Table 1.

26-Gene hypoxia signature

GeneFunction
ALDOAGlucose metabolism
ANGPTL4Lipid and glucose metabolism
ANLNCytokinesis
BNC1Keratinocyte proliferation
C20orf20Cellular proliferation
CA9pH regulation
CDKN3Cellular proliferation
COL4A6Extracellular matrix metabolism
DCBLD1Unknown
ENO1Glucose metabolism
FAM83BUnknown
FOSL1Cellular proliferation
GNAI1Signal transduction
HIG2Stress response
KCTD11Apoptosis
KRT17Keratin production
LDHAGlucose metabolism
MPRS17Mitochondrial translation
P4HA1Extracellular matrix metabolism
PGAM1Glucose metabolism
PGK1Glucose metabolism
SDC1Cellular proliferation
SLC16A1Glucose metabolism
SLC2A1Glucose metabolism
TPI1Glucose metabolism
VEGFAAngiogenesis

Abbreviations: ALDOA, aldolase A; ANGPTL4, angiopoietin-like 4; ANLN, anillin; BNC1, basonuclin 1; C20orf20, chromosome 20 open reading frame 20; CA9, carbonic anhydrase 9; CDKN3, cyclin-dependent kinase inhibitor 3; COL4A6, collagen, type IV, alpha 6; DCBLD1, discoidin, CUB and LCCL domain containing 1; ENO1, enolase 1; FAM83B, family with sequence similarity 83, member B; FOSL1, FOS-like antigen 1; GNAI1, guanine nucleotide binding protein; HIG2, hypoxia-inducible gene 2; KCTD11, potassium channel tetramerization domain containing 11; KRT17, keratin 17; LDHA, lactate dehydrogenase A; P4HA1, prolyl 4-hydroxylase; PGAM1, phosphoglycerate mutase 1; PGK1, phosphoglycerate kinase 1; SDC1, syndecan 1; SLC16A1, solute carrier family 16 member 1 (monocarboxylic acid transporter 1); SLC2A1, solute carrier family 2 (facilitated glucose transporter), member 1; TPI1, triosephosphate isomerase 1.