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Intracerebral microinfusion dramatically improves delivery of trastuzumab to the brain. 125I-radiolabeled trastuzumab was quantitated in the brain by autoradiography. After intraperitoneal delivery, trastuzumab was not detected intracerebrally. In contrast, after intracerebral microinfusion, trastuzumab saturated the entire cerebral hemisphere (P = 0.013). For details, see P. Grossi et al. in this issue.