract] [Full Text] [PDF]  

Perspectives:

J. Carl Panetta, Lisa C. Iacono, Peter C. Adamson, and Clinton F. Stewart

The Importance of Pharmacokinetic Limited Sampling Models for Childhood Cancer Drug Development
Clin Cancer Res 2003 9: 5068-5077. [Abstract] [Full Text] [PDF]  

Rita Nahta and Francisco J. Esteva

HER-2-Targeted Therapy: Lessons Learned and Future Directions
Clin Cancer Res 2003 9: 5078-5084. [Abstract] [Full Text] [PDF]  

The Biology Behind:

Nariyoshi Shinomiya and George F. Vande Woude

Suppression of Met Expression: A Possible Cancer Treatment: Commentary re: S. J. Kim et al., Reduced c-Met Expression by an Adenovirus Expressing a c-Met Ribozyme Inhibits Tumorigenic Growth and Lymph Node Metastases of PC3-LN4 Prostate Tumor Cells in an Orthotopic Nude Mouse Model. Clin. Cancer Res., 14: 5161-5170, 2003.
Clin Cancer Res 2003 9: 5085-5090. [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

I. Jolanda M. de Vries, W. Joost Lesterhuis, Nicole M. Scharenborg, Linda P. H. Engelen, Dirk J. Ruiter, Marie-Jeanne P. Gerritsen, Sandra Croockewit, Cedrik M. Britten, Ruurd Torensma, Gosse J. Adema, Carl G. Figdor, and Cornelis J. A. Punt

Maturation of Dendritic Cells Is a Prerequisite for Inducing Immune Responses in Advanced Melanoma Patients
Clin Cancer Res 2003 9: 5091-5100. [Abstract] [Full Text] [PDF]  

Beatrice M. Seddon, Geoffrey S. Payne, Laura Simmons, Ruth Ruddle, Rachel Grimshaw, Siew Tan, Alison Turner, Florence Raynaud, Gavin Halbert, Martin O. Leach, Ian Judson, and Paul Workman

A Phase I Study of SR-4554 via Intravenous Administration for Noninvasive Investigation of Tumor Hypoxia by Magnetic Resonance Spectroscopy in Patients with Malignancy
Clin Cancer Res 2003 9: 5101-5112. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Douglas D. Taylor, Çiçek Gerçel-Taylor, Karen S. Lyons, Joanna Stanson, and Theresa L. Whiteside

T-Cell Apoptosis and Suppression of T-Cell Receptor/CD3- by Fas Ligand-Containing Membrane Vesicles Shed from Ovarian Tumors
Clin Cancer Res 2003 9: 5113-5119. [Abstract] [Full Text] [PDF]  

James A. Koziol, Jian-Ying Zhang, Carlos A. Casiano, Xuan-Xian Peng, Fu-Dong Shi, Anne C. Feng, Edward K. L. Chan, and Eng M. Tan

Recursive Partitioning as an Approach to Selection of Immune Markers for Tumor Diagnosis
Clin Cancer Res 2003 9: 5120-5126. [Abstract] [Full Text] [PDF]  

Knut Ketterer, Shyam Rao, Helmut Friess, John Weiss, Markus W. Büchler, and Murray Korc

Reverse Transcription-PCR Analysis of Laser-Captured Cells Points to Potential Paracrine and Autocrine Actions of Neurotrophins in Pancreatic Cancer
Clin Cancer Res 2003 9: 5127-5136. [Abstract] [Full Text] [PDF]  

Takashi Ueno, Akira Tangoku, Shigefumi Yoshino, Toshihiro Abe, Hideto Hayashi, Hiroaki Toshimitsu, Kiichiro Hashimoto, Tomomitsu Satoh, Atsunori Oga, Tomoko Furuya, Masaaki Oka, and Kohsuke Sasaki

Prediction of Nodal Metastasis by Comparative Genomic Hybridization in Biopsy Specimens from Patients with Superficial Esophageal Squamous Cell Carcinoma
Clin Cancer Res 2003 9: 5137-5141. [Abstract] [Full Text] [PDF]  

Carrie M. Cottreau, Roberta B. Ness, Francesmary Modugno, Glenn O. Allen, and Marc T. Goodman

Endometriosis and Its Treatment with Danazol or Lupron in Relation to Ovarian Cancer
Clin Cancer Res 2003 9: 5142-5144. [Abstract] [Full Text] [PDF]  

Aliki Stathopoulou, Anna Gizi, Maria Perraki, Stella Apostolaki, Nikos Malamos, Dimitris Mavroudis, Vassilis Georgoulias, and Evi S. Lianidou

Real-Time Quantification of CK-19 mRNA-Positive Cells in Peripheral Blood of Breast Cancer Patients Using the Lightcycler System
Clin Cancer Res 2003 9: 5145-5151. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Mototsugu Muramaki, Hideaki Miyake, Isao Hara, and Sadao Kamidono

Introduction of Midkine Gene into Human Bladder Cancer Cells Enhances Their Malignant Phenotype But Increases Their Sensitivity to Antiangiogenic Therapy
Clin Cancer Res 2003 9: 5152-5160. [Abstract] [Full Text] [PDF]  

Sun Jin Kim, Marjorie Johnson, Kristen Koterba, Matthew H. Herynk, Hisanori Uehara, and Gary E. Gallick

Reduced c-Met Expression by an Adenovirus Expressing a c-Met Ribozyme Inhibits Tumorigenic Growth and Lymph Node Metastases of PC3-LN4 Prostate Tumor Cells in an Orthotopic Nude Mouse Model
Clin Cancer Res 2003 9: 5161-5170. [Abstract] [Full Text] [PDF]  

Sabine L. A. Plasschaert, Dorina M. van der Kolk, Eveline S. J. M. de Bont, Willem A. Kamps, Kuniaki Morisaki, Susan E. Bates, George L. Scheffer, Rik J. Scheper, Edo Vellenga, and Elisabeth G. E. de Vries

The Role of Breast Cancer Resistance Protein in Acute Lymphoblastic Leukemia
Clin Cancer Res 2003 9: 5171-5177. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Jeffrey G. Supko, Joseph P. Eder, Jr., David P. Ryan, Michael V. Seiden, Thomas J. Lynch, Phillip C. Amrein, Donald W. Kufe, and Jeffrey W. Clark

Phase I Clinical Trial and Pharmacokinetic Study of the Spicamycin Analog KRN5500 Administered as a 1-Hour Intravenous Infusion for Five Consecutive Days to Patients with Refractory Solid Tumors
Clin Cancer Res 2003 9: 5178-5186. [Abstract] [Full Text] [PDF]  

Ranjana Advani, George A. Fisher, Bert L. Lum, Charro Jambalos, Cheryl D. Cho, Marvin Cohen, Ashwin Gollerkeri, and Branimir I. Sikic

Phase I and Pharmacokinetic Study of BMS-188797, a New Taxane Analog, Administered on a Weekly Schedule in Patients with Advanced Malignancies
Clin Cancer Res 2003 9: 5187-5194. [Abstract] [Full Text] [PDF]  

Christian Dittrich, Herlinde Dumez, Hilary Calvert, Axel Hanauske, Marije Faber, Jantien Wanders, Murray Yule, Miroslav Ravic, and Pierre Fumoleau

Phase I and Pharmacokinetic Study of E7070, a Chloroindolyl-Sulfonamide Anticancer Agent, Administered on a Weekly Schedule to Patients with Solid Tumors
Clin Cancer Res 2003 9: 5195-5204. [Abstract] [Full Text] [PDF]  

Peter J. Baldwin, Sjoerd H. van der Burg, Christopher M. Boswell, Rienk Offringa, Julian K. Hickling, Jennifer Dobson, John St. Clair Roberts, John A. Latimer, Robin P. Moseley, Nicholas Coleman, Margaret A. Stanley, and Jane C. Sterling

Vaccinia-Expressed Human Papillomavirus 16 and 18 E6 and E7 as a Therapeutic Vaccination for Vulval and Vaginal Intraepithelial Neoplasia
Clin Cancer Res 2003 9: 5205-5213. [Abstract] [Full Text] [PDF]  

Govind Ragupathi, Philip O. Livingston, Chandra Hood, John Gathuru, Susan E. Krown, Paul B. Chapman, Jedd D. Wolchok, Linda J. Williams, Roberta C. Oldfield, and Wen-Jen Hwu

Consistent Antibody Response against Ganglioside GD2 Induced in Patients with Melanoma by a GD2 Lactone-Keyhole Limpet Hemocyanin Conjugate Vaccine plus Immunological Adjuvant QS-21
Clin Cancer Res 2003 9: 5214-5220. [Abstract] [Full Text] [PDF]  

Weijing Sun, James P. Stevenson, Maryann L. Gallagher, David Vaughn, Steven M. Hahn, Daniel G. Haller, Marvin Cohen, Justin Kopit, Gilles Gallant, and Peter J. O’Dwyer

Phase I and Pharmacokinetic Trial of the Novel Taxane BMS-184476 Administered as a 1-Hour Intravenous Infusion in Combination with Cisplatin Every 21 Days
Clin Cancer Res 2003 9: 5221-5227. [Abstract] [Full Text] [PDF]  

Ralph S. Freedman, Saroj Vadhan-Raj, Cherie Butts, Cherylyn Savary, Bohuslav Melichar, Claire Verschraegen, John J. Kavanagh, Marshall E. Hicks, Lawrence B. Levy, Jody K. Folloder, and Michael E. Garcia

Pilot Study of Flt3 Ligand Comparing Intraperitoneal with Subcutaneous Routes on Hematologic and Immunologic Responses in Patients with Peritoneal Carcinomatosis and Mesotheliomas
Clin Cancer Res 2003 9: 5228-5237. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Petra Heinmöller, Christof Gross, Kurt Beyser, Claudia Schmidtgen, Gerd Maass, Michele Pedrocchi, and Josef Rüschoff

HER2 Status in Non-Small Cell Lung Cancer: Results from Patient Screening for Enrollment to a Phase II Study of Herceptin
Clin Cancer Res 2003 9: 5238-5243. [Abstract] [Full Text] [PDF]  

Bor-Shyang Sheu, Hsiao-Bai Yang, Shew-Meei Sheu, Ay-Huey Huang, and Jiunn-Jong Wu

Higher Gastric Cycloxygenase-2 Expression and Precancerous Change in Helicobacter pylori-Infected Relatives of Gastric Cancer Patients
Clin Cancer Res 2003 9: 5245-5251. [Abstract] [Full Text] [PDF]  

Eija H. Seppälä, Tarja Ikonen, Ville Autio, Annika Rökman, Nina Mononen, Mika P. Matikainen, Teuvo L. J. Tammela, and Johanna Schleutker

Germ-Line Alterations in MSR1 Gene and Prostate Cancer Risk
Clin Cancer Res 2003 9: 5252-5256. [Abstract] [Full Text] [PDF]  

Yimin Wang, Ming Zhu Fang, Jie Liao, Guang-Yu Yang, Yan Nie, Yunlong Song, Chi So, Xiaochun Xu, Li-Dong Wang, and Chung S. Yang

Hypermethylation-Associated Inactivation of Retinoic Acid Receptor ß in Human Esophageal Squamous Cell Carcinoma
Clin Cancer Res 2003 9: 5257-5263. [Abstract] [Full Text] [PDF]  

Masato Igarashi, Takeshi Suda, Hidenori Hara, Mitsuhiro Takimoto, Minoru Nomoto, Toru Takahashi, Shogo Okoshi, Hirokazu Kawai, Yusaku Mita, Nobuo Waguri, and Yutaka Aoyagi

Interferon Can Block Telomere Erosion and in Rare Cases Result in Hepatocellular Carcinoma Development with Telomeric Repeat Binding Factor 1 Overexpression in Chronic Hepatitis C
Clin Cancer Res 2003 9: 5264-5270. [Abstract] [Full Text] [PDF]  

Joanne Edwards, N. Sarath Krishna, Caroline J. Witton, and John M. S. Bartlett

Gene Amplifications Associated with the Development of Hormone-Resistant Prostate Cancer
Clin Cancer Res 2003 9: 5271-5281. [Abstract] [Full Text] [PDF]  

Yasunori Shikada, Ichiro Yoshino, Tatsuro Okamoto, Seiichi Fukuyama, Toshifumi Kameyama, and Yoshihiko Maehara

Higher Expression of RhoC Is Related to Invasiveness in Non-Small Cell Lung Carcinoma
Clin Cancer Res 2003 9: 5282-5286. [Abstract] [Full Text] [PDF]  

Max Partridge, Ruud Brakenhoff, Elaine Phillips, Kulsan Ali, Rebecca Francis, Richard Hooper, Kenneth Lavery, Andrew Brown, and John Langdon

Detection of Rare Disseminated Tumor Cells Identifies Head and Neck Cancer Patients at Risk of Treatment Failure
Clin Cancer Res 2003 9: 5287-5294. [Abstract] [Full Text] [PDF]  

Osamu Okochi, Kenji Hibi, Mitsuru Sakai, Soichiro Inoue, Shin Takeda, Tetsuya Kaneko, and Akimasa Nakao

Methylation-Mediated Silencing of SOCS-1 Gene in Hepatocellular Carcinoma Derived from Cirrhosis
Clin Cancer Res 2003 9: 5295-5298. [Abstract] [Full Text] [PDF]  

Eddie Reed, Jing Jie Yu, Antony Davies, James Gannon, and Steven L. Armentrout

Clear Cell Tumors Have Higher mRNA Levels of ERCC1 and XPB Than Other Histological Types of Epithelial Ovarian Cancer
Clin Cancer Res 2003 9: 5299-5305. [Abstract] [Full Text] [PDF]  

Takeshi Nagasaka, Gerald B. Sharp, Kenji Notohara, Takeshi Kambara, Hiromi Sasamoto, Hiroshi Isozaki, Donald G. MacPhee, Jeremy R. Jass, Noriaki Tanaka, and Nagahide Matsubara

Hypermethylation of O⁶-Methylguanine-DNA Methyltransferase Promoter May Predict Nonrecurrence after Chemotherapy in Colorectal Cancer Cases
Clin Cancer Res 2003 9: 5306-5312. [Abstract] [Full Text] [PDF]  

Yasushi Nakamura, Hironao Yasuoka, Masahiko Tsujimoto, Qifeng Yang, Shigeru Imabun, Masaaki Nakahara, Kazuyasu Nakao, Misa Nakamura, Ichiro Mori, and Kennichi Kakudo

Flt-4-Positive Vessel Density Correlates with Vascular Endothelial Growth Factor-D Expression, Nodal Status, and Prognosis in Breast Cancer
Clin Cancer Res 2003 9: 5313-5317. [Abstract] [Full Text] [PDF]  

Sari Sillanpää, Maarit A. Anttila, Kirsi Voutilainen, Raija H. Tammi, Markku I. Tammi, Seppo V. Saarikoski, and Veli-Matti Kosma

CD44 Expression Indicates Favorable Prognosis in Epithelial Ovarian Cancer
Clin Cancer Res 2003 9: 5318-5324. [Abstract] [Full Text] [PDF]  

Kjersti Jørgensen, Ruth Holm, Gunhild M. Mælandsmo, and Vivi Ann Flørenes

Expression of Activated Extracellular Signal-Regulated Kinases 1/2 in Malignant Melanomas: Relationship with Clinical Outcome
Clin Cancer Res 2003 9: 5325-5331. [Abstract] [Full Text] [PDF]  

Valeria Masciullo, Tommaso Susini, Alessandra Zamparelli, Alessandro Bovicelli, Corrado Minimo, Daniela Massi, Gianluigi Taddei, Nicola Maggiano, Pierandrea De Iaco, Marcello Ceccaroni, Luciano Bovicelli, Gianni Amunni, Salvatore Mancuso, Giovanni Scambia, and Antonio Giordano

Frequent Loss of Expression of the Cyclin-Dependent Kinase Inhibitor p27^Kip1 in Estrogen-Related Endometrial Adenocarcinomas
Clin Cancer Res 2003 9: 5332-5338. [Abstract] [Full Text] [PDF]  

Ronnie Tung-Ping Poon, Cecilia Pik-Yuk Lau, Joanna Wen-Ying Ho, Wan-Ching Yu, Sheung-Tat Fan, and John Wong

Tissue Factor Expression Correlates with Tumor Angiogenesis and Invasiveness in Human Hepatocellular Carcinoma
Clin Cancer Res 2003 9: 5339-5345. [Abstract] [Full Text] [PDF]  

Teemu T. Junttila, Matti Laato, Tero Vahlberg, Karl-Ove Söderström, Tapio Visakorpi, Jorma Isola, and Klaus Elenius

Identification of Patients with Transitional Cell Carcinoma of the Bladder Overexpressing ErbB2, ErbB3, or Specific ErbB4 Isoforms: Real-Time Reverse Transcription-PCR Analysis in Estimation of ErbB Receptor Status from Cancer Patients
Clin Cancer Res 2003 9: 5346-5357. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Lucia Morbidelli, Sandra Donnini, Francesco Chillemi, Antonio Giachetti, and Marina Ziche

Angiosuppressive and Angiostimulatory Effects Exerted by Synthetic Partial Sequences of Endostatin
Clin Cancer Res 2003 9: 5358-5369. [Abstract] [Full Text] [PDF]  

Lucio Tentori, Carlo Leonetti, Marco Scarsella, Giulia d’Amati, Matteo Vergati, Ilaria Portarena, Weizheng Xu, Vincent Kalish, Gabriella Zupi, Jie Zhang, and Grazia Graziani

Systemic Administration of GPI 15427, a Novel Poly(ADP-Ribose) Polymerase-1 Inhibitor, Increases the Antitumor Activity of Temozolomide against Intracranial Melanoma, Glioma, Lymphoma
Clin Cancer Res 2003 9: 5370-5379. [Abstract] [Full Text] [PDF]  

Seiji Yano, Helong Zhang, Masaki Hanibuchi, Toyokazu Miki, Hisatsugu Goto, Hisanori Uehara, and Saburo Sone

Combined Therapy with a New Bisphosphonate, Minodronate (YM529), and Chemotherapy for Multiple Organ Metastases of Small Cell Lung Cancer Cells in Severe Combined Immunodeficient Mice
Clin Cancer Res 2003 9: 5380-5385. [Abstract] [Full Text] [PDF]  

Hiroya Kobayashi, Ryusuke Omiya, Benjamin Sodey, Mitsuru Yanai, Kensuke Oikawa, Keisuke Sato, Shoji Kimura, Satoru Senju, Yasuharu Nishimura, Masatoshi Tateno, and Esteban Celis

Identification of Naturally Processed Helper T-Cell Epitopes from Prostate-Specific Membrane Antigen Using Peptide-Based in Vitro Stimulation
Clin Cancer Res 2003 9: 5386-5393. [Abstract] [Full Text] [PDF]  

Merrill E. Goldsmith, Masaki Kitazono, Patrick Fok, Takashi Aikou, Susan Bates, and Tito Fojo

The Histone Deacetylase Inhibitor FK228 Preferentially Enhances Adenovirus Transgene Expression in Malignant Cells
Clin Cancer Res 2003 9: 5394-5401. [Abstract] [Full Text] [PDF]  

Maria Antonietta Sabatino, Tina Colombo, Cristina Geroni, Sergio Marchini, and Massimo Broggini

Enhancement of in Vivo Antitumor Activity of Classical Anticancer Agents by Combination with the New, Glutathione-Interacting DNA Minor Groove-Binder, Brostallicin
Clin Cancer Res 2003 9: 5402-5408. [Abstract] [Full Text] [PDF]  

Chihiro Nakahara, Katsuya Nakamura, Naoki Yamanaka, Eishi Baba, Morimasa Wada, Hisashi Matsunaga, Hirokazu Noshiro, Masao Tanaka, Takashi Morisaki, and Mitsuo Katano

Cyclosporin-A Enhances Docetaxel-Induced Apoptosis through Inhibition of Nuclear Factor-B Activation in Human Gastric Carcinoma Cells
Clin Cancer Res 2003 9: 5409-5416. [Abstract] [Full Text] [PDF]  

Marcin Makowski, Tomasz Grzela, Justyna Niderla, Maciej Lazarczyk, Pawel Mróz, Maciej Kopeé, Magdalena Legat, Katarzyna Strusinska, Katarzyna Koziak, Dominika Nowis, Piotr Mrówka, Maria Wasik, Marek Jakóbisiak, and Jakub Golab

Inhibition of Cyclooxygenase-2 Indirectly Potentiates Antitumor Effects of Photodynamic Therapy in Mice
Clin Cancer Res 2003 9: 5417-5422. [Abstract] [Full Text] [PDF]  

Takuma Fujii, David Austin, David Guo, Srinivasan Srimatkandada, Tao Wang, Kaneyuki Kubushiro, Nobuo Masumoto, Katsumi Tsukazaki, Shiro Nozawa, and Albert B. Deisseroth

Peptides Inhibitory for the Transcriptional Regulatory Function of Human Papillomavirus E2
Clin Cancer Res 2003 9: 5423-5428. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Shufeng Zhou

Correspondence re: J. Lu et al., Thalidomide Metabolites in Mice and Patients with Multiple Myeloma. Clin. Cancer Res., 9: 1680–1688, 2003.
Clin Cancer Res 2003 9: 5429. [Full Text] [PDF]  

Lai-Ming Ching, Bruce C. Baguley, Phillip Kestell, Brian D. Palmer, and Jun Lu

Reply
Clin Cancer Res 2003 9: 5429. [Full Text] [PDF]  

Theodoros P. Vassilakopoulos, Maria K. Angelopoulou, Marina P. Siakantaris, Gerassimos A. Pangalis, Christos Kittas, and Ipatia Doussis-Anagnostopoulou

Correspondence re: M. Provencio, et al. The Topoisomerase IIa Expression Correlates with Survival in Patients with Advanced Hodgkin’s Lymphoma. Clin. Cancer Res., 9: 1406–1411, 2003.
Clin Cancer Res 2003 9: 5430-5431. [Full Text] [PDF]  

Mariano Provencio, Pilar España, Felix Bonilla, and Clara Salas

Reply
Clin Cancer Res 2003 9: 5431. [Full Text] [PDF]  

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