Table 3.

Genes recurrently mutated in PCNSL

GeneGene productFunction/pathwayWt codonMutant codonAmino acid changeMutation typeExome capture (n = 4)Validation exome (n = 4)Whole population (n = 29)
MYD88Signaling adaptor proteinNF-κB and JAK/STAT3 activationCTGCCGL265PNonsynonymous3311
PIM1Proviral integration site for MuLVaSer/Thr kinaseCTCTTCL177FNonsynonymous211
TBL1XR1Transducin β-like 1 X-linked receptor 1Transcriptional regulation of NF-κB and WntGATCATD421HNonsynonymous111
TCCTTCS419FNonsynonymous111
TCCACCS419TNonsynonymous111
TTTTCTF541SNonsynonymous1
GTGGTTV445VSynomynous1
  • aMolony murine leukemia virus.