Table 2.

Notch1 mutation distribution in different domains

Cell line/tumorEGF repeatAbruptexLNRHDTAD
WSU-HN4C478FV2285I
WSU-HN13N623D
SCC9E848K
UMSCC22AC931×E1679×
SCC1C1397F
SCC1P1641L
SCC1P1641S
SCC4C1218Y
SCC5C1133Y
SCC9R203C
SCC9R217W
SCC9T232I
SCC9S1189F
SCC9N1347D
SCC9S1389I
SCC9P1641L
SCC9Q1733×
SCC9M1737I
SCC9R1762W
SCC10P1641S
SCC14C1133Y
SCC14N1713S
SCC15C1133Y
SCC19E606×
SCC21N1489D
SCC22Q1134R
SCC23Q1134R
SCC26E1084D
SCC26N1713S
SCC28Q1134R
SCC31N994K
SCC31P1641S
SCC32C1074Y
SCC33E424K
SCC35Q1080×
SCC35W1474×
SCC35N1713S
SCC42R1107×
SCC47N548D
SCC47E606G
SCC47P1641L
SCC47P1641S
SCC48R1107×
SCC48W1474×
SCC50E1084D
SCC51R1784Q

Abbreviations: LNR, Lin/NOTCH repeats (amino acids 1459 to 1574); HD, heterodimerization domain; RAM, RBP-JK–associated molecule region (amino acids 1757 to 1865).