Table 3

Summary of nadir body temperature measurements after treatment of PARP-1 wild-type and knockout mice with selected PARP-1 inhibitors

Body temperature measured at 25-min intervals for the first 5 h and 60-min intervals thereafter i.p. administration of PARP-1 inhibitor at doses presented as both mg/kg and {mol/kg}. Representative data for TI3 and PD128763 are shown in Fig. 5<$REFLINK> . Temperatures are presented as mean ± SD (n = 3 animals per group).

CompoundDose (mg/kg) {μmols/kg}Nadir body temp (°C) (mean ± SD)Nadir time (min)
+/+−/−+/+−/−
Control37 ± 137 ± 1
PD12876325 {155}32 ± 131 ± 1120120
50 {310}27 ± 228 ± 1120120
TI150 {190}33 ± 134 ± 12020
100 {380}30 ± 130 ± 15050
TI350 {178}36 ± 135 ± 25025
TI4100 {312}34 ± 133 ± 12525