Table 3.

Biochemical IC50 values for inhibition of PDGFRA kinase activity in CHO cells expressing compound-mutant kinases

KinaseExonsImatinibCrenolanibP
V561D +T674I12 + 14>1,000>1,0000.99
V561D + D842V12 + 18>1,00026 ± 60.0002
T674I + D842V14 + 18>1,00024 ± 120.006

NOTE: The values for crenolanib and imatinib represent the biochemical IC50 expressed in nmol/L units ± the SEM. Values represent the data from at least 3 replicate experiments per mutation.