Table 5.

Pharmacokinetic parameters for carfilzomib (11, 15, 20, and 27 mg/m2 on cycle 1, day 1)

11 mg/m215 mg/m220 mg/m227 mg/m2
n = 3n = 3n = 8n = 5
Cmax, ng/mL
t1/2, min
CL, mL/minute
Vss, L
AUClast, ng min/mL

Abbreviations: AUClast, area under curve to last measurable time point (includes C0); CL, systemic clearance; Cmax, maximum plasma concentration; SD, standard deviation; t1/2, elimination half-life; Vss, volume of distribution at steady state.