Table 2.

Transcriptional alteration caused by HSP90 inhibition in NF2-deficient Schwann cells ESC-FC1801

GO IDDescriptionPGenes (fold change up)Genes (fold change down)
In vitro
GO:0007049/GO:0022402 GO:0051301 GO:0007059Cell cycle/Cell cycle process Cell division Chromosome segregation1.60E-46Arhgap8, Camk2a, Cdc2l1, Cgref1, Chfr, Dusp1, Gadd45a, Mtus1, Pmp22, Ppp1cc, Rgs2, Sept4, Tex15, Usp162610039C10Rik, 4632434I11Rik, AC102494.1, Anapc1, Anapc7, Anln, Appl2, Aspm, Aurka, Aurkb, B230120H23Rik, Birc5, Brca1, Brca2, Bub1, Bub1b, C79407, Ccdc99, Ccna2, Ccnb1, Ccnb2, Ccnd1, Ccnf, Cdc123, Cdc14a, Cdc23, Cdc25c, Cdc45l, Cdc6, Cdc7, Cdca2, Cdca3, Cdca5, Cdca8, Cdkn3, Cenpe, Cenpf, Cenph, Cep110, Cep55, Chaf1a, Chaf1b, Chek2, Cit, Ckap2, Ckap5, Cks1b, Clspn, Cntrob, Ddx11, Dlgap5, Dscc1, E2f8, Ercc6l, Esco2, Espl1, Exo1, F630043A04Rik, Fam83d, Fancd2, Fanci, Gas2l3, Gsg2, Haus1, Haus5, Hells, Hjurp, Incenp, Kif11, Kif18a, Kif20b, Kntc1, Lig1, Lin9, Mcm8, Mdc1, Mki67, Mlh1, Mre11a, Myh10, Nasp, Ncapd2, Ncapd3, Ncapg2, Ndc80, Nde1, Nek1, Nek2, Nsl1, Nuf2, Nup43, Nusap1, Oip5, Plk1, Pms2, Pola1, Prc1, Prdm9, Psrc1, Pttg1, Racgap1, Rad50, Rad51, Rad51c, Rbbp8, Rbl1, Sass6, Sept10, Sept3, Sept6, Sept9, Sgol1, Sgol2, Ska1, Smc2, Spag5, Spc25, Steap3, Stmn1, Suv39h1, Suv39h2, Tacc3, Tial1, Timeless, Tpx2, Top2a, Trip13, Ube2c, Uhrf1, Wee1, Zfp318, Zwilch
GO:0048285 GO:0051640 GO:0051303Organelle fission Organelle localization Establishment of chromosome localization3.77E-29Chfr, Fis1, Usp162610039C10Rik, AC102494.1, Anapc1, Anapc7, Anln, Aspm, Aurkb, Birc5, Bub1, Bub1b, C79407, Ccdc99, Ccna2, Ccnb1, Ccnb2, Ccnf, Cdc23, Cdc25c, Cdc6, Cdca2, Cdca3, Cdca5, Cdca8, Cenpe, Cenpf, Cenph, Cep55, Cit, Ckap5, Ercc6l, F630043A04Rik, Fam83d, Haus1, Haus5, Hells, Incenp, Kif11, Kif18a, Kif20b, Kntc1, Ncapd2, Mlh1, Myh10, Myo5a, Ncapd3, Ncapg2, Ndc80, Nde1, Nek1, Nek2, Nsl1, Nuf2, Nup43, Nusap1, Oip5, Plk1, Plxna2, Pttg1, Sema6a, Sgol1, Ska1, Smc2, Spag5, Spc25, Tacc3, Timeless, Ube2c, Wee1, Zwilch
GO:0006259 GO:0006974 GO:0006260DNA metabolic process Response to DNA damage stimulus DNA replication3.51E-19Atrip, Gadd45a, Giyd2, Sgk10610007P08Rik, Atad5, Atr, Bard1, Blm, Bnip3, Brca1, Brca2, Brip1, Ccdc111, Cdc45l, Cdc6, Chaf1a, Chaf1b, Chek2, Clspn, Dclre1b, Dclre1c, Dna2, Dscc1, Dtl, Eme1, Endog, Ercc2, Esco2, Exo1, Fam175a, Fancb, Fancd2, Fancg, Fanci, Gen1, Gins2, Hells, Hmgb2, Kif22, Lig1, Lin9, Mcm10, Mcm8, Mdc1, Mlh1, Mpg, Mre11a, Nasp, Neil3, Nek1, Orc3l, Parp2, Pms2, Pola1, Pola2, Pold3, Pole, Pole2, Polg, Poli, Polm, Polq, Pot1a, Prim1, Prim2, Pttg1, Rad18, Rad50, Rad51, Rad51ap1, Rad51c, Recql4, Rfc3, Rfc4, Rtel1, Timeless, Top2a, Trip13, Ttn, Uhrf1, Xrcc2, Xrcc5
GO:0007017Microtubule-based process1.47E-08Gadd45a, Klc1Birc5, Brca1, Ccdc99, Cenpe, Ckap5, Cntrob, Espl1, Haus1, Haus5, Kif11, Kif14, Kif15, Kif16b, Kif18a, Kif18b, Kif20a, Kif20b, Kif22, Kif23, Kif2c, Kif4, Kif9, Mlh1, Nav1, Ndc80, Nde1, Nuf2, Nusap1, Psrc1, Spc25, Stmn1, Tacc3, Tpx2, Tubd1, Tube1
GO:0000910Cytokinesis2.42E-06Anln, Aurkb, Birc5, Brca2, Cit, Cntrob, Incenp, Myh10, Nusap1, Prc1, Racgap1
GO:0048168Regulation of neuronal synaptic plasticity1.48E-05Camk2a, Hras1, SncaBhlhe40, Dlg4, Egr2, Grik2, Nf1, Rims1, Syngr1
GO:0006796Phosphate metabolic process5.74E-05Bmp2k, Camk2a, Cdc2l1, Dclk3, Dusp1, Dusp14, Epha4, F2r, Gadd45g, Gnptab, Lpar3, Lyn, Map3k14, Mast2, Nrbp2, Pink1, Ppm1l, Ppp1cc, Prkci, Prkcq, Prkd1, Ptpn14, Ptprm, Sgk1, Snca, Snrk, Styk1, Tek, Tgfa, Tgfb2AC102494.1, Acvrl1, Adrbk2, Atr, Aurka, Aurkb, B230120H23Rik, BC030499, Bub1, Bub1b, Ccnb1, Ccnd1, Cdc14a, Cdc25c, Cdc7, Cdkn3, Chek2, Cit, Dusp6, Dusp7, Fgf2, Fgfr1, Gsg2, Gyk, Ick, Map2k3, Mapk9, Mastl, Melk, Mertk, Mtm1, Nek1, Nek2, Pask, Pbk, Pdik1l, Pdk1, Pdp1, Plk1, Plk4, Prkd3, Ptpn6, Rps6ka1, Rps6ka6, Tnk2, Ttn, Ulk4, Vrk1, Vrk3, Wee1, Wnk3, Wnk4, Wnt5a
GO:0006323DNA packaging9.23E-05Aifm2Asf1b, Cdca5, Cenpa, H2afz, Hells, Hist1h1b, Hist1h2bl, Hist1h4c, Hist1h4d, Hjurp, Ncapd2, Ncapd3, Ncapg2, Nusap1, Smarca2, Smc2, Suv39h1, Top2a
In vivo
GO:0007155 GO:0022610Cell adhesion Biologic adhesion6.90E-11Adam23, Arvcf, Cadm4, Cdh13, Cdh19, Cdh26, Chl1, Col16a1, Col20a1, Col27a1, Col5a3, Ddr1, Dlg1, Fat4, Gpnmb, Hes1, Hspg2, Itga6, Itga7, Itgav, Itgb8, Lama2, Lamb1-1, Mcam, Megf10, Msln, Nid1, Npnt, Nrcam, Pcdh10, Pcdh20, Ptprf, Sorbs1, Sympk, Thbs4, Tnc, Ttyh1, Wnt7bAcan, Adam12, Amigo2, App, Cd34, Cd36, Cd44, Cd93, Cdh3, Cdh5, Col12a1, Dchs1, Fbln5, Fn1, Lgals1, Lgals3bp, Pecam1, Ror2, Spp1, Tek, Wisp1
GO:0043062 GO:0030198Extracellular structure organization Extracellular matrix organization2.68E-07Adamts14, Cacna1a, Chrna1, Col5a3, Hspg2, Lrp4, Nid1, Npnt, Tnc, Vwa1, Wnt7bAcan, Apbb2, App, Atp7a, Ccdc80, Col3a1, Fbln5, Lgals3, Mmp9, Nrg1, Serpinh1, Tfip11
GO:0042552 GO:0007422Myelination Peripheral nervous system dev.1.87E-05Erbb3, Gal3st1, Gjc3, Lgi4, Mbp, Nab2, Plp1, Pmp22, Pou3f1, Scd2, Sox10Nrg1
GO:0030030 GO:0030031Cell projection organization Cell projection assembly3.28E-05Cacna1a, Ccdc88a, Chl1, Dclk1, Dnaic2, Fgd3, Fgd4, Gas7, Itga6, Kif3a, Lamb1-1, Mtap2, Nefl, Ngfr, Nrcam, Numb, Prkg1, Ptprz1, Rpl24, Rtn4rl2, Sema4f, Sema6c, Ttyh1, Tubb4Apbb2, App, Atp7a, Clu, Lpar1, Slc11a2, Vav3
GO:0042325 GO:0051338Phosphorylation Transferase activity5.68E-04Ccdc88a, Cenpe, Dlg1, Fgd4, Gnai2, Lats2, Madd, Mdfic, Pdgfrb, Sh3bp5App, Atp7a, Cd74, Dusp9, Egfr, Fabp4, Ghr, Hbb-b1, Hbb-b2, Lpar1, Map2k6, Map3k5, Nrg1, Prkce, Rgma, Spry1, Vav3
GO:0046578Regulation of Ras protein signal transduction1.91E-03Arap3, Arhgef10l, Fgd3, Fgd4, Kalrn, Plekhg2, Tbc1d24Evi5, Farp1, Git2, Iqsec2, Kras, Lpar1, Nrg1, Rabgap1, Spry1, Tbc1d1, Vav3
GO:0044271Cellular nitrogen compound biosynthetic process2.21E-03Adc, Adcy1, Atp6v0b, Hdc, Mipol1, Nmnat2, Ppox, Prodh, Qtrtd1, Rp2hAdcy7, Asns, Atp1b1, Atp2a1, Atp5o, Atp7a, Bcat1, Ldhd, Nos3, Paics, Prps1l1, Psph, Qprt, Rora, Rrm2b, Slc11a2
GO:0006029Proteoglycan metabolic process2.43E-03AC127554.1, SgshAcan, Bgn, Csgalnact2, Glce, Spock3
GO:0021675 GO:0021545Nerve development Cranial nerve development3.01E-03Erbb3, Hes1, Ngfr, Rpl24Hoxb2, Hoxb3
GO:0001501Skeletal system development3.92E-03Dlg1, Gja5, Gpnmb, Hspg2, Nab2, Pdgfrb, Smad3, Sox6Acan, Acd, Atp7a, Col1a1, Fmn1, Hoxb2, Hoxb3, Lgals3, Mmp13, Mmp14, Mmp9, Mn1, Osr2, Ror2, Spp1
GO:0009628Response to abiotic stimulus4.12E-03Bcl2l1, Brcc3, Cryab, Hspb7, Ngfr, Otop1, Ric8, Scara5, Sox2, Strbp, Tsc22d3App, Col1a1, Dclre1c, Hmgn1, Kras, Mmp13, Mmp14, Obfc2a, Stx1a, Usp1
GO:0001568Blood vessel development8.31E-03Apoe, Ccbe1, Gja5, Hdac7, Itga7, Itgav, Plcd3, Prl2c2, Tnfsf12AC158680.2, Anpep, Atp7a, Cdh5, Col1a1, Col3a1, Mmp14, Nos3, Sema3c, Sox18, Zfpm2
GO:0008088Axon cargo transport9.86E-03Nefm, Klc1, Klc2App