Table 3.

Meta-analysis results for prognostic significance of specific VEGF polymorphisms

VEGF SNPsPooled HRs from meta-analysis, (95% CI); P value
Combined heterozygosity and homozygosity results
−2578C>A0.92 (0.65–1.29); P = 0.62
−1154G>A1.07 (0.81–1.41); P = 0.63
−460T>C1.05 (0.78–1.43); P = 0.73
+405G>C0.74 (0.60–0.91); P = 0.004
+936C>T1.15 (0.86–1.53); P = 0.35
Zygosity-segregated meta-analysis results
VEGF SNPsComparisonZygosity-specific HRs from meta-analysis, (95% CI); P valueSubgroup differences P valueOverall pooled HRs from meta-analysis (95% CI)Overall P value
−2578C>AA/A vs. C/C0.93 (0.55–1.59); P = 0.790.980.91 (0.72–1.14)0.41
C/A vs. C/C0.93 (0.79–1.08); P = 0.33
−1154G>AA/A vs. G/G0.93 (0.55–1.58); P = 0.800.450.98 (0.72–1.33)0.71
G/A vs. G/G1.18 (0.89–1.56); P = 0.26
−460T>CC/C vs. T/T1.10 (0.79–1.53); P = 0.560.771.06 (0.89–1.27)0.52
T/C vs. T/T1.04 (0.84–1.29); P = 0.72
+405G>CC/C vs. G/G0.78 (0.58–1.04); P = 0.090.720.79 (0.67–0.94)0.007
G/C vs. G/G0.83 (0.68–1.00); P = 0.05
+936C>TT/T vs. C/C1.72 (0.79–3.75); P = 0.180.351.38 (0.96–1.97)0.08
C/T vs. C/C1.13 (0.78–1.64); P = 0.51

NOTE: Meta-analysis results for 5 commonly evaluated polymorphisms from our systematic review. Results from the pooled meta-analysis, in which studies were compared regardless of zygosity, are shown in the upper part of the table. Results from our zygosity-segregated analysis are shown in the lower part of the table. “Subgroup differences” measured whether there was a significant difference in the overall HRs between the 2 zygosity groups. The “Overall pooled HRs from meta-analysis” and “Overall P value” represent results when both homozygous and heterozygous results were pooled together. SNP, single-nucleotide polymorphism.