Editorials:

Gary D. Kruh

Lustrous Insights into Cisplatin Accumulation: Copper Transporters
Clin Cancer Res 2003 9: 5807-5809. [Full Text] [PDF]  

Charles F. Eisenbeis, Michael A. Caligiuri, and John C. Byrd

Rituximab: Converging Mechanisms of Action in Non-Hodgkin’s Lymphoma?
Clin Cancer Res 2003 9: 5810-5812. [Full Text] [PDF]  

Reviews:

Roy S. Herbst and Paul A. Bunn, Jr.

Targeting the Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer
Clin Cancer Res 2003 9: 5813-5824. [Abstract] [Full Text] [PDF]  

The Biology Behind:

Michael C. Heinrich

Is KIT an Important Therapeutic Target in Small Cell Lung Cancer?: Commentary re: B. E. Johnson et al., Phase II Study of Imatinib in Patients with Small Cell Lung Cancer. Clin. Cancer Res., 9: 5880–5887, 2003.
Clin Cancer Res 2003 9: 5825-5828. [Full Text] [PDF]  

Featured Articles:

   Clinical Trials:

Joseph R. Mace, Mary L. Keohan, Heinz Bernardy, Klaus Junge, Georg Niebch, Peter Romeis, Aangelika Thoma, Thomas Wagner, Udo Mueller, George Demetri, and Laurence H. Baker

Crossover Randomized Comparison of Intravenous versus Intravenous/Oral Mesna in Soft Tissue Sarcoma Treated with High-Dose Ifosfamide
Clin Cancer Res 2003 9: 5829-5834. [Abstract] [Full Text] [PDF]  

Jenny T. Mao, Michael D. Roth, Kenneth J. Serio, Felicita Baratelli, Li Zhu, E. Carmack Holmes, Robert M. Strieter, and Steven M. Dubinett

Celecoxib Modulates the Capacity for Prostaglandin E₂ and Interleukin-10 Production in Alveolar Macrophages from Active Smokers
Clin Cancer Res 2003 9: 5835-5841. [Abstract] [Full Text] [PDF]  

Jeffrey Y. C. Wong, Stephen Shibata, Lawrence E. Williams, Cheuk S. Kwok, An Liu, David Z. Chu, Dave M. Yamauchi, Sharon Wilczynski, David N. Ikle, Anna M. Wu, Paul J. Yazaki, John E. Shively, James H. Doroshow, and Andrew A. Raubitschek

A Phase I Trial of ⁹⁰Y-Anti-Carcinoembryonic Antigen Chimeric T84.66 Radioimmunotherapy with 5-Fluorouracil in Patients with Metastatic Colorectal Cancer
Clin Cancer Res 2003 9: 5842-5852. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Goli Samimi, Nissi M. Varki, Sharon Wilczynski, Roohangiz Safaei, David S. Alberts, and Stephen B. Howell

Increase in Expression of the Copper Transporter ATP7A during Platinum Drug-Based Treatment Is Associated with Poor Survival in Ovarian Cancer Patients
Clin Cancer Res 2003 9: 5853-5859. [Abstract] [Full Text] [PDF]  

Kazuyuki Kawakami, Andrew Ruszkiewicz, Graeme Bennett, James Moore, Go Watanabe, and Barry Iacopetta

The Folate Pool in Colorectal Cancers Is Associated with DNA Hypermethylation and with a Polymorphism in Methylenetetrahydrofolate Reductase
Clin Cancer Res 2003 9: 5860-5865. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Francisco J. Hernandez-Ilizaliturri, Venkata Jupudy, Julie Ostberg, Ezogelin Oflazoglu, Amy Huberman, Elizabeth Repasky, and Myron S. Czuczman

Neutrophils Contribute to the Biological Antitumor Activity of Rituximab in a Non-Hodgkin’s Lymphoma Severe Combined Immunodeficiency Mouse Model
Clin Cancer Res 2003 9: 5866-5873. [Abstract] [Full Text] [PDF]  

Xiaoming Wu, Wei Fan, Shunqing Xu, and Yikai Zhou

Sensitization to the Cytotoxicity of Cisplatin by Transfection with Nucleotide Excision Repair Gene Xeroderma Pigmentosun Group A Antisense RNA in Human Lung Adenocarcinoma Cells
Clin Cancer Res 2003 9: 5874-5879. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Bruce E. Johnson, Thomas Fischer, Berthold Fischer, David Dunlop, Danny Rischin, Sandra Silberman, Mildred Ortu Kowalski, Deanne Sayles, Sasa Dimitrijevic, Christopher Fletcher, Jason Hornick, Ravi Salgia, and Thierry Le Chevalier

Phase II Study of Imatinib in Patients with Small Cell Lung Cancer
Clin Cancer Res 2003 9: 5880-5887. [Abstract] [Full Text] [PDF]  

Yoshinobu Takahashi, Yoshio Imahori, and Katsuyoshi Mineura

Prognostic and Therapeutic Indicator of Fluoroboronophenylalanine Positron Emission Tomography in Patients with Gliomas
Clin Cancer Res 2003 9: 5888-5895. [Abstract] [Full Text] [PDF]  

Robert J. Morgan, Jr., James H. Doroshow, Timothy Synold, Dean Lim, Stephen Shibata, Kim Margolin, Roderich Schwarz, Lucille Leong, George Somlo, Przemyslaw Twardowski, Yun Yen, Warren Chow, Paul Lin, Benjamin Paz, David Chu, Paul Frankel, and Susan Stalter

Phase I Trial of Intraperitoneal Docetaxel in the Treatment of Advanced Malignancies Primarily Confined to the Peritoneal Cavity: Dose-Limiting Toxicity and Pharmacokinetics
Clin Cancer Res 2003 9: 5896-5901. [Abstract] [Full Text] [PDF]  

Lisa H. Butterfield, Antoni Ribas, Wilson S. Meng, Vivian B. Dissette, Saral Amarnani, Huong T. Vu, Elisabeth Seja, Karen Todd, John A. Glaspy, William H. McBride, and James S. Economou

T-Cell Responses to HLA-A*0201 Immunodominant Peptides Derived from -Fetoprotein in Patients with Hepatocellular Cancer
Clin Cancer Res 2003 9: 5902-5908. [Abstract] [Full Text] [PDF]  

Ji-Youn Han, Dae Ho Lee, Hyae Young Kim, Eun-A Kim, Jae Jin Lee, So Young Ju, Eun Hee Shin, and Jin Soo Lee

A Phase II Study of Weekly Irinotecan and Capecitabine in Patients with Previously Treated Non-Small Cell Lung Cancer
Clin Cancer Res 2003 9: 5909-5914. [Abstract] [Full Text] [PDF]  

Melissa Means-Markwell, R. Ilona Linnoila, John Williams, Pasi A. Jänne, Frederic Kaye, Kevin O’Neil, and Bruce E. Johnson

Prospective Study of the Airways and Pulmonary Parenchyma of Patients at Risk for a Second Lung Cancer
Clin Cancer Res 2003 9: 5915-5921. [Abstract] [Full Text] [PDF]  

Antonio C. Wolff, Deborah K. Armstrong, John H. Fetting, M. Katherine Carducci, Carol D. Riley, John F. Bender, Robert A. Casero, Jr., and Nancy E. Davidson

A Phase II Study of the Polyamine Analog N¹,N¹¹-Diethylnorspermine (DENSpm) Daily for Five Days Every 21 Days in Patients with Previously Treated Metastatic Breast Cancer
Clin Cancer Res 2003 9: 5922-5928. [Abstract] [Full Text] [PDF]  

Afshin Dowlati, Hillard M. Lazarus, Paul Hartman, James W. Jacobberger, Cecilia Whitacre, Stanton L. Gerson, Pamela Ksenich, Brenda W. Cooper, Phyllis S. Frisa, Megan Gottlieb, Anthony J. Murgo, and Scot C. Remick

Phase I and Correlative Study of Combination Bryostatin 1 and Vincristine in Relapsed B-Cell Malignancies
Clin Cancer Res 2003 9: 5929-5935. [Abstract] [Full Text] [PDF]  

Daniel J. Haraf, Fred R. Rosen, Kerstin Stenson, Athanassios Argiris, Bharat B. Mittal, Mary Ellyn Witt, Bruce E. Brockstein, Marcy A. List, Louis Portugal, Harold Pelzer, Ralph R. Weichselbaum, and Everett E. Vokes

Induction Chemotherapy followed by Concomitant TFHX Chemoradiotherapy with Reduced Dose Radiation in Advanced Head and Neck Cancer
Clin Cancer Res 2003 9: 5936-5943. [Abstract] [Full Text] [PDF]  

Giulia Bianchi, John Albanell, Wolfgang Eiermann, Giordano Vitali, David Borquez, Lucia Viganò, Rafael Molina, Günter Raab, Alberta Locatelli, Bart Vanhauwere, Luca Gianni, and Jose Baselga

Pilot Trial of Trastuzumab Starting with or after the Doxorubicin Component of a Doxorubicin plus Paclitaxel Regimen for Women with HER2-Positive Advanced Breast Cancer
Clin Cancer Res 2003 9: 5944-5951. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Diego Vieyra, Donna L. Senger, Tatsuya Toyam, Huong Muzik, Penny M. A. Brasher, Randal N. Johnston, Karl Riabowol, and Peter A. Forsyth

Altered Subcellular Localization and Low Frequency of Mutations of ING1 in Human Brain Tumors
Clin Cancer Res 2003 9: 5952-5961. [Abstract] [Full Text] [PDF]  

James S. Goydos and David H. Gorski

Vascular Endothelial Growth Factor C mRNA Expression Correlates with Stage of Progression in Patients with Melanoma
Clin Cancer Res 2003 9: 5962-5967. [Abstract] [Full Text] [PDF]  

Xiulong Xu, Roderick M. Quiros, Justin B. Maxhimer, Ping Jiang, Regina Marcinek, Kenneth B. Ain, Jeffrey L. Platt, Jikun Shen, Paolo Gattuso, and Richard A. Prinz

Inverse Correlation between Heparan Sulfate Composition and Heparanase-1 Gene Expression in Thyroid Papillary Carcinomas: A Potential Role in Tumor Metastasis
Clin Cancer Res 2003 9: 5968-5979. [Abstract] [Full Text] [PDF]  

Elaine H. Lim, Amit Aggarwal, Thirugananam Agasthian, Poo-Sing Wong, Christie Tan, Eugene Sim, Lenny Tan, Poh-Sun Goh, Shih-Chang Wang, Kay-Leong Khoo, Amartya Mukherjee, See-Meng Khoo, Gerald Chua, Barbro Nilsson, Kang-Hoe Lee, and Patrick Tan

Feasibility of Using Low-Volume Tissue Samples for Gene Expression Profiling of Advanced Non-Small Cell Lung Cancers
Clin Cancer Res 2003 9: 5980-5987. [Abstract] [Full Text] [PDF]  

Anirban Maitra, Donna E. Hansel, Pedram Argani, Raheela Ashfaq, Ayman Rahman, Ali Naji, Shaoping Deng, Joseph Geradts, LesleyAnn Hawthorne, Michael G. House, and Charles J. Yeo

Global Expression Analysis of Well-Differentiated Pancreatic Endocrine Neoplasms Using Oligonucleotide Microarrays
Clin Cancer Res 2003 9: 5988-5995. [Abstract] [Full Text] [PDF] Supplementary Data  

Yi Ren, Ronnie Tung-Ping Poon, Hong-Teng Tsui, Wen-Hong Chen, Zhi Li, Cecilia Lau, Wun-Ching Yu, and Sheung-Tat Fan

Interleukin-8 Serum Levels in Patients with Hepatocellular Carcinoma: Correlations with Clinicopathological Features and Prognosis
Clin Cancer Res 2003 9: 5996-6001. [Abstract] [Full Text] [PDF]  

Simon D. Spivack, Gregory J. Hurteau, Michael J. Fasco, and Laurence S. Kaminsky

Phase I and II Carcinogen Metabolism Gene Expression in Human Lung Tissue and Tumors
Clin Cancer Res 2003 9: 6002-6011. [Abstract] [Full Text] [PDF]  

Elisabeth Odin, Yvonne Wettergren, Staffan Nilsson, Roger Willén, Göran Carlsson, C. Paul Spears, Lars Larsson, and Bengt Gustavsson

Altered Gene Expression of Folate Enzymes in Adjacent Mucosa Is Associated with Outcome of Colorectal Cancer Patients
Clin Cancer Res 2003 9: 6012-6019. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Nicoletta Ferrari, Monica Morini, Ulrich Pfeffer, Simona Minghelli, Douglas M. Noonan, and Adriana Albini

Inhibition of Kaposi’s Sarcoma in Vivo by Fenretinide
Clin Cancer Res 2003 9: 6020-6029. [Abstract] [Full Text] [PDF]  

Jian Zhou, Zhao-You Tang, Jia Fan, Zhi-Quan Wu, Yuan Ji, Yong-Sheng Xiao, Ying-Hong Shi, Xiao-Ming Li, Qi-Man Sun, Yin-Kun Liu, and Sheng-Long Ye

Capecitabine Inhibits Postoperative Recurrence and Metastasis after Liver Cancer Resection in Nude Mice with Relation to the Expression of Platelet-Derived Endothelial Cell Growth Factor
Clin Cancer Res 2003 9: 6030-6037. [Abstract] [Full Text] [PDF]  

Ryuichi Noguchi, Hitoshi Yoshiji, Shigeki Kuriyama, Junichi Yoshii, Yasuhide Ikenaka, Koji Yanase, Tadashi Namisaki, Mitsuteru Kitade, Masaharu Yamazaki, Akira Mitoro, Hirohisa Tsujinoue, Hiroo Imazu, Tsutomu Masaki, and Hiroshi Fukui

Combination of Interferon-ß and the Angiotensin-Converting Enzyme Inhibitor, Perindopril, Attenuates Murine Hepatocellular Carcinoma Development and Angiogenesis
Clin Cancer Res 2003 9: 6038-6045. [Abstract] [Full Text] [PDF]  

Isaac Yi Kim, Dong-Hyeon Lee, Dug Keun Lee, Byung Chul Kim, Heung Tae Kim, Fredrick S. Leach, W. Marston Linehan, Ronald A. Morton, and Seong Jin Kim

Decreased Expression of Bone Morphogenetic Protein (BMP) Receptor Type II Correlates with Insensitivity to BMP-6 in Human Renal Cell Carcinoma Cells
Clin Cancer Res 2003 9: 6046-6051. [Abstract] [Full Text] [PDF]  

Christoph Jung, Monica Motwani, Jeremy Kortmansky, Francis M. Sirotnak, Yuhong She, Mithat Gonen, Adriana Haimovitz-Friedman, and Gary K. Schwartz

The Cyclin-Dependent Kinase Inhibitor Flavopiridol Potentiates -Irradiation-Induced Apoptosis in Colon and Gastric Cancer Cells
Clin Cancer Res 2003 9: 6052-6061. [Abstract] [Full Text] [PDF]  

Caroline Delmas, Dave End, Philippe Rochaix, Gilles Favre, Christine Toulas, and Elizabeth Cohen-Jonathan

The Farnesyltransferase Inhibitor R115777 Reduces Hypoxia and Matrix Metalloproteinase 2 Expression in Human Glioma Xenograft
Clin Cancer Res 2003 9: 6062-6068. [Abstract] [Full Text] [PDF]  

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