Table 3.

Drug-related adverse events of all grades (incidence >10%), and corresponding rates of grade ≥3 adverse events (or those with an incidence >5%) observed in patients treated with MLN8237

N = 87
Adverse eventAll gradesGrade ≥3
Patients with at least one drug-related adverse event, n (%)85 (98)38 (44)
 Fatigue40 (46)3 (3)
 Nausea40 (46)1 (1)
 Neutropenia37 (43)26 (30)
 Alopecia36 (41)0
 Somnolence31 (36)2 (2)
 Diarrhea29 (33)6 (7)
 Anemia28 (32)7 (8)
 Vomiting23 (26)1 (1)
 Anorexia21 (24)0
 Stomatitis21 (24)1 (1)
 Thrombocytopenia10 (11)5 (6)
 Febrile neutropenia7 (8)7 (8)