Table 4.

Calculated sirolimus pharmacokinetics

Dose cohort (mg)NCL/F, l/h (SD)Tmax, h (SD)Cmax, ng/mL (SD)AUC, ng*h/mL (SD)
10616.922 (6.08)2.3 (0.01)9.67 (2.48)615 (130)
20718.736 (11.0)2.3 (0.09)19.27 (5.69)1,084 (581)
30616.148 (10.4)2.3 (0.16)43.47 (8.43)2,713 (1,346)
60819.588 (13.6)2.2 (0.16)57.72 (22.6)3,142 (1,680)
30, 4 hours apart (total 60 mg)519.786 (15.2)2.2 (0.17)32.93 (10.7)2,054 (1,123)
30, 24 hours apart (total 60 mg)317.087 (2.90)2.3 (0.17)83.87 (18.8)3,677 (1,460)
45, 24 hours apart (total 90 mg)226.842 (1.1)2.1 (0.02)42.75 (0.08)3,356 (138)

NOTE: Mean values are shown for each parameter.