Table 4.

Cox multivariate regression analysis to evaluate the independent prognostic value of miRNAs in colorectal cancers

CombinedBlacksWhites
Prognostic variablesIndicator of poor prognosisHRa (95% CI)P valuecPrognostic variablesIndicator of poor prognosisHRa (95% CI)P valuecPrognostic variablesIndicator of poor prognosisHRa (95% CI)P valuec
All stages (N = 344)All stages (N = 106)All stages (N = 238)
miRNAmiRNATumor stage
miR-203High1.49 (1.03–2.17)0.036miR-181bHigh3.55 (1.50–8.41)0.004 II vs. III3.55 (1.08–11.63)0.038
Tumor stageTumor stage III vs. IIII6.22 (1.90–20.37)0.002
 II vs. III1.60 (0.75–3.40)0.224 II vs. III0.80 (0.27–2.40)0.701 IV vs. IIV26.43 (7.91–88.32)<0.0001
 III vs. IIII2.97 (1.41–6.28)0.004 III vs. IIII2.38 (0.83–6.79)0.107
 IV vs. IIV10.11 (4.66–21.93)<0.0001 IV vs. IIV4.19 (1.31–13.41)0.017Tumor grade
Tumor gradeTumor location High vs. lowHigh1.54 (0.99–2.38)0.057
 High vs. lowHigh1.60 (1.13–2.28)0.009Proximal colon vs. RectumProximal colon1.60 (1.13–2.28)0.061
Distal colon vs. RectumDistal colon1.43 (0.33–6.21)0.644
Tumor grade
 High vs. lowHigh2.21 (1.14–4.29)0.019
Stage I + II (N = 184)Stage I + II (N = 55)Stage I + II (N = 129)
Tumor grademiRNATumor grade
 High vs. lowHigh1.68 (0.86–3.28)0.132miR-203High5.63 (1.03–30.64)0.046 High vs. lowHigh1.52 (0.60–3.83)0.382
Tumor grade
 High vs. lowHigh3.67 (1.30–10.37)0.015
Stage III (N = 105)Stage III (N = 35)Stage III (N = 70)
miRNAmiRNATumor grade
miR-203High1.90 (1.05–3.42)0.034miR-181bHigh7.94 (1.60–39.30)0.012 High vs. lowHigh1.40 (0.63–3.12)0.416
Tumor gradeTumor grade
 High vs. lowHigh1.27 (0.66–2.42)0.480 High vs. lowHigh0.28 (0.03–2.42)0.249
Stage IV (N = 55)Stage IVb (N = 16)Stage IV (N = 39)
miRNAmiRNA
miR-21High3.25 (1.37–7.72)0.008miR-21High2.50 (1.07–5.83)0.034
miR-203High2.19 (1.10–4.33)0.026miR-203High3.01 (1.30–6.98)0.011
Tumor gradeTumor grade
 High vs. lowHigh3.76 (1.85–7.63)0.0003 High vs. lowHigh3.12 (1.29–7.53)0.012
  • aAdjusted for miRNA expression levels, age, gender, TNM tumor stage, tumor location within the colorectum, tumor grade, tumor size, and race (for analyses of the Combined patient population); CI, confidence interval.

  • bBecause the small number of available cases, multivariate analyses was not completed for stage IV black colorectal cancer patients.

  • cAdjustment for multiple comparisons has been made for the P values using the Benjamini–Hochberg method.