Table 3.

Pathways genetically targeted in the majority of pancreatic cancers

Apoptosis
DNA damage control
Regulation of G1–S phase transition
Hedgehog signaling
Homophilic cell adhesion
Integrin signaling
c-jun N-terminal kinase signaling
KRAS signaling
Regulation of invasion
Small GTPase–dependent signaling (other than KRAS)
TGF-β signaling
Wnt/Notch signaling

Data from Jones et al. (4)