VEGF SNPs | Pooled HRs from meta-analysis, (95% CI); P value | ||||
---|---|---|---|---|---|

Combined heterozygosity and homozygosity results | |||||

−2578C>A | 0.92 (0.65–1.29); P = 0.62 | ||||

−1154G>A | 1.07 (0.81–1.41); P = 0.63 | ||||

−460T>C | 1.05 (0.78–1.43); P = 0.73 | ||||

+405G>C | 0.74 (0.60–0.91); P = 0.004 | ||||

+936C>T | 1.15 (0.86–1.53); P = 0.35 | ||||

Zygosity-segregated meta-analysis results | |||||

VEGF SNPs | Comparison | Zygosity-specific HRs from meta-analysis, (95% CI); P value | Subgroup differences P value | Overall pooled HRs from meta-analysis (95% CI) | Overall P value |

−2578C>A | A/A vs. C/C | 0.93 (0.55–1.59); P = 0.79 | 0.98 | 0.91 (0.72–1.14) | 0.41 |

C/A vs. C/C | 0.93 (0.79–1.08); P = 0.33 | ||||

−1154G>A | A/A vs. G/G | 0.93 (0.55–1.58); P = 0.80 | 0.45 | 0.98 (0.72–1.33) | 0.71 |

G/A vs. G/G | 1.18 (0.89–1.56); P = 0.26 | ||||

−460T>C | C/C vs. T/T | 1.10 (0.79–1.53); P = 0.56 | 0.77 | 1.06 (0.89–1.27) | 0.52 |

T/C vs. T/T | 1.04 (0.84–1.29); P = 0.72 | ||||

+405G>C | C/C vs. G/G | 0.78 (0.58–1.04); P = 0.09 | 0.72 | 0.79 (0.67–0.94) | 0.007 |

G/C vs. G/G | 0.83 (0.68–1.00); P = 0.05 | ||||

+936C>T | T/T vs. C/C | 1.72 (0.79–3.75); P = 0.18 | 0.35 | 1.38 (0.96–1.97) | 0.08 |

C/T vs. C/C | 1.13 (0.78–1.64); P = 0.51 |

NOTE: Meta-analysis results for 5 commonly evaluated polymorphisms from our systematic review. Results from the pooled meta-analysis, in which studies were compared regardless of zygosity, are shown in the upper part of the table. Results from our zygosity-segregated analysis are shown in the lower part of the table. “Subgroup differences” measured whether there was a significant difference in the overall HRs between the 2 zygosity groups. The “Overall pooled HRs from meta-analysis” and “Overall *P* value” represent results when both homozygous and heterozygous results were pooled together. SNP, single-nucleotide polymorphism.