Table 4.

Colorectal cancer patient mortality among the 7 most common KRAS codon 12–13 mutations in 1075 BRAF wild-type cases

Colorectal cancer–specific mortalityOverall mortality
KRASBRAFTotal NNo. of eventsUnivariate HR (95% CI)Multivariate HR (95% CI)No. of eventsUnivariate HR (95% CI)Multivariate HR (95% CI)
Wild typeWild type6351491 (referent)1 (referent)2751 (referent)1 (referent)
c.34G>A (p.G12S)Wild type1262.61 (1.15–5.91)1.03 (0.44–2.44)71.63 (0.77–3.47)0.96 (0.44–2.08)
P = 0.022NSNSNS
c.34G>C (p.G12R)Wild type854.22 (1.72–10.4)3.39 (1.28–9.00)62.79 (1.24–6.31)3.19 (1.32–7.69)
P = 0.0017P = 0.014P = 0.014P = 0.010
c.34G>T (p.G12C)Wild type44161.70 (1.01–2.85)1.56 (0.92–2.65)251.48 (0.98–2.24)1.42 (0.93–2.17)
P = 0.045NSNSNS
c.35G>A (p.G12D)Wild type155491.47 (1.07–2.04)1.08 (0.76–1.51)791.38 (1.07–1.77)1.16 (0.89–1.51)
P = 0.019NSP = 0.013NS
c.35G>C (p.G12A)Wild type1961.36 (0.60–3.08)0.56 (0.24–1.30)91.03 (0.53–2.01)0.60 (0.31–1.19)
NSNSNSNS
c.35G>T (p.G12V)Wild type93371.84 (1.28–2.64)2.00 (1.38–2.90)571.61 (1.21–2.14)1.54 (1.15–2.07)
P = 0.0010P = 0.0003P = 0.0012P = 0.0042
c.38G>A (p.G13D)Wild type103311.33 (0.90–1.96)0.88 (0.59–1.30)521.21 (0.90–1.62)0.98 (0.72–1.35)
NSNSNSNS

NOTE: The multivariate Cox regression model included the same set of covariates selected as in Table 3. A P value for significance was adjusted for multiple hypothesis testing to P = 0.05/7 = 0.007. Thus, a P value between 0.05 and 0.007 should be regarded as of borderline significance.

Abbreviation: NS, not significant.