Editorials:

Jean-Pierre J. Issa

Methylation and Prognosis: Of Molecular Clocks and Hypermethylator Phenotypes
Clin Cancer Res 2003 9: 2879-2881. [Full Text] [PDF]  

The Biology Behind:

Matthew W. Harding

Immunophilins, mTOR, and Pharmacodynamic Strategies for a Targeted Cancer Therapy: Commentary re: J. M. Peralba et al., Pharmacodynamic Evaluation of CCI-779, an Inhibitor of mTOR, in Cancer Patients. Clin. Cancer Res., 9: 2887–2892, 2003.
Clin Cancer Res 2003 9: 2882-2886. [Full Text] [PDF]  

Advances in Brief:

   Clinical Trials:

Josep Maria Peralba, Linda deGraffenried, William Friedrichs, Letitia Fulcher, Viktor Grünwald, Geoffrey Weiss, and Manuel Hidalgo

Pharmacodynamic Evaluation of CCI-779, an Inhibitor of mTOR, in Cancer Patients
Clin Cancer Res 2003 9: 2887-2892. [Abstract] [Full Text] [PDF]  

Daniele Santini, Bruno Vincenzi, Giordano Dicuonzo, Giuseppe Avvisati, Cristian Massacesi, Fabrizio Battistoni, Michele Gavasci, Laura Rocci, Maria Cristina Tirindelli, Vittorio Altomare, Massimo Tocchini, Maurizio Bonsignori, and Giuseppe Tonini

Zoledronic Acid Induces Significant and Long-Lasting Modifications of Circulating Angiogenic Factors in Cancer Patients
Clin Cancer Res 2003 9: 2893-2897. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Marius van Rijnsoever, Hany Elsaleh, David Joseph, Kieran McCaul, and Barry Iacopetta

CpG Island Methylator Phenotype Is an Independent Predictor of Survival Benefit from 5-Fluorouracil in Stage III Colorectal Cancer
Clin Cancer Res 2003 9: 2898-2903. [Abstract] [Full Text] [PDF]  

Bin Ye, Daniel W. Cramer, Steven J. Skates, Steven P. Gygi, Vanessa Pratomo, Lanfei Fu, Nora K. Horick, Larry J. Licklider, John O. Schorge, Ross S. Berkowitz, and Samuel C. Mok

Haptoglobin- Subunit As Potential Serum Biomarker in Ovarian Cancer: Identification and Characterization Using Proteomic Profiling and Mass Spectrometry
Clin Cancer Res 2003 9: 2904-2911. [Abstract] [Full Text] [PDF]  

Malcolm V. Brock, Mingzhou Gou, Yoshimitsu Akiyama, Alison Muller, Tsung-Teh Wu, Elizabeth Montgomery, Mari Deasel, Paul Germonpré, Lewis Rubinson, Richard F. Heitmiller, Stephen C. Yang, Arlene A. Forastiere, Stephen B. Baylin, and James G. Herman

Prognostic Importance of Promoter Hypermethylation of Multiple Genes in Esophageal Adenocarcinoma
Clin Cancer Res 2003 9: 2912-2919. [Abstract] [Full Text] [PDF]  

Il-Jin Kim, Hio Chung Kang, Jae-Hyun Park, Yong Shin, Ja-Lok Ku, Seok-Byung Lim, So Yeon Park, Seung-Yong Jung, Hark Kyun Kim, and Jae-Gahb Park

Development and Applications of a ß-Catenin Oligonucleotide Microarray: ß-Catenin Mutations Are Dominantly Found in the Proximal Colon Cancers with Microsatellite Instability
Clin Cancer Res 2003 9: 2920-2925. [Abstract] [Full Text] [PDF]  

Rudy Komdeur, Harald J. Hoekstra, Willemina M. Molenaar, Eva van den Berg, Nynke Zwart, Elisabeth Pras, Iwan Plaza-Menacho, Robert M. W. Hofstra, and Winette T. A. van der Graaf

Clinicopathologic Assessment of Postradiation Sarcomas: KIT as a Potential Treatment Target
Clin Cancer Res 2003 9: 2926-2932. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Jesika Faridi, Lihong Wang, Gerda Endemann, and Richard A. Roth

Expression of Constitutively Active Akt-3 in MCF-7 Breast Cancer Cells Reverses the Estrogen and Tamoxifen Responsivity of these Cells in Vivo
Clin Cancer Res 2003 9: 2933-2939. [Abstract] [Full Text] [PDF]  

Regular Articles:

   Clinical Trials:

Mark R. Gilbert, Jeffrey G. Supko, Tracy Batchelor, Glenn Lesser, Joy D. Fisher, Steven Piantadosi, and Stuart Grossman

Phase I Clinical and Pharmacokinetic Study of Irinotecan in Adults with Recurrent Malignant Glioma
Clin Cancer Res 2003 9: 2940-2949. [Abstract] [Full Text] [PDF]  

Carla M. van Herpen, Richard Huijbens, Maaike Looman, Jolanda de Vries, Henri Marres, Johanna van de Ven, Rob Hermsen, Gosse J. Adema, and Pieter H. De Mulder

Pharmacokinetics and Immunological Aspects of a Phase Ib Study with Intratumoral Administration of Recombinant Human Interleukin-12 in Patients with Head and Neck Squamous Cell Carcinoma: A Decrease of T-bet in Peripheral Blood Mononuclear Cells
Clin Cancer Res 2003 9: 2950-2956. [Abstract] [Full Text] [PDF]  

Albert J. ten Tije, Jaap Verweij, Alex Sparreboom, Ate van der Gaast, Camilla Fowst, Francesco Fiorentini, Jennifer Tursi, Alessandro Antonellini, Marijke Mantel, Carla M. Hartman, Gerrit Stoter, Andre S. T. Planting, and Maja J. A. de Jonge

Phase I and Pharmacokinetic Study of Brostallicin (PNU-166196), a New DNA Minor-Groove Binder, Administered Intravenously Every 3 Weeks to Adult Patients with Metastatic Cancer
Clin Cancer Res 2003 9: 2957-2964. [Abstract] [Full Text] [PDF]  

Bernard A. Zonnenberg, Gerard Groenewegen, Todd J. Janus, Terri W. Leahy, Rod A. Humerickhouse, Jeffrey D. Isaacson, Robert A. Carr, and Emile Voest

Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Atrasentan: An Endothelin Receptor Antagonist for Refractory Prostate Cancer
Clin Cancer Res 2003 9: 2965-2972. [Abstract] [Full Text] [PDF]  

Steven A. Rosenberg, James C. Yang, Douglas J. Schwartzentruber, Patrick Hwu, Suzanne L. Topalian, Richard M. Sherry, Nicholas P. Restifo, John R. Wunderlich, Claudia A. Seipp, Linda Rogers-Freezer, Kathleen E. Morton, Sharon A. Mavroukakis, Linda Gritz, Dennis L. Panicali, and Donald E. White

Recombinant Fowlpox Viruses Encoding the Anchor-modified gp100 Melanoma Antigen Can Generate Antitumor Immune Responses in Patients with Metastatic Melanoma
Clin Cancer Res 2003 9: 2973-2980. [Abstract] [Full Text] [PDF]  

   Molecular Oncology, Markers, Clinical Correlates:

Yoram Cohen, Gad Singer, Ofer Lavie, Seung Myung Dong, Uziel Beller, and David Sidransky

The RASSF1A Tumor Suppressor Gene Is Commonly Inactivated in Adenocarcinoma of the Uterine Cervix
Clin Cancer Res 2003 9: 2981-2984. [Abstract] [Full Text] [PDF]  

Athanassios Dellas, Joachim Torhorst, Reto Gaudenz, Michael J. Mihatsch, and Holger Moch

DNA Copy Number Changes in Cervical Adenocarcinoma
Clin Cancer Res 2003 9: 2985-2991. [Abstract] [Full Text] [PDF]  

Seiichi Hasegawa, Yasuo Miyoshi, Chiyomi Egawa, Makoto Ishitobi, Tetsuya Taguchi, Yasuhiro Tamaki, Morito Monden, and Shinzaburo Noguchi

Prediction of Response to Docetaxel by Quantitative Analysis of Class I and III ß-Tubulin Isotype mRNA Expression in Human Breast Cancers
Clin Cancer Res 2003 9: 2992-2997. [Abstract] [Full Text] [PDF]  

Hassan Ghaffar, Fikret Sahin, Montserrat Sanchez-Cepedes, Gloria H. Su, Marianna Zahurak, David Sidransky, and William H. Westra

LKB1 Protein Expression in the Evolution of Glandular Neoplasia of the Lung
Clin Cancer Res 2003 9: 2998-3003. [Abstract] [Full Text] [PDF]  

Nobuo Waguri, Takeshi Suda, Minoru Nomoto, Hirokazu Kawai, Yusaku Mita, Takashi Kuroiwa, Masato Igarashi, Makoto Kobayashi, Yasuo Fukuhara, and Yutaka Aoyagi

Sensitive and Specific Detection of Circulating Cancer Cells in Patients with Hepatocellular Carcinoma; Detection of Human Telomerase Reverse Transcriptase Messenger RNA after Immunomagnetic Separation
Clin Cancer Res 2003 9: 3004-3011. [Abstract] [Full Text] [PDF]  

Lisa J. Worrillow, Lois B. Travis, Alexandra G. Smith, Sara Rollinson, Andrew J. Smith, Christopher P. Wild, Eric J. Holowaty, Betsy A. Kohler, Tom Wiklund, Eero Pukkala, Eve Roman, Gareth J. Morgan, and James M. Allan

An Intron Splice Acceptor Polymorphism in hMSH2 and Risk of Leukemia after Treatment with Chemotherapeutic Alkylating Agents
Clin Cancer Res 2003 9: 3012-3020. [Abstract] [Full Text] [PDF]  

Hany Ezzeldin, Martin R. Johnson, Yoshihiro Okamoto, and Robert Diasio

Denaturing High Performance Liquid Chromatography Analysis of the DPYD Gene in Patients with Lethal 5-Fluorouracil Toxicity
Clin Cancer Res 2003 9: 3021-3028. [Abstract] [Full Text] [PDF]  

Weizhu Zhu, Wenyi Qin, Hormoz Ehya, John Lininger, and Edward Sauter

Microsatellite Changes in Nipple Aspirate Fluid and Breast Tissue from Women with Breast Carcinoma or Its Precursors
Clin Cancer Res 2003 9: 3029-3033. [Abstract] [Full Text] [PDF]  

Shinichi Toyooka, Kiyomi O. Toyooka, Kuniharu Miyajima, Jyotsna L. Reddy, Minoru Toyota, Ubradka G. Sathyanarayana, Asha Padar, Melvyn S. Tockman, Stephen Lam, Narayan Shivapurkar, and Adi F. Gazdar

Epigenetic Down-Regulation of Death-associated Protein Kinase in Lung Cancers
Clin Cancer Res 2003 9: 3034-3041. [Abstract] [Full Text] [PDF]  

Thian Sze Wong, Dora Lai-Wen Kwong, Jonathan Shun-Tong Sham, Sai Wah Tsao, William Ignace Wei, Yok Lam Kwong, and Anthony Po-Wing Yuen

Promoter Hypermethylation of High-in-normal 1 Gene in Primary Nasopharyngeal Carcinoma
Clin Cancer Res 2003 9: 3042-3046. [Abstract] [Full Text] [PDF]  

Christian Jakob, Ivana Zavrski, Ulrike Heider, Matthias Bollow, Carsten-Oliver Schulz, Claudia Fleissner, Jan Eucker, Rainer Michael, Bernd Hamm, Kurt Possinger, and Orhan Sezer

Serum Levels of Carboxy-terminal Telopeptide of Type-I Collagen Are Elevated in Patients with Multiple Myeloma Showing Skeletal Manifestations in Magnetic Resonance Imaging but Lacking Lytic Bone Lesions in Conventional Radiography
Clin Cancer Res 2003 9: 3047-3051. [Abstract] [Full Text] [PDF]  

Shigeru Kawabata, Mikio Oka, Hiroshi Soda, Ken Shiozawa, Katsumi Nakatomi, Junji Tsurutani, Yoichi Nakamura, Seiji Doi, Takeshi Kitazaki, Kazuyuki Sugahara, Yasuaki Yamada, Shimeru Kamihira, and Shigeru Kohno

Expression and Functional Analyses of Breast Cancer Resistance Protein in Lung Cancer
Clin Cancer Res 2003 9: 3052-3057. [Abstract] [Full Text] [PDF]  

Patrick K. Ha, Nicole E. Benoit, Robert Yochem, James Sciubba, Marianna Zahurak, David Sidransky, Jonathan Pevsner, William H. Westra, and Joseph Califano

A Transcriptional Progression Model for Head and Neck Cancer
Clin Cancer Res 2003 9: 3058-3064. [Abstract] [Full Text] [PDF]  

Wendy W. J. de Leng, Anne Marie Westerman, Marian A. J. Weterman, Felix W. M. de Rooij, Herman van Dekken, Anton F. P. M. de Goeij, Stephen B. Gruber, J. H. Paul Wilson, G. Johan A. Offerhaus, Francis M. Giardiello, and Josbert J. Keller

Cyclooxygenase 2 Expression and Molecular Alterations in Peutz-Jeghers Hamartomas and Carcinomas
Clin Cancer Res 2003 9: 3065-3072. [Abstract] [Full Text] [PDF]  

Bin Zhang, Andrei Ougolkov, Kaname Yamashita, Yutaka Takahashi, Masayoshi Mai, and Toshinari Minamoto

ß-Cateninand ras Oncogenes Detect Most Human Colorectal Cancer
Clin Cancer Res 2003 9: 3073-3079. [Abstract] [Full Text] [PDF]  

Sunil Singhal, Rainer Wiewrodt, Liliana D. Malden, Kunjlata M. Amin, Kimberly Matzie, Joseph Friedberg, John C. Kucharczuk, Leslie A. Litzky, Steven W. Johnson, Larry R. Kaiser, and Steven M. Albelda

Gene Expression Profiling of Malignant Mesothelioma
Clin Cancer Res 2003 9: 3080-3097. [Abstract] [Full Text] [PDF]  

   Experimental Therapeutics, Preclinical Pharmacology:

Clovis Antônio Pinto, Paulo Eduardo de Oliveira Carvalho, Leila Antonângelo, Ana Garippo, Alecsander Guillaumon Pereira da Silva, Fernando Soares, Riad Younes, Ricardo Beyruti, Teresa Takagaki, Paulo Saldiva, Robin T. Vollmer, and Vera Luiza Capelozzi

Morphometric Evaluation of Tumor Matrix Metalloproteinase 9 Predicts Survival after Surgical Resection of Adenocarcinoma of the Lung
Clin Cancer Res 2003 9: 3098-3104. [Abstract] [Full Text] [PDF]  

Brenda J. Weigel, David A. Rodeberg, Arthur M. Krieg, and Bruce R. Blazar

CpG Oligodeoxynucleotides Potentiate the Antitumor Effects of Chemotherapy or Tumor Resection in an Orthotopic Murine Model of Rhabdomyosarcoma
Clin Cancer Res 2003 9: 3105-3114. [Abstract] [Full Text] [PDF]  

Xin Chen, John A. Beutler, Thomas G. McCloud, Amy Loehfelm, Lu Yang, Hui-Fang Dong, Oleg Y. Chertov, Rosalba Salcedo, Joost J. Oppenheim, and O. M. Zack Howard

Tannic Acid Is an Inhibitor of CXCL12 (SDF-1)/CXCR4 with Antiangiogenic Activity
Clin Cancer Res 2003 9: 3115-3123. [Abstract] [Full Text] [PDF]  

Katarzyna Kozar, Rafal Kaminski, Tomasz Switaj, Tomasz Oldak, Eugeniusz Machaj, Piotr J. Wysocki, Andrzej Mackiewicz, Witold Lasek, Marek Jakóbisiak, and Jakub Golab

Interleukin 12-based Immunotherapy Improves the Antitumor Effectiveness of a Low-Dose 5-Aza-2'-Deoxycitidine Treatment in L1210 Leukemia and B16F10 Melanoma Models in Mice
Clin Cancer Res 2003 9: 3124-3133. [Abstract] [Full Text] [PDF]  

Jin H. Kim, Mubasshir Ajaz, Anna Lokshin, and Yong J. Lee

Role of Antiapoptotic Proteins in Tumor Necrosis Factor-related Apoptosis-inducing Ligand and Cisplatin-augmented Apoptosis
Clin Cancer Res 2003 9: 3134-3141. [Abstract] [Full Text] [PDF]  

Joachim Köchling, Sven A. König-Merediz, Renata Stripecke, Dirk Buchwald, Alexander Korte, Hagen G. von Einsiedel, Florian Sack, Günter Henze, Karl Seeger, Burghardt Wittig, and Manuel Schmidt

Protection of Mice against Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia by Cell-based Vaccination Using Nonviral, Minimalistic Expression Vectors and Immunomodulatory Oligonucleotides
Clin Cancer Res 2003 9: 3142-3149. [Abstract] [Full Text] [PDF]  

Sanjeewani T. Palayoor, Philip J. Tofilon, and C. Norman Coleman

Ibuprofen-mediated Reduction of Hypoxia-inducible Factors HIF-1 and HIF-2 in Prostate Cancer Cells
Clin Cancer Res 2003 9: 3150-3157. [Abstract] [Full Text] [PDF]  

Tatsuya Manabe, Kazuhiro Mizumoto, Eishi Nagai, Kunio Matsumoto, Toshikazu Nakamura, Toshihiro Nukiwa, Masao Tanaka, and Takehisa Matsuda

Cell-based Protein Delivery System for the Inhibition of the Growth of Pancreatic Cancer: NK4 Gene-transduced Oral Mucosal Epithelial Cell Sheet
Clin Cancer Res 2003 9: 3158-3166. [Abstract] [Full Text] [PDF]  

Badar M. Mian, Colin P. N. Dinney, Carlos E. Bermejo, Paul Sweeney, Carmen Tellez, X. D. Yang, Jean M. Gudas, David J. McConkey, and Menashe Bar-Eli

Fully Human Anti-Interleukin 8 Antibody Inhibits Tumor Growth in Orthotopic Bladder Cancer Xenografts via Down-Regulation of Matrix Metalloproteases and Nuclear Factor-B
Clin Cancer Res 2003 9: 3167-3175. [Abstract] [Full Text] [PDF]  

Vaqar Mustafa Adhami, Moammir Hasan Aziz, Hasan Mukhtar, and Nihal Ahmad

Activation of Prodeath Bcl-2 Family Proteins and Mitochondrial Apoptosis Pathway by Sanguinarine in Immortalized Human HaCaT Keratinocytes
Clin Cancer Res 2003 9: 3176-3182. [Abstract] [Full Text] [PDF]  

F. Christopher Holsinger, Dao D. Doan, Samar A. Jasser, Eric A. Swan, Jayson S. Greenberg, Bradley A. Schiff, B. Nebiyou Bekele, Maher N. Younes, Corazon D. Bucana, Isaiah J. Fidler, and Jeffrey N. Myers

Epidermal Growth Factor Receptor Blockade Potentiates Apoptosis Mediated by Paclitaxel and Leads to Prolonged Survival in a Murine Model of Oral Cancer
Clin Cancer Res 2003 9: 3183-3189. [Abstract] [Full Text] [PDF]  

Igor Entin, Alex Plotnikov, Rafi Korenstein, and Yona Keisari

Tumor Growth Retardation, Cure, and Induction of Antitumor Immunity in B16 Melanoma-bearing Mice by Low Electric Field-enhanced Chemotherapy
Clin Cancer Res 2003 9: 3190-3197. [Abstract] [Full Text] [PDF]  

Zhibo Yang, Rozita Bagheri-Yarmand, Seetharaman Balasenthil, Gabriel Hortobagyi, Aysegul A. Sahin, Christopher J. Barnes, and Rakesh Kumar

HER2 Regulation of Peroxisome Proliferator-activated Receptor (PPAR) Expression and Sensitivity of Breast Cancer Cells to PPAR Ligand Therapy
Clin Cancer Res 2003 9: 3198-3203. [Abstract] [Full Text] [PDF]  

V. Ashutosh Rao and William Plunkett

Activation of a p53-mediated Apoptotic Pathway in Quiescent Lymphocytes after the Inhibition of DNA Repair by Fludarabine
Clin Cancer Res 2003 9: 3204-3212. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Laith Dabbagh, Robert W. Coupland, Carol E. Cass, and John R. Mackey

Correspondence Re: J. R. Mackey et al., Immunohistochemical Variation of Human Equilibrative Nucleoside Transporter 1 Protein in Primary Breast Cancers. Clin. Cancer Res., 8: 110ndash;116, 2002.
Clin Cancer Res 2003 9: 3213-3214. [Full Text] [PDF]  

Daniele Santini, Bruno Vincenzi, Giuseppe Tonini, Susanna Scarpa, and Alfonso Baldi

Correspondence Re: E. Corey et al., Zoledronic Acid Exhibits Inhibitory Effects on Osteoblastic and Osteolytic Metastases of Prostate Cancer. Clin. Cancer Res., 9: 295ndash;306, 2003.
Clin Cancer Res 2003 9: 3215. [Full Text] [PDF]  

Eva Corey and Celestia S. Higano

Reply
Clin Cancer Res 2003 9: 3216. [Full Text] [PDF]  

Corrections:

Correction for vol. 9, p. 1112
Clin Cancer Res 2003 9: 3217. [Full Text] [PDF]  

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