Measurable lesions | ≥5 × 5 mm^{2} by bidimensional measurements | ≥10 mm in the longest diameter |

Measurement of each lesion | The longest diameter × the longest perpendicular diameter (cm^{2}) | The longest diameter (cm) |

The sum of the measurements | The sum of the bidimensional measurements of all target lesions and new lesions if any | The sum of the longest diameters of all target lesions and new lesions if any |

Response assessment | PD: ≥25% increase from the nadir | PD: ≥20% increase from the nadir |

| PR: ≥50% decrease from baseline | PR: ≥30% decrease from baseline |

| CR: Disappearance of all lesions | CR: Disappearance of all lesions |

New lesions | The presence of new lesion(s) does not define progression. The measurements of the new lesion(s) are included in the sum of the measurements. |

Confirmation | Confirmation by 2 consecutive observations not less than 4 weeks apart was required for CR, PR, and PD |