Table 2.

Visual and quantitative analysis of [18F]FSPG PET compared with [18F]FDG PET

Visual analysisCancer
SubjectComparatorEfficacy variableLungBreast
PatientPathologySensitivity100% (10/10)60% (3/5)
Reference lesions defined by positive uptake on [18F]FDG PET (≤5 per patient)[18F]FDG uptakeHigher [18F]FSPG3% (1/30)0% (0/19)
Same [18F]FSPG70% (21/30)11% (2/19)
Lower [18F]FSPG27% (8/30)89% (17/19)
Total lesions on [18F]FDG[18F]FDGPercent agreement88% (59/67)41% (30/73)
New lesions on [18F]FSPG[18F]FDGN of new lesions7 in 2 patients0
Quantitative analysisCancer
SubjectVariablesPET tracerLung (n = 30)Breast (n = 19)
Reference lesions defined by positive uptake on [18F]FDG PET (≤5 per patient)SUVmax[18F]FDG13.0 ± 6.714.8 ± 1.2
[18F]FSPG7.6 ± 7.3a2.1 ± 1.5a
SUVR[18F]FDG7.7 ± 4.28.9 ± 7.9
[18F]FSPG9.7 ± 8.6b3.6 ± 5.4c
  • aP < 0.001 between [18F]FDG and [18F]FSPG.

  • bP = not significant between [18F]FDG and [18F]FSPG.

  • cP < 0.05 between [18F]FDG and [18F]FSPG.