Editorials:

Erika Krasnickas Keeton and Myles Brown

Coregulator Expression and Breast Cancer: Improving the Predictive Power of Estrogen Receptor
Clin Cancer Res 2003 9: 1229-1230. [Full Text] [PDF]  

Carlos L. Arteaga

Molecular Therapeutics: Is One Promiscuous Drug against Multiple Targets Better than Combinations of Molecule-specific Drugs?
Clin Cancer Res 2003 9: 1231-1232. [Full Text] [PDF]  

Edward A. Sausville

Is Another Bcr-Abl Inhibitor Needed for Chronic Myelogenous Leukemia?
Clin Cancer Res 2003 9: 1233-1234. [Full Text] [PDF]  

Minireviews:

Joseph R. Bertino and Debabrata Banerjee

Is the Measurement of Thymidylate Synthase to Determine Suitability for Treatment with 5-Fluoropyrimidines Ready for Prime Time?
Clin Cancer Res 2003 9: 1235-1239. [Full Text] [PDF]  

Brian J. Duggan, John J. McKnight, Kate E. Williamson, Maurice Loughrey, Declan O’Rourke, Peter W. Hamilton, Samuel R. Johnston, Claude C. Schulman, and Alexandre R. Zlotta

The Need to Embrace Molecular Profiling of Tumor Cells in Prostate and Bladder Cancer
Clin Cancer Res 2003 9: 1240-1247. [Abstract] [Full Text] [PDF]  

The Biology Behind:

Guido Marcucci, Danilo Perrotti, and Michael A. Caligiuri

Understanding the Molecular Basis of Imatinib Mesylate Therapy in Chronic Myelogenous Leukemia and the Related Mechanisms of Resistance: Commentary re: A. N. Mohamed et al., The Effect of Imatinib Mesylate on Patients with Philadelphia Chromosome-positive Chronic Myeloid Leukemia with Secondary Chromosomal Aberrations. Clin. Cancer Res., 9: 1333–1337, 2003.
Clin Cancer Res 2003 9: 1248-1252. [Full Text] [PDF]  

Advances in Brief:

   Molecular Oncology, Markers, Clinical Correlates:

Els M. J. J. Berns, Jan G. M. Klijn, Maxime P. Look, Nicolai Grebenchtchikov, Rolf Vossen, Harry Peters, Anneke Geurts-Moespot, Henk Portengen, Iris L. van Staveren, Marion E. Meijer-van Gelder, Bert Bakker, Fred C. G. J. Sweep, and John A. Foekens

Combined Vascular Endothelial Growth Factor and TP53 Status Predicts Poor Response to Tamoxifen Therapy in Estrogen Receptor-positive Advanced Breast Cancer
Clin Cancer Res 2003 9: 1253-1258. [Abstract] [Full Text] [PDF]  

Igor Girault, Florence Lerebours, Samira Amarir, Sengül Tozlu, Michèle Tubiana-Hulin, Rosette Lidereau, and Ivan Bièche

Expression Analysis of Estrogen Receptor Coregulators in Breast Carcinoma: Evidence That NCOR1 Expression Is Predictive of the Response to Tamoxifen
Clin Cancer Res 2003 9: 1259-1266. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

David R. Huron, Mercedes E. Gorre, Alan J. Kraker, Charles L. Sawyers, Neal Rosen, and Mark M. Moasser

A Novel Pyridopyrimidine Inhibitor of Abl Kinase Is a Picomolar Inhibitor of Bcr-abl-driven K562 Cells and Is Effective against STI571-resistant Bcr-abl Mutants
Clin Cancer Res 2003 9: 1267-1273. [Abstract] [Full Text] [PDF]  

Judit Anido, Pablo Matar, Joan Albanell, Marta Guzmán, Federico Rojo, Joaquin Arribas, Steve Averbuch, and Jose Baselga

ZD1839, a Specific Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor, Induces the Formation of Inactive EGFR/HER2 and EGFR/HER3 Heterodimers and Prevents Heregulin Signaling in HER2-overexpressing Breast Cancer Cells
Clin Cancer Res 2003 9: 1274-1283. [Abstract] [Full Text] [PDF]  

Philip J. Bergman, Joanne McKnight, Andrew Novosad, Sarah Charney, John Farrelly, Diane Craft, Michelle Wulderk, Yusuf Jeffers, Michel Sadelain, Ann E. Hohenhaus, Neil Segal, Polly Gregor, Manuel Engelhorn, Isabelle Riviere, Alan N. Houghton, and Jedd D. Wolchok

Long-Term Survival of Dogs with Advanced Malignant Melanoma after DNA Vaccination with Xenogeneic Human Tyrosinase: A Phase I Trial
Clin Cancer Res 2003 9: 1284-1290. [Abstract] [Full Text] [PDF]  

Udit N. Verma, Rama M. Surabhi, Aurelia Schmaltieg, Carlos Becerra, and Richard B. Gaynor

Small Interfering RNAs Directed against ß-Catenin Inhibit the in Vitro and in Vivo Growth of Colon Cancer Cells
Clin Cancer Res 2003 9: 1291-1300. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Vinod Pullarkat, Peter P. Lee, Ronaldo Scotland, Valerie Rubio, Susan Groshen, Conway Gee, Roy Lau, Jolie Snively, Shirley Sian, Susan L. Woulfe, Richard A. Wolfe, and Jeffrey S. Weber

A Phase I Trial of SD-9427 (Progenipoietin) with a Multipeptide Vaccine for Resected Metastatic Melanoma
Clin Cancer Res 2003 9: 1301-1312. [Abstract] [Full Text] [PDF]  

Ruth Plummer, Charlotte Rees, Andrew Hughes, Philip Beale, Martin Highley, Jose Trigo, Sathyarathnarn Gokul, Ian Judson, Hilary Calvert, Ann Jackman, Fraser Mitchell, Robert Smith, and Edwin Douglass

A Phase I Trial of ZD9331, a Water-Soluble, Nonpolyglutamatable, Thymidylate Synthase Inhibitor
Clin Cancer Res 2003 9: 1313-1322. [Abstract] [Full Text] [PDF]  

James A. Posey, Thian C. Ng, Baolian Yang, M. B. Khazaeli, Mark D. Carpenter, Floyd Fox, Mike Needle, Harlan Waksal, and Albert F. LoBuglio

A Phase I Study of Anti-Kinase Insert Domain-containing Receptor Antibody, IMC-1C11, in Patients with Liver Metastases from Colorectal Carcinoma
Clin Cancer Res 2003 9: 1323-1332. [Abstract] [Full Text] [PDF]  

Anwar N. Mohamed, Pamela Pemberton, Jeffrey Zonder, and Charles A. Schiffer

The Effect of Imatinib Mesylate on Patients with Philadelphia Chromosome-positive Chronic Myeloid Leukemia with Secondary Chromosomal Aberrations
Clin Cancer Res 2003 9: 1333-1337. [Abstract] [Full Text] [PDF]  

Sydney Welt, Gerd Ritter, Clarence Williams, Jr., Leonard S. Cohen, Mary John, Achim Jungbluth, Elizabeth A. Richards, Lloyd J. Old, and Nancy E. Kemeny

Phase I Study of Anticolon Cancer Humanized Antibody A33
Clin Cancer Res 2003 9: 1338-1346. [Abstract] [Full Text] [PDF]  

Sydney Welt, Gerd Ritter, Clarence Williams, Jr., Leonard S. Cohen, Achim Jungbluth, Elizabeth A. Richards, Lloyd J. Old, and Nancy E. Kemeny

Preliminary Report of a Phase I Study of Combination Chemotherapy and Humanized A33 Antibody Immunotherapy in Patients with Advanced Colorectal Cancer
Clin Cancer Res 2003 9: 1347-1353. [Abstract] [Full Text] [PDF]  

Thomas E. Hutson, Luis Molto, Tarek Mekhail, Paul Elson, James Finke, Charles Tannenbaum, Ernest Borden, Robert Dreicer, Thomas Olencki, and Ronald M. Bukowski

Phase I Trial of Consensus Interferon in Patients with Metastatic Renal Cell Carcinoma: Toxicity and Immunological Effects
Clin Cancer Res 2003 9: 1354-1360. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Yoshihito Yokoyama, D. Stephen Charnock-Jones, Diana Licence, Atsushi Yanaihara, Julie M. Hastings, Cathrine M. Holland, Makoto Emoto, Akiko Sakamoto, Tomomi Sakamoto, Hidetoshi Maruyama, Shigemi Sato, Hideki Mizunuma, and Stephen K. Smith

Expression of Vascular Endothelial Growth Factor (VEGF)-D and Its Receptor, VEGF Receptor 3, as a Prognostic Factor in Endometrial Carcinoma
Clin Cancer Res 2003 9: 1361-1369. [Abstract] [Full Text] [PDF]  

Susan V. Harden, Yutaka Tokumaru, William H. Westra, Steven Goodman, Steven A. Ahrendt, Stephen C. Yang, and David Sidransky

Gene Promoter Hypermethylation in Tumors and Lymph Nodes of Stage I Lung Cancer Patients
Clin Cancer Res 2003 9: 1370-1375. [Abstract] [Full Text] [PDF]  

Makoto Ishitobi, Yasuo Miyoshi, Akiko Ando, Seiichi Hasegawa, Chiyomi Egawa, Yasuhiro Tamaki, Morito Monden, and Shinzaburo Noguchi

Association of BRCA2 Polymorphism at Codon 784 (Met/Val) with Breast Cancer Risk and Prognosis
Clin Cancer Res 2003 9: 1376-1380. [Abstract] [Full Text] [PDF]  

Alexandar Tzankov, Jens Krugmann, Falko Fend, Martina Fischhofer, Richard Greil, and Stephan Dirnhofer

Prognostic Significance of CD20 Expression in Classical Hodgkin Lymphoma: A Clinicopathological Study of 119 Cases
Clin Cancer Res 2003 9: 1381-1386. [Abstract] [Full Text] [PDF]  

Catherine Shannon, Judy Kirk, Rebecca Barnetson, Justin Evans, Margaret Schnitzler, Michael Quinn, Neville Hacker, Alex Crandon, and Paul Harnett

Incidence of Microsatellite Instability in Synchronous Tumors of the Ovary and Endometrium
Clin Cancer Res 2003 9: 1387-1392. [Abstract] [Full Text] [PDF]  

Fu-Shing Liu, Jin-Tang Dong, Jung-Ta Chen, Yeun-Ting Hsieh, Esther Shih-Chu Ho, Man-Jung Hung, Chien-Hsing Lu, and Li-Ching Chiou

KAI1 Metastasis Suppressor Protein Is Down-Regulated during the Progression of Human Endometrial Cancer
Clin Cancer Res 2003 9: 1393-1398. [Abstract] [Full Text] [PDF]  

Katrin Lamszus, Ulrike Ulbricht, Jakob Matschke, Marc A. Brockmann, Regina Fillbrandt, and Manfred Westphal

Levels of Soluble Vascular Endothelial Growth Factor (VEGF) Receptor 1 in Astrocytic Tumors and Its Relation to Malignancy, Vascularity, and VEGF-A
Clin Cancer Res 2003 9: 1399-1405. [Abstract] [Full Text] [PDF]  

Mariano Provencio, Cesar Corbacho, Clara Salas, Isabel Millan, Pilar Espana, Felix Bonilla, and Santiago Ramon Cajal

The Topoisomerase II Expression Correlates with Survival in Patients with Advanced Hodgkin’s Lymphoma
Clin Cancer Res 2003 9: 1406-1411. [Abstract] [Full Text] [PDF]  

Ben Davidson, Iris Goldberg, Walter H. Gotlieb, Juri Kopolovic, Gilad Ben-Baruch, and Reuven Reich

PEA3 Is the Second Ets Family Transcription Factor Involved in Tumor Progression in Ovarian Carcinoma
Clin Cancer Res 2003 9: 1412-1419. [Abstract] [Full Text] [PDF]  

Tatiana M. Gritsko, Domenico Coppola, June E. Paciga, Lin Yang, Mei Sun, Sue A. Shelley, James V. Fiorica, Santo V. Nicosia, and Jin Q. Cheng

Activation and Overexpression of Centrosome Kinase BTAK/Aurora-A in Human Ovarian Cancer
Clin Cancer Res 2003 9: 1420-1426. [Abstract] [Full Text] [PDF]  

Robert A. Wascher, Kelly T. Huynh, Armando E. Giuliano, Nora M. Hansen, Frederick R. Singer, David Elashoff, and Dave S. B. Hoon

Stanniocalcin-1: A Novel Molecular Blood and Bone Marrow Marker for Human Breast Cancer
Clin Cancer Res 2003 9: 1427-1435. [Abstract] [Full Text] [PDF]  

Ulrike Heider, Corinna Langelotz, Christian Jakob, Ivana Zavrski, Claudia Fleissner, Jan Eucker, Kurt Possinger, Lorenz C. Hofbauer, and Orhan Sezer

Expression of Receptor Activator of Nuclear Factor B Ligand on Bone Marrow Plasma Cells Correlates with Osteolytic Bone Disease in Patients with Multiple Myeloma
Clin Cancer Res 2003 9: 1436-1440. [Abstract] [Full Text] [PDF]  

Tamotsu Kuroki, Francesco Trapasso, Sai Yendamuri, Ayumi Matsuyama, Hansjuerg Alder, Masaki Mori, and Carlo M. Croce

Promoter Hypermethylation of RASSF1A in Esophageal Squamous Cell Carcinoma
Clin Cancer Res 2003 9: 1441-1445. [Abstract] [Full Text] [PDF]  

Hiroyuki Matsubayashi, Norihiro Sato, Noriyoshi Fukushima, Charles J. Yeo, Kimberly M. Walter, Kieran Brune, Fikret Sahin, Ralph H. Hruban, and Michael Goggins

Methylation of Cyclin D2 Is Observed Frequently in Pancreatic Cancer but Is Also an Age-related Phenomenon in Gastrointestinal Tissues
Clin Cancer Res 2003 9: 1446-1452. [Abstract] [Full Text] [PDF]  

Yoichi Mizutani, Hiromi Wada, Osamu Yoshida, Masakazu Fukushima, Mitsuo Nonomura, Masahiro Nakao, and Tsuneharu Miki

Significance of Thymidylate Synthase Activity in Renal Cell Carcinoma
Clin Cancer Res 2003 9: 1453-1460. [Abstract] [Full Text] [PDF]  

Carme Balaña, Jose Luis Ramirez, Miquel Taron, Yannis Roussos, Aurelio Ariza, Rosa Ballester, Carme Sarries, Pedro Mendez, Jose Javier Sanchez, and Rafael Rosell

O⁶-methyl-guanine-DNA methyltransferase Methylation in Serum and Tumor DNA Predicts Response to 1,3-Bis(2-Chloroethyl)-1-Nitrosourea but not to Temozolamide Plus Cisplatin in Glioblastoma Multiforme
Clin Cancer Res 2003 9: 1461-1468. [Abstract] [Full Text] [PDF]  

Marie-Louise H. Fjällskog, Margareta H. Lejonklou, Kjell E. Öberg, Barbro K. Eriksson, and Eva T. Janson

Expression of Molecular Targets for Tyrosine Kinase Receptor Antagonists in Malignant Endocrine Pancreatic Tumors
Clin Cancer Res 2003 9: 1469-1473. [Abstract] [Full Text] [PDF]  

Ole J. Halvorsen, Svein A. Haukaas, and Lars A. Akslen

Combined Loss of PTEN and p27 Expression Is Associated with Tumor Cell Proliferation by Ki-67 and Increased Risk of Recurrent Disease in Localized Prostate Cancer
Clin Cancer Res 2003 9: 1474-1479. [Abstract] [Full Text] [PDF]  

Hiroya Takeuchi, Anton Bilchik, Sukamal Saha, Roderick Turner, David Wiese, Maki Tanaka, Christine Kuo, He-Jing Wang, and Dave S. B. Hoon

c-MET Expression Level in Primary Colon Cancer: A Predictor of Tumor Invasion and Lymph Node Metastases
Clin Cancer Res 2003 9: 1480-1488. [Abstract] [Full Text] [PDF]  

Goro Sashida, Junko H. Ohyashiki, Akihiro Nakajima, Masahiko Sumi, Ken Kawakubo, Tetsuzo Tauchi, and Kazuma Ohyashiki

Telomere Dynamics in Myelodysplastic Syndrome Determined by Telomere Measurement of Marrow Metaphases
Clin Cancer Res 2003 9: 1489-1496. [Abstract] [Full Text] [PDF]  

Sandra R. Reynolds, Jeff Albrecht, Richard L. Shapiro, Daniel F. Roses, Matthew N. Harris, Andrew Conrad, Anne Zeleniuch-Jacquotte, and Jean-Claude Bystryn

Changes in the Presence of Multiple Markers of Circulating Melanoma Cells Correlate with Clinical Outcome in Patients with Melanoma
Clin Cancer Res 2003 9: 1497-1502. [Abstract] [Full Text] [PDF]  

Naoya Ikeda, Yoshiyuki Nakajima, Takahiro Tokuhara, Noboru Hattori, Masayuki Sho, Hiromichi Kanehiro, and Masayuki Miyake

Clinical Significance of Aminopeptidase N/CD13 Expression in Human Pancreatic Carcinoma
Clin Cancer Res 2003 9: 1503-1508. [Abstract] [Full Text] [PDF]  

Bonnie L. King, Steven C. Tsai, Michele E. Gryga, Thomas G. D’Aquila, Steven A. Seelig, Larry E. Morrison, Kris K. B. Jacobson, Mona S. Legator, David C. Ward, David L. Rimm, and Rogsbert F. Phillips

Detection of Chromosomal Instability in Paired Breast Surgery and Ductal Lavage Specimens by Interphase Fluorescence in Situ Hybridization
Clin Cancer Res 2003 9: 1509-1516. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Katia Schlienger, Christina S. Chu, Edward Y. Woo, Patricia M. Rivers, Alanna J. Toll, Brian Hudson, Marcela V. Maus, James L. Riley, Yongwon Choi, George Coukos, Larry R. Kaiser, Stephen C. Rubin, Bruce L. Levine, Richard G. Carroll, and Carl H. June

TRANCE- and CD40 Ligand-matured Dendritic Cells Reveal MHC Class I-restricted T Cells Specific for Autologous Tumor in Late-Stage Ovarian Cancer Patients
Clin Cancer Res 2003 9: 1517-1527. [Abstract] [Full Text] [PDF]  

Yuka Suzuki, Kiyosumi Shibata, Fumitaka Kikkawa, Hiroaki Kajiyama, Kazuhiko Ino, Seiji Nomura, Masafumi Tsujimoto, and Shigehiko Mizutani

Possible Role of Placental Leucine Aminopeptidase in the Antiproliferative Effect of Oxytocin in Human Endometrial Adenocarcinoma
Clin Cancer Res 2003 9: 1528-1534. [Abstract] [Full Text] [PDF]  

Consuelo Gajate, Feiyun An, and Faustino Mollinedo

Rapid and Selective Apoptosis in Human Leukemic Cells Induced by Aplidine through a Fas/CD95- and Mitochondrial-mediated Mechanism
Clin Cancer Res 2003 9: 1535-1545. [Abstract] [Full Text] [PDF]  

Fortunato Ciardiello, Rosa Caputo, Vincenzo Damiano, Roberta Caputo, Teresa Troiani, Donatella Vitagliano, Francesca Carlomagno, Bianca Maria Veneziani, Gabriella Fontanini, A. Raffaele Bianco, and Giampaolo Tortora

Antitumor Effects of ZD6474, a Small Molecule Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, with Additional Activity against Epidermal Growth Factor Receptor Tyrosine Kinase
Clin Cancer Res 2003 9: 1546-1556. [Abstract] [Full Text] [PDF]  

Swatee Dey, Paul M. Spring, Suzanne Arnold, Joseph Valentino, Damodaran Chendil, William F. Regine, Mohammed Mohiuddin, and Mansoor M. Ahmed

Low-Dose Fractionated Radiation Potentiates the Effects of Paclitaxel in Wild-type and Mutant p53 Head and Neck Tumor Cell Lines
Clin Cancer Res 2003 9: 1557-1565. [Abstract] [Full Text] [PDF]  

Giampaolo Tortora, Rosa Caputo, Vincenzo Damiano, Davide Melisi, Roberto Bianco, Gabriella Fontanini, Bianca Maria Veneziani, Sabino De Placido, A. Raffaele Bianco, and Fortunato Ciardiello

Combination of a Selective Cyclooxygenase-2 Inhibitor with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 and Protein Kinase A Antisense Causes Cooperative Antitumor and Antiangiogenic Effect
Clin Cancer Res 2003 9: 1566-1572. [Abstract] [Full Text] [PDF]  

Corrections:

Correction for vol. 8, p. 3718
Clin Cancer Res 2003 9: 1573. [Full Text] [PDF]  

Erratum:

Correction for vol. 9, p. 295
Clin Cancer Res 2003 9: 1574-1575. [Full Text] [PDF]  

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