Table 2

Comparison of early clinical experience with antiestrogens as a treatment for advanced breast cancer

AntiestrogenDaily doseYearResponse rateToxicity
Ethamoxytriphetol500–4500 mg196025%Acute psychotic episodes
Clomiphene100–300 mg1964–197434%Fear of cataracts
Nafoxidine180–240 mg197631%Cataracts, ichthyosis, photophobia
Tamoxifen 20–40 mg1971–197331%Transient thrombocytopeniaa
  • a “The particular advantage of this drug is the low incidence of troublesome side effects (25)” . “Side effects were usually trivial (26)” .