Table 2.

Binary logistical regression for odds of pCR after neoadjuvant chemotherapy by HR status, combined MAQC and MDACCSS cohorts

HR-positive/HER2-negativeTriple-negative
CharacteristicOR (95% CI)POR (95% CI)P
Tumor size at diagnosis (TNM)0.017
 T0/T1/T21
 T3/T40.44 (0.230.87)
Modified Black's nuclear grade0.001
 1–21
 34.30 (1.7810.42)
PAM50 intrinsic subtype0.5800.898
 Luminal A11
 Luminal B11
 HER2-enriched11
 Normal11
 Basal1.32 (0.49–3.58)1.06 (0.42–2.61)
LDHB (0.60 threshold)0.018
 Low1
 High2.86 (1.196.84)
LDHB (0.94 threshold)0.004
 Low1
 High3.18 (1.456.99)

NOTE: Characteristics were included in the models if P ≤ 0.05 by univariate analysis in at least one cohort (Table 1) or the combined cohort. Cases were excluded if all characteristics were not reported. The ORs were not statistically significant if basal-like and luminal B cases were considered as one group. Values in bold were statistically significant.