Table 2.

Associations of tumor infiltrating T lymphocytes with patient and tumor characteristics

CD3+ cellsCD8+ cellsCD4+ cellsFoxP3+ cells
CharacteristicN (%)Median (range)Pn (%)Median (range)Pn (%)Median (range)Pn (%)Median (range)P
Gender
 Female81 (69.8)4.7 (0–65.0)68 (70.8)2.7 (0–18.0)65 (72.2)3.7 (0–25.0)68 (70.1)1.7 (0–64.0)
 Male35 (30.2)4.0 (0–32.3)0.11328 (29.2)3.2 (0–14.0)0.71625 (27.8)3.3 (0–10.0)0.35729 (29.9)1.3 (0–9.0)0.311
Age at diagnosis
 ≤79 y57 (49.1)4.3 (0–65.0)48 (50.0)2.5 (0–15.0)46 (51.1)3.5 (0–25.0)49 (50.5)1.7 (0–60.0)
Median
 >79 y59 (50.9)4.7 (0–61.7)0.64848 (50.0)3.7 (0–18.0)0.88044 (48.9)3.3 (0–11.0)0.29348 (49.5)1.3 (0–64.0)0.859
Stage
 I or II101 (87.1)5.3 (0–65.0)84 (87.5)3.2 (0–18.0)80 (88.9)3.5 (0–25.0)85 (87.6)1.7 (0–64.0)
 III or IV15 (12.9)2.3 (0–7.3)0.00612 (12.5)2.2 (0–10.7)0.27310 (11.1)2.7 (0–5.7)0.19512 (12.4)1.3 (0–63.0)0.974
Diameter
 ≤16 mm60 (51.7)4.3 (0–61.7)43 (44.8)2.3 (0–15.3)40 (44.4)2.5 (0–10.3)44 (45.4)1.3 (0–30.0)
Median
 >16 mm56 (48.3)5.3 (0–65.0)0.69553 (55.2)4.3 (0–18.0)0.03150 (55.6)3.9 (0–25.0)0.05253 (54.6)2.3 (0–64.0)0.024
MCPyV DNA
 Present85 (73.3)5.3 (0–65.0)69 (71.9)3.7 (0–18.0)65 (72.2)3.7 (0–15.0)70 (72.2)2.0 (0–63.3)
 Not present31 (26.7)3.3 (0.3–61.7)0.01427 (28.1)2.3 (0–14.0)0.04825 (27.8)2.7 (0–8.3)0.09427 (27.8)1.3 (0–64.0)0.037
MCPyV LTA expression
 Yes78 (67.2)5.9 (0–65.0)64 (66.7)3.5 (0–18.0)62 (68.9)3.9 (0–25.0)65 (67.0)2.0 (0–64.0)
 No38 (32.8)2.7 (0–62.7)<0.00132 (33.3)2.2 (0–14.0)0.04128 (31.1)2.3 (0–8.3)0.00832 (33.0)1.3 (0–63.3)0.006
p53 expression
 Yes17 (16.7)2.0 (0–9.7)16 (19.0)1.0 (0–7.7)15 (18.5)2.7 (0–8.3)16 (18.8)1.0 (0–64.0)
 No85 (83.3)5.3 (0–65.0)<0.00168 (81.0)3.5 (0–18.0)0.00266 (81.5)3.7 (0–25.0)0.32269 (81.2)2.0 (0–63.3)0.024
 N.A.1412912
RB expression
 Yes74 (69.8)5.5 (0–65.0)63 (70.8)3.3 (0–18.0)62 (72.1)4.0 (0–25.0)64 (71.1)2.0 (0–64.0)
 No32 (30.2)3.5 (0–61.7)0.01226 (29.2)2.2 (0–14.0)0.09924 (27.9)2.2 (0–8.3)0.00426 (28.9)1.3 (0–63.3)0.022
 N.A.10747
Cyclin E expression
 Yes86 (91.5)5.3 (0–61.7)74 (93.7)3.2 (0–18.0)72 (94.7)3.5 (0–25.0)75 (93.8)1.7 (0–64.0)
 No8 (8.5)2.7 (0–31.0)0.2105 (6.3)0.5 (0–6.7)0.0554 (5.3)3.2 (0–6.7)0.6095 (6.3)1.0 (0–3.7)0.170
 N.A.22171417
p27 expression
 Yes69 (69.7)6.0 (0–61.7)61 (72.6)3.8 (0–18.0)60 (74.1)4.0 (0–25.0)62 (72.9)1.9 (0–64.0)
 No30 (30.3)3.9 (0–18.0)0.03023 (27.4)2.3 (0–10.7)0.02221 (25.9)3.3 (0–6.7)0.05123 (27.1)1.3 (0–63.3)0.395
 N.A.1712912

Abbreviation: N.A., not available.

Associations with tumor site (head and neck region vs. trunk vs. limb), phospho-RB expression (positive vs. negative), Ki-67 expression (≤ median [56%] vs. > median), cyclin D1 expression (positive vs. negative), and p21 expression (positive vs. negative) are not shown (P > 0.10 for each comparison).