Table 1.

Patient characteristics

CharacteristicVorinostat (N = 25)Controls (N = 25)a
Median age (range)55 (34–71)52 (34–79)
Median tumor size (range)b2 cm (1.1–5.3)1.9 cm (1.0–4.8)
Tumor sizeb
 0–213 (52%)13 (52%)
 >2–511 (44%)12 (48%)
 >51 (4%)0 (0)
Nodal status
 Node-negative11 (44%)14 (56%)
 Node-positive14 (56%)11 (44%)
ER/PR Status
 ER+/PR+14 (56%)15 (60%)
 ER+/PR6 (24%)0 (0%)
 ER/PR5 (20%)10 (40%)
HER2 Status
 HER2+3 (12%)4 (16%)
 HER221 (84%)20 (80%)
 Unknown1 (4%)1 (4%)
Triple negative
 Yes4 (16%)7 (28%)
 No20 (80%)17 (68%)
 Unknown1 (4%)1 (4%)
Type of specimen collected
 Lumpectomy17 (68%)13 (52%)
 Mastectomy5 (20%)12 (48%)
 Core biopsy2 (8%)0 (0)
 None1 (4%)0 (0)
  • aTwenty-nine women enrolled but only 25 had evaluable matched samples.

  • bPathologic tumor size was recorded in 23 women, and clinical measurements on 2 women undergoing neoadjuvant chemotherapy.