Table 5.

Pharmacokinetic parameters for carfilzomib (11, 15, 20, and 27 mg/m2 on cycle 1, day 1)

11 mg/m215 mg/m220 mg/m227 mg/m2
n = 3n = 3n = 8n = 5
Cmax, ng/mL
 Mean505143528406
 SD±485±97±406±517
t1/2, min
 Mean12.913.139.426.8
 SD±6.5±3.6±28.8±4.7
CL, mL/minute
 Mean10,43730,34210,97974,575
 SD±10,973±23,890±5,880±108,935
Vss, L
 Mean68.4199.1108.41539
 SD±79.5±116.6±71.2±2,862
AUClast, ng min/mL
 Mean4,0491,4144,9113,409
 SD±3,695±919±3,495±3,964

Abbreviations: AUClast, area under curve to last measurable time point (includes C0); CL, systemic clearance; Cmax, maximum plasma concentration; SD, standard deviation; t1/2, elimination half-life; Vss, volume of distribution at steady state.