Table 3.

TRC105 pharmacokinetic at 3, 10, and 15 mg/kg

Dose level
Parameter3 mg/kg10 mg/kg15 mg/kg
No. of patients367
Tmax, h
 Median555
 Range4,54,84,5
Cmax, μg/mL
 Mean72.6269456
 SD18.064.5133
AUC0–∞, h × μg/mL
 Mean1,0019,01633,240
 SD3236,4078,808
Terminal t1/2, h
 Mean7.4310.842.8
 SD5.6–9.95.0–24.727.7–66.3
CL, mL/kg/h
 Mean3.001.110.464
 SD1.4–6.50.64–1.930.36–0.59