Table 2.

Fitted VT of [11C]erlotinib and perfusion values with associated SEs (of the fit)

VT of [11C]erlotinib ± SE (unitless)Perfusion ± SE
SampleraIDIFb(mL/cm3/min1)
NEGFRScan 1Scan 2Scan 1Scan 2Scan 1Scan 2
1WT1.12 ± 0.200.90 ± 0.010.99 ± 0.110.90 ± 0.040.36 ± 0.020.30 ± 0.04
2WT0.67 ± 0.010.67 ± 0.040.69 ± 0.010.69 ± 0.020.34 ± 0.02NA
3WT1.22 ± 0.371.17 ± 0.121.31 ± 0.361.27 ± 0.140.33 ± 0.020.33 ± 0.02
4WT1.09 ± 0.021.18 ± 0.021.11 ± 0.021.17 ± 0.020.65 ± 0.030.67 ± 0.03
5Ins Ex200.90 ± 0.041.03 ± 0.040.89 ± 0.041.20 ± 0.260.43 ± 0.040.42 ± 0.03
6Ex19del1.30 ± 0.021.76 ± 0.021.33 ± 0.031.90 ± 0.040.48 ± 0.010.57 ± 0.02
7Ex19del1.84 ± 0.072.16 ± 0.101.90 ± 0.102.20 ± 0.120.56 ± 0.020.46 ± 0.01
8Ex19del1.27 ± 0.071.25 ± 0.051.33 ± 0.071.42 ± 0.070.57 ± 0.050.65 ± 0.04
9Ex19delNA2.93 ± 0.94NA2.35 ± 0.50NA0.31 ± 0.04
10Ex19del1.57 ± 0.061.77 ± 0.062.22 ± 1.501.85 ± 0.071.29 ± 0.092.07 ± 0.17
Test vs. retestICC = 0.88 (95% CI, 0.55–0.97), P < 0.001ICC = 0.85 (95% CI, 0.46–0.96), P = 0.001ICC = 0.81 (95% CI, 0.32–0.96), P = 0.004
Mutated vs. nonmutatedMann–Whitney. 2-tailedMann–Whitney, 2-tailedMann–Whitney, 2-tailed
Scan 1 P = 0.014Scan 1 P = 0.014Scan 1 P = 0.111
Scan 2 P = 0.009Scan 2 P = 0.009Scan 2 P = 0.413

NOTE: Scans 1 and 2 refer to test and retest scans.

Abbreviations: NA, not applicable; WT, wild-type.

  • aPlasma input based on continuous arterial blood sampling (standard method).

  • bIDIF input based on limited blood sampling (less invasive method).