Table 1.

Patient characteristics

CharacteristicsTotalHPV(+)HPV(−)Pmut-PI3KCAwt-PI3KCAP
Number of cases493316839
Sex
 Male39 (79.6%)29 (87.9%)10 (62.5%)0.0487 (87.5%)30 (76.9%)0.45
 Female10 (20.4%)4 (12.1%)6 (37.5%)1 (12.5%)9 (23.1%)
Age at Dx
 Median595668.50.00357520.098
 Range35–8035–7444–8035–6038–80
 Mean595564.649.460.2
Staginga
 T1–T229 (65.9%)21 (67.7%)9 (56.3%)4 (66.7%)23 (65.7%)
 T3–T415 (34.1%)10 (32.3%)7 (43.7%)0.322 (33.3%)12 (34.3%)0.67
 N06 (13.6%)3 (9.7%)3 (18.8%)0 (0%)6 (17.1%)
 N1–338 (86.4%)28 (90.3%)13 (81.2%)0.416 (100%)29 (82.9%)0.5
 I–II4 (9.1%)2 (6.5%)2 (12.5%)0 (0%)4 (11.4%)
 III–IV40 (90.9%)29 (93.5%)14 (87.5%)0.426 (100%)31 (88.6%)0.52
Smoking history
 Smoker32 (65.3%)17 (51.51%)15 (93.75%)0 (0%)26 (70.3%)
 Non-smoker14 (28.6%)13 (39.39%)1 (6.25%)0.0096 (85.7%)8 (21.6%)0.0008
 N/Ab3 (6.1%)3 (9.1%)0 (0%)1 (14.3%)3 (8.1%)
Treatment
 RT-Chemo9 (18.4%)5 (15.2%)4 (25.0%)4 (10.3%)1 (12.5%)
 Surgery-RT-Chemo4 (8.2%)4 (12.1%)0 (0%)2 (5.1%)2 (25.0%)
 Chemo-RT-Chemo11 (22.5%)8 (24.2%)3 (18.7%)7 (17.8%)3 (37.5%)
 Chemo-RT-Chemo-surgery1 (2.0%)1 (3.0%)0 (0%)0 (0%)0 (0%)
 Surgery4 (8.2%)1 (3.0%)3 (18.7%)4 (10.3%)0 (0%)
 Surgery-RT6 (12.2%)5 (15.2%)1 (6.3%)6 (15.4%)0 (0%)
 Chemo-RT3 (6.1%)0 (0%)3 (18.7%)6 (15.4%)0 (0%)
 Chemo1 (2.0%)0 (0%)1 (6.3%)1 (2.6%)0 (0%)
 N/Ab10 (20.4%)9 (27.3%)1 (6.3%)9 (23.1%)2 (25.0%)
  • aFour patients had unknown tumor–node–metastasis staging status.

  • bNo information available for smoking status (3/49).