Editorials:

Matthew R. Smith

Antitumor Activity of Bisphosphonates
Clin Cancer Res 2003 9: 5433-5434. [Full Text] [PDF]  

David G. Kirsch and Fred H. Hochberg

Targeting HER2 in Brain Metastases from Breast Cancer
Clin Cancer Res 2003 9: 5435-5436. [Full Text] [PDF]  

The Biology Behind:

Ute M. Moll

The Role of p63 and p73 in Tumor Formation and Progression: Coming of Age Toward Clinical Usefulness: Commentary re: F. Koga et al., Impaired p63 Expression Associates with Poor Prognosis and Uroplakin III Expression in Invasive Urothelial Carcinoma of the Bladder. Clin. Cancer Res., 9: 5501–5507, 2003, and P. Puig et al., p73 Expression in Human Normal and Tumor Tissues: Loss of p73 Expression Is Associated with Tumor Progression in Bladder Cancer. Clin. Cancer Res., 9: 5642–5651, 2003.
Clin Cancer Res 2003 9: 5437-5441. [Full Text] [PDF]  

Meeting Summary:

Richard Gorlick, Peter Anderson, Irene Andrulis, Carola Arndt, G. Peter Beardsley, Mark Bernstein, Julia Bridge, Nai-Kong Cheung, Jeffrey S. Dome, David Ebb, Thomas Gardner, Mark Gebhardt, Holcombe Grier, Marc Hansen, John Healey, Lee Helman, Janet Hock, Janet Houghton, Peter Houghton, Andrew Huvos, Chand Khanna, Mark Kieran, Eugenie Kleinerman, Marc Ladanyi, Ching Lau, David Malkin, Neyssa Marina, Paul Meltzer, Paul Meyers, Deborah Schofield, Cindy Schwartz, Malcolm A. Smith, Jeffrey Toretsky, Maria Tsokos, Leonard Wexler, Jon Wigginton, Stephen Withrow, Mason Schoenfeldt, and Barry Anderson

Biology of Childhood Osteogenic Sarcoma and Potential Targets for Therapeutic Development: Meeting Summary
Clin Cancer Res 2003 9: 5442-5453. [Abstract] [Full Text] [PDF]  

Review:

Oihana Murillo, Ainhoa Arina, Iñigo Tirapu, Carlos Alfaro, Guillermo Mazzolini, Belen Palencia, Ascensión López-Diaz De Cerio, Jesús Prieto, Maurizio Bendandi, and Ignacio Melero

Potentiation of Therapeutic Immune Responses against Malignancies with Monoclonal Antibodies
Clin Cancer Res 2003 9: 5454-5464. [Abstract] [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

Anne-Marie O’Farrell, James M. Foran, Walter Fiedler, Hubert Serve, Ron L. Paquette, Maureen A. Cooper, Helene A. Yuen, Sharianne G. Louie, Heidi Kim, Susan Nicholas, Michael C. Heinrich, Wolfgang E. Berdel, Carlo Bello, Mark Jacobs, Paul Scigalla, William C. Manning, Stephen Kelsey, and Julie M. Cherrington

An Innovative Phase I Clinical Study Demonstrates Inhibition of FLT3 Phosphorylation by SU11248 in Acute Myeloid Leukemia Patients
Clin Cancer Res 2003 9: 5465-5476. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Alain Latil, Ivan Bièche, Laurent Chêne, Ingrid Laurendeau, Philippe Berthon, Olivier Cussenot, and Michel Vidaud

Gene Expression Profiling in Clinically Localized Prostate Cancer: A Four-Gene Expression Model Predicts Clinical Behavior
Clin Cancer Res 2003 9: 5477-5485. [Abstract] [Full Text] [PDF]  

Yick Fu Wong, Zachariah E. Selvanayagam, Nien Wei, Joseph Porter, Ragini Vittal, Rong Hu, Yong Lin, Jason Liao, Joe Weichung Shih, Tak Hong Cheung, Keith Wing Kit Lo, So Fan Yim, Shing Kai Yip, Danny Tse Ngong, Nelson Siu, Loucia Kit Ying Chan, Chun Sing Chan, Tony Kong, Elena Kutlina, Randall D. McKinnon, David T. Denhardt, Khew-Voon Chin, and Tony Kwok Hung Chung

Expression Genomics of Cervical Cancer: Molecular Classification and Prediction of Radiotherapy Response by DNA Microarray
Clin Cancer Res 2003 9: 5486-5492. [Abstract] [Full Text] [PDF]  

Won Kim, Seung Oe Lim, Jong-Seo Kim, Young Hee Ryu, Ji-Yeon Byeon, Hie-Joon Kim, Yong-Il Kim, Jin Seok Heo, Young Min Park, and Guhung Jung

Comparison of Proteome between Hepatitis B Virus- and Hepatitis C Virus-Associated Hepatocellular Carcinoma
Clin Cancer Res 2003 9: 5493-5500. [Abstract] [Full Text] [PDF]  

Fumitaka Koga, Satoru Kawakami, Yasuhisa Fujii, Kazutaka Saito, Yukihiro Ohtsuka, Aki Iwai, Noboru Ando, Touichiro Takizawa, Yukio Kageyama, and Kazunori Kihara

Impaired p63 Expression Associates with Poor Prognosis and Uroplakin III Expression in Invasive Urothelial Carcinoma of the Bladder
Clin Cancer Res 2003 9: 5501-5507. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Cynthia A. Znati, Maury Rosenstein, Trevor D. McKee, Edward Brown, David Turner, William D. Bloomer, Simon Watkins, Rakesh K. Jain, and Yves Boucher

Irradiation Reduces Interstitial Fluid Transport and Increases the Collagen Content in Tumors
Clin Cancer Res 2003 9: 5508-5513. [Abstract] [Full Text] [PDF]  

Peter M. Grossi, Hidenobu Ochiai, Gary E. Archer, Roger E. McLendon, Michael R. Zalutsky, Allan H. Friedman, Henry S. Friedman, Darell D. Bigner, and John H. Sampson

Efficacy of Intracerebral Microinfusion of Trastuzumab in an Athymic Rat Model of Intracerebral Metastatic Breast Cancer
Clin Cancer Res 2003 9: 5514-5520. [Abstract] [Full Text] [PDF]  

Roberto De Pascalis, Noreen R. Gonzales, Eduardo A. Padlan, Peter Schuck, Surinder K. Batra, Jeffrey Schlom, and Syed V. S. Kashmiri

In Vitro Affinity Maturation of a Specificity-Determining Region-Grafted Humanized Anticarcinoma Antibody: Isolation and Characterization of Minimally Immunogenic High-Affinity Variants
Clin Cancer Res 2003 9: 5521-5531. [Abstract] [Full Text] [PDF]  

Amir Onn, Takeshi Isobe, Satoshi Itasaka, Wenjuan Wu, Michael S. O’Reilly, Waun Ki Hong, Isaiah J. Fidler, and Roy S. Herbst

Development of an Orthotopic Model to Study the Biology and Therapy of Primary Human Lung Cancer in Nude Mice
Clin Cancer Res 2003 9: 5532-5539. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Bahram Forouzesh, Chris H. Takimoto, Andrew Goetz, Sami Diab, Lisa A. Hammond, Leslie Smetzer, Garry Schwartz, Robert Gazak, John T. Callaghan, Daniel D. Von Hoff, and Eric K. Rowinsky

A Phase I and Pharmacokinetic Study of ILX-295501, an Oral Diarylsulfonylurea, on a Weekly for 3 Weeks Every 4-Week Schedule in Patients with Advanced Solid Malignancies
Clin Cancer Res 2003 9: 5540-5549. [Abstract] [Full Text] [PDF]  

Aris Giannopoulos, Constantinos Constantinides, Eleftherios Fokaeas, Constantinos Stravodimos, Myrto Giannopoulou, Aspasia Kyroudi, and Antonia Gounaris

The Immunomodulating Effect of Interferon- Intravesical Instillations in Preventing Bladder Cancer Recurrence
Clin Cancer Res 2003 9: 5550-5558. [Abstract] [Full Text] [PDF]  

Lupe G. Salazar, John Fikes, Scott Southwood, Glenn Ishioka, Keith L. Knutson, Theodore A. Gooley, Kathy Schiffman, and Mary L. Disis

Immunization of Cancer Patients with HER-2/neu-Derived Peptides Demonstrating High-Affinity Binding to Multiple Class II Alleles
Clin Cancer Res 2003 9: 5559-5565. [Abstract] [Full Text] [PDF]  

Frédéric Baron, Pascale Frère, Georges Fillet, and Yves Beguin

Recombinant Human Erythropoietin Therapy Is Very Effective after an Autologous Peripheral Blood Stem Cell Transplant When Started Soon after Engraftment
Clin Cancer Res 2003 9: 5566-5572. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Hariklia Gakiopoulou, Lydia Nakopoulou, Argyris Siatelis, Ioannis Mavrommatis, Effie G. Panayotopoulou, Ioanna Tsirmpa, Constantinos Stravodimos, and Aris Giannopoulos

Tissue Inhibitor of Metalloproteinase-2 as a Multifunctional Molecule of Which the Expression Is Associated with Adverse Prognosis of Patients with Urothelial Bladder Carcinomas
Clin Cancer Res 2003 9: 5573-5581. [Abstract] [Full Text] [PDF]  

Stephanie Geisler, Anne-Lise Børresen-Dale, Hilde Johnsen, Turid Aas, Jürgen Geisler, Lars Andreas Akslen, Gun Anker, and Per Eystein Lønning

TP53 Gene Mutations Predict the Response to Neoadjuvant Treatment with 5-Fluorouracil and Mitomycin in Locally Advanced Breast Cancer
Clin Cancer Res 2003 9: 5582-5588. [Abstract] [Full Text] [PDF]  

Yuko Sugiyama, Shingo Dan, Yoko Yoshida, Futoshi Akiyama, Kazuo Sugiyama, Yasuo Hirai, Masaaki Matsuura, Satoshi Miyata, Masaru Ushijima, Katsuhiko Hasumi, and Takao Yamori

A Large-Scale Gene Expression Comparison of Microdissected, Small-Sized Endometrial Cancers with or without Hyperplasia Matched to Same-Patient Normal Tissue
Clin Cancer Res 2003 9: 5589-5600. [Abstract] [Full Text] [PDF]  

Pilar Gonzalez-Gomez, M. Josefa Bello, M. Eva Alonso, Jesus Lomas, Dolores Arjona, Jose M. de Campos, Jesus Vaquero, Alberto Isla, Luis Lassaletta, Manuel Gutierrez, Jose L. Sarasa, and Juan A. Rey

CpG Island Methylation in Sporadic and Neurofibromatis Type 2-Associated Schwannomas
Clin Cancer Res 2003 9: 5601-5606. [Abstract] [Full Text] [PDF]  

Alberto Bardelli, Saurabh Saha, Jason A. Sager, Kathy E. Romans, Baozhong Xin, Sanford D. Markowitz, Christoph Lengauer, Victor E. Velculescu, Kenneth W. Kinzler, and Bert Vogelstein

PRL-3 Expression in Metastatic Cancers
Clin Cancer Res 2003 9: 5607-5615. [Abstract] [Full Text] [PDF]  

Noboru Nishiumi, Yoshiyuki Abe, Yoshimasa Inoue, Hiroyuki Hatanaka, Ken-ichi Inada, Hiroshi Kijima, Hitoshi Yamazaki, Masae Tatematsu, Yoshito Ueyama, Masayuki Iwasaki, Hiroshi Inoue, and Masato Nakamura

Use of 11p15 Mucins as Prognostic Factors in Small Adenocarcinoma of the Lung
Clin Cancer Res 2003 9: 5616-5619. [Abstract] [Full Text] [PDF]  

Tatyana V. Nasedkina, Vladislav S. Zharinov, Ekaterina A. Isaeva, Olga N. Mityaeva, Roman N. Yurasov, Sergei A. Surzhikov, Alexander Y. Turigin, Alla Y. Rubina, Alexander I. Karachunskii, Ronald B. Gartenhaus, and Andrei D. Mirzabekov

Clinical Screening of Gene Rearrangements in Childhood Leukemia by Using a Multiplex Polymerase Chain Reaction-Microarray Approach
Clin Cancer Res 2003 9: 5620-5629. [Abstract] [Full Text] [PDF]  

Robin T. Vollmer, James E. Herndon, II, Jonathan D’Cunha, Naif Z. Abraham, Joette Solberg, Mitra Fatourechi, Ann Maruska, Jeffrey A. Kern, Mark R. Green, Robert A. Kratzke, and Michael A. Maddaus

Immunohistochemical Detection of Occult Lymph Node Metastases in Non-Small Cell Lung Cancer: Anatomical Pathology Results from Cancer and Leukemia Group B Trial 9761
Clin Cancer Res 2003 9: 5630-5635. [Abstract] [Full Text] [PDF]  

Makoto Suzuki, Shinichi Toyooka, Kuniharu Miyajima, Toshihiko Iizasa, Takehiko Fujisawa, Nebiyou B. Bekele, and Adi F. Gazdar

Alterations in the Mitochondrial Displacement Loop in Lung Cancers
Clin Cancer Res 2003 9: 5636-5641. [Abstract] [Full Text] [PDF]  

Pere Puig, Paola Capodieci, Marija Drobnjak, David Verbel, Carol Prives, Carlos Cordon-Cardo, and Charles J. Di Como

p73 Expression in Human Normal and Tumor Tissues: Loss of p73 Expression Is Associated with Tumor Progression in Bladder Cancer
Clin Cancer Res 2003 9: 5642-5651. [Abstract] [Full Text] [PDF]  

Francisco J. Esteva, Aysegul A. Sahin, George Z. Rassidakis, Linda X. H. Yuan, Terry L. Smith, Ying Yang, Michael Z. Gilcrease, Massimo Cristofanilli, Rita Nahta, Lajos Pusztai, and François-Xavier Claret

Jun Activation Domain Binding Protein 1 Expression Is Associated with Low p27^Kip1Levels in Node-Negative Breast Cancer
Clin Cancer Res 2003 9: 5652-5659. [Abstract] [Full Text] [PDF]  

Satoshi Ikeda, Yosuke Shimizu, Masahiko Fujimori, Yasuyo Ishizaki, Takeshi Kurihara, Yasutomo Ojima, Masazumi Okajima, and Toshimasa Asahara

Immunohistochemical and Mutational Analyses of ß-catenin, Ki-ras, and p53 in Two Subtypes of Colorectal Mucinous Carcinoma
Clin Cancer Res 2003 9: 5660-5665. [Abstract] [Full Text] [PDF]  

David Hedley, Melania Pintilie, Jennifer Woo, Andrew Morrison, Diana Birle, Anthony Fyles, Michael Milosevic, and Richard Hill

Carbonic Anhydrase IX Expression, Hypoxia, and Prognosis in Patients with Uterine Cervical Carcinomas
Clin Cancer Res 2003 9: 5666-5674. [Abstract] [Full Text] [PDF]  

Akira Hirasawa, Daisuke Aoki, Jun Inoue, Issei Imoto, Nobuyuki Susumu, Kokichi Sugano, Shiro Nozawa, and Johji Inazawa

Unfavorable Prognostic Factors Associated with High Frequency of Microsatellite Instability and Comparative Genomic Hybridization Analysis in Endometrial Cancer
Clin Cancer Res 2003 9: 5675-5682. [Abstract] [Full Text] [PDF]  

Axel Weber, Christine Huesken, Eckhard Bergmann, Wieland Kiess, Nina M. Christiansen, and Holger Christiansen

Coexpression of Insulin Receptor-Related Receptor and Insulin-Like Growth Factor 1 Receptor Correlates with Enhanced Apoptosis and Dedifferentiation in Human Neuroblastomas
Clin Cancer Res 2003 9: 5683-5692. [Abstract] [Full Text] [PDF]  

Taka-aki Masuda, Hiroshi Inoue, Koujiro Nishida, Hideto Sonoda, Yasuji Yoshikawa, Yoshihiro Kakeji, Tohru Utsunomiya, and Masaki Mori

Cyclin-Dependent Kinase 1 Gene Expression Is Associated with Poor Prognosis in Gastric Carcinoma
Clin Cancer Res 2003 9: 5693-5698. [Abstract] [Full Text] [PDF]  

Yasuo Miyoshi, Tohru Funahashi, Shinji Kihara, Tetsuya Taguchi, Yasuhiro Tamaki, Yuji Matsuzawa, and Shinzaburo Noguchi

Association of Serum Adiponectin Levels with Breast Cancer Risk
Clin Cancer Res 2003 9: 5699-5704. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Enrique Alvarez, Michael Westmore, Rachelle J. Sells Galvin, Crystal L. Clapp, Eileen L. Considine, Shawn J. Smith, Kristan Keyes, Philip W. Iversen, Dawn M. Delafuente, Shola Sulaimon, Carmen Zambrano, Linda Ma, Masahiko Sato, T. John Martin, Beverly A. Teicher, and Elizabeth J. Galbreath

Properties of Bisphosphonates in the 13762 Rat Mammary Carcinoma Model of Tumor-Induced Bone Resorption
Clin Cancer Res 2003 9: 5705-5713. [Abstract] [Full Text] [PDF]  

Maria V. Papadopoulou and William D. Bloomer

NLCQ-1 (NSC 709257): Exploiting Hypoxia with a Weak DNA-Intercalating Bioreductive Drug
Clin Cancer Res 2003 9: 5714-5720. [Abstract] [Full Text] [PDF]  

Annette T. Byrne, Leorah Ross, Joceyln Holash, Mikiye Nakanishi, Limin Hu, Judith I. Hofmann, George D. Yancopoulos, and Robert B. Jaffe

Vascular Endothelial Growth Factor-Trap Decreases Tumor Burden, Inhibits Ascites, and Causes Dramatic Vascular Remodeling in an Ovarian Cancer Model
Clin Cancer Res 2003 9: 5721-5728. [Abstract] [Full Text] [PDF]  

Nancy K. Pryer, Leslie B. Lee, Regina Zadovaskaya, Xiaoming Yu, Juthamas Sukbuntherng, Julie M. Cherrington, and Cheryl A. London

Proof of Target for SU11654: Inhibition of KIT Phosphorylation in Canine Mast Cell Tumors
Clin Cancer Res 2003 9: 5729-5734. [Abstract] [Full Text] [PDF]  

Niels W. C. J. van de Donk, Diana Schotte, Marloes M. J. Kamphuis, Ariënne M. W. van Marion, Berris van Kessel, Andries C. Bloem, and Henk M. Lokhorst

Protein Geranylgeranylation Is Critical for the Regulation of Survival and Proliferation of Lymphoma Tumor Cells
Clin Cancer Res 2003 9: 5735-5748. [Abstract] [Full Text] [PDF]  

Martha C. Kutko, Richard D. Glick, Lisa M. Butler, Dennis C. Coffey, Richard A. Rifkind, Paul A. Marks, Victoria M. Richon, and Michael P. LaQuaglia

Histone Deacetylase Inhibitors Induce Growth Suppression and Cell Death in Human Rhabdomyosarcoma in Vitro
Clin Cancer Res 2003 9: 5749-5755. [Abstract] [Full Text] [PDF]  

Claudio Pisano, Graziella Pratesi, Diletta Laccabue, Franco Zunino, Pietro Lo Giudice, Augusta Bellucci, Licia Pacifici, Barbara Camerini, Loredana Vesci, Massimo Castorina, Sandra Cicuzza, Giovanni Tredici, Paola Marmiroli, Gabriella Nicolini, Stefania Galbiati, Menotti Calvani, Paolo Carminati, and Guido Cavaletti

Paclitaxel and Cisplatin-Induced Neurotoxicity: A Protective Role of Acetyl-L-Carnitine
Clin Cancer Res 2003 9: 5756-5767. [Abstract] [Full Text] [PDF]  

Gwong-Cheung Hur, Sung Jin Cho, Chan-Hyung Kim, Min Kyu Kim, Soo In Bae, Seon Young Nam, Jong-Wan Park, Woo Ho Kim, and Byung Lan Lee

Manganese Superoxide Dismutase Expression Correlates with Chemosensitivity in Human Gastric Cancer Cell Lines
Clin Cancer Res 2003 9: 5768-5775. [Abstract] [Full Text] [PDF]  

Salomón Pérez Cuadrado, María del Carmen Moreno Koch, Cristina Fernández Pérez, Luis Miguel Castejón Castán, Carlos Pérez Villalobos, María José González Mateos, and Carlos Liñán Olmos

Immunomodulation in Established Murine Tumors: Response and Survival Rate Enhancement by Blood Leukocyte-Augmenting Substance 236 (Cl^-), a Novel Synthetic Compound
Clin Cancer Res 2003 9: 5776-5785. [Abstract] [Full Text] [PDF]  

Hidenobu Okino, Ryo Maeyama, Tatsuya Manabe, Takehisa Matsuda, and Masao Tanaka

Trans-Tissue, Sustained Release of Gemcitabine from Photocured Gelatin Gel Inhibits the Growth of Heterotopic Human Pancreatic Tumor in Nude Mice
Clin Cancer Res 2003 9: 5786-5793. [Abstract] [Full Text] [PDF]  

Edith J. Mensah-Osman, Ayad M. Al-Katib, and Ramzi M. Mohammad

Preclinical Evaluation of 2-[4-(7-Chloro-2-quinoxalinyloxy)phenoxy]-propionic Acid as a Modulator of Etoposide in Human Waldenstrom’s Macroglobulinemia Xenograft Model
Clin Cancer Res 2003 9: 5794-5797. [Abstract] [Full Text] [PDF]  

Acknowledgment to Reviewers:

Acknowledgment to Reviewers
Clin Cancer Res 2003 9: 5798-5805. [Full Text] [PDF]  

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