Table 3.

Univariate and multivariate logistic regression analyses with restricted cubic spline functions with 3 knots predicting low-, intermediate-, and high-risk class prostate cancer [OR; P (95% CI)] among the whole cohort of patients

Low-riskIntermediate-riskHigh-risk
UVA modelMVA modelsUVA modelMVA modelsUVA modelMVA models
PredictorModel 1Model 2Model 1Model 2Model 1Model 2
Age, y0.98; 0.02 (0.96–1.00)0.98; 0.08 (0.96–1.00)0.98; 0.11 (0.96–1.00]0.99; 0.92 (0.98–1.02)1.00; 0.96 (0.98–1.02)1.00; 0.99 (0.79–1.02)1.04; 0.006 (1.01–1.06)1.03; 0.03 (1.00–1.06)1.03; 0.06 (0.99–1.05)
BMI, kg/m21.00; 1.00 (0.95–1.05)1.01; 0.84 (0.95–1.06)1.01; 0.69 (0.57 1.64)1.02; 0.51 (0.97–1.06)1.01; 0.54 (0.97–1.07)1.02; 0.47 (0.43–1.07)0.98; 0.43 (0.92–1.03)0.97; 0.29 (0.91–1.03)0.96; 0.23 (0.91–1.02)
tT—; <0.001—; <0.001—; 0.12—; 0.89—; <0.001—; <0.001
 >10th–<90th vs. 10th percentile1.67; <0.001 (1.37–2.04)1.59; <0.001 (1.25–2.01)1.15; 0.07 (0.99–1.34)1.04; 0.68 (0.85–1.27)0.52; <0.001 (0.44–0.62)0.64; <0.001 (0.52–0.80)
 90th vs. 10th percentile0.56; <0.001 (0.45–0.69)0.60; <0.001 (0.47–0.77)0.91; 0.24 (0.78–1.07)0.98; 0.81 (0.80–1.19)1.93; <0.001 (1.62–2.30)1.60; <0.001 (1.29–1.98)
E2—; 0.002—; 0.69—; 0.005—; 0.05—; <0.001—; 0.008
 >10th–<90th vs. 10th percentile1.05; 0.002 (1.02–1.09)1.01; 0.59 (0.97–1.05)1.05; 0.002 (1.02–1.08)1.05; 0.02 (1.01–1.08)0.90; <0.001 (0.87–0.92)0.94; 0.002 (0.90–0.98)
 90th vs. 10th percentile0.93; 0.001 (0.90–0.97)0.98; 0.43 (0.94–1.03)0.96; 0.02 (0.93–0.99)0.96; 0.05 (0.92–1.00)1.13; <0.001 (1.10–1.17)1.07; 0.005 (1.02–1.12)
tT/E2 ratio—; 0.003—; 0.006—; 0.12—; 0.04—; <0.001—; <0.001
 >10th–<90th vs. 10th percentile1.00; 0.001 (0.88–4.37)1.27; 0.003 (1.10–1.33)1.15; 0.07 (1.13–3.69)1.55; 0.02 (0.68–1.15)0.85; <0.001 (0.80–0.90)0.85; <0.001 (0.80–0.90)
 90th vs. 10th percentile1.30; 0.02 (1.26–2.41)0.85; 0.04 (0.52–1.29)0.91; 0.24 (0.49–3.94)0.81; 0.01 (0.47–1.85)1.17; <0.001 (1.10–1.24)1.17; <0.001 (1.10–1.24)
SHBG0.96; 0.05 (0.92–0.99)0.98; 0.41 (0.94–1.02)0.97; 0.12 (0.95–1.01)1.02; 0.29 (0.98–1.05)1.03; 0.13 (0.95–1.01)1.03; 0.15 (0.90–1.06)1.01; 0.07 (1.00–1.02)1.00; 0.66 (0.99–1.02)1.01; 0.15 (1.00–1.02)

NOTE: Restricted cubic spline functions with 3 knots tested the potential nonlinear association between predictors and NCCN Guidelines prostate cancer risk classes. Two models were developed: model 1 included age, BMI, and continuously coded tT, E2, and SHBG levels; model 2 included age, BMI, and tT–E2 ratio values.

Abbreviations: MVA, multivariate; UVA, univariate.