Table 2.

Effects of therapy with danusertib on the growth of subcutaneous human GEP-NET xenografts in NOD/SCID mice

ExperimentNumberInitial (mm3) mean ± SDFinal (mm3) mean ± SDFinal (% growth) median ± SD
BON1
 Control4552.3 ± 22.6356.9 ± 224.6627.2 ± 395.4
 STZ/5-FU2944.7 ± 19.8121.1 ± 72.7a238.4 ± 194.3a
 Danusertib3547.7 ± 22.442.0 ± 332.5a,b73.9 ± 79.9a,b
QGP
 Control3549.5 ± 26.2280.9 ± 205.6436.3 ± 259.5
 STZ/5-FU2554.2 ± 23.975.3 ± 51.2a130.7 ± 86.2a
 Danusertib2245.8 ± 24.34.6 ± 9.2a,b6.3 ± 8.2a,b
  • aP < 0.001 vs. controls.

  • bP < 0.001 vs. STZ/5-FU.