Table 2.

Multivariate analysis of survival by independent predictors, including the RMH score variables (LDH, number of metastatic sites >2, and albumin) individually and then by including the RMH score by itself as a single variable

Risk factorsRR for death (95% CI)P
Albumin < 3.5 g/dLa1.66 (1.34–2.05)<0.0001
Number of metastatic sites > 2a1.34 (1.16–1.55)0.0001
LDH > 618 IU/La,b1.78 (1.53–2.06)<0.0001
Gastrointestinal tumor type1.55 (1.34–1.80)<0.0001
ECOG PS ≥ 11.32 (1.13–1.55)0.0004
Platelets > 440 K/UL1.35 (1.10–1.67)0.0047
Number of prior therapies ≥ 31.33 (1.13–1.57)0.0007
RMH score as single variable
 RMH score > 11.97 (1.67–2.32)<0.0001
 Gastrointestinal tumor type1.65 (1.43–1.92)<0.0001
 ECOG PS ≥ 11.33 (1.13–1.55)0.0004
 Platelet > 440 K/UL1.43 (1.16–1.76)0.0008
 Number of prior therapies ≥ 31.43 (1.21–1.68)<0.0001

Abbreviations: PS, performance status; RR, relative risk.

  • aVariables included in the RMH score.

  • b618 IU/L is the ULN for LDH at MDACC.