Molecular Pathways:

Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non–Small Cell Lung Cancer

Jeffrey A. Engelman and Pasi A. Jänne
Clin Cancer Res 2008 14: 2895-2899 doi: 10.1158/1078-0432.CCR-07-2248 [Abstract] [Full Text] [PDF]  

Review:

Mechanisms of Chemoresistance to Alkylating Agents in Malignant Glioma

Jann N. Sarkaria, Gaspar J. Kitange, C. David James, Ruth Plummer, Hilary Calvert, Michael Weller, and Wolfgang Wick
Clin Cancer Res 2008 14: 2900-2908 doi: 10.1158/1078-0432.CCR-07-1719 [Abstract] [Full Text] [PDF]  

Human Cancer Biology:

Helicobacter pylori Augments Growth of Gastric Cancers via the Lipopolysaccharide-Toll-like Receptor 4 Pathway whereas Its Lipopolysaccharide Attenuates Antitumor Activities of Human Mononuclear Cells

Kentaro Chochi, Takashi Ichikura, Manabu Kinoshita, Takashi Majima, Nariyoshi Shinomiya, Hironori Tsujimoto, Toshinobu Kawabata, Hidekazu Sugasawa, Satoshi Ono, Shuhji Seki, and Hidetaka Mochizuki
Clin Cancer Res 2008 14: 2909-2917 doi: 10.1158/1078-0432.CCR-07-4467 [Abstract] [Full Text] [PDF]  

Epigenetic Silencing of the Tetraspanin CD9 during Disease Progression in Multiple Myeloma Cells and Correlation with Survival

Elke De Bruyne, Tomas Jan Bos, Kewal Asosingh, Isabelle Vande Broek, Eline Menu, Els Van Valckenborgh, Peter Atadja, Valérie Coiteux, Xavier Leleu, Kris Thielemans, Ben Van Camp, Karin Vanderkerken, and Ivan Van Riet
Clin Cancer Res 2008 14: 2918-2926 doi: 10.1158/1078-0432.CCR-07-4489 [Abstract] [Full Text] [PDF]  

Detection of Copy Number Alterations in Metastatic Melanoma by a DNA Fluorescence In situ Hybridization Probe Panel and Array Comparative Genomic Hybridization: A Southwest Oncology Group Study (S9431)

Stephen R. Moore, Diane L. Persons, Jeffrey A. Sosman, Dolores Bobadilla, Victoria Bedell, David D. Smith, Sandra R. Wolman, Ralph J. Tuthill, Jim Moon, Vernon K. Sondak, and Marilyn L. Slovak
Clin Cancer Res 2008 14: 2927-2935 doi: 10.1158/1078-0432.CCR-07-4068 [Abstract] [Full Text] [PDF]  

Divergent Effects of Castration on Prostate Cancer in TRAMP Mice: Possible Implications for Therapy

Yao Tang, Linbo Wang, Olga Goloubeva, Mohammad Afnan Khan, Bin Zhang, and Arif Hussain
Clin Cancer Res 2008 14: 2936-2943 doi: 10.1158/1078-0432.CCR-07-4925 [Abstract] [Full Text] [PDF]  

Gene Expression Profiles Associated with the Presence of a Fibrotic Focus and the Growth Pattern in Lymph Node–Negative Breast Cancer

Gert G. Van den Eynden, Marcel Smid, Steven J. Van Laere, Cecile G. Colpaert, Ilse Van der Auwera, Trinh Xuan Bich, Peter van Dam, Michael A. den Bakker, Luc Y. Dirix, Eric A. Van Marck, Peter B. Vermeulen, and John A. Foekens
Clin Cancer Res 2008 14: 2944-2952 doi: 10.1158/1078-0432.CCR-07-4397 [Abstract] [Full Text] [PDF]  

Loss of Heterozygosity at the BRCA2 Locus Detected by Multiplex Ligation-Dependent Probe Amplification is Common in Prostate Cancers from Men with a Germline BRCA2 Mutation

Amber J. Willems, Sarah-Jane Dawson, Hema Samaratunga, Alessandro De Luca, Yoland C. Antill, John L. Hopper, Heather J. Thorne, and and kConFab Investigators
Clin Cancer Res 2008 14: 2953-2961 Published Online First April 29, 2008. doi: 10.1158/1078-0432.CCR-07-5237 [Abstract] [Full Text] [PDF]  

Critical Role of Notch Signaling in Osteosarcoma Invasion and Metastasis

Pingyu Zhang, Yanwen Yang, Patrick A. Zweidler-McKay, and Dennis P.M. Hughes
Clin Cancer Res 2008 14: 2962-2969 doi: 10.1158/1078-0432.CCR-07-1992 [Abstract] [Full Text] [PDF]  

Imaging, Diagnosis, Prognosis:

Imaging Bone and Soft Tissue Tumors with the Proliferation Marker [¹⁸F]Fluorodeoxythymidine

Andreas K. Buck, Ken Herrmann, Christian Meyer zum Büschenfelde, Malik E. Juweid, Mark Bischoff, Gerhard Glatting, Gregor Weirich, Peter Möller, Hans-Jürgen Wester, Klemens Scheidhauer, Tobias Dechow, Christian Peschel, Markus Schwaiger, and Sven N. Reske
Clin Cancer Res 2008 14: 2970-2977 Published Online First April 29, 2008. doi: 10.1158/1078-0432.CCR-07-4294 [Abstract] [Full Text] [PDF]  

Novel Glioblastoma Markers with Diagnostic and Prognostic Value Identified through Transcriptome Analysis

Sreekanth P. Reddy, Ramona Britto, Katyayni Vinnakota, Hebbar Aparna, Hari Kishore Sreepathi, Balaram Thota, Arpana Kumari, B.M. Shilpa, M. Vrinda, Srikantha Umesh, Cini Samuel, Mitesh Shetty, Ashwani Tandon, Paritosh Pandey, Sridevi Hegde, A.S. Hegde, Anandh Balasubramaniam, B.A. Chandramouli, Vani Santosh, Paturu Kondaiah, Kumaravel Somasundaram, and M.R. Satyanarayana Rao
Clin Cancer Res 2008 14: 2978-2987 doi: 10.1158/1078-0432.CCR-07-4821 [Abstract] [Full Text] [PDF]  

Analysis of the MammaPrint Breast Cancer Assay in a Predominantly Postmenopausal Cohort

Ben S. Wittner, Dennis C. Sgroi, Paula D. Ryan, Tako J. Bruinsma, Annuska M. Glas, Anitha Male, Sonika Dahiya, Karleen Habin, Rene Bernards, Daniel A. Haber, Laura J. Van't Veer, and Sridhar Ramaswamy
Clin Cancer Res 2008 14: 2988-2993 doi: 10.1158/1078-0432.CCR-07-4723 [Abstract] [Full Text] [PDF]  

Inverse Association between Raf Kinase Inhibitory Protein and Signal Transducers and Activators of Transcription 3 Expression in Gastric Adenocarcinoma Patients: Implications for Clinical Outcome

Devasis Chatterjee, Edmond Sabo, Rosemarie Tavares, and Murray B. Resnick
Clin Cancer Res 2008 14: 2994-3001 doi: 10.1158/1078-0432.CCR-07-4496 [Abstract] [Full Text] [PDF]  

Translocations Involving the Immunoglobulin Heavy Chain Gene Locus Predict Better Survival in Gastric Diffuse Large B-Cell Lymphoma

Shotaro Nakamura, Hongtao Ye, Chris M. Bacon, Alison Goatly, Hongxiang Liu, Lucy Kerr, Alison H. Banham, Berthold Streubel, Takashi Yao, Masazumi Tsuneyoshi, Antonella Savio, Morishige Takeshita, Peggy Dartigues, Agnès Ruskoné-Fourmestraux, Takayuki Matsumoto, Mitsuo Iida, and Ming-Qing Du
Clin Cancer Res 2008 14: 3002-3010 Published Online First April 29, 2008. doi: 10.1158/1078-0432.CCR-07-4946 [Abstract] [Full Text] [PDF]  

Bcl-B Expression in Human Epithelial and Nonepithelial Malignancies

Maryla Krajewska, Shinichi Kitada, Jane N. Winter, Daina Variakojis, Alan Lichtenstein, Dayong Zhai, Michael Cuddy, Xianshu Huang, Frederic Luciano, Cheryl H. Baker, Hoguen Kim, Eunah Shin, Susan Kennedy, Allen H. Olson, Andrzej Badzio, Jacek Jassem, Ivo Meinhold-Heerlein, Michael J. Duffy, Aaron D. Schimmer, Ming Tsao, Ewan Brown, Anne Sawyers, Michael Andreeff, Dan Mercola, Stan Krajewski, and John C. Reed
Clin Cancer Res 2008 14: 3011-3021 doi: 10.1158/1078-0432.CCR-07-1955 [Abstract] [Full Text] [PDF]  

Impact of Insulin-Like Growth Factor Type 1 Receptor, Epidermal Growth Factor Receptor, and HER2 Expressions on Outcomes of Patients with Gastric Cancer

Junichi Matsubara, Yasuhide Yamada, Yoshinori Hirashima, Daisuke Takahari, Natsuko T. Okita, Ken Kato, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, and Tadakazu Shimoda
Clin Cancer Res 2008 14: 3022-3029 doi: 10.1158/1078-0432.CCR-07-1898 [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor Expression in Ovarian Cancer: A Model for Targeted Use of Novel Therapies?

Timothy J. Duncan, Ahmad Al-Attar, Phil Rolland, Ian V. Scott, Suha Deen, David T.Y. Liu, Ian Spendlove, and Lindy G. Durrant
Clin Cancer Res 2008 14: 3030-3035 doi: 10.1158/1078-0432.CCR-07-1888 [Abstract] [Full Text] [PDF]  

N-[N-[(S)-1,3-Dicarboxypropyl]Carbamoyl]-4-[¹⁸F]Fluorobenzyl-L-Cysteine, [¹⁸F]DCFBC: A New Imaging Probe for Prostate Cancer

Ronnie C. Mease, Crystal L. Dusich, Catherine A. Foss, Hayden T. Ravert, Robert F. Dannals, Jurgen Seidel, Andrew Prideaux, James J. Fox, George Sgouros, Alan P. Kozikowski, and Martin G. Pomper
Clin Cancer Res 2008 14: 3036-3043 doi: 10.1158/1078-0432.CCR-07-1517 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Clinical:

Phase I Safety and Pharmacokinetic Study of CT-011, a Humanized Antibody Interacting with PD-1, in Patients with Advanced Hematologic Malignancies

Raanan Berger, Rinat Rotem-Yehudar, Gideon Slama, Shimon Landes, Abraham Kneller, Merav Leiba, Maya Koren-Michowitz, Avichai Shimoni, and Arnon Nagler
Clin Cancer Res 2008 14: 3044-3051 doi: 10.1158/1078-0432.CCR-07-4079 [Abstract] [Full Text] [PDF]  

Clinical and Biological Effects of Neoadjuvant Sargramostim and Thalidomide in Patients with Locally Advanced Prostate Carcinoma

Jorge A. Garcia, Eric A. Klein, Cristina Magi-Galluzzi, Paul Elson, Pierre Triozzi, and Robert Dreicer
Clin Cancer Res 2008 14: 3052-3059 doi: 10.1158/1078-0432.CCR-07-4731 [Abstract] [Full Text] [PDF]  

Pilot Study of Vaccination with Recombinant CEA-MUC-1-TRICOM Poxviral-Based Vaccines in Patients with Metastatic Carcinoma

James L. Gulley, Philip M. Arlen, Kwong-Yok Tsang, Junko Yokokawa, Claudia Palena, Diane J. Poole, Cinzia Remondo, Vittore Cereda, Jacquin L. Jones, Mary P. Pazdur, Jack P. Higgins, James W. Hodge, Seth M. Steinberg, Herbert Kotz, William L. Dahut, and Jeffrey Schlom
Clin Cancer Res 2008 14: 3060-3069 doi: 10.1158/1078-0432.CCR-08-0126 [Abstract] [Full Text] [PDF]  

Tamoxifen and Aromatase Inhibitors Differentially Affect Vascular Endothelial Growth Factor and Endostatin Levels in Women with Breast Cancer

Chris E. Holmes, Joe C. Huang, Thomas R. Pace, Alan B. Howard, and Hyman B. Muss
Clin Cancer Res 2008 14: 3070-3076 doi: 10.1158/1078-0432.CCR-07-4640 [Abstract] [Full Text] [PDF]  

Phase II Trial of Tipifarnib as Maintenance Therapy in First Complete Remission in Adults with Acute Myelogenous Leukemia and Poor-Risk Features

Judith E. Karp, B. Douglas Smith, Ivana Gojo, Jeffrey E. Lancet, Jacqueline Greer, Maureen Klein, Larry Morris, Mark J. Levis, Steven D. Gore, John J. Wright, and Elizabeth Garrett-Mayer
Clin Cancer Res 2008 14: 3077-3082 doi: 10.1158/1078-0432.CCR-07-4743 [Abstract] [Full Text] [PDF]  

Efficacy of Gemcitabine in Patients with Non–Small Cell Lung Cancer According to Promoter Polymorphisms of the Ribonucleotide Reductase M1 Gene

Soo-Ok Kim, Ju-Yeon Jeong, Mi-Ran Kim, Hyun-Ju Cho, Jin-Yung Ju, Yong-Soo Kwon, In-Jae Oh, Kyu-Sik Kim, Yu-Il Kim, Sung-Chul Lim, and Young-Chul Kim
Clin Cancer Res 2008 14: 3083-3088 doi: 10.1158/1078-0432.CCR-07-4591 [Abstract] [Full Text] [PDF]  

Phase I Study and Preliminary Pharmacology of the Novel Innate Immune Modulator rBBX-01 in Gynecologic Cancers

Janet S. Rader, Charles F. Aylsworth, David A. Juckett, David G. Mutch, Matthew A. Powell, Lynne Lippmann, and Nikolay V. Dimitrov
Clin Cancer Res 2008 14: 3089-3097 doi: 10.1158/1078-0432.CCR-07-4250 [Abstract] [Full Text] [PDF]  

Postoperative Adjuvant Dendritic Cell–Based Immunotherapy in Patients with Relapsed Glioblastoma Multiforme

Steven De Vleeschouwer, Steffen Fieuws, Stefan Rutkowski, Frank Van Calenbergh, Johannes Van Loon, Jan Goffin, Raf Sciot, Guido Wilms, Philippe Demaerel, Monika Warmuth-Metz, Niels Soerensen, Johannes E.A. Wolff, Sabine Wagner, Eckhart Kaempgen, and Stefaan W. Van Gool
Clin Cancer Res 2008 14: 3098-3104 doi: 10.1158/1078-0432.CCR-07-4875 [Abstract] [Full Text] [PDF]  

Phase I Clinical and Pharmacokinetic Study of Plitidepsin as a 1-Hour Weekly Intravenous Infusion in Patients with Advanced Solid Tumors

Miguel A. Izquierdo, Angela Bowman, Margarita García, Duncan Jodrell, Marisa Martinez, Beatriz Pardo, Javier Gómez, José A. López-Martin, José Jimeno, José R. Germá, and John F. Smyth
Clin Cancer Res 2008 14: 3105-3112 doi: 10.1158/1078-0432.CCR-07-1652 [Abstract] [Full Text] [PDF]  

Cancer Therapy: Preclinical:

Evaluation of the In vitro and In vivo Antitumor Activity of Histone Deacetylase Inhibitors for the Therapy of Retinoblastoma

Clifton Lee Dalgard, Kurtis R. Van Quill, and Joan M. O'Brien
Clin Cancer Res 2008 14: 3113-3123 doi: 10.1158/1078-0432.CCR-07-4836 [Abstract] [Full Text] [PDF]  

Inhibition of Vascular Endothelial Growth Factor-A Signaling Induces Hypertension: Examining the Effect of Cediranib (Recentin; AZD2171) Treatment on Blood Pressure in Rat and the Use of Concomitant Antihypertensive Therapy

Jon O. Curwen, Helen L. Musgrove, Jane Kendrew, Graham H.P. Richmond, Donald J. Ogilvie, and Stephen R. Wedge
Clin Cancer Res 2008 14: 3124-3131 doi: 10.1158/1078-0432.CCR-07-4783 [Abstract] [Full Text] [PDF]  

Histone Deacetylase Inhibition and Blockade of the Glycolytic Pathway Synergistically Induce Glioblastoma Cell Death

Vivian Egler, Serdar Korur, Mike Failly, Jean-Louis Boulay, Roland Imber, Maria M. Lino, and Adrian Merlo
Clin Cancer Res 2008 14: 3132-3140 doi: 10.1158/1078-0432.CCR-07-4182 [Abstract] [Full Text] [PDF]  

Interaction of Imatinib with Human Organic Ion Carriers

Shuiying Hu, Ryan M. Franke, Kelly K. Filipski, Chaoxin Hu, Shelley J. Orwick, Ernst A. de Bruijn, Herman Burger, Sharyn D. Baker, and Alex Sparreboom
Clin Cancer Res 2008 14: 3141-3148 doi: 10.1158/1078-0432.CCR-07-4913 [Abstract] [Full Text] [PDF]  

A BTB/POZ Gene, NAC-1, a Tumor Recurrence–Associated Gene, as a Potential Target for Taxol Resistance in Ovarian Cancer

Masako Ishibashi, Kentaro Nakayama, Shamima Yeasmin, Atsuko Katagiri, Kouji Iida, Naomi Nakayama, Manabu Fukumoto, and Kohji Miyazaki
Clin Cancer Res 2008 14: 3149-3155 doi: 10.1158/1078-0432.CCR-07-4358 [Abstract] [Full Text] [PDF]  

Homeostatic Proliferation Plus Regulatory T-Cell Depletion Promotes Potent Rejection of B16 Melanoma

Justin Kline, Ian E. Brown, Yuan-Yuan Zha, Christian Blank, John Strickler, Harald Wouters, Long Zhang, and Thomas F. Gajewski
Clin Cancer Res 2008 14: 3156-3167 doi: 10.1158/1078-0432.CCR-07-4696 [Abstract] [Full Text] [PDF]  

Aspirin Sensitizes Cancer Cells to TRAIL–Induced Apoptosis by Reducing Survivin Levels

Meiling Lu, Anne Strohecker, Feng Chen, Toni Kwan, Joshua Bosman, V. Craig Jordan, and Vincent L. Cryns
Clin Cancer Res 2008 14: 3168-3176 doi: 10.1158/1078-0432.CCR-07-4362 [Abstract] [Full Text] [PDF]  

Chemopreventive Efficacy of Inositol Hexaphosphate against Prostate Tumor Growth and Progression in TRAMP Mice

Komal Raina, Subapriya Rajamanickam, Rana P. Singh, and Rajesh Agarwal
Clin Cancer Res 2008 14: 3177-3184 doi: 10.1158/1078-0432.CCR-07-5275 [Abstract] [Full Text] [PDF]  

Pretreatment with Cisplatin Enhances E7-Specific CD8⁺ T-Cell–Mediated Antitumor Immunity Induced by DNA Vaccination

Chih-Wen Tseng, Chien-Fu Hung, Ronald D. Alvarez, Cornelia Trimble, Warner K. Huh, Daejin Kim, Chi-Mu Chuang, Cheng-Tao Lin, Ya-Chea Tsai, Liangmei He, Archana Monie, and T-C. Wu
Clin Cancer Res 2008 14: 3185-3192 doi: 10.1158/1078-0432.CCR-08-0037 [Abstract] [Full Text] [PDF]  

Modulation of Drug Resistance in Ovarian Adenocarcinoma by Enhancing Intracellular Ceramide Using Tamoxifen-Loaded Biodegradable Polymeric Nanoparticles

Harikrishna Devalapally, Zhenfeng Duan, Michael V. Seiden, and Mansoor M. Amiji
Clin Cancer Res 2008 14: 3193-3203 doi: 10.1158/1078-0432.CCR-07-4973 [Abstract] [Full Text] [PDF]  

Molecular Characterization of Pediatric Gastrointestinal Stromal Tumors

Narasimhan P. Agaram, Michael P. Laquaglia, Berrin Ustun, Tianhua Guo, Grace C. Wong, Nicholas D. Socci, Robert G. Maki, Ronald P. DeMatteo, Peter Besmer, and Cristina R. Antonescu
Clin Cancer Res 2008 14: 3204-3215 doi: 10.1158/1078-0432.CCR-07-1984 [Abstract] [Full Text] [PDF]  

Cancer Prevention and Susceptibility:

A Functional Epidermal Growth Factor (EGF) Polymorphism, EGF Serum Levels, and Esophageal Adenocarcinoma Risk and Outcome

Michael Lanuti, Geoffrey Liu, Jonathan M. Goodwin, Rihong Zhai, Bryan C. Fuchs, Kofi Asomaning, Li Su, Norman S. Nishioka, Kenneth K. Tanabe, and David C. Christiani
Clin Cancer Res 2008 14: 3216-3222 doi: 10.1158/1078-0432.CCR-07-4932 [Abstract] [Full Text] [PDF]  

VDR and SRD5A2 Polymorphisms Combine to Increase Risk for Prostate Cancer in Both Non–Hispanic White and Hispanic White Men

Kathleen C. Torkko, Adrie van Bokhoven, Phoung Mai, Joke Beuten, Ivana Balic, Tim E. Byers, John E. Hokanson, Jill M. Norris, Anna E. Barón, M. Scott Lucia, Ian M. Thompson, and Robin J. Leach
Clin Cancer Res 2008 14: 3223-3229 doi: 10.1158/1078-0432.CCR-07-4894 [Abstract] [Full Text] [PDF]  

Functional Variants in Cell Death Pathway Genes and Risk of Pancreatic Cancer

Ming Yang, Tong Sun, Li Wang, Dianke Yu, Xuemei Zhang, Xiaoping Miao, Junniao Liu, Dan Zhao, Hui Li, Wen Tan, and Dongxin Lin
Clin Cancer Res 2008 14: 3230-3236 doi: 10.1158/1078-0432.CCR-08-0177 [Abstract] [Full Text] [PDF]  

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