Table 2.

Correlation between changes in level of immunologic markers and disease control in patients treated with ipilimumab (41)

MarkerPatients, nMedian change between baseline and week 12, % (range)P value
LDHNo response3242.3 (−74.7; 411.5)<0.0001
Disease control25−15.8 (−78.8; 105.9)
CRPNo response3528.6 (−100; 4,940)<0.0001
Disease control27−60.3 (−100; 400)
WBCNo response5426.7 (−51; 337)0.13
Disease control3417.6 (−51; 137)
ALCNo response55−9.1 (−79; 505)0.009
Disease control3410.4 (−38; 244)
FoxP3No response31−28.6 (−100; 5,900)0.003
Disease control27−100.0 (−100; 1,400)

Abbreviation: FoxP3, Forkhead box P3.