Editorials:

Raymond N. DuBois

Evaluation of the Whole Prostaglandin Biosynthetic Pathway in Lung Cancer
Clin Cancer Res 2003 9: 1577-1578. [Full Text] [PDF]  

Minireviews:

Carlos L. Arteaga and Jose Baselga

Clinical Trial Design and End Points for Epidermal Growth Factor Receptor-targeted Therapies: Implications for Drug Development and Practice
Clin Cancer Res 2003 9: 1579-1589. [Full Text] [PDF]  

The Biology Behind:

Jonathan D. Cheng and Louis M. Weiner

Tumors and Their Microenvironments: Tilling the Soil: Commentary re: A. M. Scott et al., A Phase I Dose-Escalation Study of Sibrotuzumab in Patients with Advanced or Metastatic Fibroblast Activation Protein-positive Cancer. Clin. Cancer Res., 9: 1639–1647, 2003.
Clin Cancer Res 2003 9: 1590-1595. [Full Text] [PDF]  

Advances in Brief:

   Clinical Trials:

Blanca Segura-Pacheco, Catalina Trejo-Becerril, Enrique Perez-Cardenas, Lucia Taja-Chayeb, Ignacio Mariscal, Alma Chavez, Carmen Acuña, Ana Maria Salazar, Marcela Lizano, and Alfonso Dueñas-Gonzalez

Reactivation of Tumor Suppressor Genes by the Cardiovascular Drugs Hydralazine and Procainamide and Their Potential Use in Cancer Therapy
Clin Cancer Res 2003 9: 1596-1603. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Leander Ermert, Christian Dierkes, and Monika Ermert

Immunohistochemical Expression of Cyclooxygenase Isoenzymes and Downstream Enzymes in Human Lung Tumors
Clin Cancer Res 2003 9: 1604-1610. [Abstract] [Full Text] [PDF]  

Victor Cohen, Valerie Panet-Raymond, Nelly Sabbaghian, Isabelle Morin, Gerald Batist, and Rima Rozen

Methylenetetrahydrofolate Reductase Polymorphism in Advanced Colorectal Cancer: A Novel Genomic Predictor of Clinical Response to Fluoropyrimidine-based Chemotherapy
Clin Cancer Res 2003 9: 1611-1615. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Claudia Palena, Jeffrey Schlom, and Kwong-Yok Tsang

Differential Gene Expression Profiles in a Human T-cell Line Stimulated with a Tumor-associated Self-peptide versus an Enhancer Agonist Peptide
Clin Cancer Res 2003 9: 1616-1627. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Lee S. Rosen, Joseph Brown, Bernadette Laxa, Leny Boulos, Laura Reiswig, William D. Henner, Robert T. Lum, Steve R. Schow, Christopher A. Maack, James G. Keck, Julie C. Mascavage, Jacqueline A. Dombroski, Reinaldo F. Gomez, and Gail L. Brown

Phase I Study of TLK286 (Glutathione S-Transferase P1-1 Activated Glutathione Analogue) in Advanced Refractory Solid Malignancies
Clin Cancer Res 2003 9: 1628-1638. [Abstract] [Full Text] [PDF]  

Andrew M. Scott, Greg Wiseman, Sydney Welt, Alex Adjei, Fook-Thean Lee, Wendie Hopkins, Chaitan R. Divgi, Lorelei H. Hanson, Paul Mitchell, Denise N. Gansen, Steven M. Larson, James N. Ingle, Eric W. Hoffman, Paul Tanswell, Gerd Ritter, Leonard S. Cohen, Peter Bette, Lisa Arvay, Andree Amelsberg, Dan Vlock, Wolfgang J. Rettig, and Lloyd J. Old

A Phase I Dose-Escalation Study of Sibrotuzumab in Patients with Advanced or Metastatic Fibroblast Activation Protein-positive Cancer
Clin Cancer Res 2003 9: 1639-1647. [Abstract] [Full Text] [PDF]  

Bart C. Kuenen, Jose Tabernero, Jose Baselga, Franco Cavalli, Elisabeth Pfanner, Pier Franco Conte, Siegfried Seeber, Srinivasan Madhusudan, Gael Deplanque, Holgen Huisman, Paul Scigalla, Klaas Hoekman, and Adrian L. Harris

Efficacy and Toxicity of the Angiogenesis Inhibitor SU5416 As a Single Agent in Patients with Advanced Renal Cell Carcinoma, Melanoma, and Soft Tissue Sarcoma
Clin Cancer Res 2003 9: 1648-1655. [Abstract] [Full Text] [PDF]  

Elena Gitelson, Caitlin Hammond, Jenny Mena, Maria Lorenzo, Rena Buckstein, Neil L. Berinstein, Kevin Imrie, and David E. Spaner

Chronic Lymphocytic Leukemia-reactive T Cells during Disease Progression and after Autologous Tumor Cell Vaccines
Clin Cancer Res 2003 9: 1656-1665. [Abstract] [Full Text] [PDF]  

Bruce G. Redman, Peg Esper, Quintin Pan, Rodney L. Dunn, Hero K. Hussain, Thomas Chenevert, George J. Brewer, and Sofia D. Merajver

Phase II Trial of Tetrathiomolybdate in Patients with Advanced Kidney Cancer
Clin Cancer Res 2003 9: 1666-1672. [Abstract] [Full Text] [PDF]  

Edward J. Licitra, Viral Vyas, Kathy Nelson, Rita Musanti, Stephanie Beers, Cecilia Thomas, Elizabeth Poplin, Sharon Smith, Yong Lin, Larry. J. Schaaf, Joseph Aisner, Murugesan Gounder, Rajeev Rajendra, Ahamed Saleem, Deborah Toppmeyer, and Eric H. Rubin

Phase I Evaluation of Sequential Topoisomerase Targeting with Irinotecan/Cisplatin Followed by Etoposide in Patients with Advanced Malignancy
Clin Cancer Res 2003 9: 1673-1679. [Abstract] [Full Text] [PDF]  

Jun Lu, Brian D. Palmer, Phillip Kestell, Peter Browett, Bruce C. Baguley, George Muller, and Lai-Ming Ching

Thalidomide Metabolites in Mice and Patients with Multiple Myeloma
Clin Cancer Res 2003 9: 1680-1688. [Abstract] [Full Text] [PDF]  

Fred R. Rosen, Daniel J. Haraf, Merrill S. Kies, Kerstin Stenson, Louis Portugal, Marcy A. List, Bruce E. Brockstein, Bharat B. Mittal, Alfred W. Rademaker, Mary Ellyn Witt, Harold Pelzer, Ralph R. Weichselbaum, and Everett E. Vokes

Multicenter Randomized Phase II Study of Paclitaxel (1-Hour Infusion), Fluorouracil, Hydroxyurea, and Concomitant Twice Daily Radiation with or without Erythropoietin for Advanced Head and Neck Cancer
Clin Cancer Res 2003 9: 1689-1697. [Abstract] [Full Text] [PDF]  

Lori J. Wirth, Joan Lucca, Patricia Ostler, Panos Fidias, Cathy Lynch, Pasi A. Jänne, Roy S. Herbst, Bruce E. Johnson, David J. Sugarbaker, Douglas J. Mathisen, Jeanne M. Lukanich, Noah C. Choi, Stuart M. Berman, and Arthur T. Skarin

Induction Docetaxel and Carboplatin Followed by Weekly Docetaxel and Carboplatin with Concurrent Radiotherapy, then Surgery in Stage III Non-Small Cell Lung Cancer: A Phase I Study
Clin Cancer Res 2003 9: 1698-1704. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Basil F. El-Rayes, Shadan Ali, Lance K. Heilbrun, Samir Lababidi, David Bouwman, David Visscher, and Philip A. Philip

Cytochrome P450 and Glutathione Transferase Expression in Human Breast Cancer
Clin Cancer Res 2003 9: 1705-1709. [Abstract] [Full Text] [PDF]  

Ying Dong, Aneel Kaushal, Maria Brattsand, Jim Nicklin, and Judith A. Clements

Differential Splicing of KLK5 and KLK7 in Epithelial Ovarian Cancer Produces Novel Variants with Potential as Cancer Biomarkers
Clin Cancer Res 2003 9: 1710-1720. [Abstract] [Full Text] [PDF]  

Barbara Seliger, Derek Atkins, Michaela Bock, Ulrike Ritz, Soldano Ferrone, Christoph Huber, and Stefan Störkel

Characterization of Human Lymphocyte Antigen Class I Antigen-processing Machinery Defects in Renal Cell Carcinoma Lesions with Special Emphasis on Transporter-associated with Antigen-processing Down-Regulation
Clin Cancer Res 2003 9: 1721-1727. [Abstract] [Full Text] [PDF]  

Robin T. Vollmer, Ramaswamy Govindan, Stephen L. Graziano, Gary Gamble, Jennifer Garst, Michael J. Kelley, and Robert H. Christenson

Serum CYFRA 21-1 in Advanced Stage Non-Small Cell Lung Cancer: An Early Measure of Response
Clin Cancer Res 2003 9: 1728-1733. [Abstract] [Full Text] [PDF]  

Yasuyoshi Miyata, Shigehiko Koga, Kousuke Takehara, Hiroshi Kanetake, and Shigeru Kanda

Expression of Thrombospondin-derived 4N1K Peptide-containing Proteins in Renal Cell Carcinoma Tissues Is Associated with a Decrease in Tumor Growth and Angiogenesis
Clin Cancer Res 2003 9: 1734-1740. [Abstract] [Full Text] [PDF]  

Yasuyoshi Miyata, Shigehiko Koga, Shigeru Kanda, Masaharu Nishikido, Tomayoshi Hayashi, and Hiroshi Kanetake

Expression of Cyclooxygenase-2 in Renal Cell Carcinoma: Correlation with Tumor Cell Proliferation, Apoptosis, Angiogenesis, Expression of Matrix Metalloproteinase-2, and Survival
Clin Cancer Res 2003 9: 1741-1749. [Abstract] [Full Text] [PDF]  

Jan Akervall, Ulrike Bockmühl, I. Petersen, Kun Yang, Thomas E. Carey, and David M. Kurnit

The Gene Ratios c-MYC:Cyclin-dependent Kinase (CDK)N2A and CCND1:CDKN2A Correlate with Poor Prognosis in Squamous Cell Carcinoma of the Head and Neck
Clin Cancer Res 2003 9: 1750-1755. [Abstract] [Full Text] [PDF]  

Kazushi Shigemasa, Lijun Gu, Timothy J. O’Brien, and Koso Ohama

Skp2 Overexpression Is a Prognostic Factor in Patients with Ovarian Adenocarcinoma
Clin Cancer Res 2003 9: 1756-1763. [Abstract] [Full Text] [PDF]  

Xundi Xu, Hirofumi Yamamoto, Masato Sakon, Masayoshi Yasui, Chew Yee Ngan, Hiroki Fukunaga, Tetsushi Morita, Minoru Ogawa, Hiroaki Nagano, Shoji Nakamori, Mitsugu Sekimoto, Nariaki Matsuura, and Morito Monden

Overexpression of CDC25A Phosphatase Is Associated with Hypergrowth Activity and Poor Prognosis of Human Hepatocellular Carcinomas
Clin Cancer Res 2003 9: 1764-1772. [Abstract] [Full Text] [PDF]  

Bodo Klump, Chih-Jen Hsieh, Stephan Dette, Karlheinz Holzmann, Ralf Kießlich, Michael Jung, Udo Sinn, Marianne Ortner, Rainer Porschen, and Michael Gregor

Promoter Methylation of INK4a/ARF As Detected in Bile-Significance for the Differential Diagnosis in Biliary Disease
Clin Cancer Res 2003 9: 1773-1778. [Abstract] [Full Text] [PDF]  

Toshihiko Masui, Ryuichiro Doi, Takatomo Koshiba, Koji Fujimoto, Shoichiro Tsuji, Sanae Nakajima, Masayuki Koizumi, Eiji Toyoda, Sidhartha Tulachan, Daisuke Ito, Kazuhiro Kami, Tomohiko Mori, Michihiko Wada, Makoto Noda, and Masayuki Imamura

RECK Expression in Pancreatic Cancer: Its Correlation with Lower Invasiveness and Better Prognosis
Clin Cancer Res 2003 9: 1779-1784. [Abstract] [Full Text] [PDF]  

Jean-Charles Soria, Chulso Moon, Bonnie L. Kemp, Diane D. Liu, Lei Feng, Ximing Tang, Yoon-Soo Chang, Li Mao, and Fadlo R. Khuri

Lack of Interleukin-10 Expression Could Predict Poor Outcome in Patients with Stage I Non-Small Cell Lung Cancer
Clin Cancer Res 2003 9: 1785-1791. [Abstract] [Full Text] [PDF]  

Catherine B. Barden, Katherine W. Shister, Baixin Zhu, Gerardo Guiter, David Y. Greenblatt, Martha A. Zeiger, and Thomas J. Fahey, III

Classification of Follicular Thyroid Tumors by Molecular Signature: Results of Gene Profiling
Clin Cancer Res 2003 9: 1792-1800. [Abstract] [Full Text] [PDF]  

Alexandre de la Taille, Mark A. Rubin, Min-Wei Chen, Francis Vacherot, Sixtina Gil-Diez de Medina, Martin Burchardt, Ralph Buttyan, and Dominique Chopin

ß-Catenin-related Anomalies in Apoptosis-resistant and Hormone-refractory Prostate Cancer Cells
Clin Cancer Res 2003 9: 1801-1807. [Abstract] [Full Text] [PDF]  

B. Michael Ghadimi, Marian Grade, Torsten Liersch, Claus Langer, Alexander Siemer, László Füzesi, and Heinz Becker

Gain of Chromosome 8q23–24 Is a Predictive Marker for Lymph Node Positivity in Colorectal Cancer
Clin Cancer Res 2003 9: 1808-1814. [Abstract] [Full Text] [PDF]  

Fouad K. Habib, Margaret Ross, Colin W. Bayne, Prasad Bollina, Ken Grigor, and Karen Chapman

The Loss of 5-Reductase Type I and Type II mRNA Expression in Metastatic Prostate Cancer to Bone and Lymph Node Metastasis
Clin Cancer Res 2003 9: 1815-1819. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Chiara Corsini, Patrizia Mancuso, Saki Paul, Alessandra Burlini, Giovanni Martinelli, Giancarlo Pruneri, and Francesco Bertolini

Stroma Cells: A Novel Target of Herceptin Activity
Clin Cancer Res 2003 9: 1820-1825. [Abstract] [Full Text] [PDF]  

Koji Kawakami, Mariko Kawakami, Syed R. Husain, and Raj K. Puri

Effect of Interleukin (IL)-4 Cytotoxin on Breast Tumor Growth after in Vivo Gene Transfer of IL-4 Receptor Chain
Clin Cancer Res 2003 9: 1826-1836. [Abstract] [Full Text] [PDF]  

James W. Hodge, Douglas W. Grosenbach, Wilhelmina M. Aarts, Diane J. Poole, and Jeffrey Schlom

Vaccine Therapy of Established Tumors in the Absence of Autoimmunity
Clin Cancer Res 2003 9: 1837-1849. [Abstract] [Full Text] [PDF]  

Bo Zhu, Zhengtang Chen, Xiaoming Cheng, Zhihua Lin, Jianxiu Guo, Zhengcai Jia, Liyun Zou, Zhixin Wang, Yide Hu, Dongling Wang, and Yuzhang Wu

Identification of HLA-A*0201-restricted Cytotoxic T Lymphocyte Epitope from TRAG-3 Antigen
Clin Cancer Res 2003 9: 1850-1857. [Abstract] [Full Text] [PDF]  

Carmen C. Solorzano, Rosa Hwang, Cheryl H. Baker, Corazon D. Bucana, Peter W. Pisters, Douglas B. Evans, Jerald J. Killion, and Isaiah J. Fidler

Administration of Optimal Biological Dose and Schedule of Interferon Combined with Gemcitabine Induces Apoptosis in Tumor-associated Endothelial Cells and Reduces Growth of Human Pancreatic Carcinoma Implanted Orthotopically in Nude Mice
Clin Cancer Res 2003 9: 1858-1867. [Abstract] [Full Text] [PDF]  

Ganesan Vaidyanathan, Henry S. Friedman, Donna J. Affleck, Margaret Schottelius, Hans-Jürgen Wester, and Michael R. Zalutsky

Specific and High-Level Targeting of Radiolabeled Octreotide Analogues to Human Medulloblastoma Xenografts
Clin Cancer Res 2003 9: 1868-1876. [Abstract] [Full Text] [PDF]  

Andreja Pirkmaier, Kally Yuen, Joy Hendley, Matthew J. O’Connell, and Doris Germain

Cyclin D1 Overexpression Sensitizes Breast Cancer Cells to Fenretinide
Clin Cancer Res 2003 9: 1877-1884. [Abstract] [Full Text] [PDF]  

Helena A. Minter, John W. Eveson, Suzanne Huntley, Douglas J. E. Elder, and Angela Hague

The Cyclooxygenase 2-selective Inhibitor NS398 Inhibits Proliferation of Oral Carcinoma Cell Lines by Mechanisms Dependent and Independent of Reduced Prostaglandin E₂ Synthesis
Clin Cancer Res 2003 9: 1885-1897. [Abstract] [Full Text] [PDF]  

Gianni Sava, Sonia Zorzet, Claudia Turrin, Francesca Vita, MariaRosa Soranzo, Giuliano Zabucchi, Moreno Cocchietto, Alberta Bergamo, Stefano DiGiovine, Gabriella Pezzoni, Luigi Sartor, and Spiridione Garbisa

Dual Action of NAMI-A in Inhibition of Solid Tumor Metastasis: Selective Targeting of Metastatic Cells and Binding to Collagen
Clin Cancer Res 2003 9: 1898-1905. [Abstract] [Full Text] [PDF]  

José M. Hernández, Matthew H. T. Bui, Ken-ryu Han, Hideki Mukouyama, Danielo G. Freitas, David Nguyen, Randy Caliliw, Peter I. Shintaku, Sun H. Paik, Cho-Lea Tso, Robert A. Figlin, and Arie S. Belldegrun

Novel Kidney Cancer Immunotherapy Based on the Granulocyte- Macrophage Colony-stimulating Factor and Carbonic Anhydrase IX Fusion Gene
Clin Cancer Res 2003 9: 1906-1916. [Abstract] [Full Text] [PDF]  

Katja Wosikowski, Elfi Biedermann, Benno Rattel, Norbert Breiter, Peter Jank, Roland Löser, Gerrit Jansen, and Godefridus J. Peters

In Vitro and in Vivo Antitumor Activity of Methotrexate Conjugated to Human Serum Albumin in Human Cancer Cells
Clin Cancer Res 2003 9: 1917-1926. [Abstract] [Full Text] [PDF]  

William T. Gunning, Paula M. Kramer, Ronald A. Lubet, Vernon E. Steele, David W. End, Walter Wouters, and Michael A. Pereira

Chemoprevention of Benzo(a)pyrene-induced Lung Tumors in Mice by the Farnesyltransferase Inhibitor R115777
Clin Cancer Res 2003 9: 1927-1930. [Abstract] [Full Text] [PDF]  

Regina Loomis, Rocco Carbone, Michael Reiss, and Jill Lacy

Bcl-2 Antisense (G3139, Genasense) Enhances the in Vitro and in Vivo Response of Epstein-Barr Virus-associated Lymphoproliferative Disease to Rituximab
Clin Cancer Res 2003 9: 1931-1939. [Abstract] [Full Text] [PDF]  

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