Table 2.

Homozygous deletions (HD) and high copy gains (HCG) found in 29 PCNSLs

CytobandGenes (n)Candidate geneGene productBiologic functionEventCases (n)
6q211PRDM1PR domain zinc finger protein 1 Transcriptional repressorB-cell differentiation into plasma cellHD2
8p21.21DOCK5Dedicator of cytokinesis 5Guanine nucleotide exchange factor for GTPasesHD3
8q12.11TOXThymocyte selection-associated high mobility group boxB-cell differentiationHD1
9p211CDKN2ACyclin-dependent kinase inhibitor 2ACell-cycle G1 controlHD13
7p21.11HDAC9Histone deacetylase 9Chromatine condensationHCG1