Table 1.

Parameter estimates from the logistic regression model for ipilimumab exposure–response relationships

Exposure–response modelPredictorOR coefficient (95%CI)aPMedian Cminss (5th–95th percentile) [μg/mL]OR: 5th percentile: median of Cminss (95%CI)OR: 95th percentile: median of Cminss (95%CI)
BORLog(Cminss)b2.41 (1.66–4.26)<0.0149.3 (1.75–110)0.0531 (0.00742–0.38)2.03 (1.26–3.26)
irRCLog(Cminss)b1.76 (1.35–2.54)<0.00147.7 (1.61–106)0.146 (0.0551–0.387)1.58 (1.25–1.99)
irAEsLog(Cminss)b1.91 (1.58–2.38)<0.00143.9 (1.75–103)0.124 (0.0653–0.237)1.74 (1.46–2.06)
  • a95% CI obtained from bootstrap (N = 500).

  • bCminss was log-transformed. Log(Cminss) increases by one unit for approximately 2.7-fold increase in Cminss.