Table 2.

Possibly related adverse events in more than one patient and all grade 3 and 4 events (N = 50)

0.01 (n = 3)0.03 (n = 3)0.1 (n = 6)0.3 (n = 3)1 (n = 6)0.3 (n = 3)1 (n = 6)3 (n = 3)10 (n = 3)15 (n = 4)10 qwk (n = 3)15 qwk (n = 4)Total (n = 50)Total (%)
Drug supplyNS0NS0NS0NS0NS0CHOCHOCHOCHOCHOCHOCHO
Adverse event
Infusion reaction23121918
 Grade 1 or 21221612
 Grade 3 or 411136
Anemia11223918
 Grade 1 or 21112510
 Grade 3 or 41348
Fatigue/malaise111221816
 Grade 1 or 2111221816
Headache131510
 Grade 1 or 2131510
Telangiectasia11248
 Grade 1 or 211248
Epistaxis11136
 Grade 1 or 211136
Pain1236
 Grade 1 or 21236
Vomiting11136
 Grade 1 or 211136
Arthralgia1124
 Grade 1 or 21124
Constipation1124
 Grade 1 or 21124
Diarrhea1124
 Grade 1 or 21124
Gingival bleeding1124
 Grade 1 or 21124
Nausea1124
 Grade 1 or 21124
Pyrexia224
 Grade 1 or 2224
Gastrointestinal bleed112
 Grade 3 or 4112

NOTE: Dose-limiting toxicities are given in bold and italicized. qwk, every week.